Details for: H2 T22

Gene ID: 15039

Symbol: H2 T22

Ensembl ID: ENSMUSG00000056116

Description: histocompatibility 2, T region locus 22

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Antigen presentation: folding, assembly and peptide loading of class i mhc
    (R-MMU-983170)
  • Antigen processing-cross presentation
    (R-MMU-1236975)
  • Class i mhc mediated antigen processing & presentation
    (R-MMU-983169)
  • Dap12 interactions
    (R-MMU-2172127)
  • Endosomal/vacuolar pathway
    (R-MMU-1236977)
  • Er-phagosome pathway
    (R-MMU-1236974)
  • Immune system
    (R-MMU-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-MMU-198933)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • 14-3-3 protein binding
    (GO:0071889)
  • Adaptive immune response
    (GO:0002250)
  • Antibacterial humoral response
    (GO:0019731)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Cd8 receptor binding
    (GO:0042610)
  • Cd8-positive, alpha-beta t cell activation
    (GO:0036037)
  • Cell surface
    (GO:0009986)
  • Cis-golgi network membrane
    (GO:0033106)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Early endosome
    (GO:0005769)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Golgi membrane
    (GO:0000139)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Lysosomal membrane
    (GO:0005765)
  • Mhc class ib protein complex
    (GO:0032398)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i protein complex
    (GO:0042612)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Peptide antigen binding
    (GO:0042605)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antibody-dependent cellular cytotoxicity
    (GO:0001815)
  • Positive regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001187)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immunity
    (GO:0002717)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of trail production
    (GO:0032759)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protection from natural killer cell mediated cytotoxicity
    (GO:0042270)
  • Protein-folding chaperone binding
    (GO:0051087)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of natural killer cell mediated immunity
    (GO:0002715)
  • Signaling receptor binding
    (GO:0005102)
  • Tap1 binding
    (GO:0046978)
  • Tap2 binding
    (GO:0046979)
  • T cell receptor binding
    (GO:0042608)

Other Information

Genular Protein ID: 2788032797

Symbol: Q31615_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q31615

Database IDs:

AGR 1 ARBA 5 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 51 Gene3D 2 GeneTree 1 InterPro 9 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 1 PROSITE 3 PaxDb 1 Pfam 2 PhosphoSitePlus 1 Proteomes 2 ProteomicsDB 2 Reactome 6 RefSeq 2 RuleBase 1 SAM 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 2379238

Title: Recognition of the product of a novel MHC TL region gene (27-b) by a mouse gamma-delta T cell receptor.

PubMed ID: 2379238

DOI: 10.1016/0092-8674(90)90019-B

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 10634787

Title: Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold.

PubMed ID: 10634787

DOI: 10.1126/science.287.5451.310

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 379
  • Mass: 43256
  • Checksum: 158F75832CED91DA
  • Sequence:
    • MSWVLRAAVV CALLLQLDAR PSWTRIPLGS HSLRYFYTAV SRPGLGEPWF IIVGYVDDMQ 
VLRFSSKEET PRMAPWLEQE EADNWEQQTR IVTIQGQLSE RNLMTLVHFY NKSMDDSHTL 
QWLQGCDVEP DRHLCLWYNQ LAYDSEDLPT LNENPSSCTV GNSTVPHISQ DLKSHCSDLL 
QKYLEKGKER LLRSDPPKAH VTRHPRPEGD VTLRCWALGF YPADITLTWQ LNGEELTQDM 
ELVETRPAGD GTFQKWAAVV VPLGKEQSYT CHVYHEGLPE PLILRWEPAW YQKPWIWIVA 
MVFILFIICL CVVCICMKKN AGGRGRRDTQ EAGRDSPQDS SKTVVDDEEM GVCFWKIKSC 
KTCLGHSPGT SVGESLLSP

Genular Protein ID: 1515749144

Symbol: Q9BCZ1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9BCZ1

Database IDs:

AGR 1 ARBA 5 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 51 Gene3D 2 GeneTree 1 HOGENOM 1 IntAct 1 InterPro 9 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PROSITE 3 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 2 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15821084

Title: Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.

PubMed ID: 15821084

DOI: 10.1126/science.1106885

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 344
  • Mass: 39100
  • Checksum: A8FE34EE998E614C
  • Sequence:
    • MSWVLRAAVV CALLLQLDAR PSWTRIPLGS HSLRYFYTAV SRPGLGEPWF IIVGYVDDMQ 
VLRFSSKEET PRMAPWLEQE EADNWEQQTR IVTIQGQLSE RNLMTLVHFY NKSMDDSHTL 
QWLQGCDVEP DRHLCLWYNQ LAYDSEDLPT LNENPSSCTV GNSTVPHISQ DLKSHCSDLL 
QKYLEKGKER LLRSDPPKAH VTRHPRPEGD VTLRCWALGF YPADITLTWQ LNGEELTQDM 
ELVETRPAGD GTFQKWAAVV VPLGKEQSYT CHVYHEGLPE PLILRWGGRG RRDTQEAGRD 
SPQDSSKTVV DDEEMGVCFW KIKSCKTCLG HSPGTSVGES LLSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.