Details for: CTBP1

Gene ID: 1487

Symbol: CTBP1

Ensembl ID: ENSG00000159692

Description: C-terminal binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.61
    Marker Score: 648
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.34
    Marker Score: 1446
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.29
    Marker Score: 5268
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.28
    Marker Score: 2701
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 76708
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.24
    Marker Score: 1318
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.22
    Marker Score: 44903
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.22
    Marker Score: 12568
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.22
    Marker Score: 813
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.21
    Marker Score: 2119
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.21
    Marker Score: 3298
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.18
    Marker Score: 412
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.18
    Marker Score: 11066
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.17
    Marker Score: 7608
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.16
    Marker Score: 4474
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.15
    Marker Score: 9893
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.15
    Marker Score: 1774
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.14
    Marker Score: 10858
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.12
    Marker Score: 760
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.11
    Marker Score: 2962
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.1
    Marker Score: 2776
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1
    Marker Score: 11048
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.09
    Marker Score: 330
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.08
    Marker Score: 1215
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.08
    Marker Score: 10963
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.08
    Marker Score: 267
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.08
    Marker Score: 1587
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.07
    Marker Score: 1126
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.07
    Marker Score: 331
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.07
    Marker Score: 12012
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.06
    Marker Score: 40360
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.06
    Marker Score: 15793.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.05
    Marker Score: 3611.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.05
    Marker Score: 739
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.04
    Marker Score: 1051
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.04
    Marker Score: 1056
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.04
    Marker Score: 3684
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.02
    Marker Score: 2326.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15963.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.02
    Marker Score: 4219
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 317.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.01
    Marker Score: 241.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1
    Marker Score: 4065.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1
    Marker Score: 1056
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71596
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1
    Marker Score: 6349
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47821
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.99
    Marker Score: 1196
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Marker Score: 19654
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1023
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30369
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.97
    Marker Score: 2732
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.97
    Marker Score: 2310
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.97
    Marker Score: 644
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.96
    Marker Score: 393
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.96
    Marker Score: 7365
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.95
    Marker Score: 690
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.94
    Marker Score: 348
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.94
    Marker Score: 564
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2380
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.94
    Marker Score: 860
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.93
    Marker Score: 32338
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.93
    Marker Score: 1203
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.93
    Marker Score: 402
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.92
    Marker Score: 4439
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.92
    Marker Score: 631
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.92
    Marker Score: 553
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.92
    Marker Score: 970
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.92
    Marker Score: 1861
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.91
    Marker Score: 457
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.91
    Marker Score: 471
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.91
    Marker Score: 203.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 429.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.91
    Marker Score: 500
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.91
    Marker Score: 230
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5148
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.9
    Marker Score: 515
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.9
    Marker Score: 5846
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.89
    Marker Score: 50018
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.89
    Marker Score: 336
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.89
    Marker Score: 19043
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2668
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.89
    Marker Score: 234.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.88
    Marker Score: 312
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.88
    Marker Score: 1457
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.88
    Marker Score: 231
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.88
    Marker Score: 557
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.87
    Marker Score: 191.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.87
    Marker Score: 583
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.87
    Marker Score: 252
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.87
    Marker Score: 7576
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.87
    Marker Score: 593
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.87
    Marker Score: 238.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.87
    Marker Score: 1230
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.87
    Marker Score: 196.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.87
    Marker Score: 4556
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.86
    Marker Score: 212.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.86
    Marker Score: 6415
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.86
    Marker Score: 934

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Other Information

**Key characteristics:** * CTBP1 is a protein of the immunoglobulin superfamily. * It is a highly conserved protein with a predicted molecular weight of 120 kDa. * CTBP1 is expressed in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. * It is found in a complex with beta-catenin and other proteins involved in the beta-catenin signaling pathway. **Pathways and functions:** * CTBP1 is a key component of the beta-catenin signaling pathway, which is a major regulator of cell growth, proliferation, and differentiation. * The beta-catenin signaling pathway is activated by Wnt proteins, which are secreted proteins that are produced by cells such as colorectal carcinoma cells. * CTBP1 binds to the beta-catenin complex and helps to recruit beta-catenin to the promoter regions of target genes. * Once beta-catenin is bound to the promoter regions of target genes, it can activate transcription of those genes. **Clinical significance:** * Mutations in CTBP1 have been linked to several human cancers, including colon cancer, breast cancer, and lung cancer. * CTBP1 is a potential target for cancer therapy. * Inhibition of CTBP1 has been shown to inhibit cancer cell growth and proliferation. **Additional information:** * CTBP1 is a post-translational protein that is regulated by various signals, including Wnt proteins. * CTBP1 is a transcriptional coactivator that can enhance the activity of transcription factors. * CTBP1 is also a transcriptional corepressor that can inhibit the activity of transcription factors.

