Gzma | ENSMUSG00000023132 | NCBI 14938

Details for: Gzma

Gene ID: 14938

Symbol: Gzma

Ensembl ID: ENSMUSG00000023132

Description: granzyme A

Associated with

Cytoplasm
(GO:0005737)
Cytotoxic t cell pyroptotic process
(GO:1902483)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Granzyme-mediated programmed cell death signaling pathway
(GO:0140507)
Hydrolase activity
(GO:0016787)
Killing of cells of another organism
(GO:0031640)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of endodeoxyribonuclease activity
(GO:0032078)
Negative regulation of oxidoreductase activity
(GO:0051354)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Positive regulation of apoptotic process
(GO:0043065)
Protein homodimerization activity
(GO:0042803)
Protein maturation
(GO:0051604)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Pyroptosis
(GO:0070269)
Response to bacterium
(GO:0009617)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)

Other Information

Proteins

Granzyme A

Genular Protein ID: 1698842133

Symbol: GRAA_MOUSE

Name: Granzyme A

UniProtKB Accession Codes:

P11032 P15118

Database IDs:

Citations:

PubMed ID: 2976140

Title: cDNA clones from autocrine thymic lymphoma cells encode two mitogenic proteins, a serine protease and a truncated T-cell receptor beta-chain.

PubMed ID: 2976140

PubMed ID: 1639378

Title: Organization of the gene encoding the mouse T-cell-specific serine proteinase 'granzyme A'.

PubMed ID: 1639378

DOI: 10.1016/0888-7543(92)90117-b

PubMed ID: 1460043

Title: Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides.

PubMed ID: 1460043

DOI: 10.1016/s0021-9258(19)74067-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3292396

Title: Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation.

PubMed ID: 3292396

DOI: 10.1111/j.1600-065x.1988.tb00749.x

PubMed ID: 2422755

Title: Cloning of a cDNA for a T cell-specific serine protease from a cytotoxic T lymphocyte.

PubMed ID: 2422755

DOI: 10.1126/science.2422755

PubMed ID: 3555842

Title: A family of serine esterases in lytic granules of cytolytic T lymphocytes.

PubMed ID: 3555842

DOI: 10.1016/0092-8674(87)90544-7

PubMed ID: 3533635

Title: Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes.

PubMed ID: 3533635

DOI: 10.1016/0014-5793(86)81537-x

PubMed ID: 3260181

Title: Induction of T cell serine proteinase 1 (TSP-1)-specific mRNA in mouse T lymphocytes.

PubMed ID: 3260181

DOI: 10.1002/eji.1830180605

Sequence Information:

Length: 260
Mass: 28599
Checksum: 7705352F08DEED8D
Sequence:

MRNASGPRGP SLATLLFLLL IPEGGCERII GGDTVVPHSR PYMALLKLSS NTICAGALIE 
KNWVLTAAHC NVGKRSKFIL GAHSINKEPE QQILTVKKAF PYPCYDEYTR EGDLQLVRLK 
KKATVNRNVA ILHLPKKGDD VKPGTRCRVA GWGRFGNKSA PSETLREVNI TVIDRKICND 
EKHYNFHPVI GLNMICAGDL RGGKDSCNGD SGSPLLCDGI LRGITSFGGE KCGDRRWPGV 
YTFLSDKHLN WIKKIMKGSV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gzma

Associated with

Other Information

cDNA clones from autocrine thymic lymphoma cells encode two mitogenic proteins, a serine protease and a truncated T-cell receptor beta-chain. PubMed ID: 2976140

Organization of the gene encoding the mouse T-cell-specific serine proteinase 'granzyme A'. PubMed ID: 1639378

Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides. PubMed ID: 1460043

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation. PubMed ID: 3292396

Cloning of a cDNA for a T cell-specific serine protease from a cytotoxic T lymphocyte. PubMed ID: 2422755

A family of serine esterases in lytic granules of cytolytic T lymphocytes. PubMed ID: 3555842

Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes. PubMed ID: 3533635

Induction of T cell serine proteinase 1 (TSP-1)-specific mRNA in mouse T lymphocytes. PubMed ID: 3260181