Details for: ADRA2B

Gene ID: 151

Symbol: ADRA2B

Ensembl ID: ENSG00000274286

Description: adrenoceptor alpha 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.9640
    Cell Significance Index: 7.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.6751
    Cell Significance Index: 41.3900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.5769
    Cell Significance Index: 4.9900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5500
    Cell Significance Index: 4.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.4753
    Cell Significance Index: -1.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3964
    Cell Significance Index: 39.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3640
    Cell Significance Index: 18.9100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.2562
    Cell Significance Index: 0.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2023
    Cell Significance Index: 38.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1797
    Cell Significance Index: 29.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1743
    Cell Significance Index: 18.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1511
    Cell Significance Index: 136.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1499
    Cell Significance Index: 9.0000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1306
    Cell Significance Index: 1.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0994
    Cell Significance Index: 2.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0885
    Cell Significance Index: 4.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0713
    Cell Significance Index: 1.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0712
    Cell Significance Index: 1.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0639
    Cell Significance Index: 4.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0628
    Cell Significance Index: 1.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0446
    Cell Significance Index: 6.4800
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.0427
    Cell Significance Index: 0.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0257
    Cell Significance Index: 4.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0239
    Cell Significance Index: 2.7900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0217
    Cell Significance Index: 0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0157
    Cell Significance Index: 0.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0136
    Cell Significance Index: 0.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0117
    Cell Significance Index: 0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0111
    Cell Significance Index: 0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0105
    Cell Significance Index: 1.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0102
    Cell Significance Index: 4.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0010
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0014
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0029
    Cell Significance Index: -2.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0036
    Cell Significance Index: -2.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0039
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0058
    Cell Significance Index: -2.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0061
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0061
    Cell Significance Index: -1.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0074
    Cell Significance Index: -1.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0082
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0090
    Cell Significance Index: -1.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0095
    Cell Significance Index: -1.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0101
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0108
    Cell Significance Index: -1.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0127
    Cell Significance Index: -1.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0185
    Cell Significance Index: -1.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0202
    Cell Significance Index: -2.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0211
    Cell Significance Index: -0.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0216
    Cell Significance Index: -2.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0219
    Cell Significance Index: -1.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0243
    Cell Significance Index: -1.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0261
    Cell Significance Index: -2.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0266
    Cell Significance Index: -0.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0285
    Cell Significance Index: -0.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0299
    Cell Significance Index: -2.2300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0308
    Cell Significance Index: -0.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0310
    Cell Significance Index: -1.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0313
    Cell Significance Index: -1.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0333
    Cell Significance Index: -1.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0345
    Cell Significance Index: -0.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0345
    Cell Significance Index: -0.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0373
    Cell Significance Index: -1.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0407
    Cell Significance Index: -1.4200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0442
    Cell Significance Index: -0.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0475
    Cell Significance Index: -2.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0479
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0486
    Cell Significance Index: -1.2500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0528
    Cell Significance Index: -0.7600
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.0553
    Cell Significance Index: -0.6200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0556
    Cell Significance Index: -0.7500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0564
    Cell Significance Index: -0.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0623
    Cell Significance Index: -2.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0638
    Cell Significance Index: -1.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0640
    Cell Significance Index: -2.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0662
    Cell Significance Index: -1.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0663
    Cell Significance Index: -2.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0667
    Cell Significance Index: -1.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0670
    Cell Significance Index: -1.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0674
    Cell Significance Index: -1.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0682
    Cell Significance Index: -0.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0690
    Cell Significance Index: -1.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0692
    Cell Significance Index: -1.8200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0694
    Cell Significance Index: -0.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0710
    Cell Significance Index: -1.7700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0711
    Cell Significance Index: -0.8400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0724
    Cell Significance Index: -0.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0777
    Cell Significance Index: -1.5500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0786
    Cell Significance Index: -1.6000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0795
    Cell Significance Index: -1.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0817
    Cell Significance Index: -1.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0817
    Cell Significance Index: -2.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0822
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ADRA2B gene encodes for the alpha-2B adrenergic receptor, a G-protein coupled receptor (GPCR) that belongs to the class A/1 rhodopsin-like receptors. This receptor is characterized by its unique ligand-binding properties, specifically its ability to bind epinephrine and norepinephrine, leading to the activation of downstream signaling pathways. The ADRA2B receptor is predominantly expressed in various cell types, including mural cells, intestinal crypt stem cells, goblet cells, and cardiac endothelial cells. **Pathways and Functions:** The ADRA2B receptor is involved in several signaling pathways, including: 1. **Activation of protein kinase B activity:** The ADRA2B receptor activates protein kinase B (PKB), also known as Akt, which plays a crucial role in cell survival, proliferation, and metabolism. 2. **Adenylate cyclase-activating adrenergic receptor signaling pathway:** The ADRA2B receptor stimulates adenylate cyclase activity, leading to the production of cyclic AMP (cAMP), a key second messenger involved in various cellular processes. 3. **Adrenaline signalling through alpha-2 adrenergic receptor:** The ADRA2B receptor is a subtype of the alpha-2 adrenergic receptor, which is involved in the regulation of adrenaline release from adrenal glands. 4. **Negative regulation of epinephrine and norepinephrine secretion:** The ADRA2B receptor inhibits the release of epinephrine and norepinephrine from adrenal glands, thereby modulating the body's response to stress. The ADRA2B receptor also plays a role in various physiological processes, including: 1. **Hemostasis:** The ADRA2B receptor is involved in the regulation of platelet activation and aggregation, which is essential for maintaining blood clotting. 2. **Angiogenesis:** The ADRA2B receptor has been implicated in the regulation of angiogenesis, the process of new blood vessel formation. 3. **Cell-cell signaling:** The ADRA2B receptor is involved in cell-cell communication, influencing various cellular processes, including differentiation and proliferation. **Clinical Significance:** The ADRA2B gene has been associated with various diseases and disorders, including: 1. **Hypertension:** The ADRA2B receptor is involved in the regulation of blood pressure, and alterations in its expression or function have been linked to hypertension. 2. **Cardiovascular disease:** The ADRA2B receptor plays a role in the regulation of cardiac function, and its dysregulation has been implicated in cardiovascular disease. 3. **Reproductive disorders:** The ADRA2B receptor is involved in the regulation of uterine smooth muscle contraction, and its dysregulation has been linked to reproductive disorders, including infertility and miscarriage. 4. **Cancer:** The ADRA2B receptor has been implicated in the regulation of tumor growth and metastasis, and its dysregulation has been linked to various types of cancer. In conclusion, the ADRA2B gene plays a crucial role in various physiological processes, including immune regulation, cardiovascular function, and reproductive physiology. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of this gene in maintaining overall health and well-being. As an expert immunologist, it is essential to continue studying the ADRA2B gene to unravel its complexities and explore its potential therapeutic applications.

