Details for: H2 D1

Gene ID: 14964

Symbol: H2 D1

Ensembl ID: ENSMUSG00000073411

Description: histocompatibility 2, D region locus 1

Associated with

  • 14-3-3 protein binding
    (GO:0071889)
  • Adaptive immune response
    (GO:0002250)
  • Antibacterial humoral response
    (GO:0019731)
  • Antigen processing and presentation
    (GO:0019882)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i
    (GO:0019885)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-dependent
    (GO:0002485)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class i
    (GO:0042590)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Antigen processing and presentation of peptide antigen via mhc class i
    (GO:0002474)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Cd8 receptor binding
    (GO:0042610)
  • Cd8-positive, alpha-beta t cell activation
    (GO:0036037)
  • Cell surface
    (GO:0009986)
  • Cis-golgi network membrane
    (GO:0033106)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Detection of bacterium
    (GO:0016045)
  • Early endosome
    (GO:0005769)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum exit site
    (GO:0070971)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Golgi medial cisterna
    (GO:0005797)
  • Golgi membrane
    (GO:0000139)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Immune system process
    (GO:0002376)
  • Lumenal side of endoplasmic reticulum membrane
    (GO:0098553)
  • Lysosomal membrane
    (GO:0005765)
  • Membrane
    (GO:0016020)
  • Membrane raft
    (GO:0045121)
  • Mhc class ib protein complex
    (GO:0032398)
  • Mhc class i peptide loading complex
    (GO:0042824)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i protein complex
    (GO:0042612)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of neuron projection development
    (GO:0010977)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Peptide antigen assembly with mhc class i protein complex
    (GO:0002502)
  • Peptide antigen binding
    (GO:0042605)
  • Peptide binding
    (GO:0042277)
  • Phagocytic vesicle membrane
    (GO:0030670)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antibody-dependent cellular cytotoxicity
    (GO:0001815)
  • Positive regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001187)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of memory t cell activation
    (GO:2000568)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immunity
    (GO:0002717)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of t cell cytokine production
    (GO:0002726)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of trail production
    (GO:0032759)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protection from natural killer cell mediated cytotoxicity
    (GO:0042270)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein-folding chaperone binding
    (GO:0051087)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of natural killer cell mediated immunity
    (GO:0002715)
  • Signaling receptor binding
    (GO:0005102)
  • Tap1 binding
    (GO:0046978)
  • Tap2 binding
    (GO:0046979)
  • Tap binding
    (GO:0046977)
  • Tap complex binding
    (GO:0062061)
  • T cell mediated cytotoxicity
    (GO:0001913)
  • T cell mediated cytotoxicity directed against tumor cell target
    (GO:0002419)
  • T cell receptor binding
    (GO:0042608)
  • T cell receptor signaling pathway
    (GO:0050852)

Other Information

Genular Protein ID: 2477085868

Symbol: HA11_MOUSE

Name: H-2 class I histocompatibility antigen, D-B alpha chain

UniProtKB Accession Codes:

P01899

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 4 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 HOGENOM 1 InterPro 10 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 92 PIR 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 3680952

Title: DNA sequence analysis of the C3H H-2Kk and H-2Dk loci. Evolutionary relationships to H-2 genes from four other mouse strains.

PubMed ID: 3680952

PubMed ID: 9869916

Title: Nucleotide sequences of three H-2K and three H-2D complementary DNA clones coding mouse class I MHC heavy chain proteins.

PubMed ID: 9869916

PubMed ID: 7118211

Title: The complete amino acid sequence of the murine transplantation antigen H-2Db as deduced by molecular cloning.

PubMed ID: 7118211

DOI: 10.1007/bf00364437

PubMed ID: 7225204

Title: Primary structure of murine major histocompatibility complex alloantigens. Amino acid sequence of the NH2-terminal ninety-eight residues of the H-2Db glycoprotein.

PubMed ID: 7225204

DOI: 10.1016/s0021-9258(19)69694-8

PubMed ID: 7118212

Title: Primary structure of the H-2Db alloantigen. II. Additional amino acid sequence information, localization of a third site of glycosylation and evidence for K and D region specific sequences.

PubMed ID: 7118212

DOI: 10.1007/bf00364438

PubMed ID: 3980466

Title: Oligosaccharide microheterogeneity of the murine major histocompatibility antigens. Reproducible site-specific patterns of sialylation and branching in asparagine-linked oligosaccharides.

PubMed ID: 3980466

DOI: 10.1016/s0021-9258(18)89229-8

PubMed ID: 17502423

Title: Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3.

PubMed ID: 17502423

DOI: 10.1083/jcb.200611063

PubMed ID: 19951915

Title: Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.

PubMed ID: 19951915

DOI: 10.1083/jcb.200908036

PubMed ID: 19531064

Title: Role of the RING-CH domain of viral ligase mK3 in ubiquitination of non-lysine and lysine MHC I residues.

PubMed ID: 19531064

DOI: 10.1111/j.1600-0854.2009.00946.x

PubMed ID: 7506996

Title: The three-dimensional structure of H-2Db at 2.4-A resolution: implications for antigen-determinant selection.

PubMed ID: 7506996

DOI: 10.1016/0092-8674(94)90171-6

PubMed ID: 10993729

Title: Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex.

PubMed ID: 10993729

DOI: 10.1006/jmbi.2000.4501

Sequence Information:

  • Length: 362
  • Mass: 40836
  • Checksum: 6EE6AEF97263FA71
  • Sequence:
    • MGAMAPRTLL LLLAAALAPT QTRAGPHSMR YFETAVSRPG LEEPRYISVG YVDNKEFVRF 
DSDAENPRYE PRAPWMEQEG PEYWERETQK AKGQEQWFRV SLRNLLGYYN QSAGGSHTLQ 
QMSGCDLGSD WRLLRGYLQF AYEGRDYIAL NEDLKTWTAA DMAAQITRRK WEQSGAAEHY 
KAYLEGECVE WLHRYLKNGN ATLLRTDSPK AHVTHHPRSK GEVTLRCWAL GFYPADITLT 
WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVYHEGL PEPLTLRWEP 
PPSTDSYMVI VAVLGVLGAM AIIGAVVAFV MKRRRNTGGK GGDYALAPGS QSSEMSLRDC 
KA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.