Details for: CTH

Gene ID: 1491

Symbol: CTH

Ensembl ID: ENSG00000116761

Description: cystathionine gamma-lyase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 70.9440
    Cell Significance Index: -11.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.6834
    Cell Significance Index: -11.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.3196
    Cell Significance Index: -9.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 16.9741
    Cell Significance Index: -11.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.0636
    Cell Significance Index: -11.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1772
    Cell Significance Index: -11.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8636
    Cell Significance Index: -11.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6159
    Cell Significance Index: 84.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2409
    Cell Significance Index: 236.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0524
    Cell Significance Index: 17.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9112
    Cell Significance Index: 19.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6479
    Cell Significance Index: 17.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6193
    Cell Significance Index: 37.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5910
    Cell Significance Index: 26.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5484
    Cell Significance Index: 495.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5040
    Cell Significance Index: 14.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3590
    Cell Significance Index: 58.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2892
    Cell Significance Index: 16.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2865
    Cell Significance Index: 57.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2475
    Cell Significance Index: 17.1200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2223
    Cell Significance Index: 2.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2118
    Cell Significance Index: 42.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1835
    Cell Significance Index: 116.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1708
    Cell Significance Index: 61.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1476
    Cell Significance Index: 1.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1298
    Cell Significance Index: 8.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1192
    Cell Significance Index: 65.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1128
    Cell Significance Index: 2.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1062
    Cell Significance Index: 2.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0944
    Cell Significance Index: 177.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0912
    Cell Significance Index: 2.9200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0856
    Cell Significance Index: 0.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0851
    Cell Significance Index: 2.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0837
    Cell Significance Index: 6.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0728
    Cell Significance Index: 7.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0719
    Cell Significance Index: 2.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0515
    Cell Significance Index: 8.7900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0495
    Cell Significance Index: 0.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0449
    Cell Significance Index: 5.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0369
    Cell Significance Index: 2.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0368
    Cell Significance Index: 5.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0360
    Cell Significance Index: 1.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0358
    Cell Significance Index: 0.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0312
    Cell Significance Index: 0.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0286
    Cell Significance Index: 19.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0285
    Cell Significance Index: 52.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0260
    Cell Significance Index: 40.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0137
    Cell Significance Index: 6.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0101
    Cell Significance Index: 0.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0077
    Cell Significance Index: 3.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0020
    Cell Significance Index: 0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0005
    Cell Significance Index: -0.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0007
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0107
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0147
    Cell Significance Index: -10.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0197
    Cell Significance Index: -11.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0199
    Cell Significance Index: -12.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0228
    Cell Significance Index: -2.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0269
    Cell Significance Index: -7.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0311
    Cell Significance Index: -1.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0363
    Cell Significance Index: -0.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0378
    Cell Significance Index: -4.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0514
    Cell Significance Index: -5.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0540
    Cell Significance Index: -6.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0568
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0596
    Cell Significance Index: -12.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0660
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0719
    Cell Significance Index: -8.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0802
    Cell Significance Index: -4.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0809
    Cell Significance Index: -3.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0855
    Cell Significance Index: -2.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0892
    Cell Significance Index: -3.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0909
    Cell Significance Index: -6.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0912
    Cell Significance Index: -9.5000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0952
    Cell Significance Index: -0.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0978
    Cell Significance Index: -7.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0985
    Cell Significance Index: -7.3400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1004
    Cell Significance Index: -0.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1038
    Cell Significance Index: -2.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1060
    Cell Significance Index: -7.5000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1313
    Cell Significance Index: -1.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1430
    Cell Significance Index: -2.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1431
    Cell Significance Index: -6.3300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1475
    Cell Significance Index: -1.6100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1504
    Cell Significance Index: -2.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1573
    Cell Significance Index: -10.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1598
    Cell Significance Index: -2.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1689
    Cell Significance Index: -4.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1714
    Cell Significance Index: -6.4900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1774
    Cell Significance Index: -2.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1847
    Cell Significance Index: -5.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2001
    Cell Significance Index: -5.7100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2005
    Cell Significance Index: -3.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2011
    Cell Significance Index: -2.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2024
    Cell Significance Index: -2.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2118
    Cell Significance Index: -3.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2135
    Cell Significance Index: -5.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2391
    Cell Significance Index: -3.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Cystathionine gamma-lyase is a mitochondrial enzyme that belongs to the class of thioltransferases. It is encoded by the CTH gene, which is located on chromosome 21q22.3 in humans. The CTH protein is a homotetramer, composed of four identical subunits, each with a molecular mass of approximately 65 kDa. The enzyme is activated by calcium ions and has a high affinity for cystathionine, which is the substrate for the reaction. **Pathways and Functions** The CTH enzyme is involved in several important metabolic pathways, including: 1. **Transsulfuration pathway**: CTH catalyzes the conversion of cystathionine to cysteine, which is then used to synthesize glutathione, an important antioxidant molecule. 2. **Homocysteine metabolism**: CTH is also involved in the metabolism of homocysteine, a toxic amino acid that can be converted to cysteine or methionine, depending on the availability of methyl groups. 3. **Cell differentiation**: CTH has been shown to play a role in the regulation of cell differentiation, particularly in the development of the nervous system and the cardiovascular system. 4. **Apoptosis regulation**: CTH is involved in the negative regulation of apoptotic signaling pathways, which can help to protect cells from programmed cell death. 5. **Inflammation response**: CTH has been implicated in the regulation of the inflammatory response, particularly in the context of cardiovascular disease. **Clinical Significance** Dysregulation of the CTH gene has been implicated in several diseases, including: 1. **Homocystinuria**: A genetic disorder characterized by elevated levels of homocysteine in the blood, which can lead to cardiovascular disease and other complications. 2. **Neurodegenerative diseases**: CTH has been implicated in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CTH has been shown to play a role in the regulation of cancer cell growth and survival. 4. **Cardiovascular disease**: CTH has been implicated in the regulation of cardiovascular disease, particularly in the context of hypertension and atherosclerosis. In conclusion, cystathionine gamma-lyase is a critical enzyme involved in the transsulfuration pathway of amino acid metabolism. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 3224266294

