Details for: CTAG1B

Gene ID: 1485

Symbol: CTAG1B

Ensembl ID: ENSG00000184033

Description: cancer/testis antigen 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 14.5444
    Cell Significance Index: 370.5600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.9232
    Cell Significance Index: 67.0600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 3.8333
    Cell Significance Index: 49.6000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 3.1330
    Cell Significance Index: 33.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: 2.1408
    Cell Significance Index: 28.1700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.8313
    Cell Significance Index: 25.1100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3482
    Cell Significance Index: 5.0600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0220
    Cell Significance Index: 0.2600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0112
    Cell Significance Index: 0.0600
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.0068
    Cell Significance Index: 0.0300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0036
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0043
    Cell Significance Index: -0.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0044
    Cell Significance Index: -0.0900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0101
    Cell Significance Index: -0.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0122
    Cell Significance Index: -0.1200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0123
    Cell Significance Index: -0.1000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0124
    Cell Significance Index: -0.1100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0174
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0177
    Cell Significance Index: -0.1900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0199
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0224
    Cell Significance Index: -0.2100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0260
    Cell Significance Index: -0.3400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0313
    Cell Significance Index: -0.3500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0340
    Cell Significance Index: -0.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0376
    Cell Significance Index: -20.5200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0463
    Cell Significance Index: -0.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1458
    Cell Significance Index: -7.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1940
    Cell Significance Index: -6.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2184
    Cell Significance Index: -30.0000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2320
    Cell Significance Index: -2.5200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2832
    Cell Significance Index: -2.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2940
    Cell Significance Index: -6.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3929
    Cell Significance Index: -4.6400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4735
    Cell Significance Index: -7.6700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.5485
    Cell Significance Index: -4.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.5652
    Cell Significance Index: -6.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.6132
    Cell Significance Index: -6.2600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.6347
    Cell Significance Index: -7.7100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.7530
    Cell Significance Index: -8.9500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.7991
    Cell Significance Index: -8.7700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.8556
    Cell Significance Index: -8.8700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.8634
    Cell Significance Index: -7.1400
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.9842
    Cell Significance Index: -9.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.2712
    Cell Significance Index: -30.7900
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -1.2880
    Cell Significance Index: -12.7700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -1.3625
    Cell Significance Index: -13.3300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -1.5691
    Cell Significance Index: -14.6100
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -1.6440
    Cell Significance Index: -12.0700
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -1.6531
    Cell Significance Index: -8.2900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -2.0473
    Cell Significance Index: -22.1700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -2.0512
    Cell Significance Index: -20.9600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -2.5874
    Cell Significance Index: -19.5400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -2.6524
    Cell Significance Index: -21.1000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -3.0392
    Cell Significance Index: -28.8100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -3.0436
    Cell Significance Index: -38.4100
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -3.1294
    Cell Significance Index: -29.9600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -3.1990
    Cell Significance Index: -32.3200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -3.3035
    Cell Significance Index: -29.4700
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -3.5255
    Cell Significance Index: -43.8200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -3.8422
    Cell Significance Index: -29.8900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -4.8034
    Cell Significance Index: -50.6700
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -5.0490
    Cell Significance Index: -31.6100
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -6.0527
    Cell Significance Index: -27.9600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -6.1834
    Cell Significance Index: -58.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CTAG1B gene is characterized by its broad expression in multiple cell types, including: 1. **Neuronal cells**: CTAG1B is expressed in glutamatergic neurons, oligodendrocyte precursor cells, and microglial cells, suggesting a potential role in neuronal development and function. 2. **Hematopoietic cells**: The gene is expressed in hematopoietic stem cells, megakaryocytes, and double-negative thymocytes, indicating its involvement in blood cell development and immune system function. 3. **Endothelial cells**: CTAG1B is also expressed in blood vessel endothelial cells, which may contribute to its role in angiogenesis and vascular development. In terms of its molecular characteristics, the CTAG1B gene is a protein-coding gene that belongs to the identical protein binding and trna threonylcarbamoyladenosine metabolic process pathways. **Pathways and Functions:** The CTAG1B gene is involved in several cellular processes, including: 1. **Angiogenesis**: CTAG1B may play a role in the regulation of angiogenesis, the process of new blood vessel formation, which is essential for tumor growth and metastasis. 2. **Neuronal development**: The gene's expression in neuronal cells suggests its involvement in neuronal development and function, potentially contributing to synaptic plasticity and learning. 3. **Hematopoiesis**: CTAG1B's expression in hematopoietic stem cells and megakaryocytes indicates its role in blood cell development and immune system function. **Clinical Significance:** The CTAG1B gene's expression in various cell types and its involvement in angiogenesis, neuronal development, and hematopoiesis make it a potential target for therapeutic interventions in several diseases, including: 1. **Cancer**: CTAG1B's expression in testicular germ cells and its potential role in angiogenesis make it a potential target for cancer therapy. 2. **Neurological disorders**: The gene's expression in neuronal cells and its involvement in synaptic plasticity suggest its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune system disorders**: CTAG1B's expression in hematopoietic stem cells and its potential role in immune system function make it a potential target for therapeutic interventions in immune system disorders, such as autoimmune diseases. In conclusion, the CTAG1B gene's unique expression profile and functional roles make it an intriguing subject for further investigation into its immunological significance. Its potential involvement in various cellular processes, including angiogenesis, neuronal development, and hematopoiesis, make it a promising target for therapeutic interventions in several diseases.

Genular Protein ID: 2950022782

Symbol: CTG1B_HUMAN

Name: Cancer/testis antigen 1

UniProtKB Accession Codes:

P78358 A1L417 B7WNL9 Q7LBY4 Q9NY13

Database IDs:

ABCD 1 AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CTD 2 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 2 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 1 KEGG 2 MANE-Select 2 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9050879

Title: A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening.

PubMed ID: 9050879

DOI: 10.1073/pnas.94.5.1914

PubMed ID: 9626360

Title: LAGE-1, a new gene with tumor specificity.

PubMed ID: 9626360

DOI: 10.1002/(sici)1097-0215(19980610)76:6<903::aid-ijc22>3.0.co;2-1

PubMed ID: 9759882

Title: A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames.

PubMed ID: 9759882

PubMed ID: 10523621

Title: DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter.

PubMed ID: 10523621

DOI: 10.1128/mcb.19.11.7327

PubMed ID: 11709543

Title: Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes.

PubMed ID: 11709543

DOI: 10.1093/hmg/10.22.2557

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12065688

Title: The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ.

PubMed ID: 12065688

DOI: 10.1097/01.lab.0000017169.26718.5f

PubMed ID: 15837811

Title: Structural and kinetic basis for heightened immunogenicity of T cell vaccines.

PubMed ID: 15837811

DOI: 10.1084/jem.20042323

Sequence Information:

  • Length: 180
  • Mass: 17992
  • Checksum: B122C5C2C8BE1569
  • Sequence:
    • MQAEGRGTGG STGDADGPGG PGIPDGPGGN AGGPGEAGAT GGRGPRGAGA ARASGPGGGA 
PRGPHGGAAS GLNGCCRCGA RGPESRLLEF YLAMPFATPM EAELARRSLA QDAPPLPVPG 
VLLKEFTVSG NILTIRLTAA DHRQLQLSIS SCLQQLSLLM WITQCFLPVF LAQPPSGQRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.