Details for: CTRB1

Gene ID: 1504

Symbol: CTRB1

Ensembl ID: ENSG00000168925

Description: chymotrypsinogen B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 262.6582
    Cell Significance Index: 131.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 18.2457
    Cell Significance Index: 3115.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 14.9440
    Cell Significance Index: 1705.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.5426
    Cell Significance Index: 30.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3586
    Cell Significance Index: 32.9100
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.1706
    Cell Significance Index: 11.9000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.5079
    Cell Significance Index: 6.3800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4007
    Cell Significance Index: 5.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3725
    Cell Significance Index: 9.9800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2202
    Cell Significance Index: 4.4800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1881
    Cell Significance Index: 2.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1836
    Cell Significance Index: 2.6300
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.1004
    Cell Significance Index: 0.9200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0960
    Cell Significance Index: 1.1600
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.0842
    Cell Significance Index: 0.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0396
    Cell Significance Index: 4.5400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0283
    Cell Significance Index: 0.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0276
    Cell Significance Index: 0.6900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0267
    Cell Significance Index: 0.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0206
    Cell Significance Index: 0.6500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.0198
    Cell Significance Index: 0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0149
    Cell Significance Index: 8.4100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.0135
    Cell Significance Index: 0.1700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.0111
    Cell Significance Index: 0.1200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0111
    Cell Significance Index: 0.0800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0022
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0018
    Cell Significance Index: 0.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0016
    Cell Significance Index: 0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0016
    Cell Significance Index: 0.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0014
    Cell Significance Index: 0.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0011
    Cell Significance Index: 0.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0010
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0006
    Cell Significance Index: 0.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0005
    Cell Significance Index: 0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0005
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0011
    Cell Significance Index: -0.6100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0016
    Cell Significance Index: -0.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0020
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0042
    Cell Significance Index: -0.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0046
    Cell Significance Index: -0.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0057
    Cell Significance Index: -0.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0073
    Cell Significance Index: -0.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0077
    Cell Significance Index: -0.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0087
    Cell Significance Index: -0.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0098
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0099
    Cell Significance Index: -0.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0101
    Cell Significance Index: -0.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0107
    Cell Significance Index: -0.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0109
    Cell Significance Index: -0.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0110
    Cell Significance Index: -0.3500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0121
    Cell Significance Index: -0.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0121
    Cell Significance Index: -0.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0124
    Cell Significance Index: -0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0124
    Cell Significance Index: -0.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0125
    Cell Significance Index: -0.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0129
    Cell Significance Index: -0.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0129
    Cell Significance Index: -0.1900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0136
    Cell Significance Index: -0.2200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0137
    Cell Significance Index: -0.1800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0138
    Cell Significance Index: -0.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0145
    Cell Significance Index: -0.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0148
    Cell Significance Index: -0.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0151
    Cell Significance Index: -0.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0153
    Cell Significance Index: -0.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0166
    Cell Significance Index: -0.2800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0169
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0182
    Cell Significance Index: -0.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0183
    Cell Significance Index: -0.3800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0188
    Cell Significance Index: -0.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0189
    Cell Significance Index: -0.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0190
    Cell Significance Index: -0.5000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0194
    Cell Significance Index: -0.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0202
    Cell Significance Index: -0.4000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0203
    Cell Significance Index: -0.3000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0208
    Cell Significance Index: -0.1900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0211
    Cell Significance Index: -0.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0215
    Cell Significance Index: -0.3600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0222
    Cell Significance Index: -0.2800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0222
    Cell Significance Index: -0.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0223
    Cell Significance Index: -0.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0224
    Cell Significance Index: -0.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0231
    Cell Significance Index: -0.4000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0236
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proteolytic activity**: Chymotrypsinogen B1 is a serine-type endopeptidase that cleaves peptide bonds, playing a critical role in protein digestion in the pancreas. 2. **Precursor enzyme**: CTRB1 is synthesized as a precursor enzyme, which is then activated by trypsinogen to become the active enzyme, chymotrypsinogen B1. 3. **Tissue expression**: The CTRB1 gene is expressed in various tissues, including the pancreas, brain, and blood vessels. 4. **Regulation**: The gene is regulated by multiple factors, including transcriptional and post-transcriptional regulators, to ensure proper expression and function. **Pathways and Functions:** 1. **Activation of matrix metalloproteinases**: Chymotrypsinogen B1 activates matrix metalloproteinases (MMPs), which are involved in the degradation of the extracellular matrix and tissue remodeling. 2. **Cobalamin (cbl, vitamin B12) transport and metabolism**: The CTRB1 gene is involved in the uptake of dietary cobalamins into enterocytes, which is essential for vitamin B12 metabolism. 3. **Degradation of the extracellular matrix**: Chymotrypsinogen B1 cleaves collagen and other extracellular matrix proteins, contributing to tissue remodeling and repair. 4. **Digestion**: The enzyme plays a critical role in protein digestion in the pancreas, breaking down proteins into smaller peptides and amino acids. 5. **Extracellular matrix organization**: CTRB1 regulates the organization and remodeling of the extracellular matrix, which is essential for tissue development and maintenance. **Clinical Significance:** 1. **Pancreatic disorders**: Dysregulation of the CTRB1 gene has been implicated in various pancreatic disorders, including pancreatitis, pancreatic cancer, and diabetes. 2. **Neurological conditions**: Abnormalities in the CTRB1 gene have been linked to neurological conditions, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cobalamin deficiency**: Impaired cobalamin uptake and metabolism due to CTRB1 dysfunction can lead to vitamin B12 deficiency, which is essential for DNA synthesis and cell division. 4. **Cancer**: The CTRB1 gene is overexpressed in various cancers, including pancreatic cancer, and its dysregulation contributes to tumor progression and metastasis. In conclusion, the CTRB1 gene plays a critical role in pancreatic digestion, tissue remodeling, and vitamin B12 metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the function and regulation of this gene in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 611622343

Symbol: CTRB1_HUMAN

Name: Chymotrypsinogen B

UniProtKB Accession Codes:

P17538

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 16 DrugCentral 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2917002

Title: Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.

PubMed ID: 2917002

DOI: 10.1016/s0006-291x(89)80087-7

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 263
  • Mass: 27713
  • Checksum: EDA816A133D42DE7
  • Sequence:
    • MASLWLLSCF SLVGAAFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS LQDKTGFHFC 
GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV LKIAKVFKNP KFSILTVNND 
ITLLKLATPA RFSQTVSAVC LPSADDDFPA GTLCATTGWG KTKYNANKTP DKLQQAALPL 
LSNAECKKSW GRRITDVMIC AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSDTCST 
SSPGVYARVT KLIPWVQKIL AAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.