Details for: CTRL

Gene ID: 1506

Symbol: CTRL

Ensembl ID: ENSG00000141086

Description: chymotrypsin like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 9.5792
    Cell Significance Index: -1.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.8744
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.3435
    Cell Significance Index: 741.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7778
    Cell Significance Index: 56.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3521
    Cell Significance Index: 82.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.2085
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4290
    Cell Significance Index: 48.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4079
    Cell Significance Index: 77.6400
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.3788
    Cell Significance Index: 1.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3493
    Cell Significance Index: 9.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2936
    Cell Significance Index: 4.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2775
    Cell Significance Index: 5.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2231
    Cell Significance Index: 22.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1996
    Cell Significance Index: 180.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1779
    Cell Significance Index: 10.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1613
    Cell Significance Index: 17.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1301
    Cell Significance Index: 21.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0889
    Cell Significance Index: 6.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0783
    Cell Significance Index: 48.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0539
    Cell Significance Index: 1.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0478
    Cell Significance Index: 33.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0352
    Cell Significance Index: 7.0700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0337
    Cell Significance Index: 0.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0267
    Cell Significance Index: 0.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0255
    Cell Significance Index: 9.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0190
    Cell Significance Index: 1.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0173
    Cell Significance Index: 0.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0148
    Cell Significance Index: 2.6600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0136
    Cell Significance Index: 0.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0131
    Cell Significance Index: 0.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0130
    Cell Significance Index: 1.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0126
    Cell Significance Index: 1.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0111
    Cell Significance Index: 0.4200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0075
    Cell Significance Index: 0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0073
    Cell Significance Index: 0.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0071
    Cell Significance Index: 0.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0046
    Cell Significance Index: 0.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0031
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0024
    Cell Significance Index: 1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0002
    Cell Significance Index: 0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0014
    Cell Significance Index: -0.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0016
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0017
    Cell Significance Index: -0.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0017
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0038
    Cell Significance Index: -0.5200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0047
    Cell Significance Index: -0.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0050
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0051
    Cell Significance Index: -0.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0083
    Cell Significance Index: -0.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0093
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0117
    Cell Significance Index: -1.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0119
    Cell Significance Index: -1.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0128
    Cell Significance Index: -1.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0134
    Cell Significance Index: -0.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0138
    Cell Significance Index: -1.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0139
    Cell Significance Index: -0.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0141
    Cell Significance Index: -0.3000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0150
    Cell Significance Index: -0.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0169
    Cell Significance Index: -1.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0183
    Cell Significance Index: -0.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0201
    Cell Significance Index: -0.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0206
    Cell Significance Index: -1.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0214
    Cell Significance Index: -1.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0224
    Cell Significance Index: -1.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0226
    Cell Significance Index: -0.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0231
    Cell Significance Index: -1.2000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0231
    Cell Significance Index: -0.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0245
    Cell Significance Index: -1.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0247
    Cell Significance Index: -0.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0252
    Cell Significance Index: -1.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0264
    Cell Significance Index: -0.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0268
    Cell Significance Index: -0.9400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0268
    Cell Significance Index: -0.4500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0271
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0279
    Cell Significance Index: -0.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0284
    Cell Significance Index: -0.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0297
    Cell Significance Index: -0.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0298
    Cell Significance Index: -0.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0310
    Cell Significance Index: -0.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0321
    Cell Significance Index: -0.9200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0328
    Cell Significance Index: -0.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0336
    Cell Significance Index: -0.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0361
    Cell Significance Index: -0.9000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0374
    Cell Significance Index: -0.7600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0385
    Cell Significance Index: -0.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CTRL gene encodes a chymotrypsin-like protease, which is a type of serine peptidase that catalyzes the hydrolysis of peptide bonds in proteins. This enzyme is characterized by its high specificity for certain substrates, including proteins, peptides, and peptides with specific amino acid sequences. The CTRL gene is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** CTRL is involved in several key biological pathways, including: 1. **Proteolysis**: CTRL regulates the degradation of proteins, which is essential for cellular signaling, cell growth, and differentiation. 2. **Protein Catabolic Process**: CTRL is involved in the breakdown of proteins, which is crucial for maintaining protein homeostasis and preventing protein aggregation. 3. **Extracellular Space**: CTRL plays a role in maintaining the integrity of the extracellular matrix, which is essential for tissue architecture and function. 4. **Protein Binding**: CTRL interacts with various proteins, including receptors, transcription factors, and signaling molecules, to regulate cellular responses. **Clinical Significance:** The CTRL gene has been implicated in various clinical conditions, including: 1. **Inflammatory Diseases**: CTRL has been shown to play a role in the regulation of inflammatory responses, and its dysregulation has been linked to inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 2. **Cancer**: CTRL has been implicated in the regulation of cell growth, differentiation, and survival, and its dysregulation has been linked to various types of cancer, including breast, lung, and colon cancer. 3. **Neurological Disorders**: CTRL has been shown to play a role in the regulation of neuronal signaling and synaptic plasticity, and its dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the CTRL gene is a complex serine peptidase that plays a crucial role in various physiological processes, including proteolysis, protein catabolism, and cellular signaling. Its dysregulation has been linked to various clinical conditions, including inflammatory diseases, cancer, and neurological disorders. Further research is needed to fully understand the mechanisms by which CTRL regulates cellular homeostasis and to develop targeted therapies for the treatment of these conditions. **References:** [Insert references to relevant studies and publications] **Note:** As an expert immunologist, I would like to emphasize the importance of understanding the complex interactions between CTRL and other genes, proteins, and signaling pathways in regulating cellular homeostasis. Further research is needed to elucidate the mechanisms by which CTRL regulates cellular responses and to develop effective therapeutic strategies for the treatment of related diseases.

Genular Protein ID: 1329677692

Symbol: CTRL_HUMAN

Name: Chymotrypsin-like protease CTRL-1

UniProtKB Accession Codes:

P40313

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8268911

Title: A tight cluster of five unrelated human genes on chromosome 16q22.1.

PubMed ID: 8268911

DOI: 10.1093/hmg/2.10.1589

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 264
  • Mass: 28002
  • Checksum: 3F629F02FA6DDFB4
  • Sequence:
    • MLLLSLTLSL VLLGSSWGCG IPAIKPALSF SQRIVNGENA VLGSWPWQVS LQDSSGFHFC 
GGSLISQSWV VTAAHCNVSP GRHFVVLGEY DRSSNAEPLQ VLSVSRAITH PSWNSTTMNN 
DVTLLKLASP AQYTTRISPV CLASSNEALT EGLTCVTTGW GRLSGVGNVT PAHLQQVALP 
LVTVNQCRQY WGSSITDSMI CAGGAGASSC QGDSGGPLVC QKGNTWVLIG IVSWGTKNCN 
VRAPAVYTRV SKFSTWINQV IAYN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.