Details for: ADRA2A

Gene ID: 150

Symbol: ADRA2A

Ensembl ID: ENSG00000150594

Description: adrenoceptor alpha 2A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.29
    Marker Score: 3166
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.12
    Marker Score: 1164
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251804
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1878
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1603
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12659
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.72
    Marker Score: 262
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.71
    Marker Score: 7165
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.71
    Marker Score: 604
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.7
    Marker Score: 1308.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.68
    Marker Score: 732
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2793
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.63
    Marker Score: 322
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 360
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.6
    Marker Score: 152
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.6
    Marker Score: 420.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.59
    Marker Score: 5071
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.58
    Marker Score: 166
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.57
    Marker Score: 3733
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.57
    Marker Score: 141
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 352
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.55
    Marker Score: 133
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.52
    Marker Score: 553
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 215
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.45
    Marker Score: 123
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.43
    Marker Score: 221
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.41
    Marker Score: 153
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.4
    Marker Score: 367
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.4
    Marker Score: 116
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.4
    Marker Score: 133
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.39
    Marker Score: 191
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.38
    Marker Score: 2445
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.38
    Marker Score: 186
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.38
    Marker Score: 109
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.36
    Marker Score: 359
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.35
    Marker Score: 149
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.32
    Marker Score: 6438
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.32
    Marker Score: 763
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.32
    Marker Score: 860
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.31
    Marker Score: 224
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.31
    Marker Score: 714
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.31
    Marker Score: 87
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 299.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.29
    Marker Score: 128
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 291
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.28
    Marker Score: 267
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.28
    Marker Score: 10618
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.28
    Marker Score: 779
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.25
    Marker Score: 8543
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.25
    Marker Score: 172
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.25
    Marker Score: 86
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.24
    Marker Score: 635
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.23
    Marker Score: 393
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.23
    Marker Score: 106
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.23
    Marker Score: 259
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 130
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.23
    Marker Score: 440
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 101
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.22
    Marker Score: 68
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.22
    Marker Score: 910
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 454
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 128
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.21
    Marker Score: 262
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.21
    Marker Score: 204
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.21
    Marker Score: 75
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2
    Marker Score: 1202.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2
    Marker Score: 132.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2
    Marker Score: 99
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.2
    Marker Score: 960
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 173
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.2
    Marker Score: 352
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.2
    Marker Score: 618
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.2
    Marker Score: 50
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.19
    Marker Score: 458
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.19
    Marker Score: 63
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.18
    Marker Score: 705
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.18
    Marker Score: 40

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Other Information

**Key characteristics:** * ADRA2A is a type I transmembrane protein with seven transmembrane domains. * It is a ligand-gated ion channel, which means that it opens or closes in response to the binding of a specific ligand. * ADRA2A is a member of the alpha-2 adrenergic receptor family, which are involved in a variety of physiological processes, including blood pressure regulation, heart rate, and insulin secretion. **Pathways and functions:** * ADRA2A is a key regulator of insulin secretion. When ADRA2A is stimulated by its ligand, epinephrine or norepinephrine, it inhibits the secretion of insulin. * This is achieved by blocking the activity of the insulin receptor, which is a protein that is responsible for the uptake of insulin into cells. * ADRA2A also plays a role in the regulation of inflammation. When ADRA2A is stimulated, it can inhibit the production of inflammatory cytokines, which can help to promote inflammation. **Clinical significance:** Mutations in the ADRA2A gene have been linked to a number of human diseases, including diabetes, heart disease, and stroke. In these diseases, ADRA2A is often overexpressed or mutated, which can lead to the development of abnormal insulin secretion or inflammation. **Additional information:** * The ADRA2A gene is located on chromosome 15q21.1. * It is a relatively large gene, with a length of approximately 3300 base pairs. * There are three isoforms of ADRA2A, which are caused by alternative splicing. * ADRA2A is a promising target for the treatment of diabetes and other diseases that are characterized by abnormal insulin secretion or inflammation.

Genular Protein ID: 1283291309

Symbol: ADA2A_HUMAN

Name: Alpha-2 adrenergic receptor subtype C10

UniProtKB Accession Codes:

P08913 B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 13 EMDB 7 Ensembl 1 EvolutionaryTrace 1 GO 63 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 13 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2568356

Title: Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation.

PubMed ID: 2568356

DOI: 10.1016/s0021-9258(18)80130-2

PubMed ID: 2170371

Title: Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.

PubMed ID: 2170371

DOI: 10.1016/s0021-9258(17)44904-0

PubMed ID: 16567612

Title: Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression.

PubMed ID: 16567612

DOI: 10.1073/pnas.0601345103

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2823383

Title: Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.

PubMed ID: 2823383

DOI: 10.1126/science.2823383

PubMed ID: 10948191

Title: An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling.

PubMed ID: 10948191

DOI: 10.1074/jbc.m004550200

PubMed ID: 1849485

Title: Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.

PubMed ID: 1849485

DOI: 10.1016/0014-5793(91)80301-i

PubMed ID: 1678390

Title: A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists.

PubMed ID: 1678390

DOI: 10.1016/s0021-9258(18)98642-4

PubMed ID: 1678850

Title: Site-directed mutagenesis of alpha 2a-adrenergic receptors: Identification of amino acids involved in ligand binding and receptor activation by agonists.

PubMed ID: 1678850

PubMed ID: 23105096

Title: Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi.

PubMed ID: 23105096

DOI: 10.1074/jbc.m112.410936

PubMed ID: 11888275

Title: NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.

PubMed ID: 11888275

DOI: 10.1021/bi015811+

Sequence Information:

  • Length: 465
  • Mass: 50647
  • Checksum: 585E576149BDB696
  • Sequence:
    • MFRQEQPLAE GSFAPMGSLQ PDAGNASWNG TEAPGGGARA TPYSLQVTLT LVCLAGLLML 
LTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL VIPFSLANEV MGYWYFGKAW 
CEIYLALDVL FCTSSIVHLC AISLDRYWSI TQAIEYNLKR TPRRIKAIII TVWVISAVIS 
FPPLISIEKK GGGGGPQPAE PRCEINDQKW YVISSCIGSF FAPCLIMILV YVRIYQIAKR 
RTRVPPSRRG PDAVAAPPGG TERRPNGLGP ERSAGPGGAE AEPLPTQLNG APGEPAPAGP 
RDTDALDLEE SSSSDHAERP PGPRRPERGP RGKGKARASQ VKPGDSLPRR GPGATGIGTP 
AAGPGEERVG AAKASRWRGR QNREKRFTFV LAVVIGVFVV CWFPFFFTYT LTAVGCSVPR 
TLFKFFFWFG YCNSSLNPVI YTIFNHDFRR AFKKILCRGD RKRIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.