Symbol: CGL_HUMAN

Name: Cysteine desulfhydrase

UniProtKB Accession Codes:

P32929 B4E1R2 E9PDV0 Q53FB3 Q53Y79 Q9H4W7 Q9H4W8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 26 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 4 EMBL 8 Ensembl 3 EvolutionaryTrace 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 10 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339280

Title: Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase.

PubMed ID: 1339280

DOI: 10.1016/0006-291x(92)92265-y

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10212249

Title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration.

PubMed ID: 10212249

DOI: 10.1074/jbc.274.18.12675

PubMed ID: 10727430

Title: Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms.

PubMed ID: 10727430

DOI: 10.1042/bj3470291

PubMed ID: 19261609

Title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia.

PubMed ID: 19261609

DOI: 10.1074/jbc.m808026200

PubMed ID: 19961860

Title: Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.

PubMed ID: 19961860

DOI: 10.1016/j.jmb.2009.11.058

PubMed ID: 20305127

Title: Regulation of homocysteine metabolism and methylation in human and mouse tissues.

PubMed ID: 20305127

DOI: 10.1096/fj.09-143651

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22169477

Title: H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

PubMed ID: 22169477

DOI: 10.1126/scisignal.2002329

PubMed ID: 29254196

Title: The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts.

PubMed ID: 29254196

DOI: 10.18632/oncotarget.21514

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19019829

Title: Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.

PubMed ID: 19019829

DOI: 10.1074/jbc.m805459200

PubMed ID: 12574942

Title: Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH).

PubMed ID: 12574942

DOI: 10.1007/s00439-003-0906-8

PubMed ID: 18476726

Title: Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase.

PubMed ID: 18476726

DOI: 10.1021/bi800351a

Sequence Information:

  • Length: 405
  • Mass: 44508
  • Checksum: 003246D7C1D16723
  • Sequence:
    • MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY 
SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY 
FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG 
DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGHSDV VMGLVSVNCE SLHNRLRFLQ 
NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH 
ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL 
KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.