Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 31.07
Marker Score: 13,561 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 4.78
Marker Score: 3,370 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 4.54
Marker Score: 4,541 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.42
Marker Score: 26,869 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.98
Marker Score: 10,999 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.71
Marker Score: 9,955 - Cell Name: lung macrophage (CL1001603)
Fold Change: 3.53
Marker Score: 4,034 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.35
Marker Score: 9,764 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.34
Marker Score: 187,003 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.34
Marker Score: 5,530 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.29
Marker Score: 3,460 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 3.11
Marker Score: 4,408 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.1
Marker Score: 3,143 - Cell Name: basophil (CL0000767)
Fold Change: 3.1
Marker Score: 1,471 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.05
Marker Score: 19,479 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 3.02
Marker Score: 77,340 - Cell Name: enterocyte (CL0000584)
Fold Change: 3
Marker Score: 14,411 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.98
Marker Score: 15,664 - Cell Name: secretory cell (CL0000151)
Fold Change: 2.93
Marker Score: 5,346 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.85
Marker Score: 1,522 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.8
Marker Score: 1,169 - Cell Name: keratinocyte (CL0000312)
Fold Change: 2.77
Marker Score: 2,318 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.77
Marker Score: 6,909 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.75
Marker Score: 2,914 - Cell Name: microglial cell (CL0000129)
Fold Change: 2.75
Marker Score: 5,001 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.7
Marker Score: 23,461 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.69
Marker Score: 1,799 - Cell Name: hepatoblast (CL0005026)
Fold Change: 2.67
Marker Score: 8,743 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.66
Marker Score: 4,095 - Cell Name: classical monocyte (CL0000860)
Fold Change: 2.65
Marker Score: 10,995 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.62
Marker Score: 6,601 - Cell Name: myelocyte (CL0002193)
Fold Change: 2.6
Marker Score: 1,123 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.56
Marker Score: 16,707 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.56
Marker Score: 6,290 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.55
Marker Score: 88,280 - Cell Name: prickle cell (CL0000649)
Fold Change: 2.55
Marker Score: 16,799 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.54
Marker Score: 5,796 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.53
Marker Score: 3,733 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.48
Marker Score: 5,632 - Cell Name: acinar cell (CL0000622)
Fold Change: 2.47
Marker Score: 1,745 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.46
Marker Score: 1,935 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.44
Marker Score: 1,663 - Cell Name: basal cell (CL0000646)
Fold Change: 2.44
Marker Score: 3,151 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.44
Marker Score: 19,034 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.42
Marker Score: 4,916 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.39
Marker Score: 3,840 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.36
Marker Score: 747 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.36
Marker Score: 8,370 - Cell Name: epithelial cell (CL0000066)
Fold Change: 2.35
Marker Score: 3,740 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.33
Marker Score: 20,099 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.33
Marker Score: 2,230 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.32
Marker Score: 1,143 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.31
Marker Score: 1,079 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.31
Marker Score: 40,987 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.3
Marker Score: 4,473 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.29
Marker Score: 7,177 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.28
Marker Score: 658 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.28
Marker Score: 2,748 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.26
Marker Score: 2,134 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.25
Marker Score: 1,239 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.24
Marker Score: 2,702 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.21
Marker Score: 953 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.2
Marker Score: 723 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.16
Marker Score: 16,106 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.12
Marker Score: 867 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.1
Marker Score: 4,000 - Cell Name: pro-T cell (CL0000827)
Fold Change: 2.09
Marker Score: 8,557 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.09
Marker Score: 5,408 - Cell Name: peptic cell (CL0000155)
