Genular: Defining Cellular Identity and Function

Details for: Hadh

Gene ID: 15107

Symbol: Hadh

Ensembl ID: ENSMUSG00000027984

Description: hydroxyacyl-Coenzyme A dehydrogenase

Associated with

Beta oxidation of butanoyl-coa to acetyl-coa
(R-MMU-77352)
Beta oxidation of decanoyl-coa to octanoyl-coa-coa
(R-MMU-77346)
Beta oxidation of hexanoyl-coa to butanoyl-coa
(R-MMU-77350)
Beta oxidation of lauroyl-coa to decanoyl-coa-coa
(R-MMU-77310)
Beta oxidation of octanoyl-coa to hexanoyl-coa
(R-MMU-77348)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Mitochondrial fatty acid beta-oxidation
(R-MMU-77289)
Mitochondrial fatty acid beta-oxidation of saturated fatty acids
(R-MMU-77286)
Mitochondrial protein degradation
(R-MMU-9837999)
3-hydroxyacyl-coa dehydrogenase activity
(GO:0003857)
Cytoplasm
(GO:0005737)
Fatty acid beta-oxidation
(GO:0006635)
Fatty acid metabolic process
(GO:0006631)
Identical protein binding
(GO:0042802)
Lipid metabolic process
(GO:0006629)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Nad+ binding
(GO:0070403)
Negative regulation of insulin secretion
(GO:0046676)
Nucleoplasm
(GO:0005654)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
(GO:0016616)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Protein binding
(GO:0005515)
Regulation of insulin secretion
(GO:0050796)
Response to activity
(GO:0014823)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Genular Protein ID: 4156091733

Symbol: HCDH_MOUSE

Name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

UniProtKB Accession Codes:

Q61425 Q3TF75 Q3THK8 Q3UFI0 Q8K149 Q925U9

Database IDs:

Citations:

PubMed ID: 7642117

Title: Isolation of a cDNA clone encoding mouse 3-hydroxyacyl CoA dehydrogenase.

PubMed ID: 7642117

DOI: 10.1016/0378-1119(95)00205-k

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20670938

Title: Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.

PubMed ID: 20670938

DOI: 10.1074/jbc.m110.123638

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 314
Mass: 34464
Checksum: 366A4C075F708BC1
Sequence:

MAFVTRQFLR SMSSSSSASA AAKKILIKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE 
DILAKSKKGI EESLKRMAKK KFTENPKAGD EFVEKTLSCL STSTDAASVV HSTDLVVEAI 
VENLKLKNEL FQRLDKFAAE HTIFASNTSS LQITNIANAT TRQDRFAGLH FFNPVPMMKL 
VEVIKTPMTS QKTFESLVDF CKTLGKHPVS CKDTPGFIVN RLLVPYLIEA VRLHERGDAS 
KEDIDTAMKL GAGYPMGPFE LLDYVGLDTT KFILDGWHEM EPENPLFQPS PSMNNLVAQK 
KLGKKTGEGF YKYK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hadh

Associated with

Other Information

Isolation of a cDNA clone encoding mouse 3-hydroxyacyl CoA dehydrogenase. PubMed ID: 7642117

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. PubMed ID: 20670938

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753