Genular: Defining Cellular Identity and Function

Details for: Mr1

Gene ID: 15064

Symbol: Mr1

Ensembl ID: ENSMUSG00000026471

Description: major histocompatibility complex, class I-related

Associated with

Antigen processing and presentation of exogenous antigen
(GO:0019884)
Antigen processing and presentation of peptide antigen via mhc class i
(GO:0002474)
Beta-2-microglobulin binding
(GO:0030881)
Cytokine production involved in immune response
(GO:0002367)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
Early endosome membrane
(GO:0031901)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Interleukin-1 beta production
(GO:0032611)
Interleukin-17 production
(GO:0032620)
Late endosome membrane
(GO:0031902)
Membrane
(GO:0016020)
Mhc class i protein complex
(GO:0042612)
Plasma membrane
(GO:0005886)
Positive regulation of t cell mediated cytotoxicity directed against tumor cell target
(GO:0002854)
T cell differentiation in thymus
(GO:0033077)
T cell receptor binding
(GO:0042608)

Other Information

Proteins

Major histocompatibility complex class I-related gene protein

Genular Protein ID: 1274756835

Symbol: HMR1_MOUSE

Name: Major histocompatibility complex class I-related gene protein

UniProtKB Accession Codes:

Q8HWB0 O19478

Database IDs:

Citations:

PubMed ID: 9325151

Title: A highly conserved major histocompatibility complex class I-related gene in mammals.

PubMed ID: 9325151

DOI: 10.1006/bbrc.1997.7379

PubMed ID: 9780177

Title: Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.

PubMed ID: 9780177

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11785959

Title: Association of MR1 protein, an MHC class I-related molecule, with beta(2)-microglobulin.

PubMed ID: 11785959

DOI: 10.1006/bbrc.2001.6277

PubMed ID: 12794138

Title: Biochemical features of the MHC-related protein 1 consistent with an immunological function.

PubMed ID: 12794138

DOI: 10.4049/jimmunol.170.12.6090

PubMed ID: 12634786

Title: Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1.

PubMed ID: 12634786

DOI: 10.1038/nature01433

PubMed ID: 15802267

Title: Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.

PubMed ID: 15802267

DOI: 10.1074/jbc.m501087200

PubMed ID: 20581831

Title: Antimicrobial activity of mucosal-associated invariant T cells.

PubMed ID: 20581831

DOI: 10.1038/ni.1890

PubMed ID: 31113973

Title: Diverse MR1-restricted T cells in mice and humans.

PubMed ID: 31113973

DOI: 10.1038/s41467-019-10198-w

Sequence Information:

Length: 341
Mass: 39391
Checksum: B21D27227EEFC623
Sequence:

MMLLLPLLAV FLVKRSHTRT HSLRYFRLAV SDPGPVVPEF ISVGYVDSHP ITTYDSVTRQ 
KEPKAPWMAE NLAPDHWERY TQLLRGWQQT FKAELRHLQR HYNHSGLHTY QRMIGCELLE 
DGSTTGFLQY AYDGQDFIIF NKDTLSWLAM DYVAHITKQA WEANLHELQY QKNWLEEECI 
AWLKRFLEYG RDTLERTEHP VVRTTRKETF PGITTFFCRA HGFYPPEISM TWMKNGEEIA 
QEVDYGGVLP SGDGTYQTWL SVNLDPQSND VYSCHVEHCG RQMVLEAPRE SGDILRVSTI 
SGTTILIIAL AGVGVLIWRR SQELKEVMYQ PTQVNEGSSP S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mr1

Associated with

Other Information

A highly conserved major histocompatibility complex class I-related gene in mammals. PubMed ID: 9325151

Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene. PubMed ID: 9780177

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Association of MR1 protein, an MHC class I-related molecule, with beta(2)-microglobulin. PubMed ID: 11785959

Biochemical features of the MHC-related protein 1 consistent with an immunological function. PubMed ID: 12794138

Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. PubMed ID: 12634786

Evidence for MR1 antigen presentation to mucosal-associated invariant T cells. PubMed ID: 15802267

Antimicrobial activity of mucosal-associated invariant T cells. PubMed ID: 20581831

Diverse MR1-restricted T cells in mice and humans. PubMed ID: 31113973