Gene CTSB - ENSG00000164733 | NCBI Gene ID: 1508

Details for: CTSB

Gene ID: 1508

Symbol: CTSB

Ensembl ID: ENSG00000164733

Description: cathepsin B

Associated with

Adaptive immune system
(R-HSA-1280218)
Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Collagen degradation
(R-HSA-1442490)
Collagen formation
(R-HSA-1474290)
Degradation of the extracellular matrix
(R-HSA-1474228)
Extracellular matrix organization
(R-HSA-1474244)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Mhc class ii antigen presentation
(R-HSA-2132295)
Neutrophil degranulation
(R-HSA-6798695)
Toll-like receptor cascades
(R-HSA-168898)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Apical plasma membrane
(GO:0016324)
Cellular response to thyroid hormone stimulus
(GO:0097067)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Decidualization
(GO:0046697)
Endolysosome lumen
(GO:0036021)
Epithelial cell differentiation
(GO:0030855)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Lysosome
(GO:0005764)
Melanosome
(GO:0042470)
Peptidase activity
(GO:0008233)
Peptidase inhibitor complex
(GO:1904090)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Proteoglycan binding
(GO:0043394)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Regulation of apoptotic process
(GO:0042981)
Symbiont entry into host cell
(GO:0046718)
Thyroid hormone generation
(GO:0006590)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 15.25
Marker Score: 6654
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 7.05
Marker Score: 5519
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.8
Marker Score: 4343
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.75
Marker Score: 4528
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.5
Marker Score: 195443
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.3
Marker Score: 8068
Cell Name: endocardial cell (CL0002350)
Fold Change: 3.24
Marker Score: 1833
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.21
Marker Score: 23923
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.18
Marker Score: 4372
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.08
Marker Score: 6002
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.03
Marker Score: 3033
Cell Name: secretory cell (CL0000151)
Fold Change: 3.01
Marker Score: 5491
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.92
Marker Score: 74714
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.91
Marker Score: 1946
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.9
Marker Score: 1209
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.86
Marker Score: 1167
Cell Name: decidual cell (CL2000002)
Fold Change: 2.79
Marker Score: 12020
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.75
Marker Score: 6650
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.72
Marker Score: 1855
Cell Name: microglial cell (CL0000129)
Fold Change: 2.71
Marker Score: 4938
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.66
Marker Score: 16173
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.65
Marker Score: 2353
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.63
Marker Score: 5992
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.62
Marker Score: 6786
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.61
Marker Score: 20397
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.61
Marker Score: 90457.5
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.54
Marker Score: 6338
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.54
Marker Score: 918
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.54
Marker Score: 1184.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.52
Marker Score: 28340
Cell Name: blood cell (CL0000081)
Fold Change: 2.48
Marker Score: 28800
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.45
Marker Score: 1219
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.45
Marker Score: 21119
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.44
Marker Score: 8679
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.37
Marker Score: 4956
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.32
Marker Score: 1827
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.26
Marker Score: 1247
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.26
Marker Score: 2381
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.25
Marker Score: 3317
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.25
Marker Score: 7360
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.21
Marker Score: 3923
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.21
Marker Score: 700
Cell Name: club cell (CL0000158)
Fold Change: 2.19
Marker Score: 2557
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.18
Marker Score: 5126.5
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.17
Marker Score: 1264
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.16
Marker Score: 1111
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.15
Marker Score: 1919
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.15
Marker Score: 620
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 2.14
Marker Score: 482
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.14
Marker Score: 1057
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.14
Marker Score: 3636
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.13
Marker Score: 8382
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.09
Marker Score: 8679.5
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.09
Marker Score: 5462
Cell Name: osteoblast (CL0000062)
Fold Change: 2.05
Marker Score: 1101
Cell Name: macrophage (CL0000235)
Fold Change: 2.04
Marker Score: 2269
Cell Name: basal cell (CL0000646)
Fold Change: 2.04
Marker Score: 2632
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.02
Marker Score: 4113
Cell Name: supporting cell (CL0000630)
Fold Change: 2.01
Marker Score: 3781
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2
Marker Score: 10525
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.98
Marker Score: 6802
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.96
Marker Score: 618
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.96
Marker Score: 472
Cell Name: melanocyte (CL0000148)
Fold Change: 1.93
Marker Score: 780
Cell Name: monocyte (CL0000576)
Fold Change: 1.91
Marker Score: 2478
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.88
Marker Score: 2991
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.88
Marker Score: 12002
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.87
Marker Score: 726
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.87
Marker Score: 753
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.86
Marker Score: 528
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.85
Marker Score: 1547
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.85
Marker Score: 457
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.85
Marker Score: 1956
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.85
Marker Score: 2080
Cell Name: enterocyte (CL0000584)
Fold Change: 1.85
Marker Score: 8857
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 1.84
Marker Score: 948
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.83
Marker Score: 2666
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.83
Marker Score: 3487
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 1.83
Marker Score: 501
Cell Name: kidney cell (CL1000497)
Fold Change: 1.82
Marker Score: 1212
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.81
Marker Score: 5692
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.81
Marker Score: 1566
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.81
Marker Score: 1840
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.8
Marker Score: 1139
Cell Name: erythroblast (CL0000765)
Fold Change: 1.8
Marker Score: 1121.5
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.79
Marker Score: 11663
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.78
Marker Score: 1224
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.78
Marker Score: 1236
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.78
Marker Score: 15603
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.78
Marker Score: 1014
Cell Name: fibroblast (CL0000057)
Fold Change: 1.77
Marker Score: 1708
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.77
Marker Score: 31365
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.76
Marker Score: 1782
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.75
Marker Score: 6736
Cell Name: stromal cell (CL0000499)
Fold Change: 1.74
Marker Score: 2039
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.74
Marker Score: 22928
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.72
Marker Score: 412
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.72
Marker Score: 2766
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.72
Marker Score: 14941
Cell Name: stem cell (CL0000034)
Fold Change: 1.72
Marker Score: 4083

Hover over a box to see details here...

