CTSB | ENSG00000164733 | NCBI 1508

Details for: CTSB

Gene ID: 1508

Symbol: CTSB

Ensembl ID: ENSG00000164733

Description: cathepsin B

Associated with

Adaptive immune system
(R-HSA-1280218)
Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Collagen degradation
(R-HSA-1442490)
Collagen formation
(R-HSA-1474290)
Degradation of the extracellular matrix
(R-HSA-1474228)
Extracellular matrix organization
(R-HSA-1474244)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Mhc class ii antigen presentation
(R-HSA-2132295)
Neutrophil degranulation
(R-HSA-6798695)
Toll-like receptor cascades
(R-HSA-168898)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Apical plasma membrane
(GO:0016324)
Cellular response to thyroid hormone stimulus
(GO:0097067)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Decidualization
(GO:0046697)
Endolysosome lumen
(GO:0036021)
Epithelial cell differentiation
(GO:0030855)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Lysosome
(GO:0005764)
Melanosome
(GO:0042470)
Peptidase activity
(GO:0008233)
Peptidase inhibitor complex
(GO:1904090)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Proteoglycan binding
(GO:0043394)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Regulation of apoptotic process
(GO:0042981)
Symbiont entry into host cell
(GO:0046718)
Thyroid hormone generation
(GO:0006590)

Other Information

Proteins

Cathepsin B
Q5HYG5_HUMAN

Genular Protein ID: 907135225

Symbol: CATB_HUMAN

Name: Cathepsin B

UniProtKB Accession Codes:

P07858 B3KQR5 B3KRR5 Q503A6 Q96D87

Database IDs:

Citations:

PubMed ID: 3463996

Title: Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

PubMed ID: 3463996

DOI: 10.1073/pnas.83.20.7721

PubMed ID: 8112600

Title: Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene.

PubMed ID: 8112600

DOI: 10.1016/0378-1119(94)90750-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3972105

Title: Amino acid sequence of human liver cathepsin B.

PubMed ID: 3972105

DOI: 10.1016/0014-5793(85)81136-4

PubMed ID: 1637335

Title: Human tumour cathepsin B. Comparison with normal liver cathepsin B.

PubMed ID: 1637335

DOI: 10.1042/bj2850427

PubMed ID: 3010323

Title: Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.

PubMed ID: 3010323

DOI: 10.1073/pnas.83.9.2909

PubMed ID: 12220505

Title: Inhibition of MEPE cleavage by Phex.

PubMed ID: 12220505

DOI: 10.1016/s0006-291x(02)02125-3

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16733801

Title: Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.

PubMed ID: 16733801

DOI: 10.1007/s11010-006-9214-7

PubMed ID: 18718938

Title: Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.

PubMed ID: 18718938

DOI: 10.1093/hmg/ddn256

PubMed ID: 28457472

Title: Duplicated enhancer region increases expression of CTSB and segregates with keratolytic winter erythema in South African and Norwegian families.

PubMed ID: 28457472

DOI: 10.1016/j.ajhg.2017.03.012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1868826

Title: The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

PubMed ID: 1868826

DOI: 10.1002/j.1460-2075.1991.tb07771.x

PubMed ID: 8617355

Title: Crystal structures of human procathepsin B at 3.2- and 3.3-A resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide.

PubMed ID: 8617355

DOI: 10.1016/0014-5793(96)00309-2

PubMed ID: 9299326

Title: Crystal structure of the wild-type human procathepsin B at 2.5-A resolution reveals the native active site of a papain-like cysteine protease zymogen.

PubMed ID: 9299326

DOI: 10.1006/jmbi.1997.1218

Sequence Information:

Length: 339
Mass: 37822
Checksum: 0FC818EA4C1F6D90
Sequence:

MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG 
TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWA FGAVEAISDR 
ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC NGGYPAEAWN FWTRKGLVSG GLYESHVGCR 
PYSIPPCEHH VNGSRPPCTG EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM 
AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW 
NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI

Genular Protein ID: 1663104189

Symbol: Q5HYG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5HYG5

Database IDs:

Sequence Information:

Length: 110
Mass: 12668
Checksum: 0AF2617252D55B84
Sequence:

MWQLWASLCC LLVLANARSR PSFHPVSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG 
TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTSB

Associated with

Other Information

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. PubMed ID: 3463996

Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. PubMed ID: 8112600

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amino acid sequence of human liver cathepsin B. PubMed ID: 3972105

Human tumour cathepsin B. Comparison with normal liver cathepsin B. PubMed ID: 1637335

Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B. PubMed ID: 3010323

Inhibition of MEPE cleavage by Phex. PubMed ID: 12220505

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. PubMed ID: 12643545

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells. PubMed ID: 16733801

Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. PubMed ID: 18718938

Duplicated enhancer region increases expression of CTSB and segregates with keratolytic winter erythema in South African and Norwegian families. PubMed ID: 28457472

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. PubMed ID: 1868826

Crystal structures of human procathepsin B at 3.2- and 3.3-A resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide. PubMed ID: 8617355

Crystal structure of the wild-type human procathepsin B at 2.5-A resolution reveals the native active site of a papain-like cysteine protease zymogen. PubMed ID: 9299326