Details for: ADRA2A

Gene ID: 150

Symbol: ADRA2A

Ensembl ID: ENSG00000150594

Description: adrenoceptor alpha 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.6331
    Cell Significance Index: -10.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.5293
    Cell Significance Index: -10.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.5314
    Cell Significance Index: -9.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4999
    Cell Significance Index: -10.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1463
    Cell Significance Index: 32.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8265
    Cell Significance Index: 39.5700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.7313
    Cell Significance Index: 19.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5964
    Cell Significance Index: 38.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2052
    Cell Significance Index: 119.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1369
    Cell Significance Index: 32.7600
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.0641
    Cell Significance Index: 4.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9631
    Cell Significance Index: 8.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9128
    Cell Significance Index: 99.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7561
    Cell Significance Index: 12.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6378
    Cell Significance Index: 13.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5677
    Cell Significance Index: 7.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4749
    Cell Significance Index: 32.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3822
    Cell Significance Index: 8.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3807
    Cell Significance Index: 44.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2961
    Cell Significance Index: 7.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1994
    Cell Significance Index: 9.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1242
    Cell Significance Index: 17.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1229
    Cell Significance Index: 2.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1148
    Cell Significance Index: 2.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0651
    Cell Significance Index: 7.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0624
    Cell Significance Index: 56.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0581
    Cell Significance Index: 6.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0571
    Cell Significance Index: 35.6400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0378
    Cell Significance Index: 0.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0294
    Cell Significance Index: 2.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0284
    Cell Significance Index: 5.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0194
    Cell Significance Index: 0.3000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0184
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0094
    Cell Significance Index: 0.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0005
    Cell Significance Index: -0.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0010
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0043
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0078
    Cell Significance Index: -1.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -13.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0131
    Cell Significance Index: -9.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0134
    Cell Significance Index: -7.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0163
    Cell Significance Index: -1.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0163
    Cell Significance Index: -5.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0174
    Cell Significance Index: -2.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0186
    Cell Significance Index: -5.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0203
    Cell Significance Index: -4.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0436
    Cell Significance Index: -7.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0440
    Cell Significance Index: -8.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0543
    Cell Significance Index: -1.7400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0613
    Cell Significance Index: -0.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0684
    Cell Significance Index: -8.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0685
    Cell Significance Index: -1.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0774
    Cell Significance Index: -10.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0787
    Cell Significance Index: -3.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0936
    Cell Significance Index: -1.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0943
    Cell Significance Index: -9.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0957
    Cell Significance Index: -11.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1034
    Cell Significance Index: -10.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1145
    Cell Significance Index: -5.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1218
    Cell Significance Index: -3.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1337
    Cell Significance Index: -8.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1359
    Cell Significance Index: -4.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1402
    Cell Significance Index: -11.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1413
    Cell Significance Index: -10.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1440
    Cell Significance Index: -9.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1451
    Cell Significance Index: -2.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1637
    Cell Significance Index: -2.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1676
    Cell Significance Index: -10.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1713
    Cell Significance Index: -8.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1747
    Cell Significance Index: -9.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1791
    Cell Significance Index: -4.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1813
    Cell Significance Index: -8.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1848
    Cell Significance Index: -10.3700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1851
    Cell Significance Index: -2.9700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1906
    Cell Significance Index: -1.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1971
    Cell Significance Index: -5.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1993
    Cell Significance Index: -5.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2002
    Cell Significance Index: -10.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2042
    Cell Significance Index: -4.1000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2086
    Cell Significance Index: -1.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2381
    Cell Significance Index: -8.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2408
    Cell Significance Index: -10.6500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2432
    Cell Significance Index: -3.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2488
    Cell Significance Index: -7.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2613
    Cell Significance Index: -9.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2626
    Cell Significance Index: -9.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2971
    Cell Significance Index: -3.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3024
    Cell Significance Index: -8.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3050
    Cell Significance Index: -12.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3136
    Cell Significance Index: -7.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3317
    Cell Significance Index: -9.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3353
    Cell Significance Index: -8.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3367
    Cell Significance Index: -17.0200
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.3412
    Cell Significance Index: -3.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-protein coupled receptor (GPCR)**: ADRA2A is a member of the GPCR family, which is the largest family of membrane receptors and plays a vital role in transducing signals from hormones and neurotransmitters. 2. **Adrenergic receptor**: ADRA2A is a specific subtype of adrenergic receptor, which is activated by the endogenous catecholamines, adrenaline (epinephrine) and noradrenaline (norepinephrine). 3. **Dual signaling pathways**: ADRA2A activates both adenylate cyclase-activating and inhibiting pathways, regulating cAMP levels and modulating various cellular processes. 4. **Cellular distribution**: ADRA2A is expressed in a wide range of cell types, including immune cells, epithelial cells, neurons, and stem cells, indicating its importance in maintaining tissue homeostasis and responding to environmental cues. **Pathways and Functions:** 1. **Adenylate cyclase-activating pathway**: ADRA2A activates adenylate cyclase, a key enzyme in the cAMP signaling pathway, leading to increased cAMP levels and modulation of various cellular processes, including gene expression, cell proliferation, and differentiation. 2. **Adenylate cyclase-inhibiting pathway**: ADRA2A inhibits adenylate cyclase, leading to decreased cAMP levels and modulation of cellular processes, including insulin secretion, lipid metabolism, and vascular tone. 3. **Insulin secretion regulation**: ADRA2A negatively regulates insulin secretion, modulating glucose homeostasis and glucose metabolism. 4. **Vasodilation and vasoconstriction**: ADRA2A modulates vascular tone by regulating the activity of endothelial nitric oxide synthase and phospholipase C, leading to vasodilation or vasoconstriction. 5. **Neurotransmission and synaptic plasticity**: ADRA2A regulates neurotransmission and synaptic plasticity by modulating the activity of GABAergic and glutamatergic synapses. **Clinical Significance:** 1. **Hypertension**: ADRA2A dysfunction has been implicated in the pathogenesis of hypertension, as it regulates vascular tone and blood pressure. 2. **Diabetes**: ADRA2A negatively regulates insulin secretion, highlighting its potential role in the development of diabetes. 3. **Neurological disorders**: ADRA2A dysfunction has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and anxiety disorders. 4. **Cancer**: ADRA2A is overexpressed in certain types of cancer, including breast cancer and colon cancer, suggesting its potential role in tumor progression and metastasis. 5. **Immunological disorders**: ADRA2A is expressed in immune cells, and its dysfunction has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, the ADRA2A gene plays a complex and multifaceted role in regulating various physiological and pathological processes. Its dysfunction has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ADRA2A signaling and its clinical significance.

