Details for: Hap1
Associated with
Other Information
Genular Protein ID: 2912399857
Symbol: HAP1_MOUSE
Name: Huntingtin-associated protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9599014
Title: HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntingtons disease transgenic mice.
PubMed ID: 9599014
PubMed ID: 9657855
Title: Gene structure and map location of the murine homolog of the Huntington-associated protein, Hap1.
PubMed ID: 9657855
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12890790
Title: Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease.
PubMed ID: 12890790
PubMed ID: 15379999
Title: HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons.
PubMed ID: 15379999
PubMed ID: 17868456
Title: HAP1 can sequester a subset of TBP in cytoplasmic inclusions via specific interaction with the conserved TBP(CORE).
PubMed ID: 17868456
PubMed ID: 18636121
Title: Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice.
PubMed ID: 18636121
DOI: 10.1172/jci35339
PubMed ID: 21985783
Title: Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
PubMed ID: 21985783
DOI: 10.1172/jci57552
PubMed ID: 23532844
Title: The Joubert syndrome-associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactions.
PubMed ID: 23532844
PubMed ID: 23658157
Title: Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.
PubMed ID: 23658157
PubMed ID: 24355921
Title: Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting.
PubMed ID: 24355921
DOI: 10.1172/jci69206
PubMed ID: 24453320
Title: The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
PubMed ID: 24453320
PubMed ID: 24366265
Title: Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells.
PubMed ID: 24366265
Sequence Information:
- Length: 628
- Mass: 70116
- Checksum: AF516F61D6AB7CCB
- Sequence:
MRPKEQVQSG AGDGTGSGDP AAGTPTTQPA VGPAPEPSAE PKPAPAQGTG SGQKSGSRTK TGSFCRSMII GDSDAPWTRY VFQGPYGPRA TGLGTGKAEG IWKTPAAYIG RRPGVSGPER AAFIRELQEA LCPNPPPTKK ITEDDVKVML YLLEEKERDL NTAARIGQSL VKQNSVLMEE NNKLETMLGS AREEILHLRK QVNLRDDLLQ LYSDSDDDDD EEDEEDEEEG EEEEREGQRD QDQQHDHPYG APKPHPKAET AHRCPQLETL QQKLRLLEEE NDHLREEASH LDNLEDEEQM LILECVEQFS EASQQMAELS EVLVLRLEGY ERQQKEITQL QAEITKLQQR CQSYGAQTEK LQQMLASEKG IHSESLRAGS YMQDYGSRPR DRQEDGKSHR QRSSMPAGSV THYGYSVPLD ALPSFPETLA EELRTSLRKF ITDPAYFMER RDTHCREGRK KEQRAMPPPP AQDLKPPEDF EAPEELVPEE ELGAIEEVGT AEDGQAEENE QASEETEAWE EVEPEVDETT RMNVVVSALE ASGLGPSHLD MKYVLQQLSN WQDAHSKRQQ KQKVVPKDSP TPQQQTNMGG GILEQQPRVP TQDSQRLEED RATHSPSARE EEGPSGAT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.