Details for: H2 M3

Gene ID: 14991

Symbol: H2 M3

Ensembl ID: ENSMUSG00000016206

Description: histocompatibility 2, M region locus 3

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Antigen presentation: folding, assembly and peptide loading of class i mhc
    (R-MMU-983170)
  • Antigen processing-cross presentation
    (R-MMU-1236975)
  • Class i mhc mediated antigen processing & presentation
    (R-MMU-983169)
  • Dap12 interactions
    (R-MMU-2172127)
  • Endosomal/vacuolar pathway
    (R-MMU-1236977)
  • Er-phagosome pathway
    (R-MMU-1236974)
  • Immune system
    (R-MMU-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-MMU-198933)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • Alpha-beta t cell activation involved in immune response
    (GO:0002287)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent
    (GO:0002481)
  • Cd8 receptor binding
    (GO:0042610)
  • Cis-golgi network membrane
    (GO:0033106)
  • Defense response to bacterium
    (GO:0042742)
  • Early endosome
    (GO:0005769)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Mhc class ib protein complex
    (GO:0032398)
  • Nitric oxide biosynthetic process
    (GO:0006809)
  • Peptide antigen binding
    (GO:0042605)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protein homodimerization activity
    (GO:0042803)
  • Response to molecule of bacterial origin
    (GO:0002237)
  • Signaling receptor binding
    (GO:0005102)

Other Information

Genular Protein ID: 1395206584

Symbol: Q31093_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q31093

Database IDs:

AGR 1 ARBA 5 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 GO 24 Gene3D 2 GeneTree 1 HOGENOM 1 InterPro 9 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 1 PRINTS 1 PROSITE 3 PaxDb 1 Pfam 2 PhosphoSitePlus 1 Proteomes 2 ProteomicsDB 1 Reactome 6 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 1855254

Title: H-2M3 encodes the MHC class I molecule presenting the maternally transmitted antigen of the mouse.

PubMed ID: 1855254

DOI: 10.1016/0092-8674(91)90623-7

PubMed ID: 7664344

Title: Nonclassical binding of formylated peptide in crystal structure of the MHC class Ib molecule H2-M3.

PubMed ID: 7664344

DOI: 10.1016/0092-8674(95)90037-3

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 34176438

Title: Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides.

PubMed ID: 34176438

DOI: 10.1080/07391102.2021.1942214

Sequence Information:

  • Length: 336
  • Mass: 37856
  • Checksum: F0EE53DA1D8D98C8
  • Sequence:
    • MGSSSNRALL HMVVVSLAVT QTGSGSHSLR YFHTAVSRPG RGEPQYISVG YVDDVQFQRC 
DSIEEIPRME PRAPWMEKER PEYWKELKLK VKNIAQSARA NLRTLLRYYN QSEGGSHILQ 
WMVSCEVGPD MRLLGAHYQA AYDGSDYITL NEDLSSWTAV DMVSQITKSR LESAGTAEYF 
RAYVEGECLE LLHRFLRNGK EILQRADPPK AHVAHHPRPK GDVTLRCWAL GFYPADITLT 
WQKDEEDLTQ DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCYVHHEGL TEPLALKWGR 
SSQSSVVIMV IVASLVLLGG VITIVVVCKR RGAGER

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.