Details for: CTNNA2

Gene ID: 1496

Symbol: CTNNA2

Ensembl ID: ENSG00000066032

Description: catenin alpha 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 8.09
    Marker Score: 27,140
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 7.93
    Marker Score: 5,221
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.56
    Marker Score: 56,992
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 7.3
    Marker Score: 246,454
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 6.76
    Marker Score: 15,542
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.72
    Marker Score: 35,239
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 6.2
    Marker Score: 8,722
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.99
    Marker Score: 32,194
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.91
    Marker Score: 2,202
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.83
    Marker Score: 6,022
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 4.38
    Marker Score: 1,448
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 4.18
    Marker Score: 2,007
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.94
    Marker Score: 18,217
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.93
    Marker Score: 2,283
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 3.47
    Marker Score: 1,054
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69,790
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.17
    Marker Score: 3,837
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.02
    Marker Score: 8,618
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.96
    Marker Score: 1,139
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.96
    Marker Score: 4,964
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.96
    Marker Score: 5,601
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.89
    Marker Score: 57,501
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.85
    Marker Score: 42,668
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.82
    Marker Score: 2,446
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.74
    Marker Score: 1,536
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.7
    Marker Score: 102,631
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.64
    Marker Score: 1,543
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.6
    Marker Score: 10,774
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.59
    Marker Score: 19,889
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.59
    Marker Score: 1,083
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.39
    Marker Score: 2,960
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.39
    Marker Score: 88,262
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.36
    Marker Score: 803
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.28
    Marker Score: 8,797
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.18
    Marker Score: 20,476
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.17
    Marker Score: 1,497
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,953
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.08
    Marker Score: 1,074
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.06
    Marker Score: 21,310
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8,267
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.01
    Marker Score: 8,414
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.96
    Marker Score: 4,699
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.94
    Marker Score: 531
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18,195
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.9
    Marker Score: 2,189
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,987
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.79
    Marker Score: 1,071
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.79
    Marker Score: 3,648
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.75
    Marker Score: 1,053
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,541
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,161
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.57
    Marker Score: 1,562
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.54
    Marker Score: 1,055
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.45
    Marker Score: 486
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.43
    Marker Score: 3,374
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.42
    Marker Score: 2,580
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.36
    Marker Score: 493
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 864
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.36
    Marker Score: 425
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.35
    Marker Score: 1,243
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.35
    Marker Score: 5,640
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.31
    Marker Score: 984
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20,345
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.26
    Marker Score: 400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.19
    Marker Score: 348
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.14
    Marker Score: 539
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,768
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.09
    Marker Score: 284
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.09
    Marker Score: 1,872
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 1.08
    Marker Score: 316
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.06
    Marker Score: 1,423
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.05
    Marker Score: 424
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.03
    Marker Score: 345
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.01
    Marker Score: 6,056
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,731
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,956
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.95
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.95
    Marker Score: 494
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,263
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.92
    Marker Score: 292
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.92
    Marker Score: 1,192
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.88
    Marker Score: 1,223
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.82
    Marker Score: 922
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.8
    Marker Score: 356
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.79
    Marker Score: 8,027
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.76
    Marker Score: 265

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CTNNA2 is a cytoskeletal protein that belongs to the catenin family, which consists of three main members: alpha, beta, and gamma catenins. The alpha catenins are characterized by their ability to bind to the cytoskeletal protein actin, while also interacting with beta-catenin, a key component of the Wnt signaling pathway. CTNNA2 is specifically expressed in cells derived from the nervous system, including neurons, astrocytes, and glial cells. Its expression is also observed in epithelial cells, particularly those derived from the lung and retina. **Pathways and Functions** CTNNA2 is involved in several key cellular pathways, including: 1. **Actin Cytoskeleton Organization**: CTNNA2 interacts with actin to regulate cytoskeleton organization and dynamics. 2. **Adherens Junction Formation**: CTNNA2 plays a crucial role in the formation and maintenance of adherens junctions, which are essential for maintaining tissue structure and organization. 3. **Neuronal Migration and Axonogenesis**: CTNNA2 regulates neuronal migration, axonogenesis, and synapse structural plasticity, essential for neuronal development and function. 4. **Wnt Signaling Pathway**: CTNNA2 interacts with beta-catenin, a key component of the Wnt signaling pathway, to regulate cell-cell adhesion and cell migration. 5. **Cytoskeleton Organization**: CTNNA2 regulates the organization of the cytoskeleton, including the formation of actin filaments and microtubules. **Clinical Significance** Dysregulation of CTNNA2 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental Disorders**: CTNNA2 mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Neurodegenerative Diseases**: CTNNA2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CTNNA2 has been identified as a potential oncogene, with its expression being upregulated in certain types of cancer, including breast and lung cancer. 4. **Neurological Disorders**: CTNNA2 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and bipolar disorder. In conclusion, CTNNA2 is a critical gene involved in various cellular processes, including cell-cell adhesion, cytoskeleton organization, and neuronal development. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into the role of CTNNA2 in human health and disease.

Genular Protein ID: 3222354030

Symbol: CTNA2_HUMAN

Name: Catenin alpha-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8432524

Title: Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein (alpha-catenin).

PubMed ID: 8432524

DOI: 10.1006/geno.1993.1004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16182284

Title: Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1.

