Details for: CTSB

Gene ID: 1508

Symbol: CTSB

Ensembl ID: ENSG00000164733

Description: cathepsin B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 498.9546
    Cell Significance Index: -77.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 345.9582
    Cell Significance Index: -87.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 243.4412
    Cell Significance Index: -100.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 217.9777
    Cell Significance Index: -88.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 211.8941
    Cell Significance Index: -100.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 187.4471
    Cell Significance Index: -96.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 149.5927
    Cell Significance Index: -100.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 93.1769
    Cell Significance Index: -88.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 67.2692
    Cell Significance Index: -82.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.1120
    Cell Significance Index: -94.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.1993
    Cell Significance Index: -80.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.6034
    Cell Significance Index: -93.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.6167
    Cell Significance Index: -31.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.7432
    Cell Significance Index: 106.1500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.4851
    Cell Significance Index: 51.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6941
    Cell Significance Index: 125.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4671
    Cell Significance Index: 1347.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6971
    Cell Significance Index: 79.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6653
    Cell Significance Index: 228.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5678
    Cell Significance Index: 311.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3913
    Cell Significance Index: 37.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1811
    Cell Significance Index: 212.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1533
    Cell Significance Index: 231.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0048
    Cell Significance Index: 52.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9894
    Cell Significance Index: 34.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9890
    Cell Significance Index: 121.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9773
    Cell Significance Index: 26.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9639
    Cell Significance Index: 25.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7104
    Cell Significance Index: 314.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6984
    Cell Significance Index: 250.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6983
    Cell Significance Index: 113.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6712
    Cell Significance Index: 86.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6597
    Cell Significance Index: 49.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6593
    Cell Significance Index: 7.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6518
    Cell Significance Index: 83.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6430
    Cell Significance Index: 33.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6254
    Cell Significance Index: 13.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3530
    Cell Significance Index: 318.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3093
    Cell Significance Index: 30.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2911
    Cell Significance Index: 8.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2873
    Cell Significance Index: 8.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1853
    Cell Significance Index: 348.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1785
    Cell Significance Index: 9.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1180
    Cell Significance Index: 4.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0732
    Cell Significance Index: 7.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0688
    Cell Significance Index: 11.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0236
    Cell Significance Index: 17.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0064
    Cell Significance Index: -0.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0087
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0233
    Cell Significance Index: -16.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0497
    Cell Significance Index: -76.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0517
    Cell Significance Index: -95.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0537
    Cell Significance Index: -33.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0699
    Cell Significance Index: -95.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0782
    Cell Significance Index: -57.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0899
    Cell Significance Index: -57.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0991
    Cell Significance Index: -18.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1202
    Cell Significance Index: -67.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1528
    Cell Significance Index: -69.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1956
    Cell Significance Index: -41.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2202
    Cell Significance Index: -3.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2581
    Cell Significance Index: -19.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2780
    Cell Significance Index: -80.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3041
    Cell Significance Index: -13.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3389
    Cell Significance Index: -38.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3523
    Cell Significance Index: -51.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4187
    Cell Significance Index: -13.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4204
    Cell Significance Index: -29.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4324
    Cell Significance Index: -49.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4346
    Cell Significance Index: -50.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4609
    Cell Significance Index: -12.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4621
    Cell Significance Index: -4.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4734
    Cell Significance Index: -55.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4801
    Cell Significance Index: -24.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4830
    Cell Significance Index: -33.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5106
    Cell Significance Index: -53.1700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.6241
    Cell Significance Index: -5.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6387
    Cell Significance Index: -16.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6783
    Cell Significance Index: -15.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7152
    Cell Significance Index: -12.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8259
    Cell Significance Index: -17.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8485
    Cell Significance Index: -16.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.8951
    Cell Significance Index: -97.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9404
    Cell Significance Index: -12.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9665
    Cell Significance Index: -24.1600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.0125
    Cell Significance Index: -8.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0902
    Cell Significance Index: -86.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.1145
    Cell Significance Index: -45.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2805
    Cell Significance Index: -56.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2849
    Cell Significance Index: -72.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3471
    Cell Significance Index: -84.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3859
    Cell Significance Index: -84.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.4860
    Cell Significance Index: -22.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5435
    Cell Significance Index: -58.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7129
    Cell Significance Index: -62.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.7495
    Cell Significance Index: -50.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7702
    Cell Significance Index: -52.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.8119
    Cell Significance Index: -14.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.8315
    Cell Significance Index: -64.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cysteine-type endopeptidase**: Cathepsin B is a cysteine-dependent enzyme that catalyzes the hydrolysis of peptide bonds in proteins. 2. **Lysosomal localization**: Cathepsin B is primarily localized in the lysosomes of cells, where it is involved in protein degradation and catabolism. 3. **Broad substrate specificity**: Cathepsin B can degrade a wide range of substrates, including collagen, proteoglycans, and other extracellular matrix components. 4. **Antigen presentation**: Cathepsin B is involved in the processing and presentation of antigens to the immune system, particularly through the MHC class II pathway. 5. **Cellular expression**: Cathepsin B is expressed in various cell types, including macrophages, neutrophils, epithelial cells, and fibroblasts. **Pathways and Functions** 1. **Collagen degradation**: Cathepsin B plays a key role in the degradation of collagen, a critical component of the extracellular matrix, in tissues such as the skin, lung, and heart. 2. **Antigen presentation**: Cathepsin B is involved in the processing and presentation of antigens to the immune system, particularly through the MHC class II pathway. 3. **Neutrophil degranulation**: Cathepsin B is released from neutrophils during degranulation, where it contributes to the degradation of extracellular matrix components and the clearance of pathogens. 4. **Apoptosis regulation**: Cathepsin B has been implicated in the regulation of apoptosis, particularly in the context of tissue damage and inflammation. 5. **Tissue remodeling**: Cathepsin B plays a role in tissue remodeling, particularly in the context of wound healing and fibrosis. **Clinical Significance** 1. **Inflammatory diseases**: Cathepsin B has been implicated in various inflammatory diseases, including rheumatoid arthritis, osteoarthritis, and asthma. 2. **Cancer**: Cathepsin B has been found to be overexpressed in various types of cancer, including breast, lung, and prostate cancer, and is associated with tumor progression and metastasis. 3. **Neurodegenerative diseases**: Cathepsin B has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it may contribute to the degradation of proteins and the clearance of amyloid-β plaques. 4. **Wound healing**: Cathepsin B plays a role in wound healing, particularly in the context of tissue remodeling and collagen degradation. 5. **Fibrosis**: Cathepsin B has been implicated in the development of fibrosis, particularly in the context of lung and liver disease, where it contributes to the degradation of extracellular matrix components and the accumulation of fibrotic tissue. In conclusion, cathepsin B is a multifunctional enzyme that plays a critical role in various cellular processes, including protein degradation, collagen catabolism, and antigen presentation. Its dysregulation has been implicated in various diseases, including inflammatory diseases, cancer, and neurodegenerative diseases. Further research is needed to fully understand the mechanisms of cathepsin B and its role in human disease.

