Details for: CTSE

Gene ID: 1510

Symbol: CTSE

Ensembl ID: ENSG00000196188

Description: cathepsin E

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.15
    Marker Score: 26466
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.17
    Marker Score: 7202
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.38
    Marker Score: 2397
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.65
    Marker Score: 409
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.52
    Marker Score: 638
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.43
    Marker Score: 1726
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.4
    Marker Score: 426
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.33
    Marker Score: 995
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.24
    Marker Score: 6506
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.02
    Marker Score: 687.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.98
    Marker Score: 2020
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.91
    Marker Score: 1853
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9
    Marker Score: 259
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.89
    Marker Score: 1423
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 636
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.82
    Marker Score: 3915
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3135.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.71
    Marker Score: 246
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.66
    Marker Score: 636
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.66
    Marker Score: 294
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.62
    Marker Score: 4059
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.62
    Marker Score: 911
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 385.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.58
    Marker Score: 1385
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.58
    Marker Score: 284.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.57
    Marker Score: 7675
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 169
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.52
    Marker Score: 3439
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.5
    Marker Score: 131
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.47
    Marker Score: 404
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.47
    Marker Score: 134
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.45
    Marker Score: 234
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.43
    Marker Score: 215
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 111
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.41
    Marker Score: 257
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 749
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.38
    Marker Score: 260
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.36
    Marker Score: 375
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.36
    Marker Score: 622
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.36
    Marker Score: 224
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.33
    Marker Score: 91
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4792
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.31
    Marker Score: 169
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.29
    Marker Score: 127
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 192.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.27
    Marker Score: 99
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.26
    Marker Score: 275.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.25
    Marker Score: 153
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.25
    Marker Score: 248
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.23
    Marker Score: 231
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.21
    Marker Score: 492
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.21
    Marker Score: 50
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 69.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2
    Marker Score: 77
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2
    Marker Score: 191
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.19
    Marker Score: 200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.19
    Marker Score: 299
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.18
    Marker Score: 174
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 164
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.17
    Marker Score: 121
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.16
    Marker Score: 166
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.16
    Marker Score: 256
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.16
    Marker Score: 242
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.15
    Marker Score: 32
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.15
    Marker Score: 77
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 140
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.14
    Marker Score: 267
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.14
    Marker Score: 71
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.14
    Marker Score: 100
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 149
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.13
    Marker Score: 155
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.13
    Marker Score: 211

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Other Information

**Key characteristics:** - Cathepsin E is a transmembrane protein with a molecular weight of approximately 65 kDa. - It is expressed in high levels in cells of the immune system, including foveolar cells of the stomach, mucous neck cells, blood vessel endothelial cells, and epithelial cells of the small intestine. - It is a key enzyme in the activation of the adaptive immune system. **Pathways and functions:** - Cathepsin E is involved in the activation of the adaptive immune system by processing and presenting peptide antigens derived from extracellular bacteria and viruses. - It is a key enzyme in the maturation of MHC class II molecules, which are required for the recognition of foreign antigens. - It also plays a role in the processing of other substrates, including proteins and lipids. **Clinical significance:** - Cathepsin E is a potential therapeutic target for a variety of diseases, including cancer, autoimmune disorders, and infectious diseases. - It has been shown to be a potent activator of the immune system, and its inhibition can lead to the regression of cancer cells. - Cathepsin E is also a potential therapeutic target for autoimmune disorders, such as Crohn's disease and rheumatoid arthritis.

Genular Protein ID: 2807301519

Symbol: CATE_HUMAN

Name: Cathepsin E

UniProtKB Accession Codes:

P14091 Q5TZ01 Q5TZ02 Q9NY58 Q9UCE3 Q9UCE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 16 Ensembl 2 EvolutionaryTrace 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2674141

Title: Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases.

PubMed ID: 2674141

DOI: 10.1016/s0021-9258(19)84768-3

PubMed ID: 1370478

Title: Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32.

PubMed ID: 1370478

DOI: 10.1016/s0021-9258(18)45989-3

PubMed ID: 7983070

Title: Subcellular localization and targeting of cathepsin E.

PubMed ID: 7983070

DOI: 10.1016/s0021-9258(18)47417-0

PubMed ID: 12531480

Title: An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells.

