CTSG | ENSG00000100448 | NCBI 1511

Details for: CTSG

Gene ID: 1511

Symbol: CTSG

Ensembl ID: ENSG00000100448

Description: cathepsin G

Associated with

Activation of matrix metalloproteinases
(R-HSA-1592389)
Antimicrobial peptides
(R-HSA-6803157)
Bacterial infection pathways
(R-HSA-9824439)
Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of the extracellular matrix
(R-HSA-1474228)
Disease
(R-HSA-1643685)
Extracellular matrix organization
(R-HSA-1474244)
Immune system
(R-HSA-168256)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 processing
(R-HSA-448706)
Leishmania infection
(R-HSA-9658195)
Metabolism of angiotensinogen to angiotensins
(R-HSA-2022377)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Parasitic infection pathways
(R-HSA-9824443)
Peptide hormone metabolism
(R-HSA-2980736)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Response of mtb to phagocytosis
(R-HSA-9637690)
Signaling by interleukins
(R-HSA-449147)
Suppression of apoptosis
(R-HSA-9635465)
Angiotensin maturation
(GO:0002003)
Antibacterial humoral response
(GO:0019731)
Azurophil granule lumen
(GO:0035578)
Biofilm matrix disassembly
(GO:0098786)
Caspase binding
(GO:0089720)
Cellular response to lipopolysaccharide
(GO:0071222)
Collagen-containing extracellular matrix
(GO:0062023)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Defense response to fungus
(GO:0050832)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular exosome
(GO:0070062)
Extracellular matrix disassembly
(GO:0022617)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Heparin binding
(GO:0008201)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Monocyte chemotaxis
(GO:0002548)
Negative regulation of t cell activation
(GO:0050868)
Neutrophil-mediated killing of gram-positive bacterium
(GO:0070946)
Neutrophil activation
(GO:0042119)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of immune response
(GO:0050778)
Positive regulation of platelet aggregation
(GO:1901731)
Protein binding
(GO:0005515)
Protein metabolic process
(GO:0019538)
Protein phosphorylation
(GO:0006468)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Purinergic nucleotide receptor signaling pathway
(GO:0035590)
Receptor ligand activity
(GO:0048018)
Secretory granule
(GO:0030141)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)

Other Information

Proteins

Cathepsin G

Genular Protein ID: 3261836550

Symbol: CATG_HUMAN

Name: Cathepsin G

UniProtKB Accession Codes:

P08311 Q6IBJ6 Q9UCA5 Q9UCU6

Database IDs:

Citations:

PubMed ID: 3304423

Title: Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases.

PubMed ID: 3304423

DOI: 10.1021/bi00382a032

PubMed ID: 2569462

Title: Genomic organization and chromosomal localization of the human cathepsin G gene.

PubMed ID: 2569462

DOI: 10.1016/s0021-9258(18)80012-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8194606

Title: Identification of the U-937 membrane-associated proteinase interacting with the V3 loop of HIV-1 gp120 as cathepsin G.

PubMed ID: 8194606

DOI: 10.1016/0014-5793(94)00410-2

PubMed ID: 3799965

Title: Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil cathepsin G from normal donors.

PubMed ID: 3799965

DOI: 10.1016/0003-2697(86)90612-3

PubMed ID: 2501794

Title: Antibiotic proteins of human polymorphonuclear leukocytes.

PubMed ID: 2501794

DOI: 10.1073/pnas.86.14.5610

PubMed ID: 1861080

Title: Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G.

PubMed ID: 1861080

PubMed ID: 7897245

Title: Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis.

PubMed ID: 7897245

DOI: 10.1016/0022-1759(94)00295-8

PubMed ID: 26274980

Title: Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G.

PubMed ID: 26274980

DOI: 10.3390/biom5031832

PubMed ID: 3390156

Title: Cathepsin G is a strong platelet agonist released by neutrophils.

PubMed ID: 3390156

DOI: 10.1042/bj2510293

PubMed ID: 2383548

Title: An unusual specificity in the activation of neutrophil serine proteinase zymogens.

PubMed ID: 2383548

DOI: 10.1021/bi00474a013

PubMed ID: 2116408

Title: Identification of the primary antimicrobial domains in human neutrophil cathepsin G.

PubMed ID: 2116408

DOI: 10.1016/s0021-9258(18)77388-2

PubMed ID: 2117044

Title: Listericidal activity of human neutrophil cathepsin G.

