CTBP2 | ENSG00000175029 | NCBI 1488

Details for: CTBP2

Gene ID: 1488

Symbol: CTBP2

Ensembl ID: ENSG00000175029

Description: C-terminal binding protein 2

Associated with

Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Repression of wnt target genes
(R-HSA-4641265)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Signaling by tcf7l2 mutants
(R-HSA-5339700)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Chromatin binding
(GO:0003682)
Dna-binding transcription factor binding
(GO:0140297)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
Maintenance of presynaptic active zone structure
(GO:0048790)
Nad binding
(GO:0051287)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear retinoic acid receptor binding
(GO:0042974)
Nucleus
(GO:0005634)
Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
(GO:0016616)
Photoreceptor ribbon synapse
(GO:0098684)
Positive regulation of retinoic acid receptor signaling pathway
(GO:0048386)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Presynaptic active zone cytoplasmic component
(GO:0098831)
Presynaptic cytosol
(GO:0099523)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Structural constituent of presynaptic active zone
(GO:0098882)
Synaptic vesicle docking
(GO:0016081)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator binding
(GO:0001221)
Transcription corepressor activity
(GO:0003714)
Transcription corepressor binding
(GO:0001222)
Transcription repressor complex
(GO:0017053)
Viral genome replication
(GO:0019079)
White fat cell differentiation
(GO:0050872)

Other Information

Proteins

C-terminal-binding protein 2

Genular Protein ID: 3805130245

Symbol: CTBP2_HUMAN

Name: C-terminal-binding protein 2

UniProtKB Accession Codes:

P56545 A8K2X5 D3DRF5 O43449 Q5SQP7 Q69YI3 Q86SV0 Q8IY44 Q9H2T8

Database IDs:

Citations:

PubMed ID: 9479502

Title: A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3.

PubMed ID: 9479502

DOI: 10.1006/geno.1997.5115

PubMed ID: 11163272

Title: RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function.

PubMed ID: 11163272

DOI: 10.1016/s0896-6273(00)00159-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7479821

Title: Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.

PubMed ID: 7479821

DOI: 10.1073/pnas.92.23.10467

PubMed ID: 15542832

Title: Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.

PubMed ID: 15542832

DOI: 10.1128/mcb.24.23.10223-10235.2004

PubMed ID: 15060175

Title: Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.

PubMed ID: 15060175

DOI: 10.1093/nar/gkh524

PubMed ID: 16702210

Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.

PubMed ID: 16702210

DOI: 10.1074/jbc.m603087200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23747199

Title: Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection.

PubMed ID: 23747199

DOI: 10.1016/j.virol.2013.05.018

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25728771

Title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.

PubMed ID: 25728771

DOI: 10.1016/j.molcel.2015.01.023

Sequence Information:

Length: 445
Mass: 48945
Checksum: 0A8C21CEB36807FA
Sequence:

MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC 
DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG 
IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG 
ETLGLIGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS 
LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES 
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE 
FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP AAMEGIIPGG IPVTHNLPTV 
AHPSQAPSPN QPTKHGDNRE HPNEQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTBP2

Associated with

Other Information

A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. PubMed ID: 9479502

RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function. PubMed ID: 11163272

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. PubMed ID: 7479821

Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. PubMed ID: 15542832

Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. PubMed ID: 15060175

Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. PubMed ID: 16702210

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection. PubMed ID: 23747199

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. PubMed ID: 25728771