Details for: CCN2

Gene ID: 1490

Symbol: CCN2

Ensembl ID: ENSG00000118523

Description: cellular communication network factor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.83
    Marker Score: 2996
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.93
    Marker Score: 3816
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.73
    Marker Score: 1032
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.61
    Marker Score: 1717
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.46
    Marker Score: 83742
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.41
    Marker Score: 4804
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.35
    Marker Score: 6160
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.23
    Marker Score: 19361
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.18
    Marker Score: 5367
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.14
    Marker Score: 2939
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.12
    Marker Score: 1516
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.11
    Marker Score: 1386
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.06
    Marker Score: 8866
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.81
    Marker Score: 4258
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.78
    Marker Score: 3347
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.77
    Marker Score: 23318
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.74
    Marker Score: 3308.5
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.71
    Marker Score: 385
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.63
    Marker Score: 1960
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6
    Marker Score: 16237
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.55
    Marker Score: 1337
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.54
    Marker Score: 2962.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.5
    Marker Score: 879
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5
    Marker Score: 1001
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.47
    Marker Score: 808
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168259
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.46
    Marker Score: 658
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.45
    Marker Score: 748
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.45
    Marker Score: 410
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.44
    Marker Score: 1493
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.43
    Marker Score: 49416
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.39
    Marker Score: 2147
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.39
    Marker Score: 948
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.38
    Marker Score: 1233
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.38
    Marker Score: 5109
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.37
    Marker Score: 497
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.37
    Marker Score: 2317
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.36
    Marker Score: 1452
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.32
    Marker Score: 1913
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.25
    Marker Score: 14107
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.25
    Marker Score: 400
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.25
    Marker Score: 365
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.24
    Marker Score: 1186
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.24
    Marker Score: 2163
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.23
    Marker Score: 10596
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.23
    Marker Score: 682
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.2
    Marker Score: 305
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.19
    Marker Score: 513
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.18
    Marker Score: 301
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.17
    Marker Score: 829
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.13
    Marker Score: 391
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.12
    Marker Score: 414
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.09
    Marker Score: 283
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.09
    Marker Score: 1051
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.07
    Marker Score: 251
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.07
    Marker Score: 227
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.06
    Marker Score: 6885
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.06
    Marker Score: 438
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.04
    Marker Score: 475
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.04
    Marker Score: 392
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.03
    Marker Score: 2158.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.03
    Marker Score: 1102
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.02
    Marker Score: 252
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.01
    Marker Score: 419
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1
    Marker Score: 598
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71750
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47974
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.99
    Marker Score: 231
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.97
    Marker Score: 909
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.96
    Marker Score: 637
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.94
    Marker Score: 840
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.93
    Marker Score: 340
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.92
    Marker Score: 4543
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.92
    Marker Score: 624
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.91
    Marker Score: 776
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.9
    Marker Score: 567
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.88
    Marker Score: 1446
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.88
    Marker Score: 886
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.88
    Marker Score: 1086
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.88
    Marker Score: 586.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5261
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.87
    Marker Score: 227
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.87
    Marker Score: 782
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.86
    Marker Score: 2196
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.86
    Marker Score: 206
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.86
    Marker Score: 1066
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.85
    Marker Score: 289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1384
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.85
    Marker Score: 196
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4794
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 502
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 636
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.83
    Marker Score: 393
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 331

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Other Information

**Key characteristics:** * CCN2 is a transmembrane protein that is expressed in both endothelial cells and fibroblasts. * It is a key regulator of cell adhesion and migration. * It is also involved in cell differentiation and survival. **Pathways and functions:** * CCN2 is involved in a variety of signaling pathways, including the angiogenic, cartilage condensation, cell-matrix adhesion, and cell adhesion pathways. * It is also involved in the regulation of tissue homeostasis and the development of the cardiovascular system. **Clinical significance:** * Mutations in the CCN2 gene have been linked to a number of human diseases, including cardiovascular disease, cancer, and diabetes. * CCN2 is a potential target for therapeutic intervention in these diseases. **Additional information:** * CCN2 is a member of the immunoglobulin superfamily. * It is expressed in high levels in healthy tissues, but its expression is increased in tumors and other diseased tissues. * CCN2 is a highly conserved protein, with a similar protein found in mammals, birds, and fish.

Genular Protein ID: 1947747861

Symbol: CCN2_HUMAN

Name: Insulin-like growth factor-binding protein 8

UniProtKB Accession Codes:

P29279 E1P578 Q6LCY0 Q96A79 Q96QX2 Q9UDL6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 7 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1654338

Title: Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

PubMed ID: 1654338

DOI: 10.1083/jcb.114.6.1285

PubMed ID: 1293144

Title: Connective tissue growth factor.

PubMed ID: 1293144

DOI: 10.1111/j.1346-8138.1992.tb03748.x

PubMed ID: 9054739

Title: Human connective tissue growth factor is expressed in advanced atherosclerotic lesions.

PubMed ID: 9054739

DOI: 10.1161/01.cir.95.4.831

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 1756408

Title: Expression of a gene encoding a novel potential IGF binding protein in human tissues.

PubMed ID: 1756408

PubMed ID: 10614647

Title: Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.

PubMed ID: 10614647

DOI: 10.1210/endo.141.1.7267

PubMed ID: 12553878

Title: The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion.

PubMed ID: 12553878

DOI: 10.1677/joe.0.176r001

PubMed ID: 30232710

Title: CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.

PubMed ID: 30232710

DOI: 10.1007/s12079-018-0487-x

Sequence Information:

  • Length: 349
  • Mass: 38091
  • Checksum: 62CF878C7F57EC1F
  • Sequence:
    • MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 
AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

Genular Protein ID: 1038222721

Symbol: Q5M8T4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5M8T4

Database IDs:

ABCD 1 ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 10 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 10 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMART 4 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16501850

Title: Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy.

PubMed ID: 16501850

DOI: 10.1007/s10038-006-0368-7

Sequence Information:

  • Length: 349
  • Mass: 38069
  • Checksum: 0ECF8470B357EA95
  • Sequence:
    • MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 
AKQLGELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.