Details for: CTSH

Gene ID: 1512

Symbol: CTSH

Ensembl ID: ENSG00000103811

Description: cathepsin H

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.73
    Marker Score: 24316
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.5
    Marker Score: 8836
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.49
    Marker Score: 4208
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.2
    Marker Score: 16818
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.09
    Marker Score: 4962
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.94
    Marker Score: 5137
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.78
    Marker Score: 3184
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.67
    Marker Score: 149045
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.64
    Marker Score: 5144.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6
    Marker Score: 41717
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.5
    Marker Score: 6218.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.48
    Marker Score: 1954
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.46
    Marker Score: 3617
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.45
    Marker Score: 6340
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.42
    Marker Score: 3430
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.36
    Marker Score: 7015
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.36
    Marker Score: 60328.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.33
    Marker Score: 20269
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.23
    Marker Score: 9597
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.13
    Marker Score: 13596
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.01
    Marker Score: 839
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.01
    Marker Score: 901
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.99
    Marker Score: 23124.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.98
    Marker Score: 4488
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.96
    Marker Score: 466
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.95
    Marker Score: 11855
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.94
    Marker Score: 1822
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.92
    Marker Score: 1159
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.92
    Marker Score: 1992
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.91
    Marker Score: 6578
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.89
    Marker Score: 1153
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.89
    Marker Score: 6714
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.89
    Marker Score: 14046.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.87
    Marker Score: 3104
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.84
    Marker Score: 532
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.84
    Marker Score: 2210.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.83
    Marker Score: 4175
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.83
    Marker Score: 4465
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.81
    Marker Score: 1367
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.79
    Marker Score: 1226
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.79
    Marker Score: 780
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.78
    Marker Score: 878
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.76
    Marker Score: 2973
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.75
    Marker Score: 3190
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.75
    Marker Score: 618
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.73
    Marker Score: 1732.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.73
    Marker Score: 2016
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.71
    Marker Score: 811
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7
    Marker Score: 19127.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.69
    Marker Score: 3210
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.66
    Marker Score: 4458
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.64
    Marker Score: 405
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.64
    Marker Score: 1094
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.62
    Marker Score: 318
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.62
    Marker Score: 3910
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.62
    Marker Score: 1648
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.6
    Marker Score: 1102
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.59
    Marker Score: 6612.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.57
    Marker Score: 2730
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.56
    Marker Score: 315
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.52
    Marker Score: 888
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.51
    Marker Score: 2407.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.49
    Marker Score: 695
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.46
    Marker Score: 9318
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.46
    Marker Score: 2093
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 165890
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.45
    Marker Score: 1555
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.42
    Marker Score: 1894.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.42
    Marker Score: 342
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.41
    Marker Score: 48928
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.39
    Marker Score: 1184
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.39
    Marker Score: 1409
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.38
    Marker Score: 564
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.38
    Marker Score: 1229.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.37
    Marker Score: 305
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.36
    Marker Score: 327
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.36
    Marker Score: 1175
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.35
    Marker Score: 2466.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.35
    Marker Score: 5609
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.34
    Marker Score: 342
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3152
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.33
    Marker Score: 2514.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.33
    Marker Score: 683
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.32
    Marker Score: 653
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.32
    Marker Score: 304
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.32
    Marker Score: 1243
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.31
    Marker Score: 6292
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.3
    Marker Score: 1107
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.28
    Marker Score: 3254
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.26
    Marker Score: 1129
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.25
    Marker Score: 16839
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.24
    Marker Score: 1122
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.22
    Marker Score: 1355
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.22
    Marker Score: 1197
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.21
    Marker Score: 318
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.19
    Marker Score: 916
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.18
    Marker Score: 1940
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.18
    Marker Score: 358
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.16
    Marker Score: 333
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.15
    Marker Score: 783

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Other Information

**Key characteristics:** * The gene is located on chromosome 15q23.1. * It is a member of the cathepsin family of endopeptidases. * It is expressed under the control of various inflammatory signals, including IL-1beta, IL-4, and TNF-alpha. * It is involved in the regulation of inflammation, cell migration, and apoptosis. **Pathways and functions:** * The cathepsin H protein is a serine endopeptidase that is involved in the regulation of inflammation. * It is expressed in high levels in inflammatory cells, such as macrophages and dendritic cells. * It is thought to play a role in the recruitment of inflammatory cells to sites of infection or injury. * It is also involved in the regulation of cell migration and survival. **Clinical significance:** * Mutations in the CTSH gene have been linked to a number of inflammatory diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. * Inhibition of cathepsin H has been shown to be effective in reducing inflammation and improving disease symptoms. * Therefore, CTSH is a potential target for the treatment of inflammatory diseases. **Additional notes:** * The cathepsin H protein is a secreted protein that is found in the plasma and urine. * It is a highly potent protease that can degrade a variety of substrates, including collagen, elastin, and gelatin. * It is involved in the regulation of inflammation, cell migration, and apoptosis. * It is a key regulator of the immune response.

Genular Protein ID: 1771692746

Symbol: CATH_HUMAN

Name: Pro-cathepsin H

UniProtKB Accession Codes:

P09668 B2RBK0 Q96NY6 Q9BUM7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 2 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 48 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2587265

Title: Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase.

PubMed ID: 2587265

DOI: 10.1093/nar/17.22.9471

PubMed ID: 11796715

Title: Analysis of a truncated form of cathepsin H in human prostate tumor cells.

PubMed ID: 11796715

DOI: 10.1074/jbc.m109557200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2849458

Title: Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H.

PubMed ID: 2849458

DOI: 10.1515/bchm3.1988.369.1.469

PubMed ID: 3342889

Title: Amino acid sequences of the human kidney cathepsins H and L.

PubMed ID: 3342889

DOI: 10.1016/0014-5793(88)80028-0

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 335
  • Mass: 37394
  • Checksum: E2CF3A5EEA59C1D1
  • Sequence:
    • MWATLPLLCA GAWLLGVPVC GAAELCVNSL EKFHFKSWMS KHRKTYSTEE YHHRLQTFAS 
NWRKINAHNN GNHTFKMALN QFSDMSFAEI KHKYLWSEPQ NCSATKSNYL RGTGPYPPSV 
DWRKKGNFVS PVKNQGACGS CWTFSTTGAL ESAIAIATGK MLSLAEQQLV DCAQDFNNHG 
CQGGLPSQAF EYILYNKGIM GEDTYPYQGK DGYCKFQPGK AIGFVKDVAN ITIYDEEAMV 
EAVALYNPVS FAFEVTQDFM MYRTGIYSST SCHKTPDKVN HAVLAVGYGE KNGIPYWIVK 
NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.