Gene CTBP2 - ENSG00000175029 | NCBI Gene ID: 1488

Details for: CTBP2

Gene ID: 1488

Symbol: CTBP2

Ensembl ID: ENSG00000175029

Description: C-terminal binding protein 2

Associated with

Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Repression of wnt target genes
(R-HSA-4641265)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Signaling by tcf7l2 mutants
(R-HSA-5339700)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chromatin binding
(GO:0003682)
Dna-binding transcription factor binding
(GO:0140297)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
Maintenance of presynaptic active zone structure
(GO:0048790)
Nad binding
(GO:0051287)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear retinoic acid receptor binding
(GO:0042974)
Nucleus
(GO:0005634)
Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
(GO:0016616)
Photoreceptor ribbon synapse
(GO:0098684)
Positive regulation of retinoic acid receptor signaling pathway
(GO:0048386)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Presynaptic active zone cytoplasmic component
(GO:0098831)
Presynaptic cytosol
(GO:0099523)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Structural constituent of presynaptic active zone
(GO:0098882)
Synaptic vesicle docking
(GO:0016081)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator binding
(GO:0001221)
Transcription corepressor activity
(GO:0003714)
Transcription corepressor binding
(GO:0001222)
Transcription repressor complex
(GO:0017053)
Viral genome replication
(GO:0019079)
White fat cell differentiation
(GO:0050872)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.06
Marker Score: 5462
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.93
Marker Score: 4754
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.86
Marker Score: 7160.5
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.65
Marker Score: 2527
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.65
Marker Score: 1550
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.56
Marker Score: 1272
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.54
Marker Score: 2675
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.48
Marker Score: 2853
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.43
Marker Score: 51790
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.41
Marker Score: 1341
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.4
Marker Score: 4624
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.37
Marker Score: 1246
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.35
Marker Score: 2029
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.33
Marker Score: 2068
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.32
Marker Score: 1790
Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.29
Marker Score: 660
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.26
Marker Score: 4586
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.18
Marker Score: 1302
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.1
Marker Score: 2325
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.1
Marker Score: 1178
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.1
Marker Score: 1458
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.99
Marker Score: 623
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.98
Marker Score: 2140
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.95
Marker Score: 2433
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.9
Marker Score: 602
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.87
Marker Score: 979
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.86
Marker Score: 7769
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.84
Marker Score: 537
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.82
Marker Score: 62981
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.79
Marker Score: 3940
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.79
Marker Score: 848
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.77
Marker Score: 4244
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.76
Marker Score: 18201
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.75
Marker Score: 1980
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.74
Marker Score: 7285
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.69
Marker Score: 37870
Cell Name: contractile cell (CL0000183)
Fold Change: 1.69
Marker Score: 916
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.68
Marker Score: 103394
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.68
Marker Score: 1793
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.66
Marker Score: 969
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.65
Marker Score: 1995
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.65
Marker Score: 2397
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.65
Marker Score: 491
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.64
Marker Score: 2908
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.64
Marker Score: 3862
Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.63
Marker Score: 785
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.63
Marker Score: 3842
Cell Name: astrocyte (CL0000127)
Fold Change: 1.62
Marker Score: 1408
Cell Name: basal cell (CL0000646)
Fold Change: 1.62
Marker Score: 2088
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.62
Marker Score: 587
Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.61
Marker Score: 509
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.59
Marker Score: 60345
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.54
Marker Score: 392
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.54
Marker Score: 556
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.53
Marker Score: 1026
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.51
Marker Score: 11555
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.5
Marker Score: 13208
Cell Name: acinar cell (CL0000622)
Fold Change: 1.5
Marker Score: 1059
Cell Name: podocyte (CL0000653)
Fold Change: 1.5
Marker Score: 554
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.49
Marker Score: 1405
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.49
Marker Score: 5771
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.47
Marker Score: 3943
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.47
Marker Score: 550
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.47
Marker Score: 7702
Cell Name: lactocyte (CL0002325)
Fold Change: 1.47
Marker Score: 23539
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.46
Marker Score: 2156
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.46
Marker Score: 1153
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.46
Marker Score: 2965
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.46
Marker Score: 2767
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.44
Marker Score: 2042
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.44
Marker Score: 456
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.43
Marker Score: 25425
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.43
Marker Score: 12440.5
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.43
Marker Score: 550
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.42
Marker Score: 483
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.42
Marker Score: 1516
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.4
Marker Score: 1457
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.38
Marker Score: 4887
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.37
Marker Score: 798
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.37
Marker Score: 277
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.37
Marker Score: 1029
Cell Name: stem cell (CL0000034)
Fold Change: 1.37
Marker Score: 3243
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.36
Marker Score: 1917
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.36
Marker Score: 438
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.36
Marker Score: 1438
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.36
Marker Score: 1638
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.35
Marker Score: 788
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.34
Marker Score: 1362
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.34
Marker Score: 49457
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.34
Marker Score: 4601
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.33
Marker Score: 903
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.33
Marker Score: 2773
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.33
Marker Score: 20774
Cell Name: secretory cell (CL0000151)
Fold Change: 1.33
Marker Score: 2422
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.32
Marker Score: 497.5
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.31
Marker Score: 1404
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.31
Marker Score: 4386
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.31
Marker Score: 7013
Cell Name: supporting cell (CL0000630)
Fold Change: 1.3
Marker Score: 2450
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3
Marker Score: 1298

