Details for: CTNNA2

Gene ID: 1496

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CTNNA2

Ensembl ID: ENSG00000066032

Description: catenin alpha 2

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • sst GABAergic cortical interneuron CL4023017
    CSI 46.83
    rCSI 60.37%
    PRS 51.14
  • VIP GABAergic cortical interneuron CL4023016
    CSI 44.61
    rCSI 53.29%
    PRS 49.59
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 40.02
    rCSI 49.79%
    PRS 47.86
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 34.99
    rCSI 58.73%
    PRS 49.77
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 32.77
    rCSI 42.06%
    PRS 65.17
  • cerebellar granule cell CL0001031
    CSI 32.76
    rCSI 48.16%
    PRS 61.72
  • ependymal cell CL0000065
    CSI 31.09
    rCSI 63.08%
    PRS 47
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 30.56
    rCSI 35.3%
    PRS 61.21
  • astrocyte of the cerebral cortex CL0002605
    CSI 30.08
    rCSI 67.45%
    PRS 50.47
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 29.65
    rCSI 53.88%
    PRS 59.91
  • astrocyte CL0000127
    CSI 29.23
    rCSI 62.27%
    PRS 42.18
  • sncg GABAergic cortical interneuron CL4023015
    CSI 28.96
    rCSI 46.58%
    PRS 51.75
  • vascular leptomeningeal cell CL4023051
    CSI 28.05
    rCSI 49.18%
    PRS 61.09
  • oligodendrocyte precursor cell CL0002453
    CSI 27.83
    rCSI 61.24%
    PRS 52.29
  • inhibitory interneuron CL0000498
    CSI 27.76
    rCSI 64.07%
    PRS 56.93
  • neural crest cell CL0011012
    CSI 27.68
    rCSI 21.88%
    PRS 55.71
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 26.23
    rCSI 56.89%
    PRS 56.27
  • interneuron CL0000099
    CSI 25.79
    rCSI 51.77%
    PRS 57.8
  • retinal bipolar neuron CL0000748
    CSI 25.07
    rCSI 46.95%
    PRS 56.46
  • choroid plexus epithelial cell CL0000706
    CSI 24.6
    rCSI 40.29%
    PRS 57.64
  • radial glial cell CL0000681
    CSI 24.14
    rCSI 33.54%
    PRS 67.11
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 23.75
    rCSI 56.81%
    PRS 55.4
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 23.4
    rCSI 56.86%
    PRS 48.24
  • neuron CL0000540
    CSI 23.29
    rCSI 62.03%
    PRS 57.32
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 21.96
    rCSI 38.79%
    PRS 48.91
  • Bergmann glial cell CL0000644
    CSI 21.68
    rCSI 29.66%
    PRS 61.07
  • cerebral cortex endothelial cell CL1001602
    CSI 19.33
    rCSI 33.43%
    PRS 58.93
  • cerebral cortex neuron CL0010012
    CSI 18.54
    rCSI 75.56%
    PRS 61.85
  • amacrine cell CL0000561
    CSI 18.47
    rCSI 53.52%
    PRS 57.91
  • retina horizontal cell CL0000745
    CSI 17.98
    rCSI 27.41%
    PRS 64.92
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 17.47
    rCSI 54.63%
    PRS 54.05
  • glioblast CL0000030
    CSI 17.36
    rCSI 27.7%
    PRS 60.46
  • mature astrocyte CL0002627
    CSI 17.36
    rCSI 73.78%
    PRS 61.29
  • glutamatergic neuron CL0000679
    CSI 16.77
    rCSI 34.47%
    PRS 57.75
  • neural cell CL0002319
    CSI 16.75
    rCSI 63.2%
    PRS 53.08
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 16.27
    rCSI 58.54%
    PRS 47.99
  • L6b glutamatergic cortical neuron CL4023038
    CSI 16.16
    rCSI 50.5%
    PRS 51.53
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 15.67
    rCSI 51.5%
    PRS 55.23
  • retinal rod cell CL0000604
    CSI 15.3
    rCSI 26.96%
    PRS 64.9
  • rod bipolar cell CL0000751
    CSI 14.53
    rCSI 26.12%
    PRS 61.63
  • glycinergic amacrine cell CL4030028
    CSI 13.89
    rCSI 36.19%
