Details for: CTNNB1
Associated with
Other Information
Genular Protein ID: 3260015589
Symbol: CTNB1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7806582
Title: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
PubMed ID: 7806582
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12019147
Title: Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells.
PubMed ID: 12019147
PubMed ID: 7982500
Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.
PubMed ID: 7982500
PubMed ID: 9020842
Title: Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.
PubMed ID: 9020842
DOI: 10.1038/ng0297-170
PubMed ID: 10029085
Title: Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene.
PubMed ID: 10029085
PubMed ID: 10187801
Title: Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration.
PubMed ID: 10187801
PubMed ID: 10725230
Title: ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes.
PubMed ID: 10725230
PubMed ID: 10966653
Title: Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
PubMed ID: 10966653
DOI: 10.1038/79039
PubMed ID: 11703283
Title: Beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles.
PubMed ID: 11703283
PubMed ID: 11751639
Title: Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro.
PubMed ID: 11751639
DOI: 10.1101/gad.946501
PubMed ID: 11279024
Title: Regulation of beta-catenin structure and activity by tyrosine phosphorylation.
PubMed ID: 11279024
PubMed ID: 15003504
Title: CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression.
PubMed ID: 15003504
PubMed ID: 27226643
PubMed ID: 11590244
Title: AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.
PubMed ID: 11590244
PubMed ID: 11389839
Title: Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
PubMed ID: 11389839
PubMed ID: 11389840
Title: Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
PubMed ID: 11389840
PubMed ID: 11464291
Title: Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion.
PubMed ID: 11464291
PubMed ID: 12501215
Title: Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin.
PubMed ID: 12501215
DOI: 10.1021/bi026095u
PubMed ID: 12051714
Title: Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45.
PubMed ID: 12051714
PubMed ID: 12297051
Title: Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape.
PubMed ID: 12297051
PubMed ID: 12027456
Title: Identification of two novel regulated serines in the N-terminus of beta-catenin.
PubMed ID: 12027456
PubMed ID: 11790773
Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.
PubMed ID: 11790773
PubMed ID: 11834740
Title: Wnt signaling controls the phosphorylation status of beta-catenin.
PubMed ID: 11834740
PubMed ID: 12077367
Title: Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells.
PubMed ID: 12077367
PubMed ID: 12370829
Title: The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).
PubMed ID: 12370829
PubMed ID: 12420223
Title: The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells.
PubMed ID: 12420223
PubMed ID: 12830000
Title: EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.
PubMed ID: 12830000
PubMed ID: 10679188
Title: Regulation of beta-catenin signaling in the Wnt pathway.
PubMed ID: 10679188
PubMed ID: 12640114
Title: p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
PubMed ID: 12640114
PubMed ID: 12712206
Title: Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.
PubMed ID: 12712206
DOI: 10.1038/nature01570
PubMed ID: 14595118
Title: Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells.
PubMed ID: 14595118
PubMed ID: 16424001
Title: TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.
PubMed ID: 16424001
PubMed ID: 17047063
Title: E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion.
PubMed ID: 17047063
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16858403
Title: The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
PubMed ID: 16858403
PubMed ID: 17524503
Title: MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism.
PubMed ID: 17524503
PubMed ID: 17289029
Title: The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway.
PubMed ID: 17289029
PubMed ID: 17009320
Title: cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells.
PubMed ID: 17009320
DOI: 10.1002/jcb.21041
PubMed ID: 18077326
Title: The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
PubMed ID: 18077326
PubMed ID: 18086858
Title: beta-Catenin is a Nek2 substrate involved in centrosome separation.
PubMed ID: 18086858
DOI: 10.1101/gad.1596308
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18819930
Title: Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.
PubMed ID: 18819930
PubMed ID: 18378692
Title: CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.
PubMed ID: 18378692
DOI: 10.1128/mcb.00322-08
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19816403
Title: The kinase TNIK is an essential activator of Wnt target genes.
