Details for: ADRA2B

Gene ID: 151

Symbol: ADRA2B

Ensembl ID: ENSG00000274286

Description: adrenoceptor alpha 2B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169785
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7677
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.09
    Marker Score: 795
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.09
    Marker Score: 2072
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.06
    Marker Score: 2193
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.03
    Marker Score: 1033
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 646
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14910
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 352
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1441
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2946.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.64
    Marker Score: 203.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.49
    Marker Score: 468
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.47
    Marker Score: 333
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.4
    Marker Score: 210
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.38
    Marker Score: 933
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 205
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.35
    Marker Score: 109
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.31
    Marker Score: 169
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.3
    Marker Score: 436
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 304
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.28
    Marker Score: 214.5
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.26
    Marker Score: 67
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.24
    Marker Score: 147
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.21
    Marker Score: 83
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.21
    Marker Score: 492
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.18
    Marker Score: 76
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.18
    Marker Score: 510
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.17
    Marker Score: 427
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.15
    Marker Score: 71
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.15
    Marker Score: 34
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 129
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 135
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.13
    Marker Score: 335
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 389
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.11
    Marker Score: 156
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.08
    Marker Score: 117
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 119
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.06
    Marker Score: 162
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 92
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 20

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Other Information

**Key characteristics:** - The ADRA2B gene is located on chromosome 15q21.1. - It is a single-exon gene encoding a protein of 214 amino acids. - It is a member of the adrenoceptor superfamily of G protein-coupled receptors. - It is expressed in high levels in the heart, kidney, and gut. **Pathways and functions:** - The ADRA2B gene is involved in the regulation of the sympathetic nervous system. - It is a key regulator of vasoconstriction and vasodilation. - In the heart, it is involved in the regulation of cardiac output, heart rate, and blood pressure. - In the gut, it is involved in the regulation of mucosal blood flow, gastric secretions, and intestinal permeability. - In the immune system, it is involved in the regulation of inflammation and platelet aggregation. **Clinical significance:** - Mutations in the ADRA2B gene have been linked to a number of human diseases, including hypertension, heart failure, stroke, and cancer. - Adrenoceptor agonists, which increase the activity of the ADRA2B receptor, have been used as therapeutic agents in the treatment of these diseases. - Adra2b inhibitors, which decrease the activity of the ADRA2B receptor, have been used as therapeutic agents to treat hypertension and other cardiovascular diseases.

Genular Protein ID: 1059118239

Symbol: ADA2B_HUMAN

Name: Alpha-2B adrenergic receptor

UniProtKB Accession Codes:

P18089 A2RUS0 Q4TUH9 Q53RF2 Q9BZK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 80 DrugCentral 1 EMBL 12 EMDB 1 Ensembl 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2164221

Title: Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

PubMed ID: 2164221

DOI: 10.1073/pnas.87.13.5094

PubMed ID: 2172775

Title: Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.

PubMed ID: 2172775

PubMed ID: 11056163

Title: Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.

PubMed ID: 11056163

DOI: 10.1074/jbc.m008118200

PubMed ID: 15037199

Title: Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.

PubMed ID: 15037199

DOI: 10.1016/j.bcp.2003.09.029

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2173582

Title: In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.

PubMed ID: 2173582

DOI: 10.1016/0006-291x(90)90748-c

PubMed ID: 23105096

Title: Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi.

PubMed ID: 23105096

DOI: 10.1074/jbc.m112.410936

PubMed ID: 24114805

Title: The alpha2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy.

PubMed ID: 24114805

DOI: 10.1002/ana.24028

PubMed ID: 27901063

Title: Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.

PubMed ID: 27901063

DOI: 10.1038/srep37921

PubMed ID: 26811329

Title: GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.

PubMed ID: 26811329

DOI: 10.1128/mcb.00009-16

Sequence Information:

  • Length: 450
  • Mass: 49954
  • Checksum: 06E43857152A68ED
  • Sequence:
    • MDHQDPYSVQ ATAAIAAAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF LVSLAAADIL 
VATLIIPFSL ANELLGYWYF RRTWCEVYLA LDVLFCTSSI VHLCAISLDR YWAVSRALEY 
NSKRTPRRIK CIILTVWLIA AVISLPPLIY KGDQGPQPRG RPQCKLNQEA WYILASSIGS 
FFAPCLIMIL VYLRIYLIAK RSNRRGPRAK GGPGQGESKQ PRPDHGGALA SAKLPALASV 
ASAREVNGHS KSTGEKEEGE TPEDTGTRAL PPSWAALPNS GQGQKEGVCG ASPEDEAEEE 
EEEEEEEEEC EPQAVPVSPA SACSPPLQQP QGSRVLATLR GQVLLGRGVG AIGGQWWRRR 
AQLTREKRFT FVLAVVIGVF VLCWFPFFFS YSLGAICPKH CKVPHGLFQF FFWIGYCNSS 
LNPVIYTIFN QDFRRAFRRI LCRPWTQTAW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.