Genular Protein ID: 1283291309

Symbol: ADA2A_HUMAN

Name: Alpha-2 adrenergic receptor subtype C10

UniProtKB Accession Codes:

P08913 B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 13 EMDB 7 Ensembl 1 EvolutionaryTrace 1 GO 64 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2568356

Title: Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation.

PubMed ID: 2568356

DOI: 10.1016/s0021-9258(18)80130-2

PubMed ID: 2170371

Title: Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.

PubMed ID: 2170371

DOI: 10.1016/s0021-9258(17)44904-0

PubMed ID: 16567612

Title: Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression.

PubMed ID: 16567612

DOI: 10.1073/pnas.0601345103

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2823383

Title: Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.

PubMed ID: 2823383

DOI: 10.1126/science.2823383

PubMed ID: 10948191

Title: An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling.

PubMed ID: 10948191

DOI: 10.1074/jbc.m004550200

PubMed ID: 1849485

Title: Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.

PubMed ID: 1849485

DOI: 10.1016/0014-5793(91)80301-i

PubMed ID: 1678390

Title: A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists.

PubMed ID: 1678390

DOI: 10.1016/s0021-9258(18)98642-4

PubMed ID: 1678850

Title: Site-directed mutagenesis of alpha 2a-adrenergic receptors: Identification of amino acids involved in ligand binding and receptor activation by agonists.

PubMed ID: 1678850

PubMed ID: 23105096

Title: Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi.

PubMed ID: 23105096

DOI: 10.1074/jbc.m112.410936

PubMed ID: 11888275

Title: NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.

PubMed ID: 11888275

DOI: 10.1021/bi015811+

PubMed ID: 27376152

Title: Whole-exome sequencing identifies ADRA2A mutation in atypical familial partial lipodystrophy.

PubMed ID: 27376152

DOI: 10.1172/jci.insight.86870

Sequence Information:

  • Length: 465
  • Mass: 50647
  • Checksum: 585E576149BDB696
  • Sequence:
    • MFRQEQPLAE GSFAPMGSLQ PDAGNASWNG TEAPGGGARA TPYSLQVTLT LVCLAGLLML 
LTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL VIPFSLANEV MGYWYFGKAW 
CEIYLALDVL FCTSSIVHLC AISLDRYWSI TQAIEYNLKR TPRRIKAIII TVWVISAVIS 
FPPLISIEKK GGGGGPQPAE PRCEINDQKW YVISSCIGSF FAPCLIMILV YVRIYQIAKR 
RTRVPPSRRG PDAVAAPPGG TERRPNGLGP ERSAGPGGAE AEPLPTQLNG APGEPAPAGP 
RDTDALDLEE SSSSDHAERP PGPRRPERGP RGKGKARASQ VKPGDSLPRR GPGATGIGTP 
AAGPGEERVG AAKASRWRGR QNREKRFTFV LAVVIGVFVV CWFPFFFTYT LTAVGCSVPR 
TLFKFFFWFG YCNSSLNPVI YTIFNHDFRR AFKKILCRGD RKRIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.