Details for: CTF1

Gene ID: 1489

Symbol: CTF1

Ensembl ID: ENSG00000150281

Description: cardiotrophin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.25
    Marker Score: 1246.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2312.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.09
    Marker Score: 345
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16449
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5219
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.89
    Marker Score: 368
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1615
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.85
    Marker Score: 317
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.82
    Marker Score: 377.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.81
    Marker Score: 1373.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2818
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 205
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 355
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 281
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.57
    Marker Score: 1082
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 338
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5
    Marker Score: 733
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.49
    Marker Score: 1146
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.42
    Marker Score: 185
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.42
    Marker Score: 433
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.4
    Marker Score: 152
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.38
    Marker Score: 952
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 235
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.35
    Marker Score: 580
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.32
    Marker Score: 372
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.31
    Marker Score: 315
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.31
    Marker Score: 832
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.31
    Marker Score: 1142
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.3
    Marker Score: 852
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.29
    Marker Score: 1887
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.29
    Marker Score: 66
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.28
    Marker Score: 341
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.28
    Marker Score: 129
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.28
    Marker Score: 282
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.27
    Marker Score: 489
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.25
    Marker Score: 267
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.24
    Marker Score: 344
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.24
    Marker Score: 2110
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.24
    Marker Score: 591.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.24
    Marker Score: 107
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.23
    Marker Score: 402
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.22
    Marker Score: 239
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.22
    Marker Score: 1306
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.22
    Marker Score: 169
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.22
    Marker Score: 227
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.22
    Marker Score: 586
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.21
    Marker Score: 196
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.21
    Marker Score: 1385
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.21
    Marker Score: 712
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.21
    Marker Score: 1082
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.2
    Marker Score: 97
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2
    Marker Score: 136
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2
    Marker Score: 1196
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2
    Marker Score: 2000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.19
    Marker Score: 56
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.19
    Marker Score: 4093
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 80
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.19
    Marker Score: 679
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.19
    Marker Score: 104
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.18
    Marker Score: 204
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.18
    Marker Score: 147
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.18
    Marker Score: 192
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.18
    Marker Score: 72
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.17
    Marker Score: 136
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.16
    Marker Score: 139
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.16
    Marker Score: 113
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.16
    Marker Score: 168
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.15
    Marker Score: 364
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.15
    Marker Score: 349
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.15
    Marker Score: 1970
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.15
    Marker Score: 617
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 142

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Other Information

**Key characteristics:** * CTF1 is a protein of the cytokine family. * It is produced by a variety of cell types, including epithelial cells, immune cells, and cardiac cells. * It is a key regulator of cell growth and differentiation in various tissues. **Pathways and functions:** * CTF1 is a key cytokine in cell-cell signaling and cell surface receptor signaling pathways. * It is involved in the regulation of epithelial cell migration and differentiation. * It is also involved in the regulation of immune cell function. * CTF1 is a potent activator of the IL-6-type cytokine receptor. * It is involved in the regulation of inflammation and tissue remodeling. **Clinical significance:** * Mutations in the CTF1 gene have been linked to a number of human diseases, including cancer and autoimmune disorders. * CTF1 is a potential therapeutic target for these diseases. **Additional notes:** * CTF1 is a highly conserved protein, with a similar protein found in other mammals. * It is a secreted protein that is produced and released by cells. * It is a potent cytokine that can have both pro- and anti-inflammatory effects. * It is a key regulator of cell growth and differentiation in various tissues.

Genular Protein ID: 1667122358

Symbol: CTF1_HUMAN

Name: Cardiotrophin-1

UniProtKB Accession Codes:

Q16619 A8MVX4 Q5U5Y7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8833032

Title: Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization.

PubMed ID: 8833032

DOI: 10.1006/cyto.1996.0026

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11058912

Title: Genetic variants in the promoter (g983G>T) and coding region (A92T) of the human cardiotrophin-1 gene (CTF1) in patients with dilated cardiomyopathy.

PubMed ID: 11058912

DOI: 10.1002/1098-1004(200011)16:5<448::aid-humu19>3.0.co;2-d

Sequence Information:

  • Length: 201
  • Mass: 21227
  • Checksum: 0235A7B5745F675F
  • Sequence:
    • MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS 
FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR 
RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL 
YREWLSRTEG DLGQLLPGGS A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.