Genular: Defining Cellular Identity and Function

Details for: Gstp1

Gene ID: 14870

Symbol: Gstp1

Ensembl ID: ENSMUSG00000060803

Description: glutathione S-transferase, pi 1

Associated with

Biological oxidations
(R-MMU-211859)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Detoxification of reactive oxygen species
(R-MMU-3299685)
Drug adme
(R-MMU-9748784)
Glutathione conjugation
(R-MMU-156590)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Neutrophil degranulation
(R-MMU-6798695)
Paracetamol adme
(R-MMU-9753281)
Phase ii - conjugation of compounds
(R-MMU-156580)
Cellular response to lipopolysaccharide
(GO:0071222)
Common myeloid progenitor cell proliferation
(GO:0035726)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dinitrosyl-iron complex binding
(GO:0035731)
Fatty acid binding
(GO:0005504)
Glutathione derivative biosynthetic process
(GO:1901687)
Glutathione metabolic process
(GO:0006749)
Glutathione peroxidase activity
(GO:0004602)
Glutathione transferase activity
(GO:0004364)
Hepoxilin biosynthetic process
(GO:0051122)
Jun kinase binding
(GO:0008432)
Kinase regulator activity
(GO:0019207)
Linoleic acid metabolic process
(GO:0043651)
Lipid metabolic process
(GO:0006629)
Mitochondrion
(GO:0005739)
Negative regulation of acute inflammatory response
(GO:0002674)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of biosynthetic process
(GO:0009890)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of fibroblast proliferation
(GO:0048147)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of jun kinase activity
(GO:0043508)
Negative regulation of leukocyte proliferation
(GO:0070664)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of monocyte chemotactic protein-1 production
(GO:0071638)
Negative regulation of neutrophil aggregation
(GO:2000429)
Negative regulation of nitric-oxide synthase biosynthetic process
(GO:0051771)
Negative regulation of peroxidase activity
(GO:2000469)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of smooth muscle cell chemotaxis
(GO:0071672)
Negative regulation of stress-activated mapk cascade
(GO:0032873)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Nucleus
(GO:0005634)
Organic cyclic compound binding
(GO:0097159)
Positive regulation of superoxide anion generation
(GO:0032930)
Prostaglandin metabolic process
(GO:0006693)
Protein-containing complex
(GO:0032991)
Protein kinase binding
(GO:0019901)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of stress-activated mapk cascade
(GO:0032872)
Response to reactive oxygen species
(GO:0000302)
S-nitrosoglutathione binding
(GO:0035730)
Toxic substance binding
(GO:0015643)
Traf2-gstp1 complex
(GO:0097057)
Transferase activity
(GO:0016740)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

GST YF-YF

Genular Protein ID: 2218189871

Symbol: GSTP1_MOUSE

Name: GST YF-YF

UniProtKB Accession Codes:

P19157 Q8BNY4

Database IDs:

Citations:

PubMed ID: 2388840

Title: A cDNA sequence coding a class pi glutathione S-transferase of mouse.

PubMed ID: 2388840

DOI: 10.1093/nar/18.15.4606

PubMed ID: 8135745

Title: Isolation and characterization of two mouse PI class glutathione S-transferase genes.

PubMed ID: 8135745

DOI: 10.1042/bj2980385

PubMed ID: 7982937

Title: Two murine GSTpi genes are arranged in tandem and are differentially expressed.

PubMed ID: 7982937

DOI: 10.1016/s0021-9258(18)43807-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8605288

Title: Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferases.

PubMed ID: 8605288

DOI: 10.1021/tx00050a009

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 8145243

Title: Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors.

PubMed ID: 8145243

DOI: 10.1006/jmbi.1994.1232

PubMed ID: 9446594

Title: The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region.

PubMed ID: 9446594

DOI: 10.1074/jbc.273.5.2844

Sequence Information:

Length: 210
Mass: 23609
Checksum: DAC7762F4E34FF27
Sequence:

MPPYTIVYFP VRGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY GQLPKFEDGD 
LTLYQSNAIL RHLGRSLGLY GKNQREAAQM DMVNDGVEDL RGKYVTLIYT NYENGKNDYV 
KALPGHLKPF ETLLSQNQGG KAFIVGDQIS FADYNLLDLL LIHQVLAPGC LDNFPLLSAY 
VARLSARPKI KAFLSSPEHV NRPINGNGKQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gstp1

Associated with

Other Information

A cDNA sequence coding a class pi glutathione S-transferase of mouse. PubMed ID: 2388840

Isolation and characterization of two mouse PI class glutathione S-transferase genes. PubMed ID: 8135745

Two murine GSTpi genes are arranged in tandem and are differentially expressed. PubMed ID: 7982937

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferases. PubMed ID: 8605288

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors. PubMed ID: 8145243

The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region. PubMed ID: 9446594