Genular: Defining Cellular Identity and Function

Details for: Has2

Gene ID: 15117

Symbol: Has2

Ensembl ID: ENSMUSG00000022367

Description: hyaluronan synthase 2

Associated with

Glycosaminoglycan metabolism
(R-MMU-1630316)
Hyaluronan biosynthesis and export
(R-MMU-2142850)
Hyaluronan metabolism
(R-MMU-2142845)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Atrioventricular canal development
(GO:0036302)
Bone morphogenesis
(GO:0060349)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Endocardial cushion to mesenchymal transition
(GO:0090500)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Extracellular matrix assembly
(GO:0085029)
Extracellular polysaccharide biosynthetic process
(GO:0045226)
Extracellular vesicle
(GO:1903561)
Glycosyltransferase activity
(GO:0016757)
Golgi apparatus
(GO:0005794)
Hyaluronan biosynthetic process
(GO:0030213)
Hyaluronan metabolic process
(GO:0030212)
Hyaluronan synthase activity
(GO:0050501)
Identical protein binding
(GO:0042802)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Plasma membrane raft
(GO:0044853)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of hyaluronan biosynthetic process
(GO:1900127)
Positive regulation of keratinocyte migration
(GO:0051549)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Positive regulation of monocyte aggregation
(GO:1900625)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Regulation of extracellular matrix assembly
(GO:1901201)
Transferase activity
(GO:0016740)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Hyaluronan synthase 2

Genular Protein ID: 1432169351

Symbol: HYAS2_MOUSE

Name: Hyaluronan synthase 2

UniProtKB Accession Codes:

P70312 P70411 Q62405 Q68EF7

Database IDs:

Citations:

PubMed ID: 8798545

Title: Molecular cloning and characterization of a putative mouse hyaluronan synthase.

PubMed ID: 8798545

DOI: 10.1074/jbc.271.38.23400

PubMed ID: 9016821

Title: Coding sequence of a hyaluronan synthase homologue expressed during expansion of the mouse cumulus-oocyte complex.

PubMed ID: 9016821

DOI: 10.1006/abbi.1996.9793

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8643441

Title: Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis.

PubMed ID: 8643441

DOI: 10.1073/pnas.93.10.4548

PubMed ID: 10455188

Title: Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.

PubMed ID: 10455188

DOI: 10.1074/jbc.274.35.25085

PubMed ID: 10930438

Title: Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme.

PubMed ID: 10930438

DOI: 10.1172/jci10272

Sequence Information:

Length: 552
Mass: 63510
Checksum: B840BABC6D2260D5
Sequence:

MHCERFLCVL RIIGTTLFGV SLLLGITAAY IVGYQFIQTD NYYFSFGLYG AFLASHLIIQ 
SLFAFLEHRK MKKSLETPIK LNKTVALCIA AYQEDPDYLR KCLQSVKRLT YPGIKVVMVI 
DGNSDDDLYM MDIFSEVMGR DKSATYIWKN NFHEKGPGET EESHKESSQH VTQLVLSNKS 
ICIMQKWGGK REVMYTAFRA LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPMVGGVGG 
DVQILNKYDS WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFVEDWY 
NQEFMGNQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PIEYLRWLNQ QTRWSKSYFR 
EWLYNAMWFH KHHLWMTYEA VITGFFPFFL IATVIQLFYR GKIWNILLFL LTVQLVGLIK 
SSFASCLRGN IVMVFMSLYS VLYMSSLLPA KMFAIATINK AGWGTSGRKT IVVNFIGLIP 
VSVWFTILLG GVIFTIYKES KKPFSESKQT VLIVGTLIYA CYWVMLLTLY VVLINKCGRR 
KKGQQYDMVL DV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Has2

Associated with

Other Information

Molecular cloning and characterization of a putative mouse hyaluronan synthase. PubMed ID: 8798545

Coding sequence of a hyaluronan synthase homologue expressed during expansion of the mouse cumulus-oocyte complex. PubMed ID: 9016821

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis. PubMed ID: 8643441

Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. PubMed ID: 10455188

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. PubMed ID: 10930438