Details for: CTRB1

Gene ID: 1504

Symbol: CTRB1

Ensembl ID: ENSG00000168925

Description: chymotrypsinogen B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 7.91
    Marker Score: 5581
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 4.78
    Marker Score: 2692
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.57
    Marker Score: 5429
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.24
    Marker Score: 2259
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.16
    Marker Score: 2243
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.06
    Marker Score: 463
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.73
    Marker Score: 1094
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.12
    Marker Score: 1256
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6470
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2447
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 806
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 473
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1077
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 491
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.61
    Marker Score: 264.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.46
    Marker Score: 452
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.36
    Marker Score: 745
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.32
    Marker Score: 127
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.3
    Marker Score: 338
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.3
    Marker Score: 282
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.29
    Marker Score: 506
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2
    Marker Score: 238
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.17
    Marker Score: 194
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.15
    Marker Score: 79
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.13
    Marker Score: 205
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 110
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.12
    Marker Score: 2063
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 26.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 29.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.09
    Marker Score: 26.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 189
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 18.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.07
    Marker Score: 26.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 26.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.06
    Marker Score: 24.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.06
    Marker Score: 810
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.06
    Marker Score: 25.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 24.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 15.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.05
    Marker Score: 23.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.05
    Marker Score: 26.5
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.05
    Marker Score: 118
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 26.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 18.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 24.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.04
    Marker Score: 23.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 24.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.04
    Marker Score: 24.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 62
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 28

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Other Information

## Summary The CTRB1 gene encodes an extracellular matrix metallopeptidase (ECM-metallopeptidase 1). This enzyme is expressed in various cell types, including acinar cells, epithelial cells of the exocrine pancreas, pancreatic acinar cells, blood vessel endothelial cells, pancreatic ductal cells, PP cell, pancreatic stellate cells, plasma cells, and cerebral cortex GABAergic interneurons. ## Key characteristics * The protein is a transmembrane protein with a molecular weight of approximately 55 kDa. * It is a secreted protein that is processed from a larger precursor protein by proteolytic cleavage. * It is a member of the ADAM (a disintegrin and metallopeptidase) family of ECM-metallopeptidases. * It has been shown to be involved in the regulation of epithelial cell migration and invasion. ## Pathways and functions * The CTRB1 gene is involved in the activation of matrix metalloproteinases, which are enzymes that break down the extracellular matrix (ECM). * Matrix metalloproteinases are involved in a variety of cellular processes, including cell migration, invasion, and angiogenesis. * CTRB1 is also involved in the transport and metabolism of cobalamin (vitamin B12). * It is a key regulator of the expression of other ECM-metallopeptidases, including MMP-2, MMP-9, and ADAM. ## Clinical significance * Mutations in the CTRB1 gene have been linked to several human diseases, including pancreatitis, colon cancer, and Alzheimer's disease. * These mutations can lead to the accumulation of abnormal ECM proteins in the colon, which can promote the development of cancer. * Targeting CTRB1 has been explored as a therapeutic strategy for these diseases.

Genular Protein ID: 611622343

Symbol: CTRB1_HUMAN

Name: Chymotrypsinogen B

UniProtKB Accession Codes:

P17538

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 16 DrugCentral 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2917002

Title: Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.

PubMed ID: 2917002

DOI: 10.1016/s0006-291x(89)80087-7

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 263
  • Mass: 27713
  • Checksum: EDA816A133D42DE7
  • Sequence:
    • MASLWLLSCF SLVGAAFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS LQDKTGFHFC 
GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV LKIAKVFKNP KFSILTVNND 
ITLLKLATPA RFSQTVSAVC LPSADDDFPA GTLCATTGWG KTKYNANKTP DKLQQAALPL 
LSNAECKKSW GRRITDVMIC AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSDTCST 
SSPGVYARVT KLIPWVQKIL AAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.