Details for: CTSK

Gene ID: 1513

Symbol: CTSK

Ensembl ID: ENSG00000143387

Description: cathepsin K

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.17
    Marker Score: 4362
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.91
    Marker Score: 1270
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.69
    Marker Score: 91550
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.36
    Marker Score: 1014
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.34
    Marker Score: 10088
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.23
    Marker Score: 502
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.03
    Marker Score: 467
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.96
    Marker Score: 5136
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.87
    Marker Score: 933
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.74
    Marker Score: 19602
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.7
    Marker Score: 482
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.59
    Marker Score: 906
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.58
    Marker Score: 6627.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.36
    Marker Score: 337
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.36
    Marker Score: 567
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.36
    Marker Score: 2089
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.3
    Marker Score: 1693
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.22
    Marker Score: 1510
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.16
    Marker Score: 289
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.15
    Marker Score: 289
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4794
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.13
    Marker Score: 1095
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.06
    Marker Score: 669
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.05
    Marker Score: 755
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.98
    Marker Score: 219
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5175
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.86
    Marker Score: 349
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.86
    Marker Score: 729
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.85
    Marker Score: 5555
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.84
    Marker Score: 1579
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1655
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.74
    Marker Score: 235
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.73
    Marker Score: 247
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.64
    Marker Score: 166
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.62
    Marker Score: 1755
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.61
    Marker Score: 347
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.58
    Marker Score: 534.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.56
    Marker Score: 279
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.54
    Marker Score: 134
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.54
    Marker Score: 7113
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.53
    Marker Score: 137
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.5
    Marker Score: 258
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5
    Marker Score: 169
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.49
    Marker Score: 220
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.47
    Marker Score: 170
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 185
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.43
    Marker Score: 126
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.43
    Marker Score: 127
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.42
    Marker Score: 227
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.42
    Marker Score: 642
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.42
    Marker Score: 144
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.42
    Marker Score: 448
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4
    Marker Score: 454
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4
    Marker Score: 881.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4
    Marker Score: 24594
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.4
    Marker Score: 97
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4
    Marker Score: 263
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.4
    Marker Score: 7929
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 257
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.37
    Marker Score: 436
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 366
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.37
    Marker Score: 116
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.36
    Marker Score: 201
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.33
    Marker Score: 3124
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 87
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.33
    Marker Score: 12097
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.33
    Marker Score: 1954
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.32
    Marker Score: 212
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 5028
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.32
    Marker Score: 1231
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.32
    Marker Score: 3266
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.31
    Marker Score: 125
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.31
    Marker Score: 142
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3
    Marker Score: 206
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.3
    Marker Score: 363
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.3
    Marker Score: 1210
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.29
    Marker Score: 246
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.29
    Marker Score: 209
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.29
    Marker Score: 329
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.28
    Marker Score: 165
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.28
    Marker Score: 180
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.28
    Marker Score: 134
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.28
    Marker Score: 333
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.27
    Marker Score: 2313

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * It is a secreted protein that is expressed in high levels in epithelial cells. * It is a member of the cathepsin family of serine proteases, which are involved in the degradation of ECM proteins. * It is a key regulator of the immune response, and its expression is upregulated in inflammatory diseases. * It is also involved in cell migration and wound healing. **Pathways and functions:** * Cathepsin K is a key regulator of the ECM remodeling process. It is expressed in high levels in epithelial cells, which are responsible for maintaining the integrity of the skin and other tissues. * It is involved in the degradation of ECM proteins, which allows them to be replaced with new proteins. * It is also involved in the regulation of cell migration and wound healing. * It is a key regulator of the immune response, and its expression is upregulated in inflammatory diseases. * It is also involved in the regulation of the inflammatory response to injury. **Clinical significance:** * Mutations in the CTSK gene have been linked to a number of human diseases, including psoriasis, rheumatoid arthritis, and lung cancer. * Cathepsin K inhibitors are being investigated as potential treatments for these diseases. * The development of these inhibitors is an active area of research.

Genular Protein ID: 503677176

Symbol: CATK_HUMAN

Name: Cathepsin K

UniProtKB Accession Codes:

P43235 Q6FHS6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 23 DrugCentral 1 EC 2 EMBL 9 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 2 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 76 PDBsum 69 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7805878

Title: Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.

PubMed ID: 7805878

DOI: 10.1016/0014-5793(94)01349-6

PubMed ID: 7818555

Title: Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.

PubMed ID: 7818555

DOI: 10.1006/bbrc.1995.1013

PubMed ID: 8585423

Title: Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas.

PubMed ID: 8585423

DOI: 10.1002/jbmr.5650100809

PubMed ID: 7576232

Title: Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution.

PubMed ID: 7576232

DOI: 10.1515/bchm3.1995.376.6.379

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11082042

Title: Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.

PubMed ID: 11082042

DOI: 10.1242/jcs.113.24.4487

PubMed ID: 9033587

Title: Crystal structure of human cathepsin K complexed with a potent inhibitor.

PubMed ID: 9033587

DOI: 10.1038/nsb0297-105

PubMed ID: 9405598

Title: Design of potent and selective human cathepsin K inhibitors that span the active site.

PubMed ID: 9405598

DOI: 10.1073/pnas.94.26.14249

PubMed ID: 9893980

Title: The crystal structure of human procathepsin K.

PubMed ID: 9893980

DOI: 10.1021/bi9822271

PubMed ID: 10048321

Title: Crystal structure of wild-type human procathepsin K.

PubMed ID: 10048321

DOI: 10.1110/ps.8.2.283

PubMed ID: 8703060

Title: Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.

PubMed ID: 8703060

DOI: 10.1126/science.273.5279.1236

PubMed ID: 9529353

Title: Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis.

PubMed ID: 9529353

DOI: 10.1086/301795

PubMed ID: 10491211

Title: Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein.

PubMed ID: 10491211

DOI: 10.1359/jbmr.1999.14.10.1649

PubMed ID: 10878663

Title: Cathepsin K gene mutations and 1q21 haplotypes in at patients with pycnodysostosis in an outbred population.

PubMed ID: 10878663

DOI: 10.1038/sj.ejhg.5200481

PubMed ID: 22822386

Title: Novel Compound Heterozygous Mutations in the Cathepsin K Gene in Japanese Female Siblings with Pyknodysostosis.

PubMed ID: 22822386

DOI: 10.1159/000336581

PubMed ID: 25731711

Title: Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations.

PubMed ID: 25731711

DOI: 10.1177/0022034515573964

Sequence Information:

  • Length: 329
  • Mass: 36966
  • Checksum: 4677C3C89FF4CE85
  • Sequence:
    • MWGLKVLLLP VVSFALYPEE ILDTHWELWK KTHRKQYNNK VDEISRRLIW EKNLKYISIH 
NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLKVPLSHS RSNDTLYIPE WEGRAPDSVD 
YRKKGYVTPV KNQGQCGSCW AFSSVGALEG QLKKKTGKLL NLSPQNLVDC VSENDGCGGG 
YMTNAFQYVQ KNRGIDSEDA YPYVGQEESC MYNPTGKAAK CRGYREIPEG NEKALKRAVA 
RVGPVSVAID ASLTSFQFYS KGVYYDESCN SDNLNHAVLA VGYGIQKGNK HWIIKNSWGE 
NWGNKGYILM ARNKNNACGI ANLASFPKM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.