Genular: Defining Cellular Identity and Function

Details for: Grpr

Gene ID: 14829

Symbol: Grpr

Ensembl ID: ENSMUSG00000031364

Description: gastrin releasing peptide receptor

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Bombesin receptor activity
(GO:0004946)
G protein-coupled peptide receptor activity
(GO:0008528)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Learning or memory
(GO:0007611)
Membrane
(GO:0016020)
Motor behavior
(GO:0061744)
Neuropeptide binding
(GO:0042923)
Neuropeptide receptor activity
(GO:0008188)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of behavioral fear response
(GO:2000987)
Positive regulation of respiratory gaseous exchange
(GO:1903942)
Protein binding
(GO:0005515)
Psychomotor behavior
(GO:0036343)
Regulation of cell population proliferation
(GO:0042127)
Response to external biotic stimulus
(GO:0043207)
Signal transduction
(GO:0007165)
Social behavior
(GO:0035176)

Other Information

Proteins

Gastrin-releasing peptide receptor

Genular Protein ID: 4106954228

Symbol: GRPR_MOUSE

Name: Gastrin-releasing peptide receptor

UniProtKB Accession Codes:

P21729 Q53WV4

Database IDs:

Citations:

PubMed ID: 1671171

Title: Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.

PubMed ID: 1671171

DOI: 10.1073/pnas.88.2.395

PubMed ID: 1707129

Title: Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor.

PubMed ID: 1707129

DOI: 10.1210/mend-4-12-1956

PubMed ID: 8391296

Title: Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.

PubMed ID: 8391296

DOI: 10.1007/bf02736689

PubMed ID: 10689196

Title: Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter.

PubMed ID: 10689196

DOI: 10.1016/s0378-1119(99)00563-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9345264

Title: Generation and characterization of mice lacking gastrin-releasing peptide receptor.

PubMed ID: 9345264

DOI: 10.1006/bbrc.1997.7418

PubMed ID: 12526815

Title: Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear.

PubMed ID: 12526815

DOI: 10.1016/s0092-8674(02)01116-9

PubMed ID: 12176666

Title: Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice.

PubMed ID: 12176666

DOI: 10.1677/joe.0.1740273

PubMed ID: 17653196

Title: A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord.

PubMed ID: 17653196

DOI: 10.1038/nature06029

PubMed ID: 26658875

Title: GRPR/PI3Kgamma: partners in central transmission of itch.

PubMed ID: 26658875

DOI: 10.1523/jneurosci.2310-15.2015

PubMed ID: 26855425

Title: The peptidergic control circuit for sighing.

PubMed ID: 26855425

DOI: 10.1038/nature16964

PubMed ID: 28280205

Title: Molecular and neural basis of contagious itch behavior in mice.

PubMed ID: 28280205

DOI: 10.1126/science.aak9748

PubMed ID: 34610277

Title: Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories.

PubMed ID: 34610277

DOI: 10.1016/j.cell.2021.09.013

Sequence Information:

Length: 384
Mass: 43215
Checksum: BF6D60387AA09A2C
Sequence:

MAPNNCSHLN LDVDPFLSCN DTFNQSLSPP KMDNWFHPGF IYVIPAVYGL IIVIGLIGNI 
TLIKIFCTVK SMRNVPNLFI SSLALGDLLL LVTCAPVDAS KYLADRWLFG RIGCKLIPFI 
QLTSVGVSVF TLTALSADRY KAIVRPMDIQ ASHALMKICL KAALIWIVSM LLAIPEAVFS 
DLHPFHVKDT NQTFISCAPY PHSNELHPKI HSMASFLVFY VIPLAIISVY YYFIARNLIQ 
SAYNLPVEGN IHVKKQIESR KRLAKTVLVF VGLFAFCWLP NHVIYLYRSY HYSEVDTSML 
HFVTSICARL LAFTNSCVNP FALYLLSKSF RKQFNTQLLC CQPGLMNRSH STGRSTTCMT 
SFKSTNPSAT FSLINRNICH EGYV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grpr

Associated with

Other Information

Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. PubMed ID: 1671171

Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor. PubMed ID: 1707129

Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. PubMed ID: 8391296

Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter. PubMed ID: 10689196

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Generation and characterization of mice lacking gastrin-releasing peptide receptor. PubMed ID: 9345264

Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. PubMed ID: 12526815

Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice. PubMed ID: 12176666

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. PubMed ID: 17653196

GRPR/PI3Kgamma: partners in central transmission of itch. PubMed ID: 26658875

The peptidergic control circuit for sighing. PubMed ID: 26855425

Molecular and neural basis of contagious itch behavior in mice. PubMed ID: 28280205

Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories. PubMed ID: 34610277