Details for: CTBP1

Gene ID: 1487

Symbol: CTBP1

Ensembl ID: ENSG00000159692

Description: C-terminal binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.2627
    Cell Significance Index: -29.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.4163
    Cell Significance Index: -28.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.5771
    Cell Significance Index: -31.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.1121
    Cell Significance Index: -34.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.6621
    Cell Significance Index: -34.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 52.1294
    Cell Significance Index: -34.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.7104
    Cell Significance Index: -31.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.3246
    Cell Significance Index: -33.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0462
    Cell Significance Index: -32.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7153
    Cell Significance Index: -29.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7556
    Cell Significance Index: -34.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.7853
    Cell Significance Index: 324.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2225
    Cell Significance Index: 361.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0125
    Cell Significance Index: 203.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8913
    Cell Significance Index: 12.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8214
    Cell Significance Index: 163.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7552
    Cell Significance Index: 48.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7027
    Cell Significance Index: 126.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6709
    Cell Significance Index: 18.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6313
    Cell Significance Index: 18.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6024
    Cell Significance Index: 82.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5880
    Cell Significance Index: 210.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5387
    Cell Significance Index: 294.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5344
    Cell Significance Index: 236.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5320
    Cell Significance Index: 65.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4278
    Cell Significance Index: 19.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4150
    Cell Significance Index: 19.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4076
    Cell Significance Index: 8.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4065
    Cell Significance Index: 28.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4039
    Cell Significance Index: 21.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3663
    Cell Significance Index: 69.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2998
    Cell Significance Index: 51.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2866
    Cell Significance Index: 33.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2697
    Cell Significance Index: 12.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2601
    Cell Significance Index: 25.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2347
    Cell Significance Index: 12.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2284
    Cell Significance Index: 6.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1624
    Cell Significance Index: 20.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1521
    Cell Significance Index: 10.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1499
    Cell Significance Index: 4.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1372
    Cell Significance Index: 4.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1368
    Cell Significance Index: 7.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1269
    Cell Significance Index: 9.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1200
    Cell Significance Index: 3.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0734
    Cell Significance Index: 0.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0658
    Cell Significance Index: 8.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0329
    Cell Significance Index: 62.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0274
    Cell Significance Index: 24.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -4.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -3.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0064
    Cell Significance Index: -0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0140
    Cell Significance Index: -18.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0152
    Cell Significance Index: -6.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0176
    Cell Significance Index: -13.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0243
    Cell Significance Index: -15.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0302
    Cell Significance Index: -2.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0364
    Cell Significance Index: -2.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0413
    Cell Significance Index: -6.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0419
    Cell Significance Index: -23.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0559
    Cell Significance Index: -5.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0621
    Cell Significance Index: -1.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0840
    Cell Significance Index: -2.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0844
    Cell Significance Index: -4.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0898
    Cell Significance Index: -18.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0966
    Cell Significance Index: -5.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1078
    Cell Significance Index: -31.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1153
    Cell Significance Index: -13.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1536
    Cell Significance Index: -4.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1640
    Cell Significance Index: -5.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1643
    Cell Significance Index: -2.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2222
    Cell Significance Index: -9.8300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2416
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2462
    Cell Significance Index: -28.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2493
    Cell Significance Index: -6.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2905
    Cell Significance Index: -30.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2941
    Cell Significance Index: -3.0500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3049
    Cell Significance Index: -2.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3105
    Cell Significance Index: -8.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3295
    Cell Significance Index: -6.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3417
    Cell Significance Index: -12.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3798
    Cell Significance Index: -30.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4382
    Cell Significance Index: -4.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4712
    Cell Significance Index: -28.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4965
    Cell Significance Index: -11.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4988
    Cell Significance Index: -14.6500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5098
    Cell Significance Index: -7.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5250
    Cell Significance Index: -11.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5786
    Cell Significance Index: -12.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6494
    Cell Significance Index: -14.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6901
    Cell Significance Index: -10.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6912
    Cell Significance Index: -14.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7038
    Cell Significance Index: -16.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7038
    Cell Significance Index: -18.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7133
    Cell Significance Index: -21.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7294
    Cell Significance Index: -23.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CTBP1 is a 1.4-kilodalton protein that exhibits a unique C-terminal domain, which mediates its interactions with other proteins and transcriptional complexes. The gene is highly expressed in various cell types, including immune cells, neurons, and epithelial cells. CTBP1's ability to bind to DNA, RNA polymerase II, and other transcriptional regulators makes it a versatile transcriptional coactivator and corepressor. **Pathways and Functions:** CTBP1 is involved in multiple signaling pathways, including: 1. **Wnt/β-catenin pathway:** CTBP1 negatively regulates the deactivation of the β-catenin transcriptional complex, thereby modulating Wnt signaling, which is crucial for cell proliferation, differentiation, and survival. 2. **GABAergic and glutamatergic synapses:** CTBP1 is essential for synaptic vesicle clustering and endocytosis, regulating neurotransmitter release and synaptic plasticity. 3. **Cell cycle regulation:** CTBP1 acts as a tumor suppressor by negatively regulating cell population proliferation and DNA-templated transcription. 4. **Immune regulation:** CTBP1 is expressed in immune cells, including type A enteroendocrine cells, pro-T cells, and dopaminergic neurons, and plays a role in regulating immune responses, including the repression of Wnt target genes. **Clinical Significance:** Dysregulation of CTBP1 has been implicated in various diseases, including: 1. **Cancer:** CTBP1's tumor suppressor function is disrupted in various cancers, leading to uncontrolled cell proliferation and tumor progression. 2. **Neurological disorders:** CTBP1's involvement in synaptic function and neurotransmitter regulation makes it a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immune disorders:** CTBP1's role in immune regulation makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, CTBP1 is a multifunctional transcriptional regulator that plays a crucial role in various cellular processes, including immune regulation, cell cycle regulation, and synaptic function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying CTBP1's functions and its potential as a therapeutic target. **Recommendations:** 1. Further studies are needed to elucidate the molecular mechanisms underlying CTBP1's functions in immune regulation and disease. 2. CTBP1's role in synaptic function and neurotransmitter regulation should be explored as a potential target for the treatment of neurodegenerative diseases. 3. The potential of CTBP1 as a therapeutic target for immune disorders should be further investigated. By understanding the complex role of CTBP1 in immune regulation and disease, we can uncover new avenues for the treatment of various diseases and improve our understanding of the molecular mechanisms underlying human diseases.

