Details for: H2 Q7

Gene ID: 15018

Symbol: H2 Q7

Ensembl ID: ENSMUSG00000060550

Description: histocompatibility 2, Q region locus 7

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Antigen presentation: folding, assembly and peptide loading of class i mhc
    (R-MMU-983170)
  • Antigen processing-cross presentation
    (R-MMU-1236975)
  • Class i mhc mediated antigen processing & presentation
    (R-MMU-983169)
  • Dap12 interactions
    (R-MMU-2172127)
  • Endosomal/vacuolar pathway
    (R-MMU-1236977)
  • Er-phagosome pathway
    (R-MMU-1236974)
  • Immune system
    (R-MMU-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-MMU-198933)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • 14-3-3 protein binding
    (GO:0071889)
  • Adaptive immune response
    (GO:0002250)
  • Antibacterial humoral response
    (GO:0019731)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i
    (GO:0019885)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-dependent
    (GO:0002485)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class i
    (GO:0042590)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Antigen processing and presentation of peptide antigen via mhc class i
    (GO:0002474)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Cd8 receptor binding
    (GO:0042610)
  • Cd8-positive, alpha-beta t cell activation
    (GO:0036037)
  • Cell surface
    (GO:0009986)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Cis-golgi network membrane
    (GO:0033106)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Detection of bacterium
    (GO:0016045)
  • Early endosome
    (GO:0005769)
  • Early endosome membrane
    (GO:0031901)
  • Embryo implantation
    (GO:0007566)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum exit site
    (GO:0070971)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Golgi medial cisterna
    (GO:0005797)
  • Golgi membrane
    (GO:0000139)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Immune system process
    (GO:0002376)
  • Lumenal side of endoplasmic reticulum membrane
    (GO:0098553)
  • Lysosomal membrane
    (GO:0005765)
  • Membrane
    (GO:0016020)
  • Mhc class ib protein complex
    (GO:0032398)
  • Mhc class i peptide loading complex
    (GO:0042824)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i protein complex
    (GO:0042612)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Peptide antigen assembly with mhc class i protein complex
    (GO:0002502)
  • Peptide antigen binding
    (GO:0042605)
  • Phagocytic vesicle membrane
    (GO:0030670)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antibody-dependent cellular cytotoxicity
    (GO:0001815)
  • Positive regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001187)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of memory t cell activation
    (GO:2000568)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immunity
    (GO:0002717)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of t cell cytokine production
    (GO:0002726)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of trail production
    (GO:0032759)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protection from natural killer cell mediated cytotoxicity
    (GO:0042270)
  • Protein-folding chaperone binding
    (GO:0051087)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of natural killer cell mediated immunity
    (GO:0002715)
  • Signaling receptor binding
    (GO:0005102)
  • Tap1 binding
    (GO:0046978)
  • Tap2 binding
    (GO:0046979)
  • Tap binding
    (GO:0046977)
  • Tap complex binding
    (GO:0062061)
  • T cell mediated cytotoxicity
    (GO:0001913)
  • T cell mediated cytotoxicity directed against tumor cell target
    (GO:0002419)
  • T cell receptor binding
    (GO:0042608)
  • T cell receptor signaling pathway
    (GO:0050852)

Other Information

Genular Protein ID: 2464672941

Symbol: HA17_MOUSE

Name: H-2 class I histocompatibility antigen, Q7 alpha chain

UniProtKB Accession Codes:

P14429

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 60 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 9 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 3004940

Title: Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison.

PubMed ID: 3004940

DOI: 10.1002/j.1460-2075.1985.tb04066.x

PubMed ID: 3502706

Title: Tissue-specific expression of cell-surface Qa-2 antigen from a transfected Q7b gene of C57BL/10 mice.

PubMed ID: 3502706

DOI: 10.1084/jem.165.5.1358

PubMed ID: 6895187

Title: A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.

PubMed ID: 6895187

DOI: 10.1016/0092-8674(81)90175-6

PubMed ID: 2249652

Title: Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen.

PubMed ID: 2249652

DOI: 10.1002/j.1460-2075.1990.tb07602.x

PubMed ID: 2584927

Title: Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse.

PubMed ID: 2584927

DOI: 10.1084/jem.170.6.1837

Sequence Information:

  • Length: 334
  • Mass: 37924
  • Checksum: 1E63FAFCCBD6763B
  • Sequence:
    • MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD 
AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY 
GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY 
LEGTCMQSLR RYLQLGKETL LRTDPPKAHV THHPRSYGAV TLRCWALGFY PADITLTWQL 
NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVNHEGLPEP LTLRWGRWEP 
PPYTVSNMAT IAVVVDLGAV AIIGAVVAFV MNRR

Genular Protein ID: 1164226553

Symbol: E9PWT4_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9PWT4

Database IDs:

AGR 1 ARBA 9 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 HOGENOM 1 InterPro 9 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 310
  • Mass: 35182
  • Checksum: 8883CE305717824E
  • Sequence:
    • MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD 
AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY 
GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY 
LEGTCMQSLR RYLQLGKETL LRTDPPKAHV THHPRSYGAV TLRCWALGFY PADITLTWQL 
NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVNHEGLPEP LTLRWGRWGG 
QGGDCAPAPA

Genular Protein ID: 1889616022

Symbol: L7N260_MOUSE

Name: N/A

UniProtKB Accession Codes:

L7N260

Database IDs:

AGR 1 ARBA 7 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 4 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 215
  • Mass: 24376
  • Checksum: 6C3B1ED65C618965
  • Sequence:
    • MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD 
AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY 
GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY 
LEGTCMQSLR RYLQLGKETL LRTGGQGGDC APAPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.