Details for: AANAT

Gene ID: 15

Symbol: AANAT

Ensembl ID: ENSG00000129673

Description: aralkylamine N-acetyltransferase

Associated with

Cells (max top 100)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.22
    Marker Score: 1783.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.21
    Marker Score: 2227
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.99
    Marker Score: 1040
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.59
    Marker Score: 3281
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2152
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 675.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6949
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 391
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14454
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 405
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1705
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 484
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.83
    Marker Score: 436.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.72
    Marker Score: 423
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.72
    Marker Score: 227
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.65
    Marker Score: 210
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 372.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 361
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.46
    Marker Score: 1356
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.46
    Marker Score: 145
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 383
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.36
    Marker Score: 855
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 156
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 302
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.3
    Marker Score: 884.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.29
    Marker Score: 130
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 306
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.24
    Marker Score: 88
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.23
    Marker Score: 87
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 86
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 132
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.18
    Marker Score: 234
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.16
    Marker Score: 666
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.14
    Marker Score: 1164
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.13
    Marker Score: 231
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.12
    Marker Score: 1198
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 169
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1
    Marker Score: 290
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1
    Marker Score: 139
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.1
    Marker Score: 393
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 83
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.08
    Marker Score: 171
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.08
    Marker Score: 133
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.08
    Marker Score: 61
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.07
    Marker Score: 4388
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.07
    Marker Score: 2592
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.07
    Marker Score: 193
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.06
    Marker Score: 3561
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 17
**Key characteristics:** - AANAT is a transmembrane protein with a molecular weight of approximately 60 kDa. - It is expressed in a variety of cell types, including endothelial cells, epithelial cells, and immune cells. - It is a highly conserved enzyme with a similar sequence found in organisms from yeast to humans. **Pathways and functions:** - AANAT is involved in the regulation of circadian rhythm through its interaction with the clock protein periodin 2 (PER2). - It also plays a role in the synthesis of melatonin, a hormone that regulates the sleep-wake cycle. - AANAT is involved in the metabolism of amino acids and derivatives, including the synthesis of neurotransmitters and the degradation of damaged proteins. - It is also involved in the regulation of the immune response and inflammation. **Clinical significance:** - Mutations in AANAT have been linked to several human diseases, including circadian disorders, sleep apnea, and obesity. - AANAT inhibitors have been investigated as potential therapeutic agents for these diseases. **Additional notes:** - AANAT is a highly active enzyme that is regulated by various hormones and signaling molecules. - It is a key regulator of the body's circadian rhythm and the synthesis of melatonin. - It is also involved in the metabolism of amino acids and derivatives, which is essential for maintaining homeostasis in the body.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.