ADRA2B | ENSG00000274286 | NCBI 151

Details for: ADRA2B

Gene ID: 151

Symbol: ADRA2B

Ensembl ID: ENSG00000274286

Description: adrenoceptor alpha 2B

Associated with

Adrenaline signalling through alpha-2 adrenergic receptor
(R-HSA-392023)
Adrenoceptors
(R-HSA-390696)
Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (z) signalling events
(R-HSA-418597)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Hemostasis
(R-HSA-109582)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Activation of protein kinase b activity
(GO:0032148)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adrenergic receptor signaling pathway
(GO:0071875)
Alpha2-adrenergic receptor activity
(GO:0004938)
Angiogenesis
(GO:0001525)
Cell-cell signaling
(GO:0007267)
Cell surface
(GO:0009986)
Cytosol
(GO:0005829)
Epinephrine binding
(GO:0051379)
Female pregnancy
(GO:0007565)
G protein-coupled receptor signaling pathway
(GO:0007186)
Intracellular membrane-bounded organelle
(GO:0043231)
Mapk cascade
(GO:0000165)
Negative regulation of epinephrine secretion
(GO:0032811)
Negative regulation of norepinephrine secretion
(GO:0010700)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of uterine smooth muscle contraction
(GO:0070474)
Protein binding
(GO:0005515)
Receptor transactivation
(GO:0035624)
Regulation of vascular associated smooth muscle contraction
(GO:0003056)

Other Information

Proteins

Alpha-2B adrenergic receptor

Genular Protein ID: 1059118239

Symbol: ADA2B_HUMAN

Name: Alpha-2B adrenergic receptor

UniProtKB Accession Codes:

P18089 A2RUS0 Q4TUH9 Q53RF2 Q9BZK0

Database IDs:

Citations:

PubMed ID: 2164221

Title: Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

PubMed ID: 2164221

DOI: 10.1073/pnas.87.13.5094

PubMed ID: 2172775

Title: Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.

PubMed ID: 2172775

PubMed ID: 11056163

Title: Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.

PubMed ID: 11056163

DOI: 10.1074/jbc.m008118200

PubMed ID: 15037199

Title: Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.

PubMed ID: 15037199

DOI: 10.1016/j.bcp.2003.09.029

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2173582

Title: In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.

PubMed ID: 2173582

DOI: 10.1016/0006-291x(90)90748-c

PubMed ID: 23105096

Title: Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi.

PubMed ID: 23105096

DOI: 10.1074/jbc.m112.410936

PubMed ID: 24114805

Title: The alpha2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy.

PubMed ID: 24114805

DOI: 10.1002/ana.24028

PubMed ID: 27901063

Title: Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.

PubMed ID: 27901063

DOI: 10.1038/srep37921

PubMed ID: 26811329

Title: GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.

PubMed ID: 26811329

DOI: 10.1128/mcb.00009-16

Sequence Information:

Length: 450
Mass: 49954
Checksum: 06E43857152A68ED
Sequence:

MDHQDPYSVQ ATAAIAAAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF LVSLAAADIL 
VATLIIPFSL ANELLGYWYF RRTWCEVYLA LDVLFCTSSI VHLCAISLDR YWAVSRALEY 
NSKRTPRRIK CIILTVWLIA AVISLPPLIY KGDQGPQPRG RPQCKLNQEA WYILASSIGS 
FFAPCLIMIL VYLRIYLIAK RSNRRGPRAK GGPGQGESKQ PRPDHGGALA SAKLPALASV 
ASAREVNGHS KSTGEKEEGE TPEDTGTRAL PPSWAALPNS GQGQKEGVCG ASPEDEAEEE 
EEEEEEEEEC EPQAVPVSPA SACSPPLQQP QGSRVLATLR GQVLLGRGVG AIGGQWWRRR 
AQLTREKRFT FVLAVVIGVF VLCWFPFFFS YSLGAICPKH CKVPHGLFQF FFWIGYCNSS 
LNPVIYTIFN QDFRRAFRRI LCRPWTQTAW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADRA2B

Associated with

Other Information

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. PubMed ID: 2164221

Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor. PubMed ID: 2172775

Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. PubMed ID: 11056163

Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. PubMed ID: 15037199

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans. PubMed ID: 2173582

Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi. PubMed ID: 23105096

The alpha2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy. PubMed ID: 24114805

Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2. PubMed ID: 27901063

GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export. PubMed ID: 26811329