Genular Protein ID: 3739710398

Symbol: CTBP1_HUMAN

Name: C-terminal-binding protein 1

UniProtKB Accession Codes:

Q13363 Q4W5N3 Q7Z2Q5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 ELM 1 EMBL 8 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 6 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7479821

Title: Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.

PubMed ID: 7479821

DOI: 10.1073/pnas.92.23.10467

PubMed ID: 9858600

Title: C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate polycomb proteins.

PubMed ID: 9858600

DOI: 10.1128/mcb.19.1.777

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23707407

Title: PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

PubMed ID: 23707407

DOI: 10.1016/j.jmb.2013.05.009

PubMed ID: 8440238

Title: A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.

PubMed ID: 8440238

DOI: 10.1002/j.1460-2075.1993.tb05679.x

PubMed ID: 11568182

Title: Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.

PubMed ID: 11568182

DOI: 10.1074/jbc.m106733200

PubMed ID: 11462050

Title: Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C.

PubMed ID: 11462050

DOI: 10.1128/jvi.75.16.7749-7755.2001

PubMed ID: 11509661

Title: Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.

PubMed ID: 11509661

DOI: 10.1128/mcb.21.18.6181-6188.2001

PubMed ID: 12372828

Title: Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP).

PubMed ID: 12372828

DOI: 10.1074/jbc.m208116200

PubMed ID: 12679040

Title: The polycomb protein Pc2 is a SUMO E3.

PubMed ID: 12679040

DOI: 10.1016/s0092-8674(03)00159-4

PubMed ID: 14567915

Title: Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

PubMed ID: 14567915

DOI: 10.1016/s0092-8674(03)00802-x

PubMed ID: 15542832

Title: Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.

PubMed ID: 15542832

DOI: 10.1128/mcb.24.23.10223-10235.2004

PubMed ID: 15060175

Title: Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.

PubMed ID: 15060175

DOI: 10.1093/nar/gkh524

PubMed ID: 16061479

Title: Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.

PubMed ID: 16061479

DOI: 10.1074/jbc.m504477200

PubMed ID: 15897867

Title: Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.

PubMed ID: 15897867

DOI: 10.1038/sj.onc.1208754

PubMed ID: 16609867

Title: The FoxP subclass in Xenopus laevis development.

PubMed ID: 16609867

DOI: 10.1007/s00427-006-0073-8

PubMed ID: 16702210

Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.

PubMed ID: 16702210

DOI: 10.1074/jbc.m603087200

PubMed ID: 16393996

Title: Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators.

PubMed ID: 16393996

DOI: 10.4049/jimmunol.176.2.1081

PubMed ID: 17085477

Title: ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.

PubMed ID: 17085477

DOI: 10.1093/nar/gkl875

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18212045

Title: CtBP is an essential corepressor for BCL6 autoregulation.

PubMed ID: 18212045

DOI: 10.1128/mcb.01400-07

PubMed ID: 19103759

Title: Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1.

PubMed ID: 19103759

DOI: 10.1128/mcb.00822-08

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23747199

Title: Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection.

PubMed ID: 23747199

DOI: 10.1016/j.virol.2013.05.018

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25728771

Title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.

PubMed ID: 25728771

DOI: 10.1016/j.molcel.2015.01.023

PubMed ID: 27094857

Title: A recurrent de novo CTBP1 mutation is associated with developmental delay, hypotonia, ataxia, and tooth enamel defects.

PubMed ID: 27094857

DOI: 10.1007/s10048-016-0482-4

PubMed ID: 12419229

Title: Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase.

PubMed ID: 12419229

DOI: 10.1016/s1097-2765(02)00650-0

Sequence Information:

  • Length: 440
  • Mass: 47535
  • Checksum: F071DD30B385603F
  • Sequence:
    • MGSSHLLNKG LPLGVRPPIM NGPLHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ 
EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV 
PAASVEETAD STLCHILNLY RRATWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII 
GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG VERALGLQRV STLQDLLFHS DCVTLHCGLN 
EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS 
QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT 
HWASMDPAVV HPELNGAAYR YPPGVVGVAP TGIPAAVEGI VPSAMSLSHG LPPVAHPPHA 
PSPGQTVKPE ADRDHASDQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.