Details for: Hand2

Gene ID: 15111

Symbol: Hand2

Ensembl ID: ENSMUSG00000038193

Description: heart and neural crest derivatives expressed 2

Associated with

  • Adult heart development
    (GO:0007512)
  • Angiogenesis
    (GO:0001525)
  • Apoptotic process
    (GO:0006915)
  • Apoptotic process involved in heart morphogenesis
    (GO:0003278)
  • Cardiac muscle cell differentiation
    (GO:0055007)
  • Cardiac neural crest cell development involved in outflow tract morphogenesis
    (GO:0061309)
  • Cardiac neural crest cell migration involved in outflow tract morphogenesis
    (GO:0003253)
  • Cardiac right ventricle formation
    (GO:0003219)
  • Cardiac right ventricle morphogenesis
    (GO:0003215)
  • Cartilage morphogenesis
    (GO:0060536)
  • Cell differentiation
    (GO:0030154)
  • Cell proliferation involved in outflow tract morphogenesis
    (GO:0061325)
  • Chromatin
    (GO:0000785)
  • Coronary artery morphogenesis
    (GO:0060982)
  • Determination of heart left/right asymmetry
    (GO:0061371)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • E-box binding
    (GO:0070888)
  • Embryonic digit morphogenesis
    (GO:0042733)
  • Embryonic skeletal system development
    (GO:0048706)
  • Epithelial cell apoptotic process
    (GO:1904019)
  • Heart development
    (GO:0007507)
  • Heart looping
    (GO:0001947)
  • Heart morphogenesis
    (GO:0003007)
  • In utero embryonic development
    (GO:0001701)
  • Mesenchymal cell proliferation
    (GO:0010463)
  • Mesenchyme development
    (GO:0060485)
  • Minor groove of adenine-thymine-rich dna binding
    (GO:0003680)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna binding
    (GO:0043392)
  • Negative regulation of epithelial cell apoptotic process
    (GO:1904036)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Neural crest cell development
    (GO:0014032)
  • Norepinephrine biosynthetic process
    (GO:0042421)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Osteoblast differentiation
    (GO:0001649)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of p38mapk cascade
    (GO:1900745)
  • Positive regulation of semaphorin-plexin signaling pathway
    (GO:2001262)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription regulatory region dna binding
    (GO:2000679)
  • Primary palate development
    (GO:1903929)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of secondary heart field cardioblast proliferation
    (GO:0003266)
  • Regulation of tissue remodeling
    (GO:0034103)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Suckling behavior
    (GO:0001967)
  • Sympathetic nervous system development
    (GO:0048485)
  • Thymus development
    (GO:0048538)
  • Tongue development
    (GO:0043586)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription factor binding
    (GO:0008134)
  • Transcription regulator complex
    (GO:0005667)
  • Visceral serous pericardium development
    (GO:0061032)

Other Information

Genular Protein ID: 3191412407

Symbol: HAND2_MOUSE

Name: Heart- and neural crest derivatives-expressed protein 2

UniProtKB Accession Codes:

Q61039 Q61100

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 GO 68 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8533092

Title: A subclass of bHLH proteins required for cardiac morphogenesis.

PubMed ID: 8533092

DOI: 10.1126/science.270.5244.1995

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 7671815

Title: Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development.

PubMed ID: 7671815

DOI: 10.1242/dev.121.8.2513

PubMed ID: 9171826

Title: Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND.

PubMed ID: 9171826

DOI: 10.1038/ng0697-154

PubMed ID: 9671575

Title: A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme.

PubMed ID: 9671575

DOI: 10.1242/dev.125.16.3005

PubMed ID: 10924525

Title: The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.

PubMed ID: 10924525

DOI: 10.1074/jbc.m005888200

PubMed ID: 10804186

Title: The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.

PubMed ID: 10804186

DOI: 10.1242/dev.127.11.2461

PubMed ID: 10769237

Title: Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway.

PubMed ID: 10769237

DOI: 10.1242/dev.127.10.2133

Sequence Information:

  • Length: 217
  • Mass: 23666
  • Checksum: 528F541BB2173F1E
  • Sequence:
    • MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM 
ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLGGPRPVKR RGTANRKERR RTQSINSAFA 
ELRECIPNVP ADTKLSKIKT LRLATSYIAY LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK 
RKKELNEILK STVSSNDKKT KGRTGWPQHV WALELKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.