CTSL | ENSG00000135047 | NCBI 1514

Details for: CTSL

Gene ID: 1514

Symbol: CTSL

Ensembl ID: ENSG00000135047

Description: cathepsin L

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Attachment and entry
(R-HSA-9694614)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Collagen degradation
(R-HSA-1442490)
Collagen formation
(R-HSA-1474290)
Degradation of the extracellular matrix
(R-HSA-1474228)
Disease
(R-HSA-1643685)
Early sars-cov-2 infection events
(R-HSA-9772572)
Endosomal/vacuolar pathway
(R-HSA-1236977)
Extracellular matrix organization
(R-HSA-1474244)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Mhc class ii antigen presentation
(R-HSA-2132295)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-HSA-8939242)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Toll-like receptor cascades
(R-HSA-168898)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Transcriptional regulation by runx1
(R-HSA-8878171)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation
(GO:0019882)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Antigen processing and presentation of peptide antigen
(GO:0048002)
Apical plasma membrane
(GO:0016324)
Cd4-positive, alpha-beta t cell lineage commitment
(GO:0043373)
Cellular response to thyroid hormone stimulus
(GO:0097067)
Chromaffin granule
(GO:0042583)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Elastin catabolic process
(GO:0060309)
Endocytic vesicle lumen
(GO:0071682)
Endolysosome lumen
(GO:0036021)
Enkephalin processing
(GO:0034230)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Fusion of virus membrane with host endosome membrane
(GO:0039654)
Fusion of virus membrane with host plasma membrane
(GO:0019064)
Golgi apparatus
(GO:0005794)
Histone binding
(GO:0042393)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosomal lumen
(GO:0043202)
Lysosome
(GO:0005764)
Macrophage apoptotic process
(GO:0071888)
Multivesicular body
(GO:0005771)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Proteoglycan binding
(GO:0043394)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Receptor-mediated endocytosis of virus by host cell
(GO:0019065)
Serpin family protein binding
(GO:0097655)
Symbiont entry into host cell
(GO:0046718)
Zymogen activation
(GO:0031638)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 265.9677
Cell Significance Index: -41.3700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 216.3668
Cell Significance Index: -54.8800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 127.8075
Cell Significance Index: -52.6500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 117.6595
Cell Significance Index: -47.8000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 115.7326
Cell Significance Index: -54.6400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 103.7549
Cell Significance Index: -53.3700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 50.8095
Cell Significance Index: -48.5100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 39.4824
Cell Significance Index: -48.6800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.0384
Cell Significance Index: -53.6800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 18.1173
Cell Significance Index: 483.7600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.7707
Cell Significance Index: -54.3400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 8.3947
Cell Significance Index: 240.6400
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 4.5997
Cell Significance Index: 28.5800
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 3.0720
Cell Significance Index: 25.0500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8463
Cell Significance Index: 253.5600
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.8033
Cell Significance Index: 19.1600
Cell Name: germ cell (CL0000586)
Fold Change: 1.6111
Cell Significance Index: 12.1700
Cell Name: odontoblast (CL0000060)
Fold Change: 1.2260
Cell Significance Index: 157.1600
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.0373
Cell Significance Index: 13.2900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9724
Cell Significance Index: 45.3400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.9431
Cell Significance Index: 8.6900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9255
Cell Significance Index: 166.8400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9136
Cell Significance Index: 824.9100
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.9128
Cell Significance Index: 17.8200
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.8941
Cell Significance Index: 23.5100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.8745
Cell Significance Index: 13.5300
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.7667
Cell Significance Index: 3.5400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6585
Cell Significance Index: 17.9300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6287
Cell Significance Index: 77.3100
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.6162
Cell Significance Index: 4.8700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5132
Cell Significance Index: 83.4600
Cell Name: theca cell (CL0000503)
Fold Change: 0.4800
Cell Significance Index: 2.8200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4687
Cell Significance Index: 50.9800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4642
Cell Significance Index: 24.1800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4119
Cell Significance Index: 24.7300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4054
Cell Significance Index: 81.3200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3360
Cell Significance Index: 66.6900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2910
Cell Significance Index: 158.9400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1928
Cell Significance Index: 19.0700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1842
Cell Significance Index: 81.4500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1368
Cell Significance Index: 9.4600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1340
Cell Significance Index: 48.0600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1099
Cell Significance Index: 5.7100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1078
Cell Significance Index: 5.6600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1059
Cell Significance Index: 0.6400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0959
Cell Significance Index: 1.0900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0822
Cell Significance Index: 60.2900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0638
Cell Significance Index: 2.8900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.0512
Cell Significance Index: 0.9100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0480
Cell Significance Index: 0.6500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0302
Cell Significance Index: 0.8700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0286
Cell Significance Index: 53.8100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0165
Cell Significance Index: 3.1400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0106
Cell Significance Index: 19.5000
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0025
Cell Significance Index: 0.2600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0140
Cell Significance Index: -21.5800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0244
Cell Significance Index: -33.2300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0336
Cell Significance Index: -25.4700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0412
Cell Significance Index: -1.1100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0433
Cell Significance Index: -27.4700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0436
Cell Significance Index: -0.7300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0498
Cell Significance Index: -1.7500
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.0552
Cell Significance Index: -0.5200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0586
Cell Significance Index: -43.4200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0742
Cell Significance Index: -33.6900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0864
Cell Significance Index: -48.7300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1130
Cell Significance Index: -8.4200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1351
Cell Significance Index: -10.3700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1362
Cell Significance Index: -39.1900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1534
Cell Significance Index: -26.1900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1963
Cell Significance Index: -28.5300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2159
Cell Significance Index: -4.5200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2536
Cell Significance Index: -29.5500
Cell Name: peg cell (CL4033014)
Fold Change: -0.2558
Cell Significance Index: -5.9100
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2603
Cell Significance Index: -3.2200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2613
Cell Significance Index: -55.0500
Cell Name: kidney cell (CL1000497)
Fold Change: -0.2799
Cell Significance Index: -2.2400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2854
Cell Significance Index: -36.8700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2889
Cell Significance Index: -20.4300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3035
Cell Significance Index: -34.7700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3491
Cell Significance Index: -12.1300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3686
Cell Significance Index: -18.6300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3821
Cell Significance Index: -17.9600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4036
Cell Significance Index: -25.4400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4259
Cell Significance Index: -13.6400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4494
Cell Significance Index: -27.6200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4605
Cell Significance Index: -54.3100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4949
Cell Significance Index: -51.5300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4957
Cell Significance Index: -12.3900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5603
Cell Significance Index: -31.4400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5801
Cell Significance Index: -45.9400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.5843
Cell Significance Index: -12.1200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5966
Cell Significance Index: -36.5800
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.6633
Cell Significance Index: -6.3000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6865
Cell Significance Index: -46.1600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.7047
Cell Significance Index: -28.8800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7278
Cell Significance Index: -20.3400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7827
Cell Significance Index: -16.6700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.8062
Cell Significance Index: -14.9000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.8077
Cell Significance Index: -52.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CTSL is a member of the papain superfamily of cysteine proteases, characterized by its high specific activity and broad substrate specificity. It is predominantly expressed in lysosomes, where it regulates the degradation of proteins and peptides. CTSL is also found in the endoplasmic reticulum and Golgi apparatus, where it participates in protein processing and secretion. **Pathways and Functions** CTSL is involved in several cellular pathways, including: 1. **Antigen Processing and Presentation**: CTSL is essential for the processing and presentation of antigens via MHC class II molecules. It cleaves and truncates antigens, generating peptides that are then loaded onto MHC class II molecules, which are presented to CD4+ T cells. 2. **Protein Degradation**: CTSL is a key regulator of protein degradation in lysosomes, where it breaks down proteins into smaller peptides. 3. **Endosomal Processing**: CTSL is involved in the processing of proteins and peptides in endosomes, where it regulates the degradation and presentation of antigens. 4. **Apoptosis**: CTSL is also involved in the regulation of apoptosis, where it cleaves and activates pro-apoptotic proteins. **Clinical Significance** CTSL has been implicated in various diseases and disorders, including: 1. **Autoimmune Diseases**: CTSL has been shown to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates the presentation of antigens to CD4+ T cells. 2. **Cancer**: CTSL has been implicated in the progression of various cancers, including breast and prostate cancer, where it regulates the degradation and presentation of antigens. 3. **Neurodegenerative Diseases**: CTSL has been shown to play a role in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it regulates the degradation and presentation of proteins. 4. **SARS-CoV-2 Infection**: CTSL has been implicated in the early stages of SARS-CoV-2 infection, where it regulates the processing and presentation of antigens to CD4+ T cells. In conclusion, CTSL is a critical component of the immune system, regulating antigen processing, protein degradation, and apoptosis. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of CTSL in maintaining immune homeostasis and preventing disease. **Significantly Expressed Cells** CTSL is expressed in various cell types, including: 1. Pancreatic A cells 2. Basal cells of the epidermis 3. Fibroblasts of mammary gland and breast 4. Fibroblasts of connective tissue of prostate 5. Macrophages 6. Skeletal muscle satellite stem cells 7. Myeloid leukocytes 8. Alveolar macrophages **Proteins** CTSL has two main isoforms, CATL1_HUMAN and Q9HBQ7_HUMAN, which differ in their substrate specificity and tissue distribution. In summary, CTSL is a critical component of the immune system, regulating antigen processing, protein degradation, and apoptosis. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of CTSL in maintaining immune homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Major excreted protein
Q9HBQ7_HUMAN

