Genular: Defining Cellular Identity and Function

Details for: Hand1

Gene ID: 15110

Symbol: Hand1

Ensembl ID: ENSMUSG00000037335

Description: heart and neural crest derivatives expressed 1

Associated with

Angiogenesis
(GO:0001525)
Bhlh transcription factor binding
(GO:0043425)
Cardiac left ventricle formation
(GO:0003218)
Cardiac right ventricle formation
(GO:0003219)
Cardiac septum morphogenesis
(GO:0060411)
Cartilage morphogenesis
(GO:0060536)
Cell differentiation
(GO:0030154)
Cell fate determination
(GO:0001709)
Cytoplasm
(GO:0005737)
Determination of heart left/right asymmetry
(GO:0061371)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Embryonic heart tube development
(GO:0035050)
Embryonic heart tube formation
(GO:0003144)
Enzyme binding
(GO:0019899)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Heart morphogenesis
(GO:0003007)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Mesenchyme development
(GO:0060485)
Mesoderm formation
(GO:0001707)
Multicellular organism development
(GO:0007275)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of rna polymerase ii regulatory region sequence-specific dna binding
(GO:1903026)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transcription factor binding
(GO:0008134)
Trophoblast giant cell differentiation
(GO:0060707)
Ventricular cardiac muscle tissue morphogenesis
(GO:0055010)

Other Information

Proteins

Heart- and neural crest derivatives-expressed protein 1

Genular Protein ID: 3279690443

Symbol: HAND1_MOUSE

Name: Heart- and neural crest derivatives-expressed protein 1

UniProtKB Accession Codes:

Q64279 Q61099

Database IDs:

Citations:

PubMed ID: 7791788

Title: Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system.

PubMed ID: 7791788

DOI: 10.1128/mcb.15.7.3813

PubMed ID: 7649392

Title: Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development.

PubMed ID: 7649392

DOI: 10.1006/dbio.1995.1245

PubMed ID: 7671815

Title: Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development.

PubMed ID: 7671815

DOI: 10.1242/dev.121.8.2513

PubMed ID: 9500551

Title: The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis.

PubMed ID: 9500551

DOI: 10.1038/ng0398-271

PubMed ID: 10924525

Title: The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.

PubMed ID: 10924525

DOI: 10.1074/jbc.m005888200

PubMed ID: 16759287

Title: Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta.

PubMed ID: 16759287

DOI: 10.1111/j.1432-0436.2006.00070.x

PubMed ID: 17891141

Title: Nucleolar release of Hand1 acts as a molecular switch to determine cell fate.

PubMed ID: 17891141

DOI: 10.1038/ncb1633

Sequence Information:

Length: 216
Mass: 23806
Checksum: 307B14BB835833F1
Sequence:

MNLVGSYAHH HHHHHSHPPH PMLHEPFLFG PASRCHQERP YFQSWLLSPA DAAPDFPAGG 
PPPTTAVAAA AYGPDARPSQ SPGRLEALGS RLPKRKGSGP KKERRRTESI NSAFAELREC 
IPNVPADTKL SKIKTLRLAT SYIAYLMDVL AKDAQAGDPE AFKAELKKTD GGRESKRKRE 
LPQQPESFPP ASGPGEKRIK GRTGWPQQVW ALELNQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hand1

Associated with

Other Information

Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. PubMed ID: 7791788

Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. PubMed ID: 7649392

Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. PubMed ID: 7671815

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. PubMed ID: 9500551

The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. PubMed ID: 10924525

Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta. PubMed ID: 16759287

Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. PubMed ID: 17891141