Genular Protein ID: 1059118239

Symbol: ADA2B_HUMAN

Name: Alpha-2B adrenergic receptor

UniProtKB Accession Codes:

P18089 A2RUS0 Q4TUH9 Q53RF2 Q9BZK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 81 DrugCentral 1 EMBL 12 EMDB 1 Ensembl 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2164221

Title: Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

PubMed ID: 2164221

DOI: 10.1073/pnas.87.13.5094

PubMed ID: 2172775

Title: Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.

PubMed ID: 2172775

PubMed ID: 11056163

Title: Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.

PubMed ID: 11056163

DOI: 10.1074/jbc.m008118200

PubMed ID: 15037199

Title: Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.

PubMed ID: 15037199

DOI: 10.1016/j.bcp.2003.09.029

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2173582

Title: In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.

PubMed ID: 2173582

DOI: 10.1016/0006-291x(90)90748-c

PubMed ID: 23105096

Title: Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi.

PubMed ID: 23105096

DOI: 10.1074/jbc.m112.410936

PubMed ID: 24114805

Title: The alpha2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy.

PubMed ID: 24114805

DOI: 10.1002/ana.24028

PubMed ID: 27901063

Title: Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.

PubMed ID: 27901063

DOI: 10.1038/srep37921

PubMed ID: 26811329

Title: GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.

PubMed ID: 26811329

DOI: 10.1128/mcb.00009-16

Sequence Information:

  • Length: 450
  • Mass: 49954
  • Checksum: 06E43857152A68ED
  • Sequence:
    • MDHQDPYSVQ ATAAIAAAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF LVSLAAADIL 
VATLIIPFSL ANELLGYWYF RRTWCEVYLA LDVLFCTSSI VHLCAISLDR YWAVSRALEY 
NSKRTPRRIK CIILTVWLIA AVISLPPLIY KGDQGPQPRG RPQCKLNQEA WYILASSIGS 
FFAPCLIMIL VYLRIYLIAK RSNRRGPRAK GGPGQGESKQ PRPDHGGALA SAKLPALASV 
ASAREVNGHS KSTGEKEEGE TPEDTGTRAL PPSWAALPNS GQGQKEGVCG ASPEDEAEEE 
EEEEEEEEEC EPQAVPVSPA SACSPPLQQP QGSRVLATLR GQVLLGRGVG AIGGQWWRRR 
AQLTREKRFT FVLAVVIGVF VLCWFPFFFS YSLGAICPKH CKVPHGLFQF FFWIGYCNSS 
LNPVIYTIFN QDFRRAFRRI LCRPWTQTAW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.