Genular Protein ID: 907135225

Symbol: CATB_HUMAN

Name: Cathepsin B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3463996

Title: Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

PubMed ID: 3463996

DOI: 10.1073/pnas.83.20.7721

PubMed ID: 8112600

Title: Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene.

PubMed ID: 8112600

DOI: 10.1016/0378-1119(94)90750-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3972105

Title: Amino acid sequence of human liver cathepsin B.

PubMed ID: 3972105

DOI: 10.1016/0014-5793(85)81136-4

PubMed ID: 1637335

Title: Human tumour cathepsin B. Comparison with normal liver cathepsin B.

PubMed ID: 1637335

DOI: 10.1042/bj2850427

PubMed ID: 3010323

Title: Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.

PubMed ID: 3010323

DOI: 10.1073/pnas.83.9.2909

PubMed ID: 12220505

Title: Inhibition of MEPE cleavage by Phex.

PubMed ID: 12220505

DOI: 10.1016/s0006-291x(02)02125-3

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16733801

Title: Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.

PubMed ID: 16733801

DOI: 10.1007/s11010-006-9214-7

PubMed ID: 18718938

Title: Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.

PubMed ID: 18718938

DOI: 10.1093/hmg/ddn256

PubMed ID: 28457472

Title: Duplicated enhancer region increases expression of CTSB and segregates with keratolytic winter erythema in South African and Norwegian families.

PubMed ID: 28457472

DOI: 10.1016/j.ajhg.2017.03.012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1868826

Title: The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

PubMed ID: 1868826

DOI: 10.1002/j.1460-2075.1991.tb07771.x

PubMed ID: 8617355

Title: Crystal structures of human procathepsin B at 3.2- and 3.3-A resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide.

PubMed ID: 8617355

DOI: 10.1016/0014-5793(96)00309-2

PubMed ID: 9299326

Title: Crystal structure of the wild-type human procathepsin B at 2.5-A resolution reveals the native active site of a papain-like cysteine protease zymogen.

PubMed ID: 9299326

DOI: 10.1006/jmbi.1997.1218

Sequence Information:

  • Length: 339
  • Mass: 37822
  • Checksum: 0FC818EA4C1F6D90
  • Sequence:
  • MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG 
    TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWA FGAVEAISDR 
    ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC NGGYPAEAWN FWTRKGLVSG GLYESHVGCR 
    PYSIPPCEHH VNGSRPPCTG EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM 
    AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW 
    NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI

Genular Protein ID: 1663104189

Symbol: Q5HYG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 110
  • Mass: 12668
  • Checksum: 0AF2617252D55B84
  • Sequence:
  • MWQLWASLCC LLVLANARSR PSFHPVSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG 
    TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.