    PRS 65.19
  • melanocyte CL0000148
    CSI 13.87
    rCSI 10.27%
    PRS 61.43
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 13.38
    rCSI 50.57%
    PRS 50.39
  • GABAergic amacrine cell CL4030027
    CSI 13.05
    rCSI 44.7%
    PRS 56.67
  • serotonergic neuron CL0000850
    CSI 12.94
    rCSI 57.79%
    PRS 52.55
  • diffuse bipolar 6 cell CL4033032
    CSI 11.95
    rCSI 62.85%
    PRS 61.7
  • GABAergic neuron CL0000617
    CSI 11.5
    rCSI 38.54%
    PRS 53.16
  • Schwann cell CL0002573
    CSI 11.33
    rCSI 32.21%
    PRS 66.02
  • retinal ganglion cell CL0000740
    CSI 11.19
    rCSI 24.73%
    PRS 54.49
  • ON-bipolar cell CL0000749
    CSI 10.85
    rCSI 16.13%
    PRS 69.53
  • adipocyte CL0000136
    CSI 10.84
    rCSI 13.92%
    PRS 60.25
  • OFFx cell CL4033036
    CSI 10.66
    rCSI 50.16%
    PRS 62.56
  • dopaminergic neuron CL0000700
    CSI 10.64
    rCSI 60.13%
    PRS 53.99
  • glial cell CL0000125
    CSI 10.55
    rCSI 40.16%
    PRS 58.99
  • Mueller cell CL0000636
    CSI 10.54
    rCSI 24.05%
    PRS 60.08
  • neural progenitor cell CL0011020
    CSI 8.74
    rCSI 38.45%
    PRS 57.97
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 8.62
    rCSI 50.75%
    PRS 50.96
  • invaginating midget bipolar cell CL4033034
    CSI 8.51
    rCSI 50.24%
    PRS 62.19
  • macroglial cell CL0000126
    CSI 7.89
    rCSI 20.28%
    PRS 66.99
  • retinal cone cell CL0000573
    CSI 7.71
    rCSI 12.41%
    PRS 58.01
  • cerebellar neuron CL1001611
    CSI 6.81
    rCSI 59.95%
    PRS 56.23
  • diffuse bipolar 1 cell CL4033027
    CSI 6.8
    rCSI 51.09%
    PRS 61.36
  • central nervous system neuron CL2000029
    CSI 6.4
    rCSI 47.04%
    PRS 55.14
  • diffuse bipolar 3b cell CL4033030
    CSI 6.27
    rCSI 41.64%
    PRS 64.95
  • brain vascular cell CL4023072
    CSI 6.26
    rCSI 64.75%
    PRS 62.69
  • medium spiny neuron CL1001474
    CSI 5.86
    rCSI 50.49%
    PRS 55.76
  • basket cell CL0000118
    CSI 5.81
    rCSI 36.39%
    PRS 50.84
  • medial ganglionic eminence derived interneuron CL4023063
    CSI 5.38
    rCSI 53.75%
    PRS 27.59
  • flat midget bipolar cell CL4033033
    CSI 4.8
    rCSI 34.31%
    PRS 60.8
  • diffuse bipolar 2 cell CL4033028
    CSI 4.53
    rCSI 35.09%
    PRS 64.31
  • diffuse bipolar 4 cell CL4033031
    CSI 4.01
    rCSI 45.89%
    PRS 59.14
  • ON parasol ganglion cell CL4033052
    CSI 3.81
    rCSI 54.02%
    PRS 59.57
  • diffuse bipolar 3a cell CL4033029
    CSI 3.72
    rCSI 25.32%
    PRS 63.13
  • cerebral cortex pyramidal neuron CL4023111
    CSI 3.29
    rCSI 20.24%
    PRS 79.88
  • neuroplacodal cell CL0000032
    CSI 3.18
    rCSI 29.36%
    PRS 75.66
  • retinal pigment epithelial cell CL0002586
    CSI 3.11
    rCSI 6.19%
    PRS 65.25
  • ON midget ganglion cell CL4033046
    CSI 2.78
    rCSI 56.72%
    PRS 58.98
  • OFF midget ganglion cell CL4033047
    CSI 2.75
    rCSI 56.05%
    PRS 60.46
  • starburst amacrine cell CL0004232
    CSI 2.74
    rCSI 23.04%
    PRS 58.65
  • direct pathway medium spiny neuron CL4023026
    CSI 2.31
    rCSI 55.41%
    PRS 48.97
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.29
    rCSI 55.22%
    PRS 49.61
  • GABAergic interneuron CL0011005
    CSI 2.16
    rCSI 34.08%
    PRS 72.06
  • midbrain dopaminergic neuron CL2000097
    CSI 1.92
    rCSI 12.32%
    PRS 68.64
  • H1 horizontal cell CL0004217
    CSI 1.6
    rCSI 6.35%
    PRS 66.68
  • H2 horizontal cell CL0004218
    CSI 1.2
    rCSI 5.99%
    PRS 64.82
  • enteric neuron CL0007011
    CSI 0.13
    rCSI 1.98%
    PRS 80.22

