Details for: CTBP2

Gene ID: 1488

Symbol: CTBP2

Ensembl ID: ENSG00000175029

Description: C-terminal binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 516.5057
    Cell Significance Index: -80.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 311.3426
    Cell Significance Index: -78.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 176.9455
    Cell Significance Index: -83.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 167.1355
    Cell Significance Index: -67.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 154.6312
    Cell Significance Index: -79.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 124.6457
    Cell Significance Index: -83.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 71.2234
    Cell Significance Index: -68.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 67.2206
    Cell Significance Index: -82.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.3099
    Cell Significance Index: -84.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.9710
    Cell Significance Index: -61.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.5331
    Cell Significance Index: -42.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.8989
    Cell Significance Index: 100.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.8603
    Cell Significance Index: 216.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.2724
    Cell Significance Index: 226.3000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.5610
    Cell Significance Index: 19.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2827
    Cell Significance Index: 103.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7707
    Cell Significance Index: 135.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7257
    Cell Significance Index: 187.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.6376
    Cell Significance Index: 35.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.6014
    Cell Significance Index: 2177.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3999
    Cell Significance Index: 40.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3798
    Cell Significance Index: 1245.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3583
    Cell Significance Index: 37.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3417
    Cell Significance Index: 269.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2657
    Cell Significance Index: 691.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.2074
    Cell Significance Index: 1858.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0612
    Cell Significance Index: 191.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.0329
    Cell Significance Index: 1904.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9323
    Cell Significance Index: 48.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9147
    Cell Significance Index: 57.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8916
    Cell Significance Index: 109.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7925
    Cell Significance Index: 157.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7374
    Cell Significance Index: 101.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7154
    Cell Significance Index: 10.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6054
    Cell Significance Index: 28.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4948
    Cell Significance Index: 177.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4283
    Cell Significance Index: 296.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3971
    Cell Significance Index: 39.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3897
    Cell Significance Index: 172.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3813
    Cell Significance Index: 10.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3758
    Cell Significance Index: 23.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3379
    Cell Significance Index: 7.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3154
    Cell Significance Index: 3.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3153
    Cell Significance Index: 11.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2481
    Cell Significance Index: 157.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2269
    Cell Significance Index: 427.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2222
    Cell Significance Index: 14.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2200
    Cell Significance Index: 3.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1733
    Cell Significance Index: 22.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1665
    Cell Significance Index: 31.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1586
    Cell Significance Index: 72.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1452
    Cell Significance Index: 24.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1287
    Cell Significance Index: 8.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1158
    Cell Significance Index: 5.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1141
    Cell Significance Index: 1.9100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1098
    Cell Significance Index: 2.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0632
    Cell Significance Index: 10.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0577
    Cell Significance Index: 7.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0184
    Cell Significance Index: 0.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0046
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0208
    Cell Significance Index: -15.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0275
    Cell Significance Index: -17.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0371
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0525
    Cell Significance Index: -38.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0874
    Cell Significance Index: -66.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1165
    Cell Significance Index: -65.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1595
    Cell Significance Index: -11.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1614
    Cell Significance Index: -3.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2289
    Cell Significance Index: -23.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2474
    Cell Significance Index: -71.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2677
    Cell Significance Index: -56.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2719
    Cell Significance Index: -3.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3781
    Cell Significance Index: -13.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4620
    Cell Significance Index: -53.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4657
    Cell Significance Index: -53.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5167
    Cell Significance Index: -36.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6043
    Cell Significance Index: -36.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6297
    Cell Significance Index: -65.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6645
    Cell Significance Index: -75.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6810
    Cell Significance Index: -21.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7033
    Cell Significance Index: -82.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7881
    Cell Significance Index: -62.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9489
    Cell Significance Index: -27.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0139
    Cell Significance Index: -23.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0481
    Cell Significance Index: -64.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0495
    Cell Significance Index: -26.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2646
    Cell Significance Index: -18.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2932
    Cell Significance Index: -37.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3665
    Cell Significance Index: -36.6200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.4195
    Cell Significance Index: -20.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4323
    Cell Significance Index: -72.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.4738
    Cell Significance Index: -18.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.4848
    Cell Significance Index: -35.6100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -1.4938
    Cell Significance Index: -13.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.5167
    Cell Significance Index: -21.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.5192
    Cell Significance Index: -31.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6537
    Cell Significance Index: -35.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7206
    Cell Significance Index: -50.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7908
    Cell Significance Index: -79.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CTBP2 is a 320-kDa protein that belongs to the C-terminal-binding protein family. It is characterized by its ability to bind to DNA, RNA polymerase II, and various transcription factors, including retinoic acid receptors, Wnt proteins, and TCF7L2. CTBP2 is highly expressed in various cell types, including anterior lens cells, skeletal muscle fibers, and astrocytes, suggesting its involvement in the development and maintenance of these tissues. **Pathways and Functions:** CTBP2 is involved in multiple signaling pathways, including: 1. **Chromatin binding**: CTBP2 interacts with chromatin-binding proteins, such as histone deacetylases and histone methyltransferases, to regulate gene expression. 2. **Transcriptional regulation**: CTBP2 acts as a transcriptional corepressor, modulating the activity of numerous transcription factors, including retinoic acid receptors and Wnt proteins. 3. **Cell proliferation**: CTBP2 is involved in the regulation of cell proliferation, particularly in the context of cancer, where it can act as a tumor suppressor. 4. **Synaptic function**: CTBP2 is expressed in the central nervous system and plays a role in the regulation of synaptic function, including the maintenance of presynaptic active zones. 5. **Signaling by Wnt**: CTBP2 is a key component of the Wnt signaling pathway, which is involved in development, growth, and disease. **Clinical Significance:** CTBP2 has been implicated in various diseases, including: 1. **Cancer**: CTBP2 acts as a tumor suppressor in certain types of cancer, such as colon and breast cancer. 2. **Neurological disorders**: CTBP2 is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Neuropsychiatric disorders**: CTBP2 is implicated in the regulation of synaptic function and has been linked to neuropsychiatric disorders, such as schizophrenia and bipolar disorder. 4. **Diabetes**: CTBP2 is involved in the regulation of glucose metabolism and has been linked to type 2 diabetes. In conclusion, CTBP2 is a complex gene with far-reaching implications in cellular processes, including transcriptional regulation, cell proliferation, and synaptic function. Its clinical significance is evident in the involvement of CTBP2 in various diseases, including cancer, neurological disorders, and neuropsychiatric disorders. Further research is needed to fully elucidate the mechanisms by which CTBP2 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 3805130245

