Details for: CTPS1

Gene ID: 1503

Symbol: CTPS1

Ensembl ID: ENSG00000171793

Description: CTP synthase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 91.5489
    Cell Significance Index: -14.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.1883
    Cell Significance Index: -15.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 43.0880
    Cell Significance Index: -17.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.7162
    Cell Significance Index: -16.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0881
    Cell Significance Index: -17.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2527
    Cell Significance Index: -16.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5273
    Cell Significance Index: -17.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6953
    Cell Significance Index: -11.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8055
    Cell Significance Index: -6.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.3829
    Cell Significance Index: 40.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4388
    Cell Significance Index: 19.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1249
    Cell Significance Index: 214.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7721
    Cell Significance Index: 21.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7260
    Cell Significance Index: 20.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6492
    Cell Significance Index: 64.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6003
    Cell Significance Index: 17.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5685
    Cell Significance Index: 31.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5558
    Cell Significance Index: 110.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5285
    Cell Significance Index: 106.0200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5239
    Cell Significance Index: 8.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5116
    Cell Significance Index: 461.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4995
    Cell Significance Index: 5.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4582
    Cell Significance Index: 3.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4479
    Cell Significance Index: 28.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4479
    Cell Significance Index: 26.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3933
    Cell Significance Index: 272.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3644
    Cell Significance Index: 39.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3359
    Cell Significance Index: 54.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3228
    Cell Significance Index: 8.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2288
    Cell Significance Index: 5.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2203
    Cell Significance Index: 99.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2102
    Cell Significance Index: 75.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2066
    Cell Significance Index: 24.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2063
    Cell Significance Index: 37.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1776
    Cell Significance Index: 22.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1689
    Cell Significance Index: 11.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1663
    Cell Significance Index: 3.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1614
    Cell Significance Index: 19.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1612
    Cell Significance Index: 88.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1590
    Cell Significance Index: 5.5300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.1448
    Cell Significance Index: 3.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1447
    Cell Significance Index: 63.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1339
    Cell Significance Index: 2.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1325
    Cell Significance Index: 9.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1265
    Cell Significance Index: 5.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0774
    Cell Significance Index: 4.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0720
    Cell Significance Index: 9.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0687
    Cell Significance Index: 129.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0523
    Cell Significance Index: 2.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0519
    Cell Significance Index: 2.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0359
    Cell Significance Index: 1.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0359
    Cell Significance Index: 1.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0100
    Cell Significance Index: 6.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0035
    Cell Significance Index: -5.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -17.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0203
    Cell Significance Index: -0.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0209
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0310
    Cell Significance Index: -17.4600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0341
    Cell Significance Index: -21.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0424
    Cell Significance Index: -6.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0480
    Cell Significance Index: -6.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0481
    Cell Significance Index: -4.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0512
    Cell Significance Index: -14.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0531
    Cell Significance Index: -5.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0648
    Cell Significance Index: -1.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0720
    Cell Significance Index: -1.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0735
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0771
    Cell Significance Index: -13.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0781
    Cell Significance Index: -6.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0835
    Cell Significance Index: -9.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0864
    Cell Significance Index: -9.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1031
    Cell Significance Index: -21.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1064
    Cell Significance Index: -1.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1190
    Cell Significance Index: -3.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1208
    Cell Significance Index: -0.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1369
    Cell Significance Index: -8.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1444
    Cell Significance Index: -4.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1446
    Cell Significance Index: -7.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1539
    Cell Significance Index: -10.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1551
    Cell Significance Index: -3.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1798
    Cell Significance Index: -11.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1830
    Cell Significance Index: -5.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2057
    Cell Significance Index: -5.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2155
    Cell Significance Index: -17.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2286
    Cell Significance Index: -2.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2345
    Cell Significance Index: -14.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2428
    Cell Significance Index: -6.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2465
    Cell Significance Index: -12.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2598
    Cell Significance Index: -3.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2643
    Cell Significance Index: -5.6100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2844
    Cell Significance Index: -4.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3039
    Cell Significance Index: -7.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3567
    Cell Significance Index: -11.6800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3603
    Cell Significance Index: -5.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CTPS1 is a cytosolic enzyme that catalyzes the condensation of uridine monophosphate (UMP) and ATP to form CTP. This reaction is a crucial step in the de novo synthesis of CTP, which is essential for various cellular processes, including DNA synthesis, RNA processing, and energy metabolism. CTPS1 is highly expressed in cells that require rapid proliferation, such as immune cells, germ cells, and muscle cells. The enzyme is also found in various tissues, including the brain, heart, and kidneys. **Pathways and Functions:** CTPS1 plays a central role in several cellular pathways, including: 1. **De novo CTP biosynthetic process**: CTPS1 is the key enzyme responsible for the synthesis of CTP from UMP and ATP. This reaction is essential for DNA synthesis, RNA processing, and energy metabolism. 2. **Atp binding**: CTPS1 binds ATP, which is necessary for the catalytic activity of the enzyme. 3. **B cell proliferation**: CTPS1 is highly expressed in B cells, which require rapid proliferation to respond to antigens. 4. **T cell proliferation**: CTPS1 is also expressed in T cells, which require rapid proliferation to respond to antigens. 5. **Glutamine metabolic process**: CTPS1 is involved in the metabolism of glutamine, which is an important energy source for cells. **Clinical Significance:** Dysregulation of CTPS1 has been implicated in various diseases, including: 1. **Cancer**: CTPS1 overexpression has been observed in certain types of cancer, including lymphoma and leukemia. 2. **Immune disorders**: CTPS1 deficiency has been linked to immune disorders, such as immunodeficiency and autoimmune diseases. 3. **Neurological disorders**: CTPS1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders**: CTPS1 dysregulation has been linked to metabolic disorders, such as diabetes and obesity. In conclusion, CTPS1 is a critical enzyme that plays a vital role in cellular metabolism, immune function, and disease. Further research is needed to fully understand the mechanisms by which CTPS1 regulates cellular processes and to develop therapeutic strategies for diseases associated with CTPS1 dysregulation. **Significantly expressed cells:** - Ciliary muscle cell - Male germ cell - Primordial germ cell - Oogonial cell - Kidney proximal straight tubule epithelial cell - Cardiac muscle myoblast - Large pre-B-II cell - Centrilobular region hepatocyte - Cerebral cortex GABAergic interneuron - Forebrain radial glial cell **Proteins:** - PYRG1_HUMAN (CTP synthetase 1) - B4E1E0_HUMAN

