Details for: CTRL

Gene ID: 1506

Symbol: CTRL

Ensembl ID: ENSG00000141086

Description: chymotrypsin like

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.45
    Marker Score: 5180
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.45
    Marker Score: 2741
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4823
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48061
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14683
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.76
    Marker Score: 314
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.75
    Marker Score: 1877.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.71
    Marker Score: 327.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1368
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 376
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.61
    Marker Score: 1261
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.57
    Marker Score: 439
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 250
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.47
    Marker Score: 491
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 189
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.45
    Marker Score: 480
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.4
    Marker Score: 284
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 232
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 139
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.29
    Marker Score: 280
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.26
    Marker Score: 102
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.25
    Marker Score: 134
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 68
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.19
    Marker Score: 538
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.19
    Marker Score: 331
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 184
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.19
    Marker Score: 436
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 94
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.16
    Marker Score: 110
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 38.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 369
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.13
    Marker Score: 30
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.13
    Marker Score: 537
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.13
    Marker Score: 4702
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.12
    Marker Score: 174
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.1
    Marker Score: 128
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.09
    Marker Score: 135
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.09
    Marker Score: 137
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.09
    Marker Score: 302
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 75
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.08
    Marker Score: 3164
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.08
    Marker Score: 830
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.08
    Marker Score: 129
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.07
    Marker Score: 281
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 56
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.07
    Marker Score: 1392
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.07
    Marker Score: 43.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.07
    Marker Score: 619
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.06
    Marker Score: 1345
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.06
    Marker Score: 508
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.06
    Marker Score: 381
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.06
    Marker Score: 445
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.06
    Marker Score: 84
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.06
    Marker Score: 238
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 230
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.05
    Marker Score: 3286
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 27

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Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in pancreatic acinar cells, colon goblet cells, and cardiac endothelial cells. * It is also expressed in low levels in intestinal crypt stem cells, enterocytes, and cerebral cortex GABAergic interneurons. **Pathways and functions:** * The protein is a serine-type endopeptidase that is involved in the regulation of extracellular matrix remodeling. * It is a key regulator of the migration of epithelial cells and is involved in the formation of the intestinal epithelial barrier. * It is also involved in the regulation of cell migration and inflammation. **Clinical significance:** * Mutations in the gene encoding the protein have been linked to a number of human diseases, including cancer and heart disease. * As a result, the protein is a potential target for the treatment of these diseases. **Additional notes:** * The gene is also known as CHI3. * It is a member of the CHI3 family of serine proteases. * It is a highly conserved protein that is found in organisms from yeast to humans.

Genular Protein ID: 1329677692

Symbol: CTRL_HUMAN

Name: Chymotrypsin-like protease CTRL-1

UniProtKB Accession Codes:

P40313

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8268911

Title: A tight cluster of five unrelated human genes on chromosome 16q22.1.

PubMed ID: 8268911

DOI: 10.1093/hmg/2.10.1589

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 264
  • Mass: 28002
  • Checksum: 3F629F02FA6DDFB4
  • Sequence:
    • MLLLSLTLSL VLLGSSWGCG IPAIKPALSF SQRIVNGENA VLGSWPWQVS LQDSSGFHFC 
GGSLISQSWV VTAAHCNVSP GRHFVVLGEY DRSSNAEPLQ VLSVSRAITH PSWNSTTMNN 
DVTLLKLASP AQYTTRISPV CLASSNEALT EGLTCVTTGW GRLSGVGNVT PAHLQQVALP 
LVTVNQCRQY WGSSITDSMI CAGGAGASSC QGDSGGPLVC QKGNTWVLIG IVSWGTKNCN 
VRAPAVYTRV SKFSTWINQV IAYN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.