Details for: CTLA4
Associated with
Other Information
Genular Protein ID: 3512610246
Symbol: CTLA4_HUMAN
Name: Cytotoxic T-lymphocyte protein 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1713603
Title: CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
PubMed ID: 1713603
PubMed ID: 11735222
Title: Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
PubMed ID: 11735222
PubMed ID: 18595775
Title: Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis.
PubMed ID: 18595775
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3220103
Title: Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains.
PubMed ID: 3220103
PubMed ID: 10493833
Title: Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
PubMed ID: 10493833
PubMed ID: 1714933
Title: CTLA-4 is a second receptor for the B cell activation antigen B7.
PubMed ID: 1714933
PubMed ID: 9175836
Title: Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
PubMed ID: 9175836
PubMed ID: 9813138
Title: Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.
PubMed ID: 9813138
PubMed ID: 10842319
Title: Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
PubMed ID: 10842319
DOI: 10.1002/(sici)1097-4644(20000801)78:2<241::aid-jcb7>3.3.co;2-b
PubMed ID: 12724780
Title: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
PubMed ID: 12724780
DOI: 10.1038/nature01621
PubMed ID: 16002699
Title: Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation.
PubMed ID: 16002699
PubMed ID: 16551244
Title: A molecular perspective of CTLA-4 function.
PubMed ID: 16551244
PubMed ID: 18468488
PubMed ID: 19426230
Title: The clinical utility of inhibiting CD28-mediated costimulation.
PubMed ID: 19426230
PubMed ID: 9228944
Title: Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.
PubMed ID: 9228944
DOI: 10.1038/nsb0797-527
PubMed ID: 11279501
Title: Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
PubMed ID: 11279501
DOI: 10.1038/35069112
PubMed ID: 11279502
Title: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
PubMed ID: 11279502
DOI: 10.1038/35069118
PubMed ID: 21156796
Title: Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.
PubMed ID: 21156796
PubMed ID: 28484017
Title: Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
PubMed ID: 28484017
PubMed ID: 9259273
Title: Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.
PubMed ID: 9259273
DOI: 10.1093/hmg/6.8.1275
PubMed ID: 10189842
Title: CTLA-4 gene polymorphism is associated with predisposition to coeliac disease.
PubMed ID: 10189842
DOI: 10.1136/gut.43.2.187
PubMed ID: 10475192
Title: Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.
PubMed ID: 10475192
PubMed ID: 10924276
Title: Complex association analysis of Graves disease using a set of polymorphic markers.
PubMed ID: 10924276
PubMed ID: 10903931
Title: Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.
PubMed ID: 10903931
DOI: 10.1086/303059
PubMed ID: 15138458
Title: Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.
PubMed ID: 15138458
PubMed ID: 15452244
Title: Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
PubMed ID: 15452244
PubMed ID: 15657618
Title: A common CTLA4 haplotype associated with coeliac disease.
PubMed ID: 15657618
PubMed ID: 15688186
Title: CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.
PubMed ID: 15688186
PubMed ID: 25329329
Title: Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
PubMed ID: 25329329
DOI: 10.1038/nm.3746
PubMed ID: 25213377
Title: Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
PubMed ID: 25213377
Sequence Information:
- Length: 223
- Mass: 24656
- Checksum: 6F9466FB2E139A5A
- Sequence:
MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS RGIASFVCEY ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD SICTGTSSGN QVNLTIQGLR AMDTGLYICK VELMYPPPYY LGIGNGTQIY VIDPEPCPDS DFLLWILAAV SSGLFFYSFL LTAVSLSKML KKRSPLTTGV YVKMPPTEPE CEKQFQPYFI PIN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.