Details for: CTSH

Gene ID: 1512

Symbol: CTSH

Ensembl ID: ENSG00000103811

Description: cathepsin H

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 198.6560
    Cell Significance Index: -30.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.8353
    Cell Significance Index: -31.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 91.5165
    Cell Significance Index: -37.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.9616
    Cell Significance Index: -34.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.7533
    Cell Significance Index: -32.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.2562
    Cell Significance Index: -35.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.9573
    Cell Significance Index: -34.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.0131
    Cell Significance Index: -30.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7256
    Cell Significance Index: -34.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9675
    Cell Significance Index: -31.4400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3061
    Cell Significance Index: -15.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.8387
    Cell Significance Index: 54.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.6276
    Cell Significance Index: 85.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.1452
    Cell Significance Index: 121.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.0863
    Cell Significance Index: 212.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.7677
    Cell Significance Index: 463.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.6378
    Cell Significance Index: 64.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.5412
    Cell Significance Index: 638.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.4066
    Cell Significance Index: 648.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0816
    Cell Significance Index: 83.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8723
    Cell Significance Index: 338.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1780
    Cell Significance Index: 101.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1165
    Cell Significance Index: 19.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9974
    Cell Significance Index: 119.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8571
    Cell Significance Index: 255.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5810
    Cell Significance Index: 257.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.4573
    Cell Significance Index: 1103.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9961
    Cell Significance Index: 543.9900
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.8144
    Cell Significance Index: 1.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7545
    Cell Significance Index: 39.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6854
    Cell Significance Index: 14.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6700
    Cell Significance Index: 15.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6615
    Cell Significance Index: 597.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6015
    Cell Significance Index: 44.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5100
    Cell Significance Index: 65.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4281
    Cell Significance Index: 29.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4278
    Cell Significance Index: 42.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3996
    Cell Significance Index: 79.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2778
    Cell Significance Index: 17.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2735
    Cell Significance Index: 7.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1644
    Cell Significance Index: 21.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1145
    Cell Significance Index: 19.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0956
    Cell Significance Index: 2.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0562
    Cell Significance Index: 5.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0501
    Cell Significance Index: 36.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0428
    Cell Significance Index: 80.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0312
    Cell Significance Index: 6.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0014
    Cell Significance Index: -0.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0032
    Cell Significance Index: -1.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0047
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0072
    Cell Significance Index: -13.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0102
    Cell Significance Index: -15.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0148
    Cell Significance Index: -0.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0198
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0217
    Cell Significance Index: -13.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0412
    Cell Significance Index: -26.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0426
    Cell Significance Index: -24.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0549
    Cell Significance Index: -6.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0595
    Cell Significance Index: -1.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0609
    Cell Significance Index: -1.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0678
    Cell Significance Index: -30.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0840
    Cell Significance Index: -24.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1015
    Cell Significance Index: -4.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1083
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1144
    Cell Significance Index: -24.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1429
    Cell Significance Index: -1.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1507
    Cell Significance Index: -17.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1518
    Cell Significance Index: -22.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1859
    Cell Significance Index: -21.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2221
    Cell Significance Index: -4.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2852
    Cell Significance Index: -29.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2970
    Cell Significance Index: -22.8000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3131
    Cell Significance Index: -2.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3188
    Cell Significance Index: -3.3000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3271
    Cell Significance Index: -5.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3362
    Cell Significance Index: -26.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3710
    Cell Significance Index: -24.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3979
    Cell Significance Index: -28.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4008
    Cell Significance Index: -16.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4085
    Cell Significance Index: -11.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4101
    Cell Significance Index: -25.1500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.4435
    Cell Significance Index: -3.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4538
    Cell Significance Index: -28.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4555
    Cell Significance Index: -12.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5568
    Cell Significance Index: -16.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5730
    Cell Significance Index: -35.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5776
    Cell Significance Index: -32.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6078
    Cell Significance Index: -31.9100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6572
    Cell Significance Index: -4.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6682
    Cell Significance Index: -17.5700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.7144
    Cell Significance Index: -14.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7501
    Cell Significance Index: -33.1800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.7549
    Cell Significance Index: -6.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7619
    Cell Significance Index: -26.6900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.7683
    Cell Significance Index: -13.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7886
    Cell Significance Index: -21.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7977
    Cell Significance Index: -27.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8208
    Cell Significance Index: -30.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proteolytic Activity:** Cathepsin H is a cysteine endopeptidase with a broad substrate specificity, capable of cleaving a wide range of proteins. 2. **Lysosomal Localization:** Cathepsin H is primarily localized to lysosomes, where it participates in protein degradation and recycling. 3. **Antigen Processing:** Cathepsin H is involved in the processing and presentation of antigens to T-cells, facilitating immune recognition and response. 4. **Cellular Expression:** Cathepsin H is expressed in various cell types, including epithelial cells, immune cells, and germ cells. **Pathways and Functions:** 1. **Adaptive Immune Response:** Cathepsin H plays a crucial role in antigen processing and presentation, enabling the activation of T-cells and subsequent immune response. 2. **Apoptosis Regulation:** Cathepsin H can modulate apoptotic processes, influencing cell survival and death. 3. **Innate Immunity:** Cathepsin H is involved in the recognition and elimination of pathogens through its role in antigen processing and presentation. 4. **Cell Migration and Proliferation:** Cathepsin H can regulate cell migration, proliferation, and differentiation, influencing tissue development and repair. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of cathepsin H has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where immune responses are impaired. 2. **Cancer:** Cathepsin H expression is often elevated in cancer cells, contributing to tumor progression and metastasis. 3. **Infectious Diseases:** Cathepsin H plays a role in the recognition and elimination of pathogens, making it a potential target for antimicrobial therapies. 4. **Neurological Disorders:** Cathepsin H has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where protein degradation and aggregation contribute to disease pathology. In conclusion, cathepsin H is a multifaceted enzyme with a complex role in immune regulation, disease, and cellular processes. Further research is necessary to fully elucidate its functions and potential therapeutic applications in various diseases.

Genular Protein ID: 1771692746

Symbol: CATH_HUMAN

Name: Pro-cathepsin H

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2587265

Title: Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase.

PubMed ID: 2587265

DOI: 10.1093/nar/17.22.9471

PubMed ID: 11796715

Title: Analysis of a truncated form of cathepsin H in human prostate tumor cells.

PubMed ID: 11796715

DOI: 10.1074/jbc.m109557200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2849458

Title: Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H.

PubMed ID: 2849458

DOI: 10.1515/bchm3.1988.369.1.469

PubMed ID: 3342889

Title: Amino acid sequences of the human kidney cathepsins H and L.

PubMed ID: 3342889

DOI: 10.1016/0014-5793(88)80028-0

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 335
  • Mass: 37394
  • Checksum: E2CF3A5EEA59C1D1
  • Sequence:
  • MWATLPLLCA GAWLLGVPVC GAAELCVNSL EKFHFKSWMS KHRKTYSTEE YHHRLQTFAS 
    NWRKINAHNN GNHTFKMALN QFSDMSFAEI KHKYLWSEPQ NCSATKSNYL RGTGPYPPSV 
    DWRKKGNFVS PVKNQGACGS CWTFSTTGAL ESAIAIATGK MLSLAEQQLV DCAQDFNNHG 
    CQGGLPSQAF EYILYNKGIM GEDTYPYQGK DGYCKFQPGK AIGFVKDVAN ITIYDEEAMV 
    EAVALYNPVS FAFEVTQDFM MYRTGIYSST SCHKTPDKVN HAVLAVGYGE KNGIPYWIVK 
    NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.