Details for: CTNNB1

Gene ID: 1499

Symbol: CTNNB1

Ensembl ID: ENSG00000168036

Description: catenin beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.57
    Marker Score: 98923.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.7
    Marker Score: 125115
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.05
    Marker Score: 2501
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.97
    Marker Score: 2633
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.74
    Marker Score: 2927.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.47
    Marker Score: 10329
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.47
    Marker Score: 1712
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.46
    Marker Score: 2594
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.44
    Marker Score: 3544
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.44
    Marker Score: 1455
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.36
    Marker Score: 2247
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.34
    Marker Score: 1183
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.28
    Marker Score: 3065
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.24
    Marker Score: 57424.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.24
    Marker Score: 2711
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.18
    Marker Score: 699
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.16
    Marker Score: 2794
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.16
    Marker Score: 1938
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.13
    Marker Score: 676
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.13
    Marker Score: 8870
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.12
    Marker Score: 4426.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.11
    Marker Score: 71752
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.1
    Marker Score: 5813
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.08
    Marker Score: 1448
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.06
    Marker Score: 8103.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.06
    Marker Score: 584
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.06
    Marker Score: 5195
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.05
    Marker Score: 27079
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.05
    Marker Score: 70886
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.04
    Marker Score: 20576
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.03
    Marker Score: 2335
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.03
    Marker Score: 7201
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.01
    Marker Score: 9896
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.01
    Marker Score: 1431
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2
    Marker Score: 577
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2
    Marker Score: 8621
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.99
    Marker Score: 2137
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.98
    Marker Score: 505
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.97
    Marker Score: 5291
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.97
    Marker Score: 10344
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.96
    Marker Score: 3339.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.95
    Marker Score: 2236
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.95
    Marker Score: 563
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.95
    Marker Score: 1101
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.95
    Marker Score: 3658
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.95
    Marker Score: 3190
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.94
    Marker Score: 7197
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.94
    Marker Score: 2525.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.94
    Marker Score: 10174
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.92
    Marker Score: 1662
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.92
    Marker Score: 458
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.92
    Marker Score: 2036
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.91
    Marker Score: 3822
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.91
    Marker Score: 2815
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.91
    Marker Score: 1344
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.91
    Marker Score: 2054
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.89
    Marker Score: 12350
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.89
    Marker Score: 28254.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.87
    Marker Score: 14328.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.86
    Marker Score: 1934
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.86
    Marker Score: 1088
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.85
    Marker Score: 70138
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.84
    Marker Score: 2021
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.84
    Marker Score: 29492
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.83
    Marker Score: 8789
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.82
    Marker Score: 2063.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.82
    Marker Score: 1214
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.82
    Marker Score: 1941
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.81
    Marker Score: 3983
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.81
    Marker Score: 7009
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.8
    Marker Score: 1695
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.79
    Marker Score: 1817
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.79
    Marker Score: 2088.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.79
    Marker Score: 3441
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.78
    Marker Score: 670.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.78
    Marker Score: 20051
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.77
    Marker Score: 9511
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.77
    Marker Score: 437
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.77
    Marker Score: 3130
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.76
    Marker Score: 1616
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.76
    Marker Score: 649
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.75
    Marker Score: 11381
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.74
    Marker Score: 2037
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.74
    Marker Score: 37039
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.73
    Marker Score: 5816
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.73
    Marker Score: 4231
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.73
    Marker Score: 1860.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.72
    Marker Score: 10453
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.72
    Marker Score: 7004
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.72
    Marker Score: 2852
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.72
    Marker Score: 1819
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.71
    Marker Score: 3114
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.71
    Marker Score: 691
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.69
    Marker Score: 4091
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.69
    Marker Score: 690
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.69
    Marker Score: 2376
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.69
    Marker Score: 5798
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.68
    Marker Score: 12514
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.68
    Marker Score: 3946.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.67
    Marker Score: 61781.5

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Other Information

**Key characteristics:** * CTNNB1 is a type I transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including neurons, astrocytes, and endothelial cells. * It is a key component of desmosomes, which are cell adhesion complexes that hold cells together in tissues. * It is involved in cell-cell adhesion, migration, and signaling. **Pathways and functions:** * CTNNB1 is involved in cell-cell adhesion and migration. It is a key component of desmosomes, which are cell adhesion complexes that hold cells together in tissues. * It is also involved in cell signaling, as it interacts with various signaling molecules, including beta-catenin and cadherins. * It is involved in tissue morphogenesis, as it is expressed in developing tissues and is essential for the formation of neural tissue. * It is also involved in disease processes, such as cancer and cardiovascular disease. **Clinical significance:** * Mutations in CTNNB1 have been linked to several human diseases, including cancer, cardiovascular disease, and developmental disorders. * CTNNB1 inhibitors are being investigated as potential therapies for these diseases. **Additional notes:** * CTNNB1 is a highly conserved protein, with a similar gene found in humans, mice, and rats. * It is a key target for cancer immunotherapy, as it is frequently overexpressed in cancer cells. * It is a promising target for developing new therapies for cancer and cardiovascular disease.

Genular Protein ID: 3260015589

Symbol: CTNB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P35222 A8K1L7 Q8NEW9 Q8NI94 Q9H391

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 6 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 10 EPD 1 Ensembl 24 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 16 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 10 OrthoDB 1 PANTHER 2 PDB 38 PDBsum 31 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 32 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7806582

Title: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

PubMed ID: 7806582

DOI: 10.1083/jcb.127.6.2061

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12019147

Title: Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells.

PubMed ID: 12019147

PubMed ID: 7982500

Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.

PubMed ID: 7982500

DOI: 10.1016/0014-5793(94)01205-9

PubMed ID: 9020842

Title: Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.

PubMed ID: 9020842

DOI: 10.1038/ng0297-170

PubMed ID: 10029085

Title: Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene.

PubMed ID: 10029085

PubMed ID: 10187801

Title: Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration.

PubMed ID: 10187801

DOI: 10.1074/jbc.274.15.10173

PubMed ID: 10725230

Title: ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes.

PubMed ID: 10725230

DOI: 10.1242/jcs.113.8.1481

PubMed ID: 10966653

Title: Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.

PubMed ID: 10966653

DOI: 10.1038/79039

PubMed ID: 11703283

Title: Beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles.

PubMed ID: 11703283

DOI: 10.1046/j.1365-2133.2001.04455.x

PubMed ID: 11751639

Title: Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro.

PubMed ID: 11751639

DOI: 10.1101/gad.946501

PubMed ID: 11279024

Title: Regulation of beta-catenin structure and activity by tyrosine phosphorylation.

PubMed ID: 11279024

DOI: 10.1074/jbc.m100194200

PubMed ID: 15003504

Title: CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression.

PubMed ID: 15003504

DOI: 10.1016/j.bbrc.2004.02.011

PubMed ID: 27226643

Title:

PubMed ID: 27226643

DOI: 10.1074/jbc.a116.100194

PubMed ID: 11590244

Title: AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.

PubMed ID: 11590244

DOI: 10.1242/jcs.114.17.3177

PubMed ID: 11389839

Title: Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.

PubMed ID: 11389839

DOI: 10.1016/s1097-2765(01)00242-8

PubMed ID: 11389840

Title: Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.

PubMed ID: 11389840

DOI: 10.1016/s1097-2765(01)00241-6

PubMed ID: 11464291

Title: Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion.

PubMed ID: 11464291

DOI: 10.1038/sj.onc.1204557

PubMed ID: 12501215

Title: Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin.

PubMed ID: 12501215

DOI: 10.1021/bi026095u

PubMed ID: 12051714

Title: Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45.

PubMed ID: 12051714

DOI: 10.1016/s0006-291x(02)00485-0

PubMed ID: 12297051

Title: Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape.

PubMed ID: 12297051

DOI: 10.1016/s0092-8674(02)00912-1

PubMed ID: 12027456

Title: Identification of two novel regulated serines in the N-terminus of beta-catenin.

PubMed ID: 12027456

DOI: 10.1006/excr.2002.5520

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 11834740

Title: Wnt signaling controls the phosphorylation status of beta-catenin.

PubMed ID: 11834740

DOI: 10.1074/jbc.m111635200

PubMed ID: 12077367

Title: Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells.

PubMed ID: 12077367

DOI: 10.1242/jcs.115.13.2771

PubMed ID: 12370829

Title: The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).

PubMed ID: 12370829

DOI: 10.1038/sj.onc.1205858

PubMed ID: 12420223

Title: The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells.

PubMed ID: 12420223

DOI: 10.1038/sj.onc.1205991

PubMed ID: 12830000

Title: EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.

PubMed ID: 12830000

DOI: 10.1053/jhep.2003.50270

PubMed ID: 10679188

Title: Regulation of beta-catenin signaling in the Wnt pathway.

PubMed ID: 10679188

DOI: 10.1006/bbrc.1999.1860

PubMed ID: 12640114

Title: p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.

PubMed ID: 12640114

DOI: 10.1128/mcb.23.7.2287-2297.2003

PubMed ID: 12712206

Title: Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.

PubMed ID: 12712206

DOI: 10.1038/nature01570

PubMed ID: 14595118

Title: Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells.

PubMed ID: 14595118

DOI: 10.1091/mbc.e03-05-0281

PubMed ID: 16424001

Title: TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.

PubMed ID: 16424001

DOI: 10.1158/0008-5472.can-05-3124

PubMed ID: 17047063

Title: E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion.

PubMed ID: 17047063

DOI: 10.1158/0008-5472.can-05-3096

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16858403

Title: The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.

PubMed ID: 16858403

DOI: 10.1038/sj.emboj.7601230

PubMed ID: 17524503

Title: MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism.

PubMed ID: 17524503

DOI: 10.1016/j.bbamcr.2007.04.009

PubMed ID: 17289029

Title: The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway.

PubMed ID: 17289029

DOI: 10.1016/j.febslet.2007.01.058

PubMed ID: 17009320

Title: cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells.

PubMed ID: 17009320

DOI: 10.1002/jcb.21041

PubMed ID: 18077326

Title: The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.

PubMed ID: 18077326

DOI: 10.1073/pnas.0703664105

PubMed ID: 18086858

Title: beta-Catenin is a Nek2 substrate involved in centrosome separation.

PubMed ID: 18086858

DOI: 10.1101/gad.1596308

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18819930

Title: Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.

PubMed ID: 18819930

DOI: 10.1158/1541-7786.mcr-07-2175

PubMed ID: 18378692

Title: CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.

PubMed ID: 18378692

DOI: 10.1128/mcb.00322-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19816403

Title: The kinase TNIK is an essential activator of Wnt target genes.

PubMed ID: 19816403

DOI: 10.1038/emboj.2009.285

PubMed ID: 18957423

Title: Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells.

PubMed ID: 18957423

DOI: 10.1074/jbc.m805612200

PubMed ID: 19433865

Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

PubMed ID: 19433865

DOI: 10.1074/jbc.m109.007237

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20307497

Title: Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.

PubMed ID: 20307497

DOI: 10.1016/j.bbrc.2010.03.099

PubMed ID: 20164195

Title: The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.

PubMed ID: 20164195

DOI: 10.1074/jbc.m109.068304

PubMed ID: 19996314

Title: Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.

PubMed ID: 19996314

DOI: 10.1074/jbc.m109.060301

PubMed ID: 19693690

Title: Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling.

PubMed ID: 19693690

DOI: 10.1007/s11033-009-9752-7

PubMed ID: 20026641

Title: Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.

PubMed ID: 20026641

DOI: 10.1242/jcs.053264

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21262353

Title: Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization.

PubMed ID: 21262353

DOI: 10.1016/j.cellsig.2011.01.019

PubMed ID: 21132015

Title: Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling.

PubMed ID: 21132015

DOI: 10.1038/embor.2010.185

PubMed ID: 21247902

Title: Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor.

PubMed ID: 21247902

DOI: 10.1074/jbc.m110.170803

PubMed ID: 22056988

Title: Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation.

PubMed ID: 22056988

DOI: 10.1038/nature10598

PubMed ID: 21623382

Title: Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome.

PubMed ID: 21623382

DOI: 10.1038/nm.2380

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22647378

Title: The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells.

PubMed ID: 22647378

DOI: 10.4161/cc.20765

PubMed ID: 22699938

Title: Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling.

PubMed ID: 22699938

DOI: 10.1038/embor.2012.88

PubMed ID: 22155184

Title: Beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.

PubMed ID: 22155184

DOI: 10.1053/j.gastro.2011.11.041

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25183871

Title: Simplet/Fam53b is required for Wnt signal transduction by regulating beta-catenin nuclear localization.

PubMed ID: 25183871

DOI: 10.1242/dev.108415

PubMed ID: 24342833

Title: beta-catenin is O-GlcNAc glycosylated at Serine 23: implications for beta-catenin's subcellular localization and transactivator function.

PubMed ID: 24342833

DOI: 10.1016/j.yexcr.2013.11.021

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25266658

Title: The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of beta-catenin.

PubMed ID: 25266658

DOI: 10.1128/mcb.00731-14

PubMed ID: 24824780

Title: MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.

PubMed ID: 24824780

DOI: 10.1002/ijc.28967

PubMed ID: 25169422

Title: HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.

PubMed ID: 25169422

DOI: 10.1002/jcb.24956

PubMed ID: 25807484

Title: Loss of delta-catenin function in severe autism.

PubMed ID: 25807484

DOI: 10.1038/nature14186

PubMed ID: 28829046

Title: Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.

PubMed ID: 28829046

DOI: 10.1038/cr.2017.107

PubMed ID: 28051089

Title: Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.

PubMed ID: 28051089

DOI: 10.1038/mi.2016.120

PubMed ID: 29432739

Title: KSHV vPK inhibits Wnt signaling via preventing interactions between beta-catenin and TCF4.

PubMed ID: 29432739

DOI: 10.1016/j.bbrc.2018.02.089

PubMed ID: 29367600

Title: Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/beta-catenin pathway.

PubMed ID: 29367600

DOI: 10.1038/s41419-017-0128-y

PubMed ID: 28575650

Title: Defects in the cell signaling mediator beta-catenin cause the retinal vascular condition FEVR.

PubMed ID: 28575650

DOI: 10.1016/j.ajhg.2017.05.001

PubMed ID: 29374064

Title: Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-beta-Catenin Signaling Axis.

PubMed ID: 29374064

DOI: 10.1158/0008-5472.can-17-2403

PubMed ID: 29739711

Title: SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of beta-Catenin in Lung Cancer.

PubMed ID: 29739711

DOI: 10.1016/j.ebiom.2018.04.026

PubMed ID: 30097457

Title: FLYWCH1, a Novel Suppressor of Nuclear beta-Catenin, Regulates Migration and Morphology in Colorectal Cancer.

PubMed ID: 30097457

DOI: 10.1158/1541-7786.mcr-18-0262

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 31801859

Title: beta-Catenin Is Required for the cGAS/STING Signaling Pathway but Antagonized by the Herpes Simplex Virus 1 US3 Protein.

PubMed ID: 31801859

DOI: 10.1128/jvi.01847-19

PubMed ID: 11136974

Title: Crystal structure of a beta-catenin/Tcf complex.

PubMed ID: 11136974

DOI: 10.1016/s0092-8674(00)00192-6

PubMed ID: 11713475

Title: Tcf4 can specifically recognize beta-catenin using alternative conformations.

PubMed ID: 11713475

DOI: 10.1038/nsb718

PubMed ID: 11713476

Title: Structure of a human Tcf4-beta-catenin complex.

PubMed ID: 11713476

DOI: 10.1038/nsb720

PubMed ID: 12408824

Title: The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT.

PubMed ID: 12408824

DOI: 10.1016/s1097-2765(02)00637-8

PubMed ID: 17052462

Title: Crystal structure of a beta-catenin/BCL9/Tcf4 complex.

PubMed ID: 17052462

DOI: 10.1016/j.molcel.2006.09.001

PubMed ID: 9065402

Title: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.

PubMed ID: 9065402

DOI: 10.1126/science.275.5307.1787

PubMed ID: 9927029

Title: Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.

PubMed ID: 9927029

PubMed ID: 10398436

Title: Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma.

PubMed ID: 10398436

DOI: 10.1002/(sici)1098-2264(199908)25:4<399::aid-gcc14>3.3.co;2-o

PubMed ID: 10391090

Title: Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: frequent mutations in endometrioid carcinomas.

PubMed ID: 10391090

DOI: 10.1111/j.1349-7006.1999.tb00777.x

PubMed ID: 10655994

Title: A novel case of a sporadic desmoid tumour with mutation of the beta catenin gene.

PubMed ID: 10655994

DOI: 10.1136/jcp.52.9.695

PubMed ID: 10192393

Title: A common human skin tumour is caused by activating mutations in beta-catenin.

PubMed ID: 10192393

DOI: 10.1038/7747

PubMed ID: 10435629

Title: Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.

PubMed ID: 10435629

DOI: 10.1038/sj.onc.1202800

PubMed ID: 10666372

Title: APC mutations in sporadic medulloblastomas.

PubMed ID: 10666372

DOI: 10.1016/s0002-9440(10)64747-5

PubMed ID: 25326669

Title: De novo mutations in beta-catenin (CTNNB1) appear to be a frequent cause of intellectual disability: expanding the mutational and clinical spectrum.

PubMed ID: 25326669

DOI: 10.1007/s00439-014-1498-1

Sequence Information:

  • Length: 781
  • Mass: 85497
  • Checksum: CB78F165A3EEF86E
  • Sequence:
    • MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS 
QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT 
NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 
KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 
VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA 
GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 
AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 
AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 
VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 
RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEPLGYR QDDPSYRSFH 
SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD 
L

Genular Protein ID: 1188022148

Symbol: B4DGU4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGU4

Database IDs:

ARBA 15 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 10 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PROSITE-ProRule 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 774
  • Mass: 84766
  • Checksum: 785874CCE2EC6DC2
  • Sequence:
    • MELDMAMEPD RKAAVSHWQQ QSYLDSGIHS GATTTAPSLS GKGNPEEEDV DTSQVLYEWE 
QGFSQSFTQE QVADIDGQYA MTRAQRVRAA MFPETLDEGM QIPSTQFDAA HPTNVQRLAE 
PSQMLKHAVV NLINYQDDAE LATRAIPELT KLLNDEDQVV VNKAAVMVHQ LSKKEASRHA 
IMRSPQMVSA IVRTMQNTND VETARCTAGT LHNLSHHREG LLAIFKSGGI PALVKMLGSP 
VDSVLFYAIT TLHNLLLHQE GAKMAVRLAG GLQKMVALLN KTNVKFLAIT TDCLQILAYG 
NQESKLIILA SGGPQALVNI MRTYTYEKLL WTTSRVLKVL SVCSSNKPAI VEAGGMQALG 
LHLTDPSQRL VQNCLWTLRN LSDAATKQEG MEGLLGTLVQ LLGSDDINVV TCAAGILSNL 
TCNNYKNKMM VCQVGGIEAL VRTVLRAGDR EDITEPAICA LRHLTSRHQE AEMAQNAVRL 
HYGLPVVVKL LHPPSHWPLI KATVGLIRNL ALCPANHAPL REQGAIPRLV QLLVRAHQDT 
QRRTSMGGTQ QQFVEGVRME EIVEGCTGAL HILARDVHNR IVIRGLNTIP LFVQLLYSPI 
ENIQRVAAGV LCELAQDKEA AEAIEAEGAT APLTELLHSR NEGVATYAAA VLFRMSEDKP 
QDYKKRLSVE LTSSLFRTEP MAWNETADLG LDIGAQGEPL GYRQDDPSYR SFHSGGYGQD 
ALGMDPMMEH EMGGHHPGAD YPVDGLPDLG HAQDLMDGLP PGDSNQLAWF DTDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.