CCN2 | ENSG00000118523 | NCBI 1490

Details for: CCN2

Gene ID: 1490

Symbol: CCN2

Ensembl ID: ENSG00000118523

Description: cellular communication network factor 2

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates yap1-mediated transcription
(R-HSA-8951671)
Transcriptional regulation by runx3
(R-HSA-8878159)
Yap1- and wwtr1 (taz)-stimulated gene expression
(R-HSA-2032785)
Angiogenesis
(GO:0001525)
Cartilage condensation
(GO:0001502)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell migration
(GO:0016477)
Chondrocyte differentiation
(GO:0002062)
Chondrocyte proliferation
(GO:0035988)
Collagen-containing extracellular matrix
(GO:0062023)
Dna biosynthetic process
(GO:0071897)
Epidermis development
(GO:0008544)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Golgi apparatus
(GO:0005794)
Heparin binding
(GO:0008201)
Insulin-like growth factor binding
(GO:0005520)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Intracellular membrane-bounded organelle
(GO:0043231)
Lung development
(GO:0030324)
Negative regulation of gene expression
(GO:0010629)
Ossification
(GO:0001503)
Plasma membrane
(GO:0005886)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of stress fiber assembly
(GO:0051496)
Protein binding
(GO:0005515)
Reactive oxygen species metabolic process
(GO:0072593)
Regulation of chondrocyte differentiation
(GO:0032330)
Response to wounding
(GO:0009611)
Signal transduction
(GO:0007165)
Tissue homeostasis
(GO:0001894)

Other Information

Proteins

Insulin-like growth factor-binding protein 8
Q5M8T4_HUMAN

Genular Protein ID: 1947747861

Symbol: CCN2_HUMAN

Name: Insulin-like growth factor-binding protein 8

UniProtKB Accession Codes:

P29279 E1P578 Q6LCY0 Q96A79 Q96QX2 Q9UDL6

Database IDs:

Citations:

PubMed ID: 1654338

Title: Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

PubMed ID: 1654338

DOI: 10.1083/jcb.114.6.1285

PubMed ID: 1293144

Title: Connective tissue growth factor.

PubMed ID: 1293144

DOI: 10.1111/j.1346-8138.1992.tb03748.x

PubMed ID: 9054739

Title: Human connective tissue growth factor is expressed in advanced atherosclerotic lesions.

PubMed ID: 9054739

DOI: 10.1161/01.cir.95.4.831

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 1756408

Title: Expression of a gene encoding a novel potential IGF binding protein in human tissues.

PubMed ID: 1756408

PubMed ID: 10614647

Title: Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.

PubMed ID: 10614647

DOI: 10.1210/endo.141.1.7267

PubMed ID: 12553878

Title: The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion.

PubMed ID: 12553878

DOI: 10.1677/joe.0.176r001

PubMed ID: 30232710

Title: CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.

PubMed ID: 30232710

DOI: 10.1007/s12079-018-0487-x

Sequence Information:

Length: 349
Mass: 38091
Checksum: 62CF878C7F57EC1F
Sequence:

MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 
AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

Genular Protein ID: 1038222721

Symbol: Q5M8T4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5M8T4

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16501850

Title: Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy.

PubMed ID: 16501850

DOI: 10.1007/s10038-006-0368-7

Sequence Information:

Length: 349
Mass: 38069
Checksum: 0ECF8470B357EA95
Sequence:

MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 
AKQLGELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCN2

Associated with

Other Information

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. PubMed ID: 1654338

Connective tissue growth factor. PubMed ID: 1293144

Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. PubMed ID: 9054739

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Expression of a gene encoding a novel potential IGF binding protein in human tissues. PubMed ID: 1756408

Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. PubMed ID: 10614647

The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. PubMed ID: 12553878

CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi. PubMed ID: 30232710

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy. PubMed ID: 16501850