PubMed ID: 19816403
PubMed ID: 18957423
Title: Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells.
PubMed ID: 18957423
PubMed ID: 19433865
Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
PubMed ID: 19433865
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20307497
Title: Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.
PubMed ID: 20307497
PubMed ID: 20164195
Title: The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.
PubMed ID: 20164195
PubMed ID: 19996314
Title: Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.
PubMed ID: 19996314
PubMed ID: 19693690
Title: Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling.
PubMed ID: 19693690
PubMed ID: 20026641
Title: Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.
PubMed ID: 20026641
DOI: 10.1242/jcs.053264
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21262353
Title: Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization.
PubMed ID: 21262353
PubMed ID: 21132015
Title: Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling.
PubMed ID: 21132015
PubMed ID: 21247902
Title: Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor.
PubMed ID: 21247902
PubMed ID: 22056988
Title: Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation.
PubMed ID: 22056988
DOI: 10.1038/nature10598
PubMed ID: 21623382
Title: Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome.
PubMed ID: 21623382
DOI: 10.1038/nm.2380
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22647378
Title: The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells.
PubMed ID: 22647378
DOI: 10.4161/cc.20765
PubMed ID: 22699938
Title: Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling.
PubMed ID: 22699938
PubMed ID: 22155184
Title: Beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.
PubMed ID: 22155184
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 25183871
Title: Simplet/Fam53b is required for Wnt signal transduction by regulating beta-catenin nuclear localization.
PubMed ID: 25183871
DOI: 10.1242/dev.108415
PubMed ID: 24342833
Title: beta-catenin is O-GlcNAc glycosylated at Serine 23: implications for beta-catenin's subcellular localization and transactivator function.
PubMed ID: 24342833
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25266658
Title: The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of beta-catenin.
PubMed ID: 25266658
DOI: 10.1128/mcb.00731-14
PubMed ID: 24824780
Title: MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.
PubMed ID: 24824780
DOI: 10.1002/ijc.28967
PubMed ID: 25169422
Title: HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.
PubMed ID: 25169422
DOI: 10.1002/jcb.24956
PubMed ID: 25807484
Title: Loss of delta-catenin function in severe autism.
PubMed ID: 25807484
DOI: 10.1038/nature14186
PubMed ID: 28829046
Title: Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
PubMed ID: 28829046
DOI: 10.1038/cr.2017.107
PubMed ID: 28051089
Title: Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.
PubMed ID: 28051089
DOI: 10.1038/mi.2016.120
PubMed ID: 29432739
Title: KSHV vPK inhibits Wnt signaling via preventing interactions between beta-catenin and TCF4.
PubMed ID: 29432739
PubMed ID: 29367600
Title: Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/beta-catenin pathway.
PubMed ID: 29367600
PubMed ID: 28575650
Title: Defects in the cell signaling mediator beta-catenin cause the retinal vascular condition FEVR.
PubMed ID: 28575650
PubMed ID: 29374064
Title: Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-beta-Catenin Signaling Axis.
PubMed ID: 29374064
PubMed ID: 29739711
Title: SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of beta-Catenin in Lung Cancer.
PubMed ID: 29739711
PubMed ID: 30097457
Title: FLYWCH1, a Novel Suppressor of Nuclear beta-Catenin, Regulates Migration and Morphology in Colorectal Cancer.
PubMed ID: 30097457
PubMed ID: 31073040
Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.
PubMed ID: 31073040
PubMed ID: 31801859
Title: beta-Catenin Is Required for the cGAS/STING Signaling Pathway but Antagonized by the Herpes Simplex Virus 1 US3 Protein.
PubMed ID: 31801859
DOI: 10.1128/jvi.01847-19
PubMed ID: 11136974
Title: Crystal structure of a beta-catenin/Tcf complex.