Genular Protein ID: 1142374600

Symbol: CATL1_HUMAN

Name: Major excreted protein

UniProtKB Accession Codes:

P07711 Q6IAV1 Q96QJ0

Database IDs:

Citations:

PubMed ID: 3421948

Title: Isolation and sequence of a cDNA for human pro-(cathepsin L).

PubMed ID: 3421948

DOI: 10.1042/bj2530303

PubMed ID: 2835398

Title: Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.

PubMed ID: 2835398

DOI: 10.1172/jci113497

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3342889

Title: Amino acid sequences of the human kidney cathepsins H and L.

PubMed ID: 3342889

DOI: 10.1016/0014-5793(88)80028-0

PubMed ID: 3550705

Title: The major ras induced protein in NIH3T3 cells is cathepsin L.

PubMed ID: 3550705

DOI: 10.1093/nar/15.7.3186

PubMed ID: 3545185

Title: The N-terminal amino acid sequences of the heavy and light chains of human cathepsin L. Relationship to a cDNA clone for a major cysteine proteinase from a mouse macrophage cell line.

PubMed ID: 3545185

DOI: 10.1042/bj2400373

PubMed ID: 9468501

Title: Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro.

PubMed ID: 9468501

DOI: 10.1074/jbc.273.8.4478

PubMed ID: 10716919

Title: Secreted cathepsin L generates endostatin from collagen XVIII.

PubMed ID: 10716919

DOI: 10.1093/emboj/19.6.1187

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15099520

Title: A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.

PubMed ID: 15099520

DOI: 10.1016/s1097-2765(04)00209-6

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16081529

Title: Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.

PubMed ID: 16081529

DOI: 10.1073/pnas.0505577102

PubMed ID: 16339146

Title: SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.

PubMