Gene AANAT - ENSG00000129673 | NCBI Gene ID: 15

Details for: AANAT

Gene ID: 15

Symbol: AANAT

Ensembl ID: ENSG00000129673

Description: aralkylamine N-acetyltransferase

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of amine-derived hormones
(R-HSA-209776)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Serotonin and melatonin biosynthesis
(R-HSA-209931)
14-3-3 protein binding
(GO:0071889)
Aralkylamine n-acetyltransferase activity
(GO:0004059)
Arylamine n-acetyltransferase activity
(GO:0004060)
Cellular response to camp
(GO:0071320)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Indolalkylamine biosynthetic process
(GO:0046219)
Melatonin biosynthetic process
(GO:0030187)
N-terminal protein amino acid acetylation
(GO:0006474)
Perinuclear region of cytoplasm
(GO:0048471)
Photoperiodism
(GO:0009648)
Protein binding
(GO:0005515)
Response to calcium ion
(GO:0051592)
Response to copper ion
(GO:0046688)
Response to corticosterone
(GO:0051412)
Response to cytokine
(GO:0034097)
Response to insulin
(GO:0032868)
Response to light stimulus
(GO:0009416)
Response to prostaglandin e
(GO:0034695)
Response to zinc ion
(GO:0010043)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 3.22
Marker Score: 1783.5
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.21
Marker Score: 2227
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.99
Marker Score: 1040
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1173
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.59
Marker Score: 3281
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 858
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4820
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.14
Marker Score: 2152
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.06
Marker Score: 675.5
Cell Name: goblet cell (CL0000160)
Fold Change: 1.05
Marker Score: 6949
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71832
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48057
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 511
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.94
Marker Score: 391
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5353
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.92
Marker Score: 14454
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.88
Marker Score: 405
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.84
Marker Score: 1705
Cell Name: mast cell (CL0000097)
Fold Change: 0.83
Marker Score: 484
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.83
Marker Score: 436.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 596
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398
Cell Name: pericyte (CL0000669)
Fold Change: 0.72
Marker Score: 423
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.72
Marker Score: 227
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.65
Marker Score: 210
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.58
Marker Score: 372.5
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 236
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 450
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.55
Marker Score: 361
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.49
Marker Score: 129
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.46
Marker Score: 1356
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.46
Marker Score: 145
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.46
Marker Score: 277
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 383
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.36
Marker Score: 855
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.33
Marker Score: 156
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.3
Marker Score: 302
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.3
Marker Score: 884.5
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.29
Marker Score: 130
Cell Name: macrophage (CL0000235)
Fold Change: 0.28
Marker Score: 306
Cell Name: podocyte (CL0000653)
Fold Change: 0.24
Marker Score: 88
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.23
Marker Score: 87
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.22
Marker Score: 56
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.19
Marker Score: 86
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.19
Marker Score: 132
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.18
Marker Score: 104
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.18
Marker Score: 126
Cell Name: monocyte (CL0000576)
Fold Change: 0.18
Marker Score: 234
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.18
Marker Score: 105
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.17
Marker Score: 49
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.16
Marker Score: 58
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.16
Marker Score: 666
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.14
Marker Score: 1164
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.13
Marker Score: 61
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.13
Marker Score: 130
Cell Name: microglial cell (CL0000129)
Fold Change: 0.13
Marker Score: 231
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.12
Marker Score: 50
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.12
Marker Score: 1198
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.11
Marker Score: 169
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1
Marker Score: 290
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.1
Marker Score: 139
Cell Name: neuron (CL0000540)
Fold Change: 0.1
Marker Score: 393
Cell Name: astrocyte (CL0000127)
Fold Change: 0.1
Marker Score: 83
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.08
Marker Score: 171
Cell Name: melanocyte (CL0000148)
Fold Change: 0.08
Marker Score: 34
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.08
Marker Score: 133
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.08
Marker Score: 18
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.08
Marker Score: 61
Cell Name: stromal cell (CL0000499)
Fold Change: 0.08
Marker Score: 93
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.08
Marker Score: 18
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.08
Marker Score: 70
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.07
Marker Score: 42
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.07
Marker Score: 4388
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.07
Marker Score: 18
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.07
Marker Score: 18
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.07
Marker Score: 2592
Cell Name: plasma cell (CL0000786)
Fold Change: 0.07
Marker Score: 77
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.07
Marker Score: 193
Cell Name: B cell (CL0000236)
Fold Change: 0.07
Marker Score: 64
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.07
Marker Score: 16
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.07
Marker Score: 62
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.06
Marker Score: 34
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.06
Marker Score: 3561
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.06
Marker Score: 79
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.06
Marker Score: 17

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**Key characteristics:** - AANAT is a transmembrane protein with a molecular weight of approximately 60 kDa. - It is expressed in a variety of cell types, including endothelial cells, epithelial cells, and immune cells. - It is a highly conserved enzyme with a similar sequence found in organisms from yeast to humans. **Pathways and functions:** - AANAT is involved in the regulation of circadian rhythm through its interaction with the clock protein periodin 2 (PER2). - It also plays a role in the synthesis of melatonin, a hormone that regulates the sleep-wake cycle. - AANAT is involved in the metabolism of amino acids and derivatives, including the synthesis of neurotransmitters and the degradation of damaged proteins. - It is also involved in the regulation of the immune response and inflammation. **Clinical significance:** - Mutations in AANAT have been linked to several human diseases, including circadian disorders, sleep apnea, and obesity. - AANAT inhibitors have been investigated as potential therapeutic agents for these diseases. **Additional notes:** - AANAT is a highly active enzyme that is regulated by various hormones and signaling molecules. - It is a key regulator of the body's circadian rhythm and the synthesis of melatonin. - It is also involved in the metabolism of amino acids and derivatives, which is essential for maintaining homeostasis in the body.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serotonin N-acetyltransferase

Genular Protein ID: 1782899179

Symbol: SNAT_HUMAN

Name: Serotonin N-acetyltransferase

UniProtKB Accession Codes:

Q16613 A0AVF2 J3KMZ5 Q562F4

Database IDs:

Citations:

PubMed ID: 8661026

Title: The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression.

PubMed ID: 8661026

DOI: 10.1006/geno.1996.0243

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11313340

Title: cAMP regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation.

PubMed ID: 11313340

DOI: 10.1074/jbc.m011298200

PubMed ID: 11427721

Title: Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

PubMed ID: 11427721

DOI: 10.1073/pnas.141118798

PubMed ID: 18212399

Title: Role of melatonin in upper gastrointestinal tract.

PubMed ID: 18212399

PubMed ID: 12736803

Title: Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome.

PubMed ID: 12736803

DOI: 10.1007/s10048-002-0141-9

Sequence Information:

Length: 207
Mass: 23344
Checksum: 7476612F3661E0D5
Sequence:

MSTQSTHPLK PEAPRLPPGI PESPSCQRRH TLPASEFRCL TPEDAVSAFE IEREAFISVL 
GVCPLYLDEI RHFLTLCPEL SLGWFEEGCL VAFIIGSLWD KERLMQESLT LHRSGGHIAH 
LHVLAVHRAF RQQGRGPILL WRYLHHLGSQ PAVRRAALMC EDALVPFYER FSFHAVGPCA 
ITVGSLTFME LHCSLRGHPF LRRNSGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: AANAT

Associated with

Cells (max top 100)

Other Information

The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. PubMed ID: 8661026

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cAMP regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. PubMed ID: 11313340

Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. PubMed ID: 11427721

Role of melatonin in upper gastrointestinal tract. PubMed ID: 18212399

Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome. PubMed ID: 12736803