Details for: CTBS

Gene ID: 1486

Symbol: CTBS

Ensembl ID: ENSG00000117151

Description: chitobiase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.51
    Marker Score: 38644
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.4
    Marker Score: 3753
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.17
    Marker Score: 13588
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.16
    Marker Score: 64729
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.13
    Marker Score: 2194
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.12
    Marker Score: 1948
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.11
    Marker Score: 446
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.09
    Marker Score: 1088
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.04
    Marker Score: 2368
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.01
    Marker Score: 587
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1
    Marker Score: 34550
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71661
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47884.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30383
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.97
    Marker Score: 8399
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.97
    Marker Score: 6170.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.96
    Marker Score: 404
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.96
    Marker Score: 2379
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.93
    Marker Score: 511
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14257
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2691
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.89
    Marker Score: 201
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.88
    Marker Score: 539
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.86
    Marker Score: 5234
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5213
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.86
    Marker Score: 2074
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.85
    Marker Score: 402
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.85
    Marker Score: 898
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.85
    Marker Score: 1402
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.84
    Marker Score: 860.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.84
    Marker Score: 961
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.84
    Marker Score: 237
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.84
    Marker Score: 3604
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.83
    Marker Score: 846.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4717
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.81
    Marker Score: 1432.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.81
    Marker Score: 1071
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.8
    Marker Score: 1526
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1631
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8
    Marker Score: 3440
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.8
    Marker Score: 396
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.79
    Marker Score: 724
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.78
    Marker Score: 170
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.77
    Marker Score: 2659
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.77
    Marker Score: 268
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.76
    Marker Score: 263
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.75
    Marker Score: 344
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.75
    Marker Score: 901
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.74
    Marker Score: 1330
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.74
    Marker Score: 536
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.74
    Marker Score: 5503.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.74
    Marker Score: 491
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.74
    Marker Score: 504
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.74
    Marker Score: 176
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.73
    Marker Score: 1803.5
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.73
    Marker Score: 305
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.73
    Marker Score: 1329
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.72
    Marker Score: 166
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.72
    Marker Score: 1816
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.72
    Marker Score: 179
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.71
    Marker Score: 269
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.71
    Marker Score: 793
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.71
    Marker Score: 355
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.71
    Marker Score: 450
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.71
    Marker Score: 531.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.71
    Marker Score: 601
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.7
    Marker Score: 243
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7
    Marker Score: 4515
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7
    Marker Score: 2759.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.7
    Marker Score: 137.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.7
    Marker Score: 397
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.7
    Marker Score: 1365
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.69
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2906
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.69
    Marker Score: 620
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.69
    Marker Score: 750
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 454
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.69
    Marker Score: 361
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.69
    Marker Score: 299
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.68
    Marker Score: 1173.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.68
    Marker Score: 319
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.68
    Marker Score: 496.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.68
    Marker Score: 1359
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.68
    Marker Score: 235
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.68
    Marker Score: 670
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.68
    Marker Score: 4076
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 616
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.67
    Marker Score: 184
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.67
    Marker Score: 202
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.67
    Marker Score: 35485
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.67
    Marker Score: 453

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * Gene name: CTBS * Ensembl ID: ENSG00000117151 * Protein product: DIAC_HUMAN (Di-N-acetylchitobiase) * Pathway: Chitinase activity, Chitin binding, Chitin catabolic process, Extracellular space, Lysosome, Oligosaccharide catabolic process * Significantly expressed cells: * Alveolar macrophage * Kidney loop of Henle thick ascending limb epithelial cell * Blood cell * CD14-positive, CD16-negative classical monocyte * CD14-positive, CD16-positive monocyte * Germ cell * Type A enteroendocrine cell * Kupffer cell * Acinar cell of salivary gland * Luminal cell of prostate epithelium **Pathways and functions:** * Chitinase activity: Chitobiase enzymes break down chitin into simpler molecules that can be used by other enzymes. This process is important for the degradation of extracellular matrix components and the remodeling of tissues. * Chitin binding: Chitobiase enzymes can bind to chitinous substrates and facilitate the formation of complex assemblies, such as microvilli and extracellular matrix remodeling complexes. * Chitin catabolic process: Chitobiase enzymes can also degrade chitin into smaller molecules, which can be further metabolized by other enzymes. **Clinical significance:** * Dysfunction of CTBS genes has been linked to various diseases, including cancer, autoimmune disorders, and developmental abnormalities. * CTBS inhibitors are being investigated as potential therapeutic agents for these diseases, as they could inhibit the activity of chitobiase enzymes and block the degradation of extracellular matrix components.

Genular Protein ID: 3153694949

Symbol: DIAC_HUMAN

Name: Di-N-acetylchitobiase

UniProtKB Accession Codes:

Q01459 Q5VX50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1527079

Title: Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase.

PubMed ID: 1527079

DOI: 10.1016/s0021-9258(18)41818-2

PubMed ID: 10336991

Title: Structure of the human gene for lysosomal di-N-acetylchitobiase.

PubMed ID: 10336991

DOI: 10.1093/glycob/9.6.589

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 385
  • Mass: 43760
  • Checksum: 0A9D14C8B26B52EE
  • Sequence:
    • MSRPQLRRWR LVSSPPSGVP GLALLALLAL LALRLAAGTD CPCPEPELCR PIRHHPDFEV 
FVFDVGQKTW KSYDWSQITT VATFGKYDSE LMCYAHSKGA RVVLKGDVSL KDIIDPAFRA 
SWIAQKLNLA KTQYMDGINI DIEQEVNCLS PEYDALTALV KETTDSFHRE IEGSQVTFDV 
AWSPKNIDRR CYNYTGIADA CDFLFVMSYD EQSQIWSECI AAANAPYNQT LTGYNDYIKM 
SINPKKLVMG VPWYGYDYTC LNLSEDHVCT IAKVPFRGAP CSDAAGRQVP YKTIMKQINS 
SISGNLWDKD QRAPYYNYKD PAGHFHQVWY DNPQSISLKA TYIQNYRLRG IGMWNANCLD 
YSGDAVAKQQ TEEMWEVLKP KLLQR

Genular Protein ID: 87567104

Symbol: Q8TC97_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TC97

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 105
  • Mass: 11757
  • Checksum: 8B6BD6451D354A5C
  • Sequence:
    • MSRPQLRRWR LVSSPPSGVP GLALLALLAL RLAAGTDCPC PEPELCRPIR HHPDFEVFVF 
DVGQKTWKSY DWSQITTVAT FGKYDSELMC YAHSKGARVV LKGNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.