PubMed ID: 16182284

DOI: 10.1016/j.yexcr.2005.06.018

PubMed ID: 18163523

Title: Regulation of a novel alphaN-catenin splice variant in schizophrenic smokers.

PubMed ID: 18163523

DOI: 10.1002/ajmg.b.30679

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 30013181

Title: Biallelic loss of human CTNNA2, encoding alphaN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration.

PubMed ID: 30013181

DOI: 10.1038/s41588-018-0166-0

Sequence Information:

  • Length: 953
  • Mass: 105313
  • Checksum: 5FC88907B37E8A6C
  • Sequence:
  • MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK KGRSKKAHVL 
    AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG ETMRIASSEF ADDPCSSVKR 
    GTMVRAARAL LSAVTRLLIL ADMADVMRLL SHLKIVEEAL EAVKNATNEQ DLANRFKEFG 
    KEMVKLNYVA ARRQQELKDP HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR 
    DYVFKQVQEA IAGISNAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR 
    PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM NNTGRKEKGD 
    PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN EKEVKEYAQV 
    FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA ARPQSKVAQD 
    NMDVFKDQWE KQVRVLTEAV DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA 
    GAIRGRAARV IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV 
    PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR SRTSVQTEDD 
    QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE VAKWDDSGND IIVLAKQMCM 
    IMMEMTDFTR GKGPLKNTSD VINAAKKIAE AGSRMDKLAR AVADQCPDSA CKQDLLAYLQ 
    RIALYCHQLN ICSKVKAEVQ NLGGELIVSG TGVQSTFTTF YEVDCDVIDG GRASQLSTHL 
    PTCAEGAPIG SGSSDSSMLD SATSLIQAAK NLMNAVVLTV KASYVASTKY QKVYGTAAVN 
    SPVVSWKMKA PEKKPLVKRE KPEEFQTRVR RGSQKKHISP VQALSEFKAM DSF

Genular Protein ID: 3050901922

Symbol: F6KRI5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 21708131

Title: Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms.

PubMed ID: 21708131

DOI: 10.1016/j.bbrc.2011.06.085

Sequence Information:

  • Length: 537
  • Mass: 59868
  • Checksum: 71B24F41F0B4D6FB
  • Sequence:
  • MTKKTRDLRR QLRKAVMDHI SDSFLETNVP LLVLIEAAKS GNEKEVKEYA QVFREHANKL 
    VEVANLACSI SNNEEGVKLV RMAATQIDSL CPQVINAALT LAARPQSKVA QDNMDVFKDQ 
    WEKQVRVLTE AVDDITSVDD FLSVSENHIL EDVNKCVIAL QEGDVDTLDR TAGAIRGRAA 
    RVIHIINAEM ENYEAGVYTE KVLEATKLLS ETVMPRFAEQ VEVAIEALSA NVPQPFEENE 
    FIDASRLVYD GVRDIRKAVL MIRTPEELED DSDFEQEDYD VRSRTSVQTE DDQLIAGQSA 
    RAIMAQLPQE EKAKIAEQVE IFHQEKSKLD AEVAKWDDSG NDIIVLAKQM CMIMMEMTDF 
    TRGKGPLKNT SDVINAAKKI AEAGSRMDKL ARAVADQCPD SACKQDLLAY LQRIALYCHQ 
    LNICSKVKAE VQNLGGELIV SGLDSATSLI QAAKNLMNAV VLTVKASYVA STKYQKVYGT 
    AAVNSPVVSW KMKAPEKKPL VKREKPEEFQ TRVRRGSQKK HISPVQALSE FKAMDSF

Genular Protein ID: 3029910206

Symbol: Q49AD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 687
  • Mass: 76384
  • Checksum: C7FB874BFAFCA16D
  • Sequence:
  • MLYTASQAFL RHPDVAATRA NRDYVFKQVQ EAIAGISNAA QATSPTDEAK GHTGIGELAA 
    ALNEFDNKII LDPMTFSEAR FRQSLEERLE SIISGAALMA DSSCTRDDRR ERIVAECNAV 
    RQALQDLLSE YMNNTGRKEK GDPLNIAIDK MTKKTRDLRR QLRKAVMDHI SDSFLETNVP 
    LLVLIEAAKS GNEKEVKEYA QVFREHANKL VEVANLACSI SNNEEGVKLV RMAATQIDSL 
    CPQVINAALT LAARPQSKVA QDNMDVFKDQ WEKQVRVLTE AVDDITSVDD FLSVSENHIL 
    EDVNKCVIAL QEGDVDTLDR TAGAIRGRAA RVIHIINAEM ENYEAGVYTE KVLEATKLLS 
    ETVMPRFAEQ VEVAIEALSA NVPQPFEENE FIDASRLVYD GVRDIRKAVL MIRTPEELED 
    DSDFEQEDYD VRSRTSVQTE DDQLIAGQSA RAIMAQLPQE EKAKIAEQVE IFHQEKSKLD 
    AEVAKWDDSG NDIIVLAKQM CMIMMEMTDF TRGKGPLKNT SDVINAAKKI AEAGSRMDKL 
    ARAVADQCPD SACKQDLLAY LQRIALYCHQ LNICSKVKAE VQNLGGELIV SGLDSATSLI 
    QAAKNLMNAV VLTVKASYVA STKYQKVYGT AAVNSPVVSW KMKAPEKKPL VKREKPEEFQ 
    TRVRRGSQKK HISPVQALSE FKAMDSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.