**Key characteristics:** * Gene name: CTSB * Ensembl ID: ENSG00000164733 * Protein: CATB_HUMAN (Cathepsin B) * Protein length: 117 amino acids * Subcellular location: Cytoplasm * Cellular functions: * Collagen degradation * Extracellular matrix organization * Immune surveillance **Pathways and functions:** * Cathepsin B is involved in the assembly of collagen fibrils and other multimeric structures. * It is a key regulator of skin homeostasis and wound healing. * It is expressed in high levels in the epidermis, where it is involved in the remodeling and repair of the skin barrier. * Cathepsin B also plays a role in the regulation of immune responses. * It is expressed in immune cells, where it is involved in the degradation of extracellular matrix proteins and the activation of immune responses. **Clinical significance:** * Mutations in the CTSB gene have been linked to several human diseases, including psoriasis, rheumatoid arthritis, and cancer. * Cathepsin B inhibitors are being investigated as potential treatments for these diseases. * Understanding the role of CTSB in human health and disease is important for the development of new therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cathepsin B
Q5HYG5_HUMAN

Genular Protein ID: 907135225

Symbol: CATB_HUMAN

Name: Cathepsin B

UniProtKB Accession Codes:

P07858 B3KQR5 B3KRR5 Q503A6 Q96D87

Database IDs:

Citations:

PubMed ID: 3463996

Title: Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

PubMed ID: 3463996

DOI: 10.1073/pnas.83.20.7721

PubMed ID: 8112600

Title: Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene.

PubMed ID: 8112600

DOI: 10.1016/0378-1119(94)90750-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3972105

Title: Amino acid sequence of human liver cathepsin B.

PubMed ID: 3972105

DOI: 10.1016/0014-5793(85)81136-4

PubMed ID: 1637335

Title: Human tumour cathepsin B. Comparison with normal liver cathepsin B.

PubMed ID: 1637335

DOI: 10.1042/bj2850427

PubMed ID: 3010323

Title: Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.

PubMed ID: 3010323

DOI: 10.1073/pnas.83.9.2909

PubMed ID: 12220505

Title: Inhibition of MEPE cleavage by Phex.

PubMed ID: 12220505

DOI: 10.1016/s0006-291x(02)02125-3

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16733801

Title: Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.

PubMed ID: 16733801

DOI: 10.1007/s11010-006-9214-7

PubMed ID: 18718938

Title: Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.

PubMed ID: 18718938

DOI: 10.1093/hmg/ddn256

PubMed ID: 28457472

Title: Duplicated enhancer region increases expression of CTSB and segregates with keratolytic winter erythema in South African and Norwegian families.

PubMed ID: 28457472

DOI: 10.1016/j.ajhg.2017.03.012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1868826

Title: The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

PubMed ID: 1868826

DOI: 10.1002/j.1460-2075.1991.tb07771.x

PubMed ID: 8617355

Title: Crystal structures of human procathepsin B at 3.2- and 3.3-A resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide.

PubMed ID: 8617355

DOI: 10.1016/0014-5793(96)00309-2

PubMed ID: 9299326

Title: Crystal structure of the wild-type human procathepsin B at 2.5-A resolution reveals the native active site of a papain-like cysteine protease zymogen.

PubMed ID: 9299326

DOI: 10.1006/jmbi.1997.1218

Sequence Information:

Length: 339
Mass: 37822
Checksum: 0FC818EA4C1F6D90
Sequence:

MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG 
TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWA FGAVEAISDR 
ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC NGGYPAEAWN FWTRKGLVSG GLYESHVGCR 
PYSIPPCEHH VNGSRPPCTG EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM 
AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW 
NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI

Genular Protein ID: 1663104189

Symbol: Q5HYG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5HYG5

Database IDs:

Sequence Information:

Length: 110
Mass: 12668
Checksum: 0AF2617252D55B84
Sequence:

MWQLWASLCC LLVLANARSR PSFHPVSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG 
TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CTSB

Associated with

Cells (max top 100)

Other Information

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. PubMed ID: 3463996

Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. PubMed ID: 8112600

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amino acid sequence of human liver cathepsin B. PubMed ID: 3972105

Human tumour cathepsin B. Comparison with normal liver cathepsin B. PubMed ID: 1637335

Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B. PubMed ID: 3010323

Inhibition of MEPE cleavage by Phex. PubMed ID: 12220505

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. PubMed ID: 12643545

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells. PubMed ID: 16733801

Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. PubMed ID: 18718938

Duplicated enhancer region increases expression of CTSB and segregates with keratolytic winter erythema in South African and Norwegian families. PubMed ID: 28457472

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. PubMed ID: 1868826

Crystal structures of human procathepsin B at 3.2- and 3.3-A resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide. PubMed ID: 8617355

Crystal structure of the wild-type human procathepsin B at 2.5-A resolution reveals the native active site of a papain-like cysteine protease zymogen. PubMed ID: 9299326