Details for: CCN2

Gene ID: 1490

Symbol: CCN2

Ensembl ID: ENSG00000118523

Description: cellular communication network factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 277.6041
    Cell Significance Index: -43.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 172.6834
    Cell Significance Index: -43.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 95.9588
    Cell Significance Index: -39.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.9221
    Cell Significance Index: -41.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.2142
    Cell Significance Index: -35.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.0134
    Cell Significance Index: -43.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7475
    Cell Significance Index: -42.4100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 10.6093
    Cell Significance Index: 62.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 7.5345
    Cell Significance Index: 51.0500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 6.9783
    Cell Significance Index: 36.7200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 6.7920
    Cell Significance Index: 31.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.2064
    Cell Significance Index: 177.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.1050
    Cell Significance Index: 40.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.8144
    Cell Significance Index: 67.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.7297
    Cell Significance Index: 478.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8384
    Cell Significance Index: 183.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.5730
    Cell Significance Index: 89.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.5380
    Cell Significance Index: 53.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.0917
    Cell Significance Index: 22.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.0686
    Cell Significance Index: 23.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8998
    Cell Significance Index: 49.9600
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.5415
    Cell Significance Index: 7.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5113
    Cell Significance Index: 106.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3371
    Cell Significance Index: 730.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0460
    Cell Significance Index: 28.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9664
    Cell Significance Index: 427.2800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.8608
    Cell Significance Index: 5.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8524
    Cell Significance Index: 7.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6825
    Cell Significance Index: 93.7200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3721
    Cell Significance Index: 4.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3452
    Cell Significance Index: 44.6000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2987
    Cell Significance Index: 4.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2687
    Cell Significance Index: 5.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2487
    Cell Significance Index: 11.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2210
    Cell Significance Index: 25.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1522
    Cell Significance Index: 28.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1449
    Cell Significance Index: 130.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1027
    Cell Significance Index: 139.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0596
    Cell Significance Index: 11.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0548
    Cell Significance Index: 4.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0381
    Cell Significance Index: 0.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0379
    Cell Significance Index: 0.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0320
    Cell Significance Index: 3.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0203
    Cell Significance Index: 1.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0045
    Cell Significance Index: 6.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0180
    Cell Significance Index: -2.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0182
    Cell Significance Index: -13.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0187
    Cell Significance Index: -11.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0199
    Cell Significance Index: -37.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0255
    Cell Significance Index: -17.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0302
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0410
    Cell Significance Index: -1.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0591
    Cell Significance Index: -26.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0662
    Cell Significance Index: -49.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0819
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0834
    Cell Significance Index: -52.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0879
    Cell Significance Index: -49.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0951
    Cell Significance Index: -3.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1019
    Cell Significance Index: -18.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1060
    Cell Significance Index: -38.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1129
    Cell Significance Index: -32.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1260
    Cell Significance Index: -5.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1417
    Cell Significance Index: -3.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1466
    Cell Significance Index: -18.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1481
    Cell Significance Index: -16.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1858
    Cell Significance Index: -31.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1910
    Cell Significance Index: -4.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1942
    Cell Significance Index: -38.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1945
    Cell Significance Index: -19.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2485
    Cell Significance Index: -52.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2735
    Cell Significance Index: -39.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3012
    Cell Significance Index: -14.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3050
    Cell Significance Index: -21.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3245
    Cell Significance Index: -19.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3307
    Cell Significance Index: -8.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3571
    Cell Significance Index: -42.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4112
    Cell Significance Index: -42.8200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.4327
    Cell Significance Index: -2.5400
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.4564
    Cell Significance Index: -2.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4915
    Cell Significance Index: -38.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4921
    Cell Significance Index: -37.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5130
    Cell Significance Index: -31.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5656
    Cell Significance Index: -31.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5664
    Cell Significance Index: -15.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5968
    Cell Significance Index: -36.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6090
    Cell Significance Index: -19.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6214
    Cell Significance Index: -32.3700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.6355
    Cell Significance Index: -3.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6483
    Cell Significance Index: -43.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6695
    Cell Significance Index: -19.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6987
    Cell Significance Index: -30.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8361
    Cell Significance Index: -27.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.8577
    Cell Significance Index: -13.2700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8641
    Cell Significance Index: -12.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8693
    Cell Significance Index: -45.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8738
    Cell Significance Index: -55.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8824
    Cell Significance Index: -45.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8862
    Cell Significance Index: -23.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCN2 is a member of the CCN family of extracellular matrix-associated proteins, which are known to regulate various cellular functions through interactions with integrins, growth factors, and other signaling molecules. The protein consists of an insulin-like growth factor-binding domain, a collagen-binding domain, and a heparin-binding domain, which confer its ability to interact with different cellular components. CCN2 has been shown to modulate signaling pathways involved in cell adhesion, migration, and proliferation, including the integrin-mediated signaling pathway, the fibroblast growth factor receptor signaling pathway, and the ERK1/2 and JNK cascades. **Pathways and Functions** CCN2 regulates various cellular processes through its interactions with different signaling molecules and extracellular matrix components. Some of the key pathways and functions associated with CCN2 include: 1. **Angiogenesis**: CCN2 promotes angiogenesis by regulating the expression of pro-angiogenic factors and inhibiting anti-angiogenic factors. 2. **Cell Adhesion**: CCN2 modulates cell adhesion through its interactions with integrins and other adhesion molecules, influencing cell migration and proliferation. 3. **Chondrocyte Differentiation**: CCN2 regulates chondrocyte differentiation and proliferation, influencing cartilage development and maintenance. 4. **Osteogenesis**: CCN2 promotes osteogenesis by regulating the expression of osteogenic factors and inhibiting osteoclastic activity. 5. **Cell Migration**: CCN2 modulates cell migration through its interactions with integrins and other signaling molecules. 6. **Inflammation**: CCN2 regulates inflammation by modulating the expression of pro-inflammatory and anti-inflammatory factors. **Clinical Significance** CCN2 has been implicated in various diseases, including: 1. **Osteoarthritis**: CCN2 has been shown to promote cartilage degradation and osteoarthritis progression. 2. **Cancer**: CCN2 has been implicated in cancer progression, including angiogenesis, metastasis, and tumor growth. 3. **Cardiovascular Disease**: CCN2 regulates vascular remodeling and atherosclerosis progression. 4. **Thyroid Disease**: CCN2 has been implicated in thyroid disease, including thyroid cancer and hyperplasia. 5. **Wound Healing**: CCN2 regulates wound healing by modulating cell migration, proliferation, and differentiation. In summary, CCN2 is a multifunctional protein that plays a crucial role in various cellular processes, including cell adhesion, migration, proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of CCN2 in maintaining tissue homeostasis and preventing disease progression.