Hover over a box to see details here...

**Key characteristics:** * CTBP2 is a protein of the immunoglobulin superfamily. * It is a highly conserved protein with a predicted molecular weight of 130 kDa. * It is found in the nucleus and cytoplasm of eukaryotic cells. * It is a known transcriptional coactivator. **Pathways and functions:** * CTBP2 is involved in the regulation of gene expression. It is a key regulator of the development and maintenance of the eye. * It is involved in the regulation of cell growth, differentiation, and apoptosis. * It is also involved in the regulation of inflammation. * CTBP2 has been linked to a number of diseases, including cancer and cardiovascular disease. **Clinical significance:** * Mutations in CTBP2 have been linked to a number of eye diseases, including cataracts, glaucoma, and macular degeneration. * CTBP2 is a potential target for the treatment of eye diseases. * Inhibition of CTBP2 has been shown to inhibit the growth of tumor cells. **Other relevant information:** * CTBP2 is a highly conserved protein that is found in all vertebrates. * It is expressed in a variety of cell types, including eye cells, immune cells, and cancer cells. * It is a known target for the treatment of cancer. * It is a promising target for the development of new cancer therapies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

C-terminal-binding protein 2

Genular Protein ID: 3805130245

Symbol: CTBP2_HUMAN

Name: C-terminal-binding protein 2

UniProtKB Accession Codes:

P56545 A8K2X5 D3DRF5 O43449 Q5SQP7 Q69YI3 Q86SV0 Q8IY44 Q9H2T8

Database IDs:

Citations:

PubMed ID: 9479502

Title: A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3.

PubMed ID: 9479502

DOI: 10.1006/geno.1997.5115

PubMed ID: 11163272

Title: RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function.

PubMed ID: 11163272

DOI: 10.1016/s0896-6273(00)00159-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7479821

Title: Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.

PubMed ID: 7479821

DOI: 10.1073/pnas.92.23.10467

PubMed ID: 15542832

Title: Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.

PubMed ID: 15542832

DOI: 10.1128/mcb.24.23.10223-10235.2004

PubMed ID: 15060175

Title: Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.

PubMed ID: 15060175

DOI: 10.1093/nar/gkh524

PubMed ID: 16702210

Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.

PubMed ID: 16702210

DOI: 10.1074/jbc.m603087200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23747199

Title: Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection.

PubMed ID: 23747199

DOI: 10.1016/j.virol.2013.05.018

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25728771

Title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.

PubMed ID: 25728771

DOI: 10.1016/j.molcel.2015.01.023

Sequence Information:

Length: 445
Mass: 48945
Checksum: 0A8C21CEB36807FA
Sequence:

MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC 
DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG 
IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG 
ETLGLIGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS 
LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES 
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE 
FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP AAMEGIIPGG IPVTHNLPTV 
AHPSQAPSPN QPTKHGDNRE HPNEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CTBP2

Associated with

Cells (max top 100)

Other Information

A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. PubMed ID: 9479502

RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. PubMed ID: 11163272

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. PubMed ID: 7479821

Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. PubMed ID: 15542832

Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. PubMed ID: 15060175

Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. PubMed ID: 16702210

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection. PubMed ID: 23747199

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. PubMed ID: 25728771