Details for: H2 M10 1

Gene ID: 14985

Symbol: H2 M10 1

Ensembl ID: ENSMUSG00000024448

Description: histocompatibility 2, M region locus 10.1

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Antigen presentation: folding, assembly and peptide loading of class i mhc
    (R-MMU-983170)
  • Antigen processing-cross presentation
    (R-MMU-1236975)
  • Class i mhc mediated antigen processing & presentation
    (R-MMU-983169)
  • Dap12 interactions
    (R-MMU-2172127)
  • Endosomal/vacuolar pathway
    (R-MMU-1236977)
  • Er-phagosome pathway
    (R-MMU-1236974)
  • Immune system
    (R-MMU-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-MMU-198933)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • 14-3-3 protein binding
    (GO:0071889)
  • Adaptive immune response
    (GO:0002250)
  • Antibacterial humoral response
    (GO:0019731)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Cd8 receptor binding
    (GO:0042610)
  • Cd8-positive, alpha-beta t cell activation
    (GO:0036037)
  • Cell surface
    (GO:0009986)
  • Cis-golgi network membrane
    (GO:0033106)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Early endosome
    (GO:0005769)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Golgi membrane
    (GO:0000139)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Lysosomal membrane
    (GO:0005765)
  • Mhc class ib protein complex
    (GO:0032398)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i protein complex
    (GO:0042612)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Peptide antigen binding
    (GO:0042605)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antibody-dependent cellular cytotoxicity
    (GO:0001815)
  • Positive regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001187)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immunity
    (GO:0002717)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of trail production
    (GO:0032759)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protection from natural killer cell mediated cytotoxicity
    (GO:0042270)
  • Protein-folding chaperone binding
    (GO:0051087)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of natural killer cell mediated immunity
    (GO:0002715)
  • Signaling receptor binding
    (GO:0005102)
  • Tap1 binding
    (GO:0046978)
  • Tap2 binding
    (GO:0046979)
  • T cell receptor binding
    (GO:0042608)

Other Information

Genular Protein ID: 1521878987

Symbol: Q860W7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q860W7

Database IDs:

AGR 1 ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 51 Gene3D 2 Genevisible 1 InterPro 9 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SUPFAM 2

Citations:

PubMed ID: 12628182

Title: Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules.

PubMed ID: 12628182

DOI: 10.1016/S0092-8674(03)00153-3

Sequence Information:

  • Length: 331
  • Mass: 37680
  • Checksum: 5DF79CC1DE6148C0
  • Sequence:
    • MRNTGPCTLL LLLMVALDLN HYCAGSHWLQ TFNIVILEPG MLEPRFIQVT YVDSIQYQGF 
DSKDPSAGMQ PRAAWIELEP PEYWEKETSR VLELSQVERQ VLRLMVKKNG HKMDGYHTLQ 
EVYGCNVAND GSFLGGHYRL TYYGYDYLTL NEDLSSWTAE GKGAQHAKSR WEDAGEAKRR 
KTYLQGECVQ RLLRYLDLGK ETLLCSDAPQ THVTHHVRPE GNVTLRCWAL GFYPADITMT 
WKRDGNNLTQ DMELPDTRPA GDGTFQKWAA VVVPSGEELR YTCHVHHEGL PEPLTLKWEP 
PHTIPIIAIL IGLVLGTLVV GTVVIFLVWR K

Genular Protein ID: 3312934348

Symbol: O19443_MOUSE

Name: N/A

UniProtKB Accession Codes:

O19443

Database IDs:

AGR 1 ARBA 9 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 51 Gene3D 2 GeneTree 1 InterPro 9 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PaxDb 1 Pfam 2 PhosphoSitePlus 1 Proteomes 2 Reactome 6 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9435345

Title: Characterization of two class I genes from the H2-M region: evidence for a new subfamily.

PubMed ID: 9435345

DOI: 10.1007/s002510050356

PubMed ID: 12620187

Title: Combinatorial coexpression of neural and immune multigene families in mouse vomeronasal sensory neurons.

PubMed ID: 12620187

DOI: 10.1016/S0960-9822(03)00092-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 331
  • Mass: 37666
  • Checksum: 46F65A6DB56269F2
  • Sequence:
    • MRNTGPCTLL LLLMVALDLN HYCAGSHWLQ TFNIVILEPG MLEPRFIQVS YVDSIQYQGF 
DSKDPSAGMQ PRAAWIELEP PEYWEKETSR VLELSQVERQ VLRLMVKKNG HKMDGYHTLQ 
EVYGCNVAND GSFLGGHYRL TYYGYDYLTL NEDLSSWTAE GKGAQHAKSR WEDAGEAKRR 
KTYLQGECVQ RLLRYLDLGK ETLLCSDAPQ THVTHHVRPE GNVTLRCWAL GFYPADITMT 
WKRDGNNLTQ DMELPDTRPA GDGTFQKWAA VVVPSGEELR YTCHVHHEGL PEPLTLKWEP 
PHTIPIIAIL IGLVLGTLVV GTVVIFLVWR K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.