Fold Change: 2.08
Marker Score: 872 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 2.04
Marker Score: 494 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.03
Marker Score: 7,986 - Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 2.03
Marker Score: 556 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 2.03
Marker Score: 467 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.03
Marker Score: 12,952 - Cell Name: paneth cell (CL0000510)
Fold Change: 2.02
Marker Score: 1,405 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.99
Marker Score: 481 - Cell Name: leukocyte (CL0000738)
Fold Change: 1.98
Marker Score: 1,138 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.98
Marker Score: 456 - Cell Name: granulocyte (CL0000094)
Fold Change: 1.98
Marker Score: 886 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.97
Marker Score: 5,162 - Cell Name: neutrophil (CL0000775)
Fold Change: 1.97
Marker Score: 1,200 - Cell Name: ciliated cell (CL0000064)
Fold Change: 1.97
Marker Score: 6,759 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.96
Marker Score: 2,038 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.96
Marker Score: 930 - Cell Name: mature T cell (CL0002419)
Fold Change: 1.96
Marker Score: 19,388 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.96
Marker Score: 1,745 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.95
Marker Score: 467 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.95
Marker Score: 734 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.95
Marker Score: 483 - Cell Name: B-1a B cell (CL0000820)
Fold Change: 1.94
Marker Score: 465 - Cell Name: centrocyte (CL0009111)
Fold Change: 1.94
Marker Score: 461 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.93
Marker Score: 411 - Cell Name: blood cell (CL0000081)
Fold Change: 1.93
Marker Score: 22,415 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.91
Marker Score: 1,273 - Cell Name: Merkel cell (CL0000242)
Fold Change: 1.9
Marker Score: 885 - Cell Name: club cell (CL0000158)
Fold Change: 1.9
Marker Score: 2,218 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.9
Marker Score: 1,168 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.89
Marker Score: 413 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.89
Marker Score: 1,085 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.88
Marker Score: 421
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3300545362
Symbol: CATD_HUMAN
Name: Cathepsin D
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3927292
Title: Cloning and sequence analysis of cDNA for human cathepsin D.
PubMed ID: 3927292
PubMed ID: 3588310
Title: Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells.
PubMed ID: 3588310
PubMed ID: 2069717
Title: Molecular organization of the human cathepsin D gene.
PubMed ID: 2069717
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8262386
Title: The human cathepsin D-encoding gene is transcribed from an estrogen-regulated and a constitutive start point.
PubMed ID: 8262386
PubMed ID: 7935485
Title: Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
PubMed ID: 7935485
PubMed ID: 1426530
Title: Proteolytic processing sites producing the mature form of human cathepsin D.
PubMed ID: 1426530
PubMed ID: 12643545
Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
PubMed ID: 12643545
DOI: 10.1021/pr025562r
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16670177
Title: Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
PubMed ID: 16670177
DOI: 10.1093/brain/awl107
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 20551380
Title: Proteomics characterization of extracellular space components in the human aorta.
PubMed ID: 20551380
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23234360
Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.
PubMed ID: 23234360
DOI: 10.1021/pr300963h
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27333034
Title: ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
PubMed ID: 27333034
PubMed ID: 8467789
Title: Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.
PubMed ID: 8467789
PubMed ID: 8393577
Title: Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
PubMed ID: 8393577
PubMed ID: 10716266
Title: A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.
PubMed ID: 10716266
DOI: 10.1002/1531-8249(200003)47:3<399::aid-ana22>3.3.co;2-x
PubMed ID: 16685649
Title: Cathepsin D deficiency is associated with a human neurodegenerative disorder.
PubMed ID: 16685649
DOI: 10.1086/504159
PubMed ID: 21990111
Title: Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses.
PubMed ID: 21990111
DOI: 10.1002/humu.21624
Sequence Information:
- Length: 412
- Mass: 44552
- Checksum: 903FB8412E0CF0B0
- Sequence:
MQPSSLLPLA LCLLAAPASA LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG PVSKYSQAVP AVTEGPIPEV LKNYMDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWIH HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC QSASSASALG GVKVERQVFG EATKQPGITF IAAKFDGILG MAYPRISVNN VLPVFDNLMQ QKLVDQNIFS FYLSRDPDAQ PGGELMLGGT DSKYYKGSLS YLNVTRKAYW QVHLDQVEVA SGLTLCKEGC EAIVDTGTSL MVGPVDEVRE LQKAIGAVPL IQGEYMIPCE KVSTLPAITL KLGGKGYKLS PEDYTLKVSQ AGKTLCLSGF MGMDIPPPSG PLWILGDVFI GRYYTVFDRD NNRVGFAEAA RL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.