PubMed ID: 2117044

DOI: 10.1099/00221287-136-6-997

PubMed ID: 2126324

Title: Molecular mechanism for the antigonococcal action of lysosomal cathepsin G.

PubMed ID: 2126324

DOI: 10.1111/j.1365-2958.1990.tb00706.x

PubMed ID: 1937776

Title: Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa.

PubMed ID: 1937776

DOI: 10.1128/iai.59.11.4193-4200.1991

PubMed ID: 7842483

Title: Stimulation of human lymphocytes by cathepsin G.

PubMed ID: 7842483

DOI: 10.1016/0008-8749(95)80005-4

PubMed ID: 7744748

Title: Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.

PubMed ID: 7744748

DOI: 10.1074/jbc.270.19.11168

PubMed ID: 7499346

Title: Human cathepsin G lacking functional glycosylation site is proteolytically processed and targeted for storage in granules after transfection to the rat basophilic/mast cell line RBL or the murine myeloid cell line 32D.

PubMed ID: 7499346

DOI: 10.1074/jbc.270.47.28413

PubMed ID: 8920993

Title: Activation of Mac-1 (CD11b/CD18)-bound factor X by released cathepsin G defines an alternative pathway of leucocyte initiation of coagulation.

PubMed ID: 8920993

DOI: 10.1042/bj3190873

PubMed ID: 9000539

Title: Cathepsin G binds to human lymphocytes.

PubMed ID: 9000539

DOI: 10.1002/jlb.61.1.73

PubMed ID: 9536127

Title: Cathepsin G enhances human natural killer cytotoxicity.

PubMed ID: 9536127

DOI: 10.1046/j.1365-2567.1998.00397.x

PubMed ID: 10702240

Title: Cathepsin G activates protease-activated receptor-4 in human platelets.

PubMed ID: 10702240

DOI: 10.1074/jbc.275.10.6819

PubMed ID: 11259672

Title: The human brm protein is cleaved during apoptosis: the role of cathepsin G.

PubMed ID: 11259672

DOI: 10.1073/pnas.071057398

PubMed ID: 15385470

Title: The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.

PubMed ID: 15385470

DOI: 10.1128/iai.72.10.5712-5721.2004

PubMed ID: 15210802

Title: Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor.

PubMed ID: 15210802

DOI: 10.4049/jimmunol.173.1.428

PubMed ID: 15100291

Title: Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes.

PubMed ID: 15100291

DOI: 10.4049/jimmunol.172.9.5495

PubMed ID: 16963625

Title: N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant.

PubMed ID: 16963625

DOI: 10.1189/jlb.0406290

PubMed ID: 18586676

Title: The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase.

PubMed ID: 18586676

DOI: 10.1074/jbc.m710286200

PubMed ID: 18217133

Title: Cathepsin G, a leukocyte protease, activates coagulation factor VIII.

PubMed ID: 18217133

DOI: 10.1160/th07-08-0495

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22275911

Title: Inhibition of the plasma-membrane-associated serine protease cathepsin G by Mycobacterium tuberculosis Rv3364c suppresses caspase-1 and pyroptosis in macrophages.

PubMed ID: 22275911

DOI: 10.3389/fmicb.2011.00281

PubMed ID: 22879591

Title: Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.

PubMed ID: 22879591

DOI: 10.1074/jbc.m112.394452

PubMed ID: 22307629

Title: IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G.

PubMed ID: 22307629

DOI: 10.1073/pnas.1115884109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29077095

Title: Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.

PubMed ID: 29077095

DOI: 10.1038/cdd.2017.167

PubMed ID: 29652924

Title: Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities.

PubMed ID: 29652924

DOI: 10.1371/journal.pone.0195077

PubMed ID: 30804664

Title: Cathepsin G cleaves and activates IL-36gamma and promotes the inflammation of psoriasis.

PubMed ID: 30804664

DOI: 10.2147/dddt.s194765

PubMed ID: 32144329

Title: Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin.

PubMed ID: 32144329

DOI: 10.1038/s41598-020-61161-5

PubMed ID: 33589665

Title:

PubMed ID: 33589665

DOI: 10.1038/s41598-020-77619-5

PubMed ID: 32995850

Title: Cathepsin G Degrades Staphylococcus aureus Biofilms.

