Genular: Defining Cellular Identity and Function

Details for: H3f3a

Gene ID: 15078

Symbol: H3f3a

Ensembl ID: ENSMUSG00000060743

Description: H3.3 histone A

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Chromosome maintenance
(R-MMU-73886)
Condensation of prophase chromosomes
(R-MMU-2299718)
Epigenetic regulation of gene expression
(R-MMU-212165)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hemostasis
(R-MMU-109582)
Inhibition of dna recombination at telomere
(R-MMU-9670095)
Mitotic prophase
(R-MMU-68875)
M phase
(R-MMU-68886)
Prc2 methylates histones and dna
(R-MMU-212300)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-MMU-8936459)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Telomere maintenance
(R-MMU-157579)
Transcriptional regulation by runx1
(R-MMU-8878171)
Barr body
(GO:0001740)
Cell population proliferation
(GO:0008283)
Chromatin
(GO:0000785)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Chromosome, telomeric region
(GO:0000781)
Inner kinetochore
(GO:0000939)
Multicellular organism growth
(GO:0035264)
Muscle cell differentiation
(GO:0042692)
Negative regulation of chromosome condensation
(GO:1902340)
Nucleoplasm
(GO:0005654)
Nucleosomal dna binding
(GO:0031492)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Oocyte maturation
(GO:0001556)
Oogenesis
(GO:0048477)
Osteoblast differentiation
(GO:0001649)
Pericentric heterochromatin formation
(GO:0031508)
Protein-containing complex
(GO:0032991)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Single fertilization
(GO:0007338)
Spermatogenesis
(GO:0007283)
Structural constituent of chromatin
(GO:0030527)
Subtelomeric heterochromatin formation
(GO:0031509)

Other Information

Proteins

Histone H3.3

Genular Protein ID: 3685496076

Symbol: H33_MOUSE

Name: Histone H3.3

UniProtKB Accession Codes:

P84244 P06351 P33155 Q3TW79 Q3U6D6 Q569U8 Q5HZY8 Q6TXQ5 Q8VDJ2 Q9D0H3 Q9V3W4

Database IDs:

Citations:

PubMed ID: 2470025

Title: Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition.

PubMed ID: 2470025

DOI: 10.1093/nar/17.7.2449

PubMed ID: 9373943

Title: Differential expression of the murine histone genes H3.3A and H3.3B.

PubMed ID: 9373943

DOI: 10.1046/j.1432-0436.1997.6210013.x

PubMed ID: 9174168

Title: H3.3A variant histone mRNA containing an alpha-globin insertion: modulated expression during mouse gametogenesis correlates with meiotic onset.

PubMed ID: 9174168

DOI: 10.1089/dna.1997.16.639

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15638457

Title: A new family of 'H3L-like' histone genes.

PubMed ID: 15638457

DOI: 10.1007/s00239-004-2637-4

PubMed ID: 10464286

Title: Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.

PubMed ID: 10464286

DOI: 10.1074/jbc.274.36.25543

PubMed ID: 11441012

Title: Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1.

PubMed ID: 11441012

DOI: 10.1074/jbc.m103973200

PubMed ID: 12498683

Title: Crosstalk between CARM1 methylation and CBP acetylation on histone H3.

PubMed ID: 12498683

DOI: 10.1016/s0960-9822(02)01387-8

PubMed ID: 11751582

Title: Methylation at arginine 17 of histone H3 is linked to gene activation.

PubMed ID: 11751582

DOI: 10.1093/embo-reports/kvf013

PubMed ID: 11856369

Title: Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.

PubMed ID: 11856369

DOI: 10.1046/j.1356-9597.2001.00498.x

PubMed ID: 13678296

Title: Identification of methylation and acetylation sites on mouse histone H3 using matrix-assisted laser desorption/ionization time-of-flight and nanoelectrospray ionization tandem mass spectrometry.

PubMed ID: 13678296

DOI: 10.1023/a:1025334006014

PubMed ID: 15339660

Title: Histone deimination antagonizes arginine methylation.

PubMed ID: 15339660

DOI: 10.1016/j.cell.2004.08.020

PubMed ID: 15485929

Title: Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.

PubMed ID: 15485929

DOI: 10.1128/mcb.24.21.9630-9645.2004

PubMed ID: 15616592

Title: Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression.

PubMed ID: 15616592

DOI: 10.1038/sj.emboj.7600500

PubMed ID: 15681610

Title: The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.

PubMed ID: 15681610

DOI: 10.1101/gad.1267105

PubMed ID: 15684425

Title: Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.

PubMed ID: 15684425

DOI: 10.1074/jbc.m410521200

PubMed ID: 15870105

Title: MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2.

PubMed ID: 15870105

DOI: 10.1242/jcs.02373

PubMed ID: 15735677

Title: Stimulation of the Ras-MAPK pathway leads to independent phosphorylation of histone H3 on serine 10 and 28.

PubMed ID: 15735677

DOI: 10.1038/sj.onc.1208521

PubMed ID: 17194708

Title: Organismal differences in post-translational modifications in histones H3 and H4.

PubMed ID: 17194708

DOI: 10.1074/jbc.m607900200

PubMed ID: 17189264

Title: Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.

PubMed ID: 17189264

DOI: 10.1074/jbc.m607909200

PubMed ID: 20122409

Title: The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.

PubMed ID: 20122409

DOI: 10.1016/j.molcel.2009.12.035

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 30279482

Title: Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.

PubMed ID: 30279482

DOI: 10.1038/s41598-018-32927-9

PubMed ID: 30867594

Title: Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

PubMed ID: 30867594

DOI: 10.1038/s41586-019-1024-7

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

Sequence Information:

Length: 136
Mass: 15328
Checksum: 5158ED279E6F9E1C
Sequence:

MARTKQTARK STGGKAPRKQ LATKAARKSA PSTGGVKKPH RYRPGTVALR EIRRYQKSTE 
LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY LVGLFEDTNL CAIHAKRVTI 
MPKDIQLARR IRGERA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H3f3a

Associated with

Other Information

Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition. PubMed ID: 2470025

Differential expression of the murine histone genes H3.3A and H3.3B. PubMed ID: 9373943

H3.3A variant histone mRNA containing an alpha-globin insertion: modulated expression during mouse gametogenesis correlates with meiotic onset. PubMed ID: 9174168

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A new family of 'H3L-like' histone genes. PubMed ID: 15638457

Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. PubMed ID: 10464286

Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1. PubMed ID: 11441012

Crosstalk between CARM1 methylation and CBP acetylation on histone H3. PubMed ID: 12498683

Methylation at arginine 17 of histone H3 is linked to gene activation. PubMed ID: 11751582

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. PubMed ID: 11856369

Identification of methylation and acetylation sites on mouse histone H3 using matrix-assisted laser desorption/ionization time-of-flight and nanoelectrospray ionization tandem mass spectrometry. PubMed ID: 13678296

Histone deimination antagonizes arginine methylation. PubMed ID: 15339660

Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. PubMed ID: 15485929

Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. PubMed ID: 15616592

The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. PubMed ID: 15681610

Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. PubMed ID: 15684425

MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2. PubMed ID: 15870105

Stimulation of the Ras-MAPK pathway leads to independent phosphorylation of histone H3 on serine 10 and 28. PubMed ID: 15735677

Organismal differences in post-translational modifications in histones H3 and H4. PubMed ID: 17194708

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. PubMed ID: 17189264

The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining. PubMed ID: 20122409

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. PubMed ID: 27105113

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. PubMed ID: 30279482

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. PubMed ID: 30867594

Metabolic regulation of gene expression by histone lactylation. PubMed ID: 31645732