Symbol: CTBP2_HUMAN

Name: C-terminal-binding protein 2

UniProtKB Accession Codes:

P56545 A8K2X5 D3DRF5 O43449 Q5SQP7 Q69YI3 Q86SV0 Q8IY44 Q9H2T8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EMDB 2 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 23 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9479502

Title: A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3.

PubMed ID: 9479502

DOI: 10.1006/geno.1997.5115

PubMed ID: 11163272

Title: RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function.

PubMed ID: 11163272

DOI: 10.1016/s0896-6273(00)00159-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7479821

Title: Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.

PubMed ID: 7479821

DOI: 10.1073/pnas.92.23.10467

PubMed ID: 15542832

Title: Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.

PubMed ID: 15542832

DOI: 10.1128/mcb.24.23.10223-10235.2004

PubMed ID: 15060175

Title: Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.

PubMed ID: 15060175

DOI: 10.1093/nar/gkh524

PubMed ID: 16702210

Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.

PubMed ID: 16702210

DOI: 10.1074/jbc.m603087200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23747199

Title: Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection.

PubMed ID: 23747199

DOI: 10.1016/j.virol.2013.05.018

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25728771

Title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.

PubMed ID: 25728771

DOI: 10.1016/j.molcel.2015.01.023

Sequence Information:

  • Length: 445
  • Mass: 48945
  • Checksum: 0A8C21CEB36807FA
  • Sequence:
    • MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC 
DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG 
IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG 
ETLGLIGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS 
LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES 
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE 
FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP AAMEGIIPGG IPVTHNLPTV 
AHPSQAPSPN QPTKHGDNRE HPNEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.