Genular Protein ID: 3739710398

Symbol: CTBP1_HUMAN

Name: C-terminal-binding protein 1

UniProtKB Accession Codes:

Q13363 Q4W5N3 Q7Z2Q5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 ELM 1 EMBL 8 EMDB 1 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 10 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7479821

Title: Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.

PubMed ID: 7479821

DOI: 10.1073/pnas.92.23.10467

PubMed ID: 9858600

Title: C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate polycomb proteins.

PubMed ID: 9858600

DOI: 10.1128/mcb.19.1.777

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23707407

Title: PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

PubMed ID: 23707407

DOI: 10.1016/j.jmb.2013.05.009

PubMed ID: 8440238

Title: A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.

PubMed ID: 8440238

DOI: 10.1002/j.1460-2075.1993.tb05679.x

PubMed ID: 11568182

Title: Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.

PubMed ID: 11568182

DOI: 10.1074/jbc.m106733200

PubMed ID: 11462050

Title: Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C.

PubMed ID: 11462050

DOI: 10.1128/jvi.75.16.7749-7755.2001

PubMed ID: 11509661

Title: Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.

PubMed ID: 11509661

DOI: 10.1128/mcb.21.18.6181-6188.2001

PubMed ID: 12372828

Title: Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP).

PubMed ID: 12372828

DOI: 10.1074/jbc.m208116200

PubMed ID: 12679040

Title: The polycomb protein Pc2 is a SUMO E3.

PubMed ID: 12679040

DOI: 10.1016/s0092-8674(03)00159-4

PubMed ID: 14567915

Title: Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

PubMed ID: 14567915

DOI: 10.1016/s0092-8674(03)00802-x

PubMed ID: 15542832

Title: Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.

PubMed ID: 15542832

DOI: 10.1128/mcb.24.23.10223-10235.2004

PubMed ID: 15060175

Title: Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.

PubMed ID: 15060175

DOI: 10.1093/nar/gkh524

PubMed ID: 16061479

Title: Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.

PubMed ID: 16061479

DOI: 10.1074/jbc.m504477200

PubMed ID: 15897867

Title: Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.

PubMed ID: 15897867

DOI: 10.1038/sj.onc.1208754

PubMed ID: 16609867

Title: The FoxP subclass in Xenopus laevis development.

PubMed ID: 16609867

DOI: 10.1007/s00427-006-0073-8

PubMed ID: 16702210

Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.

PubMed ID: 16702210

DOI: 10.1074/jbc.m603087200

PubMed ID: 16393996

Title: Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators.

PubMed ID: 16393996

DOI: 10.4049/jimmunol.176.2.1081

PubMed ID: 17085477

Title: ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.

PubMed ID: 17085477

DOI: 10.1093/nar/gkl875

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18212045

Title: CtBP is an essential corepressor for BCL6 autoregulation.

PubMed ID: 18212045

DOI: 10.1128/mcb.01400-07

PubMed ID: 19103759

Title: Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1.

PubMed ID: 19103759

DOI: 10.1128/mcb.00822-08

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23747199

Title: Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection.

PubMed ID: 23747199

DOI: 10.1016/j.virol.2013.05.018

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25728771

Title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.

PubMed ID: 25728771

DOI: 10.1016/j.molcel.2015.01.023

PubMed ID: 27094857

Title: A recurrent de novo CTBP1 mutation is associated with developmental delay, hypotonia, ataxia, and tooth enamel defects.

PubMed ID: 27094857

DOI: 10.1007/s10048-016-0482-4

PubMed ID: 12419229

Title: Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase.

PubMed ID: 12419229

DOI: 10.1016/s1097-2765(02)00650-0

Sequence Information:

  • Length: 440
  • Mass: 47535
  • Checksum: F071DD30B385603F
  • Sequence:
    • MGSSHLLNKG LPLGVRPPIM NGPLHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ 
EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV 
PAASVEETAD STLCHILNLY RRATWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII 
GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG VERALGLQRV STLQDLLFHS DCVTLHCGLN 
EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS 
QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT 
HWASMDPAVV HPELNGAAYR YPPGVVGVAP TGIPAAVEGI VPSAMSLSHG LPPVAHPPHA 
PSPGQTVKPE ADRDHASDQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.