CTSD | ENSG00000117984 | NCBI 1509

Details for: CTSD

Gene ID: 1509

Symbol: CTSD

Ensembl ID: ENSG00000117984

Description: cathepsin D

Associated with

Adaptive immune system
(R-HSA-1280218)
Collagen degradation
(R-HSA-1442490)
Degradation of the extracellular matrix
(R-HSA-1474228)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Extracellular matrix organization
(R-HSA-1474244)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of angiotensinogen to angiotensins
(R-HSA-2022377)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Neutrophil degranulation
(R-HSA-6798695)
Peptide hormone metabolism
(R-HSA-2980736)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Aspartic-type endopeptidase activity
(GO:0004190)
Aspartic-type peptidase activity
(GO:0070001)
Autophagosome assembly
(GO:0000045)
Collagen-containing extracellular matrix
(GO:0062023)
Cysteine-type endopeptidase activity
(GO:0004197)
Endosome lumen
(GO:0031904)
Endosome membrane
(GO:0010008)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Insulin catabolic process
(GO:1901143)
Insulin receptor recycling
(GO:0038020)
Lipoprotein catabolic process
(GO:0042159)
Lysosomal lumen
(GO:0043202)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Melanosome
(GO:0042470)
Membrane raft
(GO:0045121)
Peptidase activity
(GO:0008233)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of establishment of protein localization
(GO:0070201)
Specific granule lumen
(GO:0035580)
Tertiary granule lumen
(GO:1904724)

Other Information

Proteins

Cathepsin D

Genular Protein ID: 3300545362

Symbol: CATD_HUMAN

Name: Cathepsin D

UniProtKB Accession Codes:

P07339 Q6IB57

Database IDs:

Citations:

PubMed ID: 3927292

Title: Cloning and sequence analysis of cDNA for human cathepsin D.

PubMed ID: 3927292

DOI: 10.1073/pnas.82.15.4910

PubMed ID: 3588310

Title: Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells.

PubMed ID: 3588310

DOI: 10.1093/nar/15.9.3773

PubMed ID: 2069717

Title: Molecular organization of the human cathepsin D gene.

PubMed ID: 2069717

DOI: 10.1089/dna.1991.10.423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8262386

Title: The human cathepsin D-encoding gene is transcribed from an estrogen-regulated and a constitutive start point.

PubMed ID: 8262386

DOI: 10.1016/0378-1119(93)90107-e

PubMed ID: 7935485

Title: Characterization of the proximal estrogen-responsive element of human cathepsin D gene.

PubMed ID: 7935485

DOI: 10.1210/mend.8.6.7935485

PubMed ID: 1426530

Title: Proteolytic processing sites producing the mature form of human cathepsin D.

PubMed ID: 1426530

DOI: 10.1016/0020-711x(92)90076-d

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16670177

Title: Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.

PubMed ID: 16670177

DOI: 10.1093/brain/awl107

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20551380

Title: Proteomics characterization of extracellular space components in the human aorta.

PubMed ID: 20551380

DOI: 10.1074/mcp.m110.001693

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27333034

Title: ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.

PubMed ID: 27333034

DOI: 10.1016/j.ebiom.2016.06.002

PubMed ID: 8467789

Title: Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.

PubMed ID: 8467789

DOI: 10.1002/j.1460-2075.1993.tb05774.x

PubMed ID: 8393577

Title: Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

PubMed ID: 8393577

DOI: 10.1073/pnas.90.14.6796

PubMed ID: 10716266

Title: A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.

PubMed ID: 10716266

DOI: 10.1002/1531-8249(200003)47:3<399::aid-ana22>3.3.co;2-x

PubMed ID: 16685649

Title: Cathepsin D deficiency is associated with a human neurodegenerative disorder.

PubMed ID: 16685649

DOI: 10.1086/504159

PubMed ID: 21990111

Title: Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses.

PubMed ID: 21990111

DOI: 10.1002/humu.21624

Sequence Information:

Length: 412
Mass: 44552
Checksum: 903FB8412E0CF0B0
Sequence:

MQPSSLLPLA LCLLAAPASA LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG PVSKYSQAVP 
AVTEGPIPEV LKNYMDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWIH 
HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC QSASSASALG GVKVERQVFG 
EATKQPGITF IAAKFDGILG MAYPRISVNN VLPVFDNLMQ QKLVDQNIFS FYLSRDPDAQ 
PGGELMLGGT DSKYYKGSLS YLNVTRKAYW QVHLDQVEVA SGLTLCKEGC EAIVDTGTSL 
MVGPVDEVRE LQKAIGAVPL IQGEYMIPCE KVSTLPAITL KLGGKGYKLS PEDYTLKVSQ 
AGKTLCLSGF MGMDIPPPSG PLWILGDVFI GRYYTVFDRD NNRVGFAEAA RL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTSD

Associated with

Other Information

Cloning and sequence analysis of cDNA for human cathepsin D. PubMed ID: 3927292

Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells. PubMed ID: 3588310

Molecular organization of the human cathepsin D gene. PubMed ID: 2069717

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human cathepsin D-encoding gene is transcribed from an estrogen-regulated and a constitutive start point. PubMed ID: 8262386

Characterization of the proximal estrogen-responsive element of human cathepsin D gene. PubMed ID: 7935485

Proteolytic processing sites producing the mature form of human cathepsin D. PubMed ID: 1426530

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. PubMed ID: 12643545

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis. PubMed ID: 16670177

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Proteomics characterization of extracellular space components in the human aorta. PubMed ID: 20551380

Initial characterization of the human central proteome. PubMed ID: 21269460

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease. PubMed ID: 27333034

Two crystal structures for cathepsin D: the lysosomal targeting signal and active site. PubMed ID: 8467789

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design. PubMed ID: 8393577

A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease. PubMed ID: 10716266

Cathepsin D deficiency is associated with a human neurodegenerative disorder. PubMed ID: 16685649

Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses. PubMed ID: 21990111