Details for: CTH

Gene ID: 1491

Symbol: CTH

Ensembl ID: ENSG00000116761

Description: cystathionine gamma-lyase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169357
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2
    Marker Score: 10539
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48023
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15553
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Marker Score: 1880
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.93
    Marker Score: 2179
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1876
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5108
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.88
    Marker Score: 2162
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.85
    Marker Score: 5457
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.84
    Marker Score: 491
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8
    Marker Score: 3437
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.77
    Marker Score: 655
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 471
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 289
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 633
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.69
    Marker Score: 518
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.67
    Marker Score: 3608
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.66
    Marker Score: 710
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.66
    Marker Score: 164.5
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.66
    Marker Score: 164.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 387
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.64
    Marker Score: 187
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.63
    Marker Score: 3784
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.62
    Marker Score: 572
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.58
    Marker Score: 325
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.58
    Marker Score: 12344
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 181
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.57
    Marker Score: 885
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.57
    Marker Score: 379
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.56
    Marker Score: 523
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.55
    Marker Score: 344
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 226
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.54
    Marker Score: 943
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 257
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.54
    Marker Score: 223
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5
    Marker Score: 170
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.49
    Marker Score: 2055
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.47
    Marker Score: 178
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.46
    Marker Score: 316
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.46
    Marker Score: 4749
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.45
    Marker Score: 113
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.45
    Marker Score: 393
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.45
    Marker Score: 114
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 193
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.43
    Marker Score: 918
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.43
    Marker Score: 4122
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.43
    Marker Score: 3683
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.42
    Marker Score: 1642
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 16010
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.42
    Marker Score: 528
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.42
    Marker Score: 25525
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.41
    Marker Score: 101
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.4
    Marker Score: 3763
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.38
    Marker Score: 173
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.38
    Marker Score: 7518
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.38
    Marker Score: 158
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.38
    Marker Score: 197
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 95
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.36
    Marker Score: 362
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.36
    Marker Score: 380
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.36
    Marker Score: 105
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.34
    Marker Score: 11649
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.34
    Marker Score: 119
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.34
    Marker Score: 356
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.33
    Marker Score: 161
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.33
    Marker Score: 152
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.33
    Marker Score: 1581
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.33
    Marker Score: 1335
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.33
    Marker Score: 218
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.33
    Marker Score: 220.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.32
    Marker Score: 155
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.32
    Marker Score: 75
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.32
    Marker Score: 398
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 84
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.31
    Marker Score: 1024
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.31
    Marker Score: 11467
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3
    Marker Score: 201
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.3
    Marker Score: 374.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3
    Marker Score: 627
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.3
    Marker Score: 230
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.3
    Marker Score: 348
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.29
    Marker Score: 472

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Other Information

**Key characteristics:** * CTH is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in both soluble and membrane-bound forms. * It is a key regulator of cysteine metabolism and plays a role in maintaining cellular redox balance. **Pathways and functions:** * CTH is involved in the regulation of cysteine metabolism, including the formation of cystathionine from homocysteine and the degradation of cysteine and homocysteine. * It also plays a role in the metabolism of other amino acids and derivatives, such as L-cysteine and L-cystine. * It is involved in the degradation of lipid molecules and the metabolism of semet, sec, and mesec. * CTH also has a role in the regulation of sulfur amino acid metabolism and the detoxification of selenocystathionine. **Clinical significance:** * Mutations in the CTH gene have been linked to several human diseases, including liver diseases, cardiovascular disease, and cancer. * CTH inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional points:** * CTH is a highly conserved protein with homologs in other species. * It is a target for several drugs, including carnitine, which can inhibit its activity. * CTH is a promising target for the treatment of human diseases.

Genular Protein ID: 3224266294

Symbol: CGL_HUMAN

Name: Cysteine desulfhydrase

UniProtKB Accession Codes:

P32929 B4E1R2 E9PDV0 Q53FB3 Q53Y79 Q9H4W7 Q9H4W8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 26 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 4 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 10 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339280

Title: Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase.

PubMed ID: 1339280

DOI: 10.1016/0006-291x(92)92265-y

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10212249

Title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration.

PubMed ID: 10212249

DOI: 10.1074/jbc.274.18.12675

PubMed ID: 10727430

Title: Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms.

PubMed ID: 10727430

DOI: 10.1042/bj3470291

PubMed ID: 19261609

Title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia.

PubMed ID: 19261609

DOI: 10.1074/jbc.m808026200

PubMed ID: 19961860

Title: Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.

PubMed ID: 19961860

DOI: 10.1016/j.jmb.2009.11.058

PubMed ID: 20305127

Title: Regulation of homocysteine metabolism and methylation in human and mouse tissues.

PubMed ID: 20305127

DOI: 10.1096/fj.09-143651

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22169477

Title: H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

PubMed ID: 22169477

DOI: 10.1126/scisignal.2002329

PubMed ID: 29254196

Title: The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts.

PubMed ID: 29254196

DOI: 10.18632/oncotarget.21514

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19019829

Title: Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.

PubMed ID: 19019829

DOI: 10.1074/jbc.m805459200

PubMed ID: 12574942

Title: Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH).

PubMed ID: 12574942

DOI: 10.1007/s00439-003-0906-8

PubMed ID: 18476726

Title: Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase.

PubMed ID: 18476726

DOI: 10.1021/bi800351a

Sequence Information:

  • Length: 405
  • Mass: 44508
  • Checksum: 003246D7C1D16723
  • Sequence:
    • MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY 
SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY 
FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG 
DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGHSDV VMGLVSVNCE SLHNRLRFLQ 
NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH 
ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL 
KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.