PubMed ID: 32995850

DOI: 10.1093/infdis/jiaa612

PubMed ID: 8896442

Title: The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities.

PubMed ID: 8896442

DOI: 10.1002/j.1460-2075.1996.tb00933.x

PubMed ID: 11942800

Title: Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design.

PubMed ID: 11942800

DOI: 10.1021/ja017506h

PubMed ID: 15741158

Title: A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.

PubMed ID: 15741158

DOI: 10.1074/jbc.m501302200

PubMed ID: 32303641

Title: Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases.

PubMed ID: 32303641

DOI: 10.1074/jbc.ra120.013601

PubMed ID: 8454293

Title: Sequence variant of the human cathepsin G gene.

PubMed ID: 8454293

DOI: 10.1007/bf00230230

Sequence Information:

Length: 255
Mass: 28837
Checksum: 6228E741E6A43889
Sequence:

MQPLLLLLAF LLPTGAEAGE IIGGRESRPH SRPYMAYLQI QSPAGQSRCG GFLVREDFVL 
TAAHCWGSNI NVTLGAHNIQ RRENTQQHIT ARRAIRHPQY NQRTIQNDIM LLQLSRRVRR 
NRNVNPVALP RAQEGLRPGT LCTVAGWGRV SMRRGTDTLR EVQLRVQRDR QCLRIFGSYD 
PRRQICVGDR RERKAAFKGD SGGPLLCNNV AHGIVSYGKS SGVPPEVFTR VSSFLPWIRT 
TMRSFKLLDQ METPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTSG

Associated with

Other Information

Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. PubMed ID: 3304423

Genomic organization and chromosomal localization of the human cathepsin G gene. PubMed ID: 2569462

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the U-937 membrane-associated proteinase interacting with the V3 loop of HIV-1 gp120 as cathepsin G. PubMed ID: 8194606

Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil cathepsin G from normal donors. PubMed ID: 3799965

Antibiotic proteins of human polymorphonuclear leukocytes. PubMed ID: 2501794

Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G. PubMed ID: 1861080

Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis. PubMed ID: 7897245

Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G. PubMed ID: 26274980

Cathepsin G is a strong platelet agonist released by neutrophils. PubMed ID: 3390156

An unusual specificity in the activation of neutrophil serine proteinase zymogens. PubMed ID: 2383548

Identification of the primary antimicrobial domains in human neutrophil cathepsin G. PubMed ID: 2116408

Listericidal activity of human neutrophil cathepsin G. PubMed ID: 2117044

Molecular mechanism for the antigonococcal action of lysosomal cathepsin G. PubMed ID: 2126324

Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. PubMed ID: 1937776

Stimulation of human lymphocytes by cathepsin G. PubMed ID: 7842483

Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G. PubMed ID: 7744748

Human cathepsin G lacking functional glycosylation site is proteolytically processed and targeted for storage in granules after transfection to the rat basophilic/mast cell line RBL or the murine myeloid cell line 32D. PubMed ID: 7499346

Activation of Mac-1 (CD11b/CD18)-bound factor X by released cathepsin G defines an alternative pathway of leucocyte initiation of coagulation. PubMed ID: 8920993

Cathepsin G binds to human lymphocytes. PubMed ID: 9000539

Cathepsin G enhances human natural killer cytotoxicity. PubMed ID: 9536127

Cathepsin G activates protease-activated receptor-4 in human platelets. PubMed ID: 10702240

The human brm protein is cleaved during apoptosis: the role of cathepsin G. PubMed ID: 11259672

The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli. PubMed ID: 15385470

Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor. PubMed ID: 15210802

Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes. PubMed ID: 15100291

N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant. PubMed ID: 16963625

The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. PubMed ID: 18586676

Cathepsin G, a leukocyte protease, activates coagulation factor VIII. PubMed ID: 18217133

Initial characterization of the human central proteome. PubMed ID: 21269460

Inhibition of the plasma-membrane-associated serine protease cathepsin G by Mycobacterium tuberculosis Rv3364c suppresses caspase-1 and pyroptosis in macrophages. PubMed ID: 22275911

Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions. PubMed ID: 22879591

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. PubMed ID: 22307629

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. PubMed ID: 29077095

Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities. PubMed ID: 29652924

Cathepsin G cleaves and activates IL-36gamma and promotes the inflammation of psoriasis. PubMed ID: 30804664

Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin. PubMed ID: 32144329