Genular Protein ID: 1947747861

Symbol: CCN2_HUMAN

Name: Insulin-like growth factor-binding protein 8

UniProtKB Accession Codes:

P29279 E1P578 Q6LCY0 Q96A79 Q96QX2 Q9UDL6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1654338

Title: Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

PubMed ID: 1654338

DOI: 10.1083/jcb.114.6.1285

PubMed ID: 1293144

Title: Connective tissue growth factor.

PubMed ID: 1293144

DOI: 10.1111/j.1346-8138.1992.tb03748.x

PubMed ID: 9054739

Title: Human connective tissue growth factor is expressed in advanced atherosclerotic lesions.

PubMed ID: 9054739

DOI: 10.1161/01.cir.95.4.831

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 1756408

Title: Expression of a gene encoding a novel potential IGF binding protein in human tissues.

PubMed ID: 1756408

PubMed ID: 10614647

Title: Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.

PubMed ID: 10614647

DOI: 10.1210/endo.141.1.7267

PubMed ID: 12553878

Title: The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion.

PubMed ID: 12553878

DOI: 10.1677/joe.0.176r001

PubMed ID: 30232710

Title: CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.

PubMed ID: 30232710

DOI: 10.1007/s12079-018-0487-x

Sequence Information:

  • Length: 349
  • Mass: 38091
  • Checksum: 62CF878C7F57EC1F
  • Sequence:
    • MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 
AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

Genular Protein ID: 1038222721

Symbol: Q5M8T4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5M8T4

Database IDs:

ABCD 1 ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 GO 8 Gene3D 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 10 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMART 4 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16501850

Title: Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy.

PubMed ID: 16501850

DOI: 10.1007/s10038-006-0368-7

Sequence Information:

  • Length: 349
  • Mass: 38069
  • Checksum: 0ECF8470B357EA95
  • Sequence:
    • MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 
AKQLGELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.