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CTNNA2](/details-gene/1496) (catenin alpha 2) is a protein-coding gene located on chromosome 2p12 that encodes alpha-N-catenin, a crucial component of cell-cell adhesion structures. As a member of the catenin family, it functions as a linker protein, connecting cadherin-based adhesion complexes to the actin cytoskeleton. Expression data reveals that [CTNNA2](/details-gene/1496) is predominantly active in the central nervous system. It shows particularly high significance in various subtypes of GABAergic cortical interneurons, such as [sst GABAergic cortical interneuron](/details-cell/CL4023017) and [VIP GABAergic cortical interneuron](/details-cell/CL4023016), as well as in neuronal progenitors like [neuroblast (sensu Vertebrata)](/details-cell/CL0000031) and glial cells including [astrocytes](/details-cell/CL0000127). Functionally, it is integral to processes governing neuronal development, including axonogenesis, cell migration, and synapse plasticity. Loss-of-function mutations have been clinically linked to disordered cortical neuronal migration ([Link](https://doi.org/10.1038/s41588-018-0166-0)), and its regulation has been associated with schizophrenia ([Link](https://doi.org/10.1002/ajmg.b.30679)), highlighting its importance in both neural architecture and function. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [CTNNA2](/details-gene/1496) firmly establishes it as a key protein in the central nervous system, where it plays a specialized role in both mature neurons and developing neural cells. Its highest significance scores are observed in multiple classes of inhibitory neurons, including [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 46.83), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 44.61), and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 40.02), suggesting it is a foundational component for establishing or maintaining the unique adhesive and cytoskeletal properties of these interneuron subtypes. Beyond mature neurons, [CTNNA2](/details-gene/1496) is also highly significant in progenitor populations, including [neuroblast (sensu Vertebrata)](/details-cell/CL0000031) (CSI: 32.77) and [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 27.83). This expression pattern is consistent with its established role in guiding neuronal migration and development. The gene also demonstrates notable significance in glial support cells, such as [ependymal cell](/details-cell/CL0000065) (CSI: 31.09) and [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 30.08), indicating a broader role in maintaining the structural integrity and organization of brain tissue. This widespread but highly specific expression within the neural lineage underscores its fundamental importance in brain morphogenesis and homeostasis. ## Pathways and Molecular Function The molecular functions of [CTNNA2](/details-gene/1496) are centered on its role as an adaptor protein within the [Catenin complex](/details-go/GO0016342) at [Adherens junctions](/details-go/GO0005912). Through its capacity for [Cadherin binding](/details-go/GO0045296) and [Beta-catenin binding](/details-go/GO0008013), it physically links cell-surface adhesion molecules to the intracellular [Actin cytoskeleton](/details-go/GO0015629), a process critical for [Cell-cell adhesion](/details-go/GO0098609). This core function is leveraged in numerous biological processes essential for nervous system development, as reflected in its annotation for [Developmental biology](/details-reactome/R-HSA-1266738). Specifically, [CTNNA2](/details-gene/1496) is implicated in [Regulation of neuron migration](/details-go/GO2001222), [Axonogenesis](/details-go/GO0007409), and [Dendrite morphogenesis](/details-go/GO0048813). Its involvement in cytoskeletal dynamics is further specified by its role in the [Negative regulation of arp2/3 complex-mediated actin nucleation](/details-go/GO0034316). Research has shown that biallelic loss of [CTNNA2](/details-gene/1496) leads to overactivity of the ARP2/3 complex, resulting in disordered neuronal migration ([Link](https://doi.org/10.1038/s41588-018-0166-0)). This provides a direct mechanistic link between its molecular function and its critical role in building the layered structure of the cerebral cortex. Furthermore, its contribution to the [Regulation of synapse structural plasticity](/details-go/GO0051823) is consistent with its high expression in mature interneurons, where it likely contributes to the dynamic remodeling of synaptic connections. ## Research Directions The specific enrichment of [CTNNA2](/details-gene/1496) in cortical interneurons, combined with reports of its dysregulation in neuropsychiatric disorders ([Link](https://doi.org/10.1002/ajmg.b.30679)), suggests that its role extends beyond early development to mature circuit function and pathology. **Proposed Hypotheses:** 1. Dysregulation of specific [CTNNA2](/details-gene/1496) splice variants in [GABAergic cortical interneurons](/details-cell/CL4023017) contributes to the etiology of schizophrenia. This aberrant splicing may disrupt adherens junction stability and synaptic plasticity, leading to the deficits in cortical inhibition and cognitive function characteristic of the disorder. 2. Phosphorylation-dependent regulation of [CTNNA2](/details-gene/1496) serves as a molecular switch that governs the transition of [neuroblasts](/details-cell/CL0000031) from a migratory to a stationary, synaptically-integrated state. Alterations in signaling pathways that control CTNNA2 phosphorylation could underlie certain neurodevelopmental disorders characterized by abnormal cortical layering. **Experimental Approach:** To test the first hypothesis regarding splice variants in schizophrenia, one could employ patient-derived induced pluripotent stem cells (iPSCs) from both healthy controls and individuals with schizophrenia. These iPSCs would be differentiated into cortical organoids containing a mixed population of neurons, including [GABAergic cortical interneurons](/details-cell/CL4023017). Using long-read RNA sequencing (e.g., Oxford Nanopore), specific [CTNNA2](/details-gene/1496) isoform expression could be precisely quantified in sorted interneuron populations. Subsequently, antisense oligonucleotides (ASOs) designed to correct the disease-associated splicing pattern could be introduced into patient-derived organoids to determine if this manipulation can rescue functional deficits, such as abnormal network synchrony, as measured by multi-electrode array recordings. **Therapeutic Potential:** [CTNNA2](/details-gene/1496) presents a complex therapeutic target. Given that its complete loss of function leads to severe defects in brain development ([Link](https://doi.org/10.1038/s41588-018-0166-0)), broad inhibition of the protein would likely be highly toxic. However, its association with specific disease-related splice variants opens a potential therapeutic window. Strategies aimed at modulating its function, rather than complete inhibition, may be more viable. For example, therapies such as ASOs that can selectively target and correct aberrant splicing in specific neuronal populations could restore normal protein function without affecting its essential roles elsewhere. This approach would represent a highly precise therapeutic strategy for neuropsychiatric or neurodevelopmental disorders linked to [CTNNA2](/details-gene/1496) dysregulation.

