Details for: H2 Q10

Gene ID: 15007

Symbol: H2 Q10

Ensembl ID: ENSMUSG00000067235

Description: histocompatibility 2, Q region locus 10

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Antigen presentation: folding, assembly and peptide loading of class i mhc
    (R-MMU-983170)
  • Antigen processing-cross presentation
    (R-MMU-1236975)
  • Class i mhc mediated antigen processing & presentation
    (R-MMU-983169)
  • Dap12 interactions
    (R-MMU-2172127)
  • Endosomal/vacuolar pathway
    (R-MMU-1236977)
  • Er-phagosome pathway
    (R-MMU-1236974)
  • Immune system
    (R-MMU-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-MMU-198933)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • 14-3-3 protein binding
    (GO:0071889)
  • Adaptive immune response
    (GO:0002250)
  • Antibacterial humoral response
    (GO:0019731)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i
    (GO:0019885)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-dependent
    (GO:0002485)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class i
    (GO:0042590)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Antigen processing and presentation of peptide antigen via mhc class i
    (GO:0002474)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Cd8 receptor binding
    (GO:0042610)
  • Cd8-positive, alpha-beta t cell activation
    (GO:0036037)
  • Cell surface
    (GO:0009986)
  • Cis-golgi network membrane
    (GO:0033106)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Detection of bacterium
    (GO:0016045)
  • Early endosome
    (GO:0005769)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum exit site
    (GO:0070971)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Golgi medial cisterna
    (GO:0005797)
  • Golgi membrane
    (GO:0000139)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Immune system process
    (GO:0002376)
  • Lumenal side of endoplasmic reticulum membrane
    (GO:0098553)
  • Lysosomal membrane
    (GO:0005765)
  • Membrane
    (GO:0016020)
  • Mhc class ib protein complex
    (GO:0032398)
  • Mhc class i peptide loading complex
    (GO:0042824)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i protein complex
    (GO:0042612)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Peptide antigen assembly with mhc class i protein complex
    (GO:0002502)
  • Peptide antigen binding
    (GO:0042605)
  • Peptide binding
    (GO:0042277)
  • Phagocytic vesicle membrane
    (GO:0030670)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antibody-dependent cellular cytotoxicity
    (GO:0001815)
  • Positive regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001187)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of memory t cell activation
    (GO:2000568)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immunity
    (GO:0002717)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of t cell cytokine production
    (GO:0002726)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of trail production
    (GO:0032759)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protection from natural killer cell mediated cytotoxicity
    (GO:0042270)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein-folding chaperone binding
    (GO:0051087)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of natural killer cell mediated immunity
    (GO:0002715)
  • Signaling receptor binding
    (GO:0005102)
  • Tap1 binding
    (GO:0046978)
  • Tap2 binding
    (GO:0046979)
  • Tap binding
    (GO:0046977)
  • Tap complex binding
    (GO:0062061)
  • T cell mediated cytotoxicity
    (GO:0001913)
  • T cell mediated cytotoxicity directed against tumor cell target
    (GO:0002419)
  • T cell receptor binding
    (GO:0042608)
  • T cell receptor signaling pathway
    (GO:0050852)

Other Information

Genular Protein ID: 1198713626

Symbol: HA10_MOUSE

Name: H-2 class I histocompatibility antigen, Q10 alpha chain

UniProtKB Accession Codes:

P01898 O19475 Q31214 Q95HC3

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 EPD 1 Ensembl 2 GO 60 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 9 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 3 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 6420070

Title: A nonpolymorphic class I gene in the murine major histocompatibility complex.

PubMed ID: 6420070

DOI: 10.1016/0092-8674(84)90082-5

PubMed ID: 2767053

Title: Organization and structure of the Qa genes of the major histocompatibility complex of the C3H mouse: implications for Qa function and class I evolution.

PubMed ID: 2767053

DOI: 10.1002/j.1460-2075.1989.tb03568.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3510743

Title: Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression.

PubMed ID: 3510743

DOI: 10.1016/0092-8674(86)90760-9

PubMed ID: 6411351

Title: Secretion of a transplantation-related antigen.

PubMed ID: 6411351

DOI: 10.1016/0092-8674(83)90149-6

PubMed ID: 2584927

Title: Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse.

PubMed ID: 2584927

DOI: 10.1084/jem.170.6.1837

PubMed ID: 17330941

Title: Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.

PubMed ID: 17330941

DOI: 10.1021/pr0604559

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 325
  • Mass: 37251
  • Checksum: 82B8B7B9140CD72A
  • Sequence:
    • MGAMAPRTLL LLLAAALAPT QTQAGSHSMR YFETSVSRPG LGEPRFIIVG YVDDTQFVRF 
DSDAETPRME PRAPWMEQEG PEYWERETQR AKGNEQSFHV SLRTLLGYYN QSESGSHTIQ 
WMYGCKVGSD GRFLRGYLQY AYDGRDYIAL NEDLKTWTAA DVAAIITRRK WEQAGAAEYY 
RAYLEAECVE WLLRYLELGK ETLLRTDPPK THVTHHPGSE GDVTLRCWAL GFYPADITLT 
WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCHVYHEGL PEPLTLRWEP 
PPSTDSIMSH IADLLWPSLK LWWYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.