Details for: H2 K1

Gene ID: 14972

Symbol: H2 K1

Ensembl ID: ENSMUSG00000061232

Description: histocompatibility 2, K1, K region

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Antigen presentation: folding, assembly and peptide loading of class i mhc
    (R-MMU-983170)
  • Antigen processing-cross presentation
    (R-MMU-1236975)
  • Class i mhc mediated antigen processing & presentation
    (R-MMU-983169)
  • Dap12 interactions
    (R-MMU-2172127)
  • Endosomal/vacuolar pathway
    (R-MMU-1236977)
  • Er-phagosome pathway
    (R-MMU-1236974)
  • Immune system
    (R-MMU-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-MMU-198933)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • 14-3-3 protein binding
    (GO:0071889)
  • Adaptive immune response
    (GO:0002250)
  • Antibacterial humoral response
    (GO:0019731)
  • Antigen processing and presentation
    (GO:0019882)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i
    (GO:0019885)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-dependent
    (GO:0002485)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class i
    (GO:0042590)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Antigen processing and presentation of peptide antigen via mhc class i
    (GO:0002474)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Cd8 receptor binding
    (GO:0042610)
  • Cd8-positive, alpha-beta t cell activation
    (GO:0036037)
  • Cell surface
    (GO:0009986)
  • Cis-golgi network membrane
    (GO:0033106)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Detection of bacterium
    (GO:0016045)
  • Early endosome
    (GO:0005769)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum exit site
    (GO:0070971)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Golgi medial cisterna
    (GO:0005797)
  • Golgi membrane
    (GO:0000139)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Immune system process
    (GO:0002376)
  • Inner ear development
    (GO:0048839)
  • Lumenal side of endoplasmic reticulum membrane
    (GO:0098553)
  • Lysosomal membrane
    (GO:0005765)
  • Membrane
    (GO:0016020)
  • Mhc class ib protein complex
    (GO:0032398)
  • Mhc class i peptide loading complex
    (GO:0042824)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i protein complex
    (GO:0042612)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of neuron projection development
    (GO:0010977)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Peptide antigen assembly with mhc class i protein complex
    (GO:0002502)
  • Peptide antigen binding
    (GO:0042605)
  • Peptide binding
    (GO:0042277)
  • Phagocytic vesicle membrane
    (GO:0030670)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antibody-dependent cellular cytotoxicity
    (GO:0001815)
  • Positive regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001187)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of memory t cell activation
    (GO:2000568)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immunity
    (GO:0002717)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of t cell cytokine production
    (GO:0002726)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of trail production
    (GO:0032759)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protection from natural killer cell mediated cytotoxicity
    (GO:0042270)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein-folding chaperone binding
    (GO:0051087)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of natural killer cell mediated immunity
    (GO:0002715)
  • Signaling receptor binding
    (GO:0005102)
  • Tap1 binding
    (GO:0046978)
  • Tap2 binding
    (GO:0046979)
  • Tap binding
    (GO:0046977)
  • Tap complex binding
    (GO:0062061)
  • T cell mediated cytotoxicity
    (GO:0001913)
  • T cell mediated cytotoxicity directed against tumor cell target
    (GO:0002419)
  • T cell receptor binding
    (GO:0042608)
  • T cell receptor signaling pathway
    (GO:0050852)

Other Information

Genular Protein ID: 3656403512

Symbol: HA1B_MOUSE

Name: H-2 class I histocompatibility antigen, K-B alpha chain

UniProtKB Accession Codes:

P01901

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 4 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 66 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 91 PDBsum 84 PIR 1 PRINTS 1 PROSITE 2 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 11894963

Title: The DNA sequence of the H-2K(b) gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibility antigens.

PubMed ID: 11894963

DOI: 10.1002/j.1460-2075.1983.tb01444.x

PubMed ID: 9869916

Title: Nucleotide sequences of three H-2K and three H-2D complementary DNA clones coding mouse class I MHC heavy chain proteins.

PubMed ID: 9869916

PubMed ID: 6954478

Title: Isolation of a cDNA clone for the murine transplantation antigen H-2Kb.

PubMed ID: 6954478

DOI: 10.1073/pnas.79.10.3270

PubMed ID: 7306483

Title: Amino acid sequence of the carboxyl-terminal hydrophilic region of the H-2Kb MHC alloantigen. Completion of the entire primary structure of the H-2Kb molecule.

PubMed ID: 7306483

DOI: 10.1021/bi00524a003

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 1323877

Title: Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb.

PubMed ID: 1323877

DOI: 10.1126/science.1323877

PubMed ID: 9806638

Title: Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb.

PubMed ID: 9806638

DOI: 10.1016/s1074-7613(00)80635-4

PubMed ID: 10023770

Title: Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL.

PubMed ID: 10023770

DOI: 10.1016/s1074-7613(00)80006-0

Sequence Information:

  • Length: 369
  • Mass: 41302
  • Checksum: 3D2F125318193443
  • Sequence:
    • MVPCTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGE PRYMEVGYVD DTEFVRFDSD 
AENPRYEPRA RWMEQEGPEY WERETQKAKG NEQSFRVDLR TLLGYYNQSK GGSHTIQVIS 
GCEVGSDGRL LRGYQQYAYD GCDYIALNED LKTWTAADMA ALITKHKWEQ AGEAERLRAY 
LEGTCVEWLR RYLKNGNATL LRTDSPKAHV THHSRPEDKV TLRCWALGFY PADITLTWQL 
NGEELIQDME LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS 
TVSNMATVAV LVVLGAAIVT GAVVAFVMKM RRRNTGGKGG DYALAPGSQT SDLSLPDCKV 
MVHDPHSLA

Genular Protein ID: 428085060

Symbol: Q3TH01_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TH01

Database IDs:

AGR 1 ARBA 9 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HOGENOM 1 InterPro 10 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 3 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 360
  • Mass: 40286
  • Checksum: D115FCD057E59359
  • Sequence:
    • MVPCTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGE PRYMEVGYVD DTEFVRFDSD 
AENPRYEPRA RWMEQEGPEY WERETQKAKG NEQSFRVDLR TLLGYYNQSK GGSHTIQVIS 
GCEVGSDGRL LRGYQQYAYD GCDYIALNED LKTWTAADMA ALITKHKWEQ AGEAERLRAY 
LEGTCVEWLR RYLKNGNATL LRTDSPKAHV THHSRPEDKV TLRCWALGFY PADITLTWQL 
NGEELIQDME LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS 
TVSNMATVAV LVVLGAAIVT GAVVAFVMKM RRRNTGGKGG DYALAPGSQT SDLSLPDCKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.