Details for: CTLA4

Gene ID: 1493

Symbol: CTLA4

Ensembl ID: ENSG00000163599

Description: cytotoxic T-lymphocyte associated protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.53
    Marker Score: 5600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.78
    Marker Score: 539
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.76
    Marker Score: 3577
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.64
    Marker Score: 3106
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.43
    Marker Score: 820
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.36
    Marker Score: 1071
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.28
    Marker Score: 639.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.24
    Marker Score: 1370
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7614
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.03
    Marker Score: 6607
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.03
    Marker Score: 273
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.02
    Marker Score: 610
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.97
    Marker Score: 338
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2438
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5322
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.87
    Marker Score: 8624
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.86
    Marker Score: 233
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.75
    Marker Score: 440
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.72
    Marker Score: 11306
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.7
    Marker Score: 217
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.65
    Marker Score: 543
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 412.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.61
    Marker Score: 442
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 449
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.55
    Marker Score: 359.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 257
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 202
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.48
    Marker Score: 245
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.42
    Marker Score: 304
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.42
    Marker Score: 391
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.42
    Marker Score: 345
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 394
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.39
    Marker Score: 20858.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.35
    Marker Score: 176
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.35
    Marker Score: 902
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.34
    Marker Score: 755
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.32
    Marker Score: 631
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.31
    Marker Score: 296
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.3
    Marker Score: 191
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.29
    Marker Score: 213
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.28
    Marker Score: 204
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 120
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.25
    Marker Score: 268
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.23
    Marker Score: 655
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.23
    Marker Score: 246
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.22
    Marker Score: 382
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.21
    Marker Score: 89
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.2
    Marker Score: 855
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.2
    Marker Score: 90
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.19
    Marker Score: 330
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.19
    Marker Score: 158
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.17
    Marker Score: 1975
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.17
    Marker Score: 148
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.16
    Marker Score: 253
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.16
    Marker Score: 203
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 252
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.14
    Marker Score: 163
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.13
    Marker Score: 28
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.12
    Marker Score: 172
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.11
    Marker Score: 85
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 333.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.11
    Marker Score: 65
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.11
    Marker Score: 149
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.1
    Marker Score: 89

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Other Information

**Key characteristics:** - CTLA4 is a cell surface protein that is expressed on regulatory T cells. - It is a member of the immunoglobulin superfamily. - CTLA4 is responsible for blocking the activation of T cells by interacting with the CD28 protein on the surface of antigen-presenting cells. - CTLA4 is a key negative regulator of T cell responses. **Pathways and functions:** - CTLA4 is involved in the regulation of the adaptive immune response. - It is expressed in high levels on regulatory T cells, which are responsible for suppressing immune responses. - CTLA4 binds to CD28 on antigen-presenting cells, blocking the activation of the T cell and preventing the development of an immune response. - CTLA4 also inhibits the activation of other immune cells, such as dendritic cells and macrophages. - By blocking T cell activation, CTLA4 helps to maintain immune tolerance and prevent excessive immune responses. **Clinical significance:** - CTLA4 is a potential therapeutic target for autoimmune diseases, such as rheumatoid arthritis, psoriasis, and lupus. - Antibodies that block CTLA4 have shown promise in preclinical studies of these diseases, resulting in a reduction in inflammation and disease activity. - CTLA4 is a promising target for the development of novel immunotherapies for autoimmune diseases.

Genular Protein ID: 3512610246

Symbol: CTLA4_HUMAN

Name: Cytotoxic T-lymphocyte protein 4

UniProtKB Accession Codes:

P16410 A0N1S0 E9PDH0 O95653 Q0PP65 Q52MC1 Q53TD5 Q5S005 Q8WXJ1 Q96P43 Q9UKN9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTC 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 14 Ensembl 3 EvolutionaryTrace 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 20 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1713603

Title: CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

PubMed ID: 1713603

PubMed ID: 11735222

Title: Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.

PubMed ID: 11735222

DOI: 10.1006/geno.2001.6655

PubMed ID: 18595775

Title: Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis.

PubMed ID: 18595775

DOI: 10.1016/j.clim.2008.05.006

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3220103

Title: Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains.

PubMed ID: 3220103

DOI: 10.1002/eji.1830181206

PubMed ID: 10493833

Title: Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.