PubMed ID: 12531480

DOI: 10.1016/s0167-4781(02)00595-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8346912

Title: Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes.

PubMed ID: 8346912

DOI: 10.1006/abbi.1993.1361

PubMed ID: 2334440

Title: Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E.

PubMed ID: 2334440

DOI: 10.1016/0006-291x(90)92403-m

PubMed ID: 7789521

Title: Monomeric human cathepsin E.

PubMed ID: 7789521

DOI: 10.1016/0014-5793(95)00501-y

PubMed ID: 8765029

Title: Regulation of cathepsin E expression during human B cell differentiation in vitro.

PubMed ID: 8765029

DOI: 10.1002/eji.1830260826

PubMed ID: 11322887

Title: Regulation of human and mouse procathepsin E gene expression.

PubMed ID: 11322887

DOI: 10.1046/j.1432-1327.2001.02159.x

Sequence Information:

  • Length: 396
  • Mass: 42794
  • Checksum: 40B643C5FB01521E
  • Sequence:
    • MKTLLLLLLV LLELGEAQGS LHRVPLRRHP SLKKKLRARS QLSEFWKSHN LDMIQFTESC 
SMDQSAKEPL INYLDMEYFG TISIGSPPQN FTVIFDTGSS NLWVPSVYCT SPACKTHSRF 
QPSQSSTYSQ PGQSFSIQYG TGSLSGIIGA DQVSVEGLTV VGQQFGESVT EPGQTFVDAE 
FDGILGLGYP SLAVGGVTPV FDNMMAQNLV DLPMFSVYMS SNPEGGAGSE LIFGGYDHSH 
FSGSLNWVPV TKQAYWQIAL DNIQVGGTVM FCSEGCQAIV DTGTSLITGP SDKIKQLQNA 
IGAAPVDGEY AVECANLNVM PDVTFTINGV PYTLSPTAYT LLDFVDGMQF CSSGFQGLDI 
HPPAGPLWIL GDVFIRQFYS VFDRGNNRVG LAPAVP

Genular Protein ID: 3631343282

Symbol: B4DNU8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNU8

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EC 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 4 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 288
  • Mass: 30854
  • Checksum: DE4BC6CB3FB1B942
  • Sequence:
    • MEYFGTISIG SPPQNFTVIF DTGSSNLWVP SVYCTSPACK THSRFQPSQS STYSQPGQSF 
SIQYGTGSLS GIIGADQVSV EGLTVVGQQF GESVTEPGQT FVDAEFDGIL GLGYPSLAVG 
GVTPVFDNMM AQNLVDLPMF SVYMSSNPEG GAGSELIFGG YDHSHFSGSL NWVPVTKQAY 
WQIALDNMLW SVPTLTSCRM SPSPLTESPI PSAQLPTPYW TSWMECSSAA VAFKDLTSTL 
QLGPSGSWGM SSFDSFTQSL TVGITVWDWP QQSPKEGPCV CACLSDRP

Genular Protein ID: 4056755029

Symbol: A0A7P0MPN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7P0MPN9

Database IDs:

ARBA 11 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EC 1 EMBL 2 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 OMA 1 PANTHER 2 PIRSR 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 401
  • Mass: 43390
  • Checksum: 8CC2BA373271F5D2
  • Sequence:
    • MKTLLLLLLV LLELGEAQGS LHRVPLRRHP SLKKKLRARS QLSEFWKSHN LDMIQFTESC 
SMDQSAKEPL INYLDMEYFG TISIGSPPQN FTVIFDTGSS NLWVPSVYCT SPACKTHSRF 
QPSQSSTYSQ PGQSFSIQYG TGSLSGIIGA DQVSAFSYQV EGLTVVGQQF GESVTEPGQT 
FVDAEFDGIL GLGYPSLAVG GVTPVFDNMM AQNLVDLPMF SVYMSSNPEG GAGSELIFGG 
YDHSHFSGSL NWVPVTKQAY WQIALDNIQV GGTVMFCSEG CQAIVDTGTS LITGPSDKIK 
QLQNAIGAAP VDGEYAVECA NLNVMPDVTF TINGVPYTLS PTAYTLLDFV DGMQFCSSGF 
QGLDIHPPAG PLWILGDVFI RQFYSVFDRG NNRVGLAPAV P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.