Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 604.6473
Cell Significance Index: -94.0500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 344.9725
Cell Significance Index: -87.5000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 222.0821
Cell Significance Index: -104.8500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 199.5975
Cell Significance Index: -102.6700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 156.7608
Cell Significance Index: -105.1900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 80.5341
Cell Significance Index: -99.3000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 29.3782
Cell Significance Index: -78.7000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 28.3709
Cell Significance Index: -87.1400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 25.7853
Cell Significance Index: -101.7500 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 19.1778
Cell Significance Index: 50.5900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 6.0714
Cell Significance Index: 55.9100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 4.6802
Cell Significance Index: 63.8600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.6787
Cell Significance Index: 663.1600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.6499
Cell Significance Index: 67.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.3198
Cell Significance Index: 408.2000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 3.1683
Cell Significance Index: 911.6200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.4005
Cell Significance Index: 124.7000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.1737
Cell Significance Index: 1187.1400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.1549
Cell Significance Index: 100.4700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.1339
Cell Significance Index: 112.0400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.6612
Cell Significance Index: 228.1300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1650
Cell Significance Index: 31.7100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0932
Cell Significance Index: 118.9100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.9550
Cell Significance Index: 25.5900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8257
Cell Significance Index: 365.0700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.7588
Cell Significance Index: 97.2700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7205
Cell Significance Index: 32.6600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.6502
Cell Significance Index: 111.0300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6017
Cell Significance Index: 28.2800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5880
Cell Significance Index: 17.2700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4931
Cell Significance Index: 63.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4443
Cell Significance Index: 33.1100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3789
Cell Significance Index: 37.4800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3664
Cell Significance Index: 131.4100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3204
Cell Significance Index: 8.5700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3133
Cell Significance Index: 62.8400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2822
Cell Significance Index: 206.8800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2805
Cell Significance Index: 53.3800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1967
Cell Significance Index: 13.9100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1451
Cell Significance Index: 109.8000 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0646
Cell Significance Index: 6.6000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0623
Cell Significance Index: 2.1900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0165
Cell Significance Index: 0.4400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0398
Cell Significance Index: -35.9600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0402
Cell Significance Index: -29.8000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0546
Cell Significance Index: -102.8600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0780
Cell Significance Index: -3.9400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0943
Cell Significance Index: -15.3400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0992
Cell Significance Index: -61.9300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1270
Cell Significance Index: -71.6200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1521
Cell Significance Index: -9.8200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2384
Cell Significance Index: -50.2200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2460
Cell Significance Index: -28.1800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2546
Cell Significance Index: -10.4300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4472
Cell Significance Index: -5.0800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5181
Cell Significance Index: -11.9700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.5293
Cell Significance Index: -105.0500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5415
Cell Significance Index: -63.1100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7366
Cell Significance Index: -107.0800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.7631
Cell Significance Index: -87.1100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7776
Cell Significance Index: -27.0200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.8028
Cell Significance Index: -94.6800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.8564
Cell Significance Index: -65.7200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8573
Cell Significance Index: -21.9000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.9423
Cell Significance Index: -14.1200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.9989
Cell Significance Index: -24.9700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.0065
Cell Significance Index: -69.6100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.0806
Cell Significance Index: -30.2000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1074
Cell Significance Index: -87.7100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.1159
Cell Significance Index: -18.6800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.1694
Cell Significance Index: -30.0600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.2261
Cell Significance Index: -18.9700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.2307
Cell Significance Index: -26.2100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.2389
Cell Significance Index: -39.6800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3005
Cell Significance Index: -79.7300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.3158
Cell Significance Index: -82.9300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.4115
Cell Significance Index: -30.5800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4262
Cell Significance Index: -87.6600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.4484
Cell Significance Index: -41.5200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.6318
Cell Significance Index: -91.5700 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -1.8091
Cell Significance Index: -37.7300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.8566
Cell Significance Index: -54.6900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -2.0342
Cell Significance Index: -53.4900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -2.0480
Cell Significance Index: -16.7000 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.0536
Cell Significance Index: -17.2500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.2255
Cell Significance Index: -81.7000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -2.2739
Cell Significance Index: -65.5200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.2746
Cell Significance Index: -100.6100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.3770
Cell Significance Index: -83.2700 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -2.4194
Cell Significance Index: -23.0200 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -2.4249
Cell Significance Index: -9.2900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -2.6458
Cell Significance Index: -46.7600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.6720
Cell Significance Index: -101.1800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -2.6787
Cell Significance Index: -56.0700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.6915
Cell Significance Index: -88.1200 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -2.7050
Cell Significance Index: -55.0400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.7835
Cell Significance Index: -88.6500 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -2.8136
Cell Significance Index: -55.0100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -3.0685
Cell Significance Index: -31.7700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -3.0691
Cell Significance Index: -59.9000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3300545362
Symbol: CATD_HUMAN
Name: Cathepsin D
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3927292
Title: Cloning and sequence analysis of cDNA for human cathepsin D.
PubMed ID: 3927292
PubMed ID: 3588310
Title: Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells.
PubMed ID: 3588310
PubMed ID: 2069717
Title: Molecular organization of the human cathepsin D gene.
PubMed ID: 2069717
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8262386
Title: The human cathepsin D-encoding gene is transcribed from an estrogen-regulated and a constitutive start point.
PubMed ID: 8262386
PubMed ID: 7935485
Title: Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
PubMed ID: 7935485
PubMed ID: 1426530
Title: Proteolytic processing sites producing the mature form of human cathepsin D.
PubMed ID: 1426530
PubMed ID: 12643545
Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
PubMed ID: 12643545
DOI: 10.1021/pr025562r
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16670177
Title: Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
PubMed ID: 16670177
DOI: 10.1093/brain/awl107
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 20551380
Title: Proteomics characterization of extracellular space components in the human aorta.
PubMed ID: 20551380
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23234360
Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.
PubMed ID: 23234360
DOI: 10.1021/pr300963h
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27333034
Title: ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
PubMed ID: 27333034
PubMed ID: 8467789
Title: Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.
PubMed ID: 8467789
PubMed ID: 8393577
Title: Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
PubMed ID: 8393577
PubMed ID: 10716266
Title: A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.
PubMed ID: 10716266
DOI: 10.1002/1531-8249(200003)47:3<399::aid-ana22>3.3.co;2-x
PubMed ID: 16685649
Title: Cathepsin D deficiency is associated with a human neurodegenerative disorder.
PubMed ID: 16685649
DOI: 10.1086/504159
PubMed ID: 21990111
Title: Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses.
PubMed ID: 21990111
DOI: 10.1002/humu.21624
Sequence Information:
- Length: 412
- Mass: 44552
- Checksum: 903FB8412E0CF0B0
- Sequence:
MQPSSLLPLA LCLLAAPASA LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG PVSKYSQAVP AVTEGPIPEV LKNYMDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWIH HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC QSASSASALG GVKVERQVFG EATKQPGITF IAAKFDGILG MAYPRISVNN VLPVFDNLMQ QKLVDQNIFS FYLSRDPDAQ PGGELMLGGT DSKYYKGSLS YLNVTRKAYW QVHLDQVEVA SGLTLCKEGC EAIVDTGTSL MVGPVDEVRE LQKAIGAVPL IQGEYMIPCE KVSTLPAITL KLGGKGYKLS PEDYTLKVSQ AGKTLCLSGF MGMDIPPPSG PLWILGDVFI GRYYTVFDRD NNRVGFAEAA RL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.