PubMed ID: 11136974
PubMed ID: 11713475
Title: Tcf4 can specifically recognize beta-catenin using alternative conformations.
PubMed ID: 11713475
DOI: 10.1038/nsb718
PubMed ID: 11713476
PubMed ID: 12408824
Title: The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT.
PubMed ID: 12408824
PubMed ID: 17052462
Title: Crystal structure of a beta-catenin/BCL9/Tcf4 complex.
PubMed ID: 17052462
PubMed ID: 9065402
Title: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
PubMed ID: 9065402
PubMed ID: 9927029
Title: Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.
PubMed ID: 9927029
PubMed ID: 10398436
Title: Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma.
PubMed ID: 10398436
DOI: 10.1002/(sici)1098-2264(199908)25:4<399::aid-gcc14>3.3.co;2-o
PubMed ID: 10391090
Title: Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: frequent mutations in endometrioid carcinomas.
PubMed ID: 10391090
PubMed ID: 10655994
Title: A novel case of a sporadic desmoid tumour with mutation of the beta catenin gene.
PubMed ID: 10655994
DOI: 10.1136/jcp.52.9.695
PubMed ID: 10192393
Title: A common human skin tumour is caused by activating mutations in beta-catenin.
PubMed ID: 10192393
DOI: 10.1038/7747
PubMed ID: 10435629
Title: Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.
PubMed ID: 10435629
PubMed ID: 10666372
Title: APC mutations in sporadic medulloblastomas.
PubMed ID: 10666372
PubMed ID: 25326669
Title: De novo mutations in beta-catenin (CTNNB1) appear to be a frequent cause of intellectual disability: expanding the mutational and clinical spectrum.
PubMed ID: 25326669
Sequence Information:
- Length: 781
- Mass: 85497
- Checksum: CB78F165A3EEF86E
- Sequence:
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEPLGYR QDDPSYRSFH SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L
Genular Protein ID: 1188022148
Symbol: B4DGU4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 774
- Mass: 84766
- Checksum: 785874CCE2EC6DC2
- Sequence:
MELDMAMEPD RKAAVSHWQQ QSYLDSGIHS GATTTAPSLS GKGNPEEEDV DTSQVLYEWE QGFSQSFTQE QVADIDGQYA MTRAQRVRAA MFPETLDEGM QIPSTQFDAA HPTNVQRLAE PSQMLKHAVV NLINYQDDAE LATRAIPELT KLLNDEDQVV VNKAAVMVHQ LSKKEASRHA IMRSPQMVSA IVRTMQNTND VETARCTAGT LHNLSHHREG LLAIFKSGGI PALVKMLGSP VDSVLFYAIT TLHNLLLHQE GAKMAVRLAG GLQKMVALLN KTNVKFLAIT TDCLQILAYG NQESKLIILA SGGPQALVNI MRTYTYEKLL WTTSRVLKVL SVCSSNKPAI VEAGGMQALG LHLTDPSQRL VQNCLWTLRN LSDAATKQEG MEGLLGTLVQ LLGSDDINVV TCAAGILSNL TCNNYKNKMM VCQVGGIEAL VRTVLRAGDR EDITEPAICA LRHLTSRHQE AEMAQNAVRL HYGLPVVVKL LHPPSHWPLI KATVGLIRNL ALCPANHAPL REQGAIPRLV QLLVRAHQDT QRRTSMGGTQ QQFVEGVRME EIVEGCTGAL HILARDVHNR IVIRGLNTIP LFVQLLYSPI ENIQRVAAGV LCELAQDKEA AEAIEAEGAT APLTELLHSR NEGVATYAAA VLFRMSEDKP QDYKKRLSVE LTSSLFRTEP MAWNETADLG LDIGAQGEPL GYRQDDPSYR SFHSGGYGQD ALGMDPMMEH EMGGHHPGAD YPVDGLPDLG HAQDLMDGLP PGDSNQLAWF DTDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.