Genular Protein ID: 3185243367

Symbol: PYRG1_HUMAN

Name: CTP synthetase 1

UniProtKB Accession Codes:

P17812 B4DR64 D3DPW1 Q5VW67 Q96GK6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 6 EMDB 6 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2113467

Title: Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes.

PubMed ID: 2113467

DOI: 10.1002/j.1460-2075.1990.tb07377.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16179339

Title: Expression of human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.

PubMed ID: 16179339

DOI: 10.1074/jbc.m509622200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24870241

Title: CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation.

PubMed ID: 24870241

DOI: 10.1038/nature13386

PubMed ID: 25223282

Title: Ack kinase regulates CTP synthase filaments during Drosophila oogenesis.

PubMed ID: 25223282

DOI: 10.15252/embr.201438688

PubMed ID: 16820675

Title: Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.

PubMed ID: 16820675

DOI: 10.1107/s1744309106018136

Sequence Information:

  • Length: 591
  • Mass: 66690
  • Checksum: 0B04F9D9390C4152
  • Sequence:
    • MKYILVTGGV ISGIGKGIIA SSVGTILKSC GLHVTSIKID PYINIDAGTF SPYEHGEVFV 
LDDGGEVDLD LGNYERFLDI RLTKDNNLTT GKIYQYVINK ERKGDYLGKT VQVVPHITDA 
IQEWVMRQAL IPVDEDGLEP QVCVIELGGT VGDIESMPFI EAFRQFQFKV KRENFCNIHV 
SLVPQPSSTG EQKTKPTQNS VRELRGLGLS PDLVVCRCSN PLDTSVKEKI SMFCHVEPEQ 
VICVHDVSSI YRVPLLLEEQ GVVDYFLRRL DLPIERQPRK MLMKWKEMAD RYDRLLETCS 
IALVGKYTKF SDSYASVIKA LEHSALAINH KLEIKYIDSA DLEPITSQEE PVRYHEAWQK 
LCSAHGVLVP GGFGVRGTEG KIQAIAWARN QKKPFLGVCL GMQLAVVEFS RNVLGWQDAN 
STEFDPTTSH PVVVDMPEHN PGQMGGTMRL GKRRTLFQTK NSVMRKLYGD ADYLEERHRH 
RFEVNPVWKK CLEEQGLKFV GQDVEGERME IVELEDHPFF VGVQYHPEFL SRPIKPSPPY 
FGLLLASVGR LSHYLQKGCR LSPRDTYSDR SGSSSPDSEI TELKFPSINH D

Genular Protein ID: 1098899016

Symbol: B4E1E0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E1E0

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SUPFAM 2 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 435
  • Mass: 49695
  • Checksum: 6FF471FBC7746644
  • Sequence:
    • MPFIEAFRQF QFKVKRENFC NIHVSLVPQP SSTGEQKTKP TQNSVRELRG LGLSPDLVVC 
RCSNPLDTSV KEKISMFCHV EPEQVICVHD VSSIYRVPLL LEEQGVVDYF LRRLDLPIER 
QPRKMLMKWK EMADRYDRLL ETCSIALVGK YTKFSDSYAS VIKALEHSAL AINHKLEIKY 
IDSADLEPIT SQEEPVRYHE AWQKLCSAHG VLVPGGFGVR GTEGKIQAIA WARNQKKPFL 
GVCLGMQLAV VEFSRNVLGW QDANSTEFDP TTSHPVVVDM PEHNPGQMGG TMRLGKRRTL 
FQTKNSVMRK LYGDADYLEE RHRHRFEVNP VWKKCLEEQG LKFVGQDVEG ERMEIVELED 
HPFFVGVQYH PEFLSRPIKP SPPYFGLLLA SVGRLSHYLQ KGCRLSPRDT YSDRSGSSSP 
DSEITELKFP SINHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.