Genular Protein ID: 3222354030

Symbol: CTNA2_HUMAN

Name: Catenin alpha-2

UniProtKB Accession Codes:

P26232 B3KXE5 B7Z2W7 B7Z352 B7Z898 Q4ZFW1 Q53R26 Q53R33 Q53T67 Q53T71 Q53TM8 Q7Z3L1 Q7Z3Y0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 EMDB 1 Ensembl 6 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 10 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8432524

Title: Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein (alpha-catenin).

PubMed ID: 8432524

DOI: 10.1006/geno.1993.1004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16182284

Title: Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1.

PubMed ID: 16182284

DOI: 10.1016/j.yexcr.2005.06.018

PubMed ID: 18163523

Title: Regulation of a novel alphaN-catenin splice variant in schizophrenic smokers.

PubMed ID: 18163523

DOI: 10.1002/ajmg.b.30679

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 30013181

Title: Biallelic loss of human CTNNA2, encoding alphaN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration.

PubMed ID: 30013181

DOI: 10.1038/s41588-018-0166-0

Sequence Information:

  • Length: 953
  • Mass: 105313
  • Checksum: 5FC88907B37E8A6C
  • Sequence:
    • MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK KGRSKKAHVL 
AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG ETMRIASSEF ADDPCSSVKR 
GTMVRAARAL LSAVTRLLIL ADMADVMRLL SHLKIVEEAL EAVKNATNEQ DLANRFKEFG 
KEMVKLNYVA ARRQQELKDP HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR 
DYVFKQVQEA IAGISNAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR 
PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM NNTGRKEKGD 
PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN EKEVKEYAQV 
FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA ARPQSKVAQD 
NMDVFKDQWE KQVRVLTEAV DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA 
GAIRGRAARV IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV 
PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR SRTSVQTEDD 
QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE VAKWDDSGND IIVLAKQMCM 
IMMEMTDFTR GKGPLKNTSD VINAAKKIAE AGSRMDKLAR AVADQCPDSA CKQDLLAYLQ 
RIALYCHQLN ICSKVKAEVQ NLGGELIVSG TGVQSTFTTF YEVDCDVIDG GRASQLSTHL 
PTCAEGAPIG SGSSDSSMLD SATSLIQAAK NLMNAVVLTV KASYVASTKY QKVYGTAAVN 
SPVVSWKMKA PEKKPLVKRE KPEEFQTRVR RGSQKKHISP VQALSEFKAM DSF

Genular Protein ID: 3050901922

Symbol: F6KRI5_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6KRI5

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 11 Gene3D 2 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 21708131

Title: Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms.

PubMed ID: 21708131

DOI: 10.1016/j.bbrc.2011.06.085

Sequence Information:

  • Length: 537
  • Mass: 59868
  • Checksum: 71B24F41F0B4D6FB
  • Sequence:
    • MTKKTRDLRR QLRKAVMDHI SDSFLETNVP LLVLIEAAKS GNEKEVKEYA QVFREHANKL 
VEVANLACSI SNNEEGVKLV RMAATQIDSL CPQVINAALT LAARPQSKVA QDNMDVFKDQ 
WEKQVRVLTE AVDDITSVDD FLSVSENHIL EDVNKCVIAL QEGDVDTLDR TAGAIRGRAA 
RVIHIINAEM ENYEAGVYTE KVLEATKLLS ETVMPRFAEQ VEVAIEALSA NVPQPFEENE 
FIDASRLVYD GVRDIRKAVL MIRTPEELED DSDFEQEDYD VRSRTSVQTE DDQLIAGQSA 
RAIMAQLPQE EKAKIAEQVE IFHQEKSKLD AEVAKWDDSG NDIIVLAKQM CMIMMEMTDF 
TRGKGPLKNT SDVINAAKKI AEAGSRMDKL ARAVADQCPD SACKQDLLAY LQRIALYCHQ 
LNICSKVKAE VQNLGGELIV SGLDSATSLI QAAKNLMNAV VLTVKASYVA STKYQKVYGT 
AAVNSPVVSW KMKAPEKKPL VKREKPEEFQ TRVRRGSQKK HISPVQALSE FKAMDSF

Genular Protein ID: 3029910206

Symbol: Q49AD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q49AD3

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 11 Gene3D 2 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 687
  • Mass: 76384
  • Checksum: C7FB874BFAFCA16D
  • Sequence:
    • MLYTASQAFL RHPDVAATRA NRDYVFKQVQ EAIAGISNAA QATSPTDEAK GHTGIGELAA 
ALNEFDNKII LDPMTFSEAR FRQSLEERLE SIISGAALMA DSSCTRDDRR ERIVAECNAV 
RQALQDLLSE YMNNTGRKEK GDPLNIAIDK MTKKTRDLRR QLRKAVMDHI SDSFLETNVP 
LLVLIEAAKS GNEKEVKEYA QVFREHANKL VEVANLACSI SNNEEGVKLV RMAATQIDSL 
CPQVINAALT LAARPQSKVA QDNMDVFKDQ WEKQVRVLTE AVDDITSVDD FLSVSENHIL 
EDVNKCVIAL QEGDVDTLDR TAGAIRGRAA RVIHIINAEM ENYEAGVYTE KVLEATKLLS 
ETVMPRFAEQ VEVAIEALSA NVPQPFEENE FIDASRLVYD GVRDIRKAVL MIRTPEELED 
DSDFEQEDYD VRSRTSVQTE DDQLIAGQSA RAIMAQLPQE EKAKIAEQVE IFHQEKSKLD 
AEVAKWDDSG NDIIVLAKQM CMIMMEMTDF TRGKGPLKNT SDVINAAKKI AEAGSRMDKL 
ARAVADQCPD SACKQDLLAY LQRIALYCHQ LNICSKVKAE VQNLGGELIV SGLDSATSLI 
QAAKNLMNAV VLTVKASYVA STKYQKVYGT AAVNSPVVSW KMKAPEKKPL VKREKPEEFQ 
TRVRRGSQKK HISPVQALSE FKAMDSF