Details for: CTF1

Gene ID: 1489

Symbol: CTF1

Ensembl ID: ENSG00000150281

Description: cardiotrophin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.7090
    Cell Significance Index: -5.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8096
    Cell Significance Index: -5.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7951
    Cell Significance Index: 89.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6520
    Cell Significance Index: 101.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5053
    Cell Significance Index: -5.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2511
    Cell Significance Index: 64.9900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7446
    Cell Significance Index: 12.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5702
    Cell Significance Index: 108.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5636
    Cell Significance Index: 15.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5130
    Cell Significance Index: 13.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4969
    Cell Significance Index: 6.7800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.4403
    Cell Significance Index: 6.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3559
    Cell Significance Index: 7.5800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3482
    Cell Significance Index: 4.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2913
    Cell Significance Index: 28.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2764
    Cell Significance Index: 16.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2468
    Cell Significance Index: 222.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2331
    Cell Significance Index: 25.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1994
    Cell Significance Index: 24.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1845
    Cell Significance Index: 1.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1726
    Cell Significance Index: 28.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1582
    Cell Significance Index: 28.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1390
    Cell Significance Index: 1.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1004
    Cell Significance Index: 6.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0832
    Cell Significance Index: 1.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0807
    Cell Significance Index: 9.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0781
    Cell Significance Index: 10.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0609
    Cell Significance Index: 26.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0576
    Cell Significance Index: 1.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0575
    Cell Significance Index: 31.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0519
    Cell Significance Index: 2.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0481
    Cell Significance Index: 6.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0479
    Cell Significance Index: 6.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0444
    Cell Significance Index: 3.4100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0339
    Cell Significance Index: 0.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0314
    Cell Significance Index: 0.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0115
    Cell Significance Index: 1.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0046
    Cell Significance Index: 0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0017
    Cell Significance Index: 1.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -4.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0033
    Cell Significance Index: -0.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0045
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -3.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0076
    Cell Significance Index: -0.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -6.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0102
    Cell Significance Index: -4.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0106
    Cell Significance Index: -5.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0115
    Cell Significance Index: -0.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0130
    Cell Significance Index: -0.5900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0150
    Cell Significance Index: -0.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0156
    Cell Significance Index: -0.7900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0190
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0205
    Cell Significance Index: -3.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0210
    Cell Significance Index: -4.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0217
    Cell Significance Index: -2.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0245
    Cell Significance Index: -1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0262
    Cell Significance Index: -3.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0293
    Cell Significance Index: -1.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0304
    Cell Significance Index: -0.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0312
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0312
    Cell Significance Index: -6.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0321
    Cell Significance Index: -0.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0335
    Cell Significance Index: -0.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0405
    Cell Significance Index: -2.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0407
    Cell Significance Index: -3.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0552
    Cell Significance Index: -5.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0603
    Cell Significance Index: -0.8900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0618
    Cell Significance Index: -1.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0634
    Cell Significance Index: -1.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0657
    Cell Significance Index: -0.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0722
    Cell Significance Index: -4.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0740
    Cell Significance Index: -4.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0745
    Cell Significance Index: -1.9600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0747
    Cell Significance Index: -1.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0781
    Cell Significance Index: -3.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0858
    Cell Significance Index: -5.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0895
    Cell Significance Index: -4.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0912
    Cell Significance Index: -1.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0942
    Cell Significance Index: -1.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0956
    Cell Significance Index: -2.7400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1103
    Cell Significance Index: -1.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1158
    Cell Significance Index: -6.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1191
    Cell Significance Index: -5.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1210
    Cell Significance Index: -0.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1272
    Cell Significance Index: -4.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1336
    Cell Significance Index: -3.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1345
    Cell Significance Index: -5.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1347
    Cell Significance Index: -5.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1376
    Cell Significance Index: -4.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1381
    Cell Significance Index: -5.0700
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1386
    Cell Significance Index: -1.3200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1402
    Cell Significance Index: -1.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular Localization**: CTF1 is widely expressed in various cell types, including immune cells, muscle cells, neural cells, and epithelial cells. 2. **Receptor Binding**: CTF1 binds to its receptor, IL-6R, to activate its signaling pathway. 3. **Signaling Pathway**: The CTF1-IL-6R interaction triggers a cascade of intracellular signaling events, including tyrosine phosphorylation of STAT proteins, which regulate gene expression and cell proliferation. 4. **Protein Structure**: CTF1 is a glycoprotein with a molecular weight of approximately 17 kDa, consisting of two subunits, alpha and beta. **Pathways and Functions** 1. **Cell-Cell Signaling**: CTF1 mediates cell-cell communication through its interaction with IL-6R, influencing various cellular processes, including proliferation, differentiation, and survival. 2. **Cytokine Activity**: As a member of the IL-6 family, CTF1 participates in cytokine signaling, regulating the immune response and inflammation. 3. **Muscle Organ Development**: CTF1 is involved in muscle development and differentiation, particularly in cardiac muscle myoblasts. 4. **Neuron Development and Differentiation**: CTF1 also plays a role in neural development and differentiation, including the development of GABAergic interneurons in the cerebral cortex. 5. **Positive Regulation of Cell Population Proliferation**: CTF1 promotes cell proliferation by regulating the expression of genes involved in cell cycle progression. **Clinical Significance** 1. **Immunological Disorders**: Alterations in CTF1 expression or function may contribute to immunological disorders, such as autoimmune diseases, inflammatory conditions, and cancer. 2. **Muscular Dystrophy**: CTF1 has been implicated in muscular dystrophy, particularly in Duchenne muscular dystrophy, where it may play a role in muscle cell differentiation and survival. 3. **Neurological Disorders**: Abnormalities in CTF1 expression or function have been linked to various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. 4. **Cancer**: CTF1 may contribute to cancer development and progression by regulating cell proliferation, survival, and differentiation. In conclusion, CTF1 is a multifunctional protein involved in various cellular processes, including cell signaling, proliferation, and differentiation. Its dysregulation has been implicated in several clinical disorders, highlighting the importance of further research into its mechanisms and functions.

Genular Protein ID: 1667122358

Symbol: CTF1_HUMAN

Name: Cardiotrophin-1

UniProtKB Accession Codes:

Q16619 A8MVX4 Q5U5Y7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8833032

Title: Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization.

PubMed ID: 8833032

DOI: 10.1006/cyto.1996.0026

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11058912

Title: Genetic variants in the promoter (g983G>T) and coding region (A92T) of the human cardiotrophin-1 gene (CTF1) in patients with dilated cardiomyopathy.

PubMed ID: 11058912

DOI: 10.1002/1098-1004(200011)16:5<448::aid-humu19>3.0.co;2-d

Sequence Information:

  • Length: 201
  • Mass: 21227
  • Checksum: 0235A7B5745F675F
  • Sequence:
    • MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS 
FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR 
RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL 
YREWLSRTEG DLGQLLPGGS A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.