CTH | ENSG00000116761 | NCBI 1491

Details for: CTH

Gene ID: 1491

Symbol: CTH

Ensembl ID: ENSG00000116761

Description: cystathionine gamma-lyase

Associated with

Cysteine formation from homocysteine
(R-HSA-1614603)
Degradation of cysteine and homocysteine
(R-HSA-1614558)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of ingested semet, sec, mesec into h2se
(R-HSA-2408508)
Selenoamino acid metabolism
(R-HSA-2408522)
Sulfur amino acid metabolism
(R-HSA-1614635)
Calmodulin binding
(GO:0005516)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cystathionine gamma-lyase activity
(GO:0004123)
Cysteine biosynthetic process
(GO:0019344)
Cysteine biosynthetic process via cystathionine
(GO:0019343)
Cysteine metabolic process
(GO:0006534)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Extracellular exosome
(GO:0070062)
Homocysteine desulfhydrase activity
(GO:0047982)
Hydrogen sulfide biosynthetic process
(GO:0070814)
Identical protein binding
(GO:0042802)
L-cysteine desulfhydrase activity
(GO:0080146)
L-cystine l-cysteine-lyase (deaminating)
(GO:0044540)
Lipid metabolic process
(GO:0006629)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Positive regulation of aortic smooth muscle cell differentiation
(GO:1904831)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Protein-pyridoxal-5-phosphate linkage via peptidyl-n6-pyridoxal phosphate-l-lysine
(GO:0018272)
Protein binding
(GO:0005515)
Protein homotetramerization
(GO:0051289)
Protein sulfhydration
(GO:0044524)
Pyridoxal phosphate binding
(GO:0030170)
Selenocystathionine gamma-lyase activity
(GO:0098606)
Transsulfuration
(GO:0019346)

Other Information

Proteins

Cysteine desulfhydrase

Genular Protein ID: 3224266294

Symbol: CGL_HUMAN

Name: Cysteine desulfhydrase

UniProtKB Accession Codes:

P32929 B4E1R2 E9PDV0 Q53FB3 Q53Y79 Q9H4W7 Q9H4W8

Database IDs:

Citations:

PubMed ID: 1339280

Title: Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase.

PubMed ID: 1339280

DOI: 10.1016/0006-291x(92)92265-y

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10212249

Title: Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration.

PubMed ID: 10212249

DOI: 10.1074/jbc.274.18.12675

PubMed ID: 10727430

Title: Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms.

PubMed ID: 10727430

DOI: 10.1042/bj3470291

PubMed ID: 19261609

Title: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia.

PubMed ID: 19261609

DOI: 10.1074/jbc.m808026200

PubMed ID: 19961860

Title: Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production.

PubMed ID: 19961860

DOI: 10.1016/j.jmb.2009.11.058

PubMed ID: 20305127

Title: Regulation of homocysteine metabolism and methylation in human and mouse tissues.

PubMed ID: 20305127

DOI: 10.1096/fj.09-143651

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22169477

Title: H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

PubMed ID: 22169477

DOI: 10.1126/scisignal.2002329

PubMed ID: 29254196

Title: The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts.

PubMed ID: 29254196

DOI: 10.18632/oncotarget.21514

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19019829

Title: Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.

PubMed ID: 19019829

DOI: 10.1074/jbc.m805459200

PubMed ID: 12574942

Title: Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH).

PubMed ID: 12574942

DOI: 10.1007/s00439-003-0906-8

PubMed ID: 18476726

Title: Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase.

PubMed ID: 18476726

DOI: 10.1021/bi800351a

Sequence Information:

Length: 405
Mass: 44508
Checksum: 003246D7C1D16723
Sequence:

MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY 
SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY 
FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG 
DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGHSDV VMGLVSVNCE SLHNRLRFLQ 
NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH 
ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL 
KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTH

Associated with

Other Information

Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase. PubMed ID: 1339280

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration. PubMed ID: 10212249

Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms. PubMed ID: 10727430

H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. PubMed ID: 19261609

Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production. PubMed ID: 19961860

Regulation of homocysteine metabolism and methylation in human and mouse tissues. PubMed ID: 20305127

Initial characterization of the human central proteome. PubMed ID: 21269460

H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. PubMed ID: 22169477

The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts. PubMed ID: 29254196

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S. PubMed ID: 19019829

Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH). PubMed ID: 12574942

Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase. PubMed ID: 18476726