PubMed ID: 10493833

DOI: 10.1006/geno.1999.5930

PubMed ID: 1714933

Title: CTLA-4 is a second receptor for the B cell activation antigen B7.

PubMed ID: 1714933

DOI: 10.1084/jem.174.3.561

PubMed ID: 9175836

Title: Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.

PubMed ID: 9175836

DOI: 10.1016/s1074-7613(00)80346-5

PubMed ID: 9813138

Title: Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.

PubMed ID: 9813138

DOI: 10.1006/bbrc.1998.9559

PubMed ID: 10842319

Title: Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.

PubMed ID: 10842319

DOI: 10.1002/(sici)1097-4644(20000801)78:2<241::aid-jcb7>3.3.co;2-b

PubMed ID: 12724780

Title: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

PubMed ID: 12724780

DOI: 10.1038/nature01621

PubMed ID: 16002699

Title: Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation.

PubMed ID: 16002699

DOI: 10.4049/jimmunol.175.2.996

PubMed ID: 16551244

Title: A molecular perspective of CTLA-4 function.

PubMed ID: 16551244

DOI: 10.1146/annurev.immunol.24.021605.090535

PubMed ID: 18468488

Title: CTLA-4 trafficking and surface expression.

PubMed ID: 18468488

DOI: 10.1016/j.it.2008.02.011

PubMed ID: 19426230

Title: The clinical utility of inhibiting CD28-mediated costimulation.

PubMed ID: 19426230

DOI: 10.1111/j.1600-065x.2009.00780.x

PubMed ID: 9228944

Title: Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.

PubMed ID: 9228944

DOI: 10.1038/nsb0797-527

PubMed ID: 11279501

Title: Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.

PubMed ID: 11279501

DOI: 10.1038/35069112

PubMed ID: 11279502

Title: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.

PubMed ID: 11279502

DOI: 10.1038/35069118

PubMed ID: 21156796

Title: Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.

PubMed ID: 21156796

DOI: 10.1074/jbc.m110.182394

PubMed ID: 28484017

Title: Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.

PubMed ID: 28484017

DOI: 10.1073/pnas.1617941114

PubMed ID: 9259273

Title: Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.

PubMed ID: 9259273

DOI: 10.1093/hmg/6.8.1275

PubMed ID: 10189842

Title: CTLA-4 gene polymorphism is associated with predisposition to coeliac disease.

PubMed ID: 10189842

DOI: 10.1136/gut.43.2.187

PubMed ID: 10475192

Title: Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.

PubMed ID: 10475192

DOI: 10.1016/s0140-6736(99)01465-8

PubMed ID: 10924276

Title: Complex association analysis of Graves disease using a set of polymorphic markers.

PubMed ID: 10924276

DOI: 10.1006/mgme.2000.3007

PubMed ID: 10903931

Title: Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.

PubMed ID: 10903931

DOI: 10.1086/303059

PubMed ID: 15138458

Title: Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.

PubMed ID: 15138458

DOI: 10.1038/sj.ejhg.5201214

PubMed ID: 15452244

Title: Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.

PubMed ID: 15452244

DOI: 10.1128/jvi.78.20.11258-11262.2004

PubMed ID: 15657618

Title: A common CTLA4 haplotype associated with coeliac disease.

PubMed ID: 15657618

DOI: 10.1038/sj.ejhg.5201357

PubMed ID: 15688186

Title: CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.

PubMed ID: 15688186

DOI: 10.1007/s00439-004-1244-1

PubMed ID: 25329329

Title: Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.

PubMed ID: 25329329

DOI: 10.1038/nm.3746

PubMed ID: 25213377

Title: Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.

PubMed ID: 25213377

DOI: 10.1126/science.1255904

Sequence Information:

  • Length: 223
  • Mass: 24656
  • Checksum: 6F9466FB2E139A5A
  • Sequence:
    • MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS RGIASFVCEY 
ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD SICTGTSSGN QVNLTIQGLR 
AMDTGLYICK VELMYPPPYY LGIGNGTQIY VIDPEPCPDS DFLLWILAAV SSGLFFYSFL 
LTAVSLSKML KKRSPLTTGV YVKMPPTEPE CEKQFQPYFI PIN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.