Details for: H2 Q2

Gene ID: 15013

Symbol: H2 Q2

Ensembl ID: ENSMUSG00000091705

Description: histocompatibility 2, Q region locus 2

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Antigen presentation: folding, assembly and peptide loading of class i mhc
    (R-MMU-983170)
  • Antigen processing-cross presentation
    (R-MMU-1236975)
  • Class i mhc mediated antigen processing & presentation
    (R-MMU-983169)
  • Dap12 interactions
    (R-MMU-2172127)
  • Endosomal/vacuolar pathway
    (R-MMU-1236977)
  • Er-phagosome pathway
    (R-MMU-1236974)
  • Immune system
    (R-MMU-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-MMU-198933)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • 14-3-3 protein binding
    (GO:0071889)
  • Adaptive immune response
    (GO:0002250)
  • Antibacterial humoral response
    (GO:0019731)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i
    (GO:0019885)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-dependent
    (GO:0002485)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class i
    (GO:0042590)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Cd8 receptor binding
    (GO:0042610)
  • Cd8-positive, alpha-beta t cell activation
    (GO:0036037)
  • Cell surface
    (GO:0009986)
  • Cis-golgi network membrane
    (GO:0033106)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Detection of bacterium
    (GO:0016045)
  • Early endosome
    (GO:0005769)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum exit site
    (GO:0070971)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Female pregnancy
    (GO:0007565)
  • Golgi apparatus
    (GO:0005794)
  • Golgi medial cisterna
    (GO:0005797)
  • Golgi membrane
    (GO:0000139)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Lysosomal membrane
    (GO:0005765)
  • Mhc class ib protein complex
    (GO:0032398)
  • Mhc class i peptide loading complex
    (GO:0042824)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i protein complex
    (GO:0042612)
  • Multicellular organism growth
    (GO:0035264)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Peptide antigen assembly with mhc class i protein complex
    (GO:0002502)
  • Peptide antigen binding
    (GO:0042605)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antibody-dependent cellular cytotoxicity
    (GO:0001815)
  • Positive regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001187)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of memory t cell activation
    (GO:2000568)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immunity
    (GO:0002717)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of t cell cytokine production
    (GO:0002726)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of trail production
    (GO:0032759)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protection from natural killer cell mediated cytotoxicity
    (GO:0042270)
  • Protein-folding chaperone binding
    (GO:0051087)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of natural killer cell mediated immunity
    (GO:0002715)
  • Signaling receptor binding
    (GO:0005102)
  • Tap1 binding
    (GO:0046978)
  • Tap2 binding
    (GO:0046979)
  • Tap binding
    (GO:0046977)
  • Tap complex binding
    (GO:0062061)
  • T cell mediated cytotoxicity
    (GO:0001913)
  • T cell mediated cytotoxicity directed against tumor cell target
    (GO:0002419)
  • T cell receptor binding
    (GO:0042608)
  • T cell receptor signaling pathway
    (GO:0050852)

Other Information

Genular Protein ID: 1161780236

Symbol: Q4KN81_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q4KN81

Database IDs:

AGR 1 ARBA 9 Bgee 1 BioGRID-ORCS 1 CDD 1 DNASU 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 60 Gene3D 2 GeneTree 1 HOGENOM 1 InterPro 10 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PaxDb 1 Pfam 3 PhosphoSitePlus 1 Proteomes 2 ProteomicsDB 2 Reactome 6 RefSeq 1 RuleBase 1 SAM 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16210630

Title: The murine family of gut-restricted class Ib MHC includes alternatively spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC".

PubMed ID: 16210630

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 360
  • Mass: 40431
  • Checksum: D6718F726872A49D
  • Sequence:
    • MALRRLLLLL VAALKLTETR AGSHSLRYFT TAVSRPGLGE PRFIIVGYVD DTQFVRFDSD 
AENPRMEPRA PWMEQEGPEY WERNTQVSKE NEQSFRVSLG TALSYYNQSK GGSHTLQWLV 
GCDLGPDGSL LRGYEQSAYD GRDYLALNED LITWTAADLA ALKTRSKLEQ AGLAEKRRAY 
LEVDCLTWLR RYLELGKETL LHTDPPKAHV THHPSSQGDV TLRCWALGFY PADITLTWQL 
NGEDLTQDME LVETRPSGDG TFQKWASVMV PFGEEPRYTC HVEHEGLPEP LTLRWEPPPS 
TDSYMVIIAV LVVLGAVIII GAVVAFVMKR GRNTGGKVRD YAQDPGRDSP QSSDISLLEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.