ADRA2A | ENSG00000150594 | NCBI 150

Details for: ADRA2A

Gene ID: 150

Symbol: ADRA2A

Ensembl ID: ENSG00000150594

Description: adrenoceptor alpha 2A

Associated with

Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Adrenaline signalling through alpha-2 adrenergic receptor
(R-HSA-392023)
Adrenoceptors
(R-HSA-390696)
Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (z) signalling events
(R-HSA-418597)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Hemostasis
(R-HSA-109582)
Integration of energy metabolism
(R-HSA-163685)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Regulation of insulin secretion
(R-HSA-422356)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Surfactant metabolism
(R-HSA-5683826)
Actin cytoskeleton organization
(GO:0030036)
Activation of protein kinase activity
(GO:0032147)
Activation of protein kinase b activity
(GO:0032148)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-inhibiting adrenergic receptor signaling pathway
(GO:0071881)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Adrenergic receptor signaling pathway
(GO:0071875)
Alpha-1b adrenergic receptor binding
(GO:0031692)
Alpha-2c adrenergic receptor binding
(GO:0031696)
Alpha2-adrenergic receptor activity
(GO:0004938)
Axon terminus
(GO:0043679)
Basolateral plasma membrane
(GO:0016323)
Cellular response to hormone stimulus
(GO:0032870)
Cytoplasm
(GO:0005737)
Dna replication
(GO:0006260)
Dopaminergic synapse
(GO:0098691)
Epinephrine binding
(GO:0051379)
Fear response
(GO:0042596)
Female pregnancy
(GO:0007565)
Gaba-ergic synapse
(GO:0098982)
Glucose homeostasis
(GO:0042593)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heterotrimeric g-protein binding
(GO:0032795)
Intestinal absorption
(GO:0050892)
Negative regulation of calcium ion-dependent exocytosis
(GO:0045955)
Negative regulation of calcium ion transmembrane transporter activity
(GO:1901020)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of epinephrine secretion
(GO:0032811)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061179)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of norepinephrine secretion
(GO:0010700)
Negative regulation of uterine smooth muscle contraction
(GO:0070473)
Neuronal cell body
(GO:0043025)
Norepinephrine binding
(GO:0051380)
Phospholipase c-activating adrenergic receptor signaling pathway
(GO:0071882)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of membrane protein ectodomain proteolysis
(GO:0051044)
Positive regulation of potassium ion transport
(GO:0043268)
Positive regulation of wound healing
(GO:0090303)
Postsynaptic density membrane
(GO:0098839)
Presynaptic active zone membrane
(GO:0048787)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Ras protein signal transduction
(GO:0007265)
Receptor complex
(GO:0043235)
Receptor transactivation
(GO:0035624)
Regulation of vasoconstriction
(GO:0019229)
Rho protein signal transduction
(GO:0007266)
Thermoception
(GO:0050955)
Thioesterase binding
(GO:0031996)
Vasodilation
(GO:0042311)

Other Information

Proteins

Alpha-2 adrenergic receptor subtype C10

Genular Protein ID: 1283291309

Symbol: ADA2A_HUMAN

Name: Alpha-2 adrenergic receptor subtype C10

UniProtKB Accession Codes:

P08913 B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Database IDs:

Citations:

PubMed ID: 2568356

Title: Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation.

PubMed ID: 2568356

DOI: 10.1016/s0021-9258(18)80130-2

PubMed ID: 2170371

Title: Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.

PubMed ID: 2170371

DOI: 10.1016/s0021-9258(17)44904-0

PubMed ID: 16567612

Title: Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression.

PubMed ID: 16567612

DOI: 10.1073/pnas.0601345103

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2823383

Title: Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.

PubMed ID: 2823383

DOI: 10.1126/science.2823383

PubMed ID: 10948191

Title: An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling.

PubMed ID: 10948191

DOI: 10.1074/jbc.m004550200

PubMed ID: 1849485

Title: Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.

PubMed ID: 1849485

DOI: 10.1016/0014-5793(91)80301-i

PubMed ID: 1678390

Title: A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists.

PubMed ID: 1678390

DOI: 10.1016/s0021-9258(18)98642-4

PubMed ID: 1678850

Title: Site-directed mutagenesis of alpha 2a-adrenergic receptors: Identification of amino acids involved in ligand binding and receptor activation by agonists.

PubMed ID: 1678850

PubMed ID: 23105096

Title: Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi.

PubMed ID: 23105096

DOI: 10.1074/jbc.m112.410936

PubMed ID: 11888275

Title: NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.

PubMed ID: 11888275

DOI: 10.1021/bi015811+

Sequence Information:

Length: 465
Mass: 50647
Checksum: 585E576149BDB696
Sequence:

MFRQEQPLAE GSFAPMGSLQ PDAGNASWNG TEAPGGGARA TPYSLQVTLT LVCLAGLLML 
LTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL VIPFSLANEV MGYWYFGKAW 
CEIYLALDVL FCTSSIVHLC AISLDRYWSI TQAIEYNLKR TPRRIKAIII TVWVISAVIS 
FPPLISIEKK GGGGGPQPAE PRCEINDQKW YVISSCIGSF FAPCLIMILV YVRIYQIAKR 
RTRVPPSRRG PDAVAAPPGG TERRPNGLGP ERSAGPGGAE AEPLPTQLNG APGEPAPAGP 
RDTDALDLEE SSSSDHAERP PGPRRPERGP RGKGKARASQ VKPGDSLPRR GPGATGIGTP 
AAGPGEERVG AAKASRWRGR QNREKRFTFV LAVVIGVFVV CWFPFFFTYT LTAVGCSVPR 
TLFKFFFWFG YCNSSLNPVI YTIFNHDFRR AFKKILCRGD RKRIV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADRA2A

Associated with

Other Information

Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation. PubMed ID: 2568356

Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs. PubMed ID: 2170371

Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression. PubMed ID: 16567612

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. PubMed ID: 2823383

An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. PubMed ID: 10948191

Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR. PubMed ID: 1849485

A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists. PubMed ID: 1678390

Site-directed mutagenesis of alpha 2a-adrenergic receptors: Identification of amino acids involved in ligand binding and receptor activation by agonists. PubMed ID: 1678850

Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi. PubMed ID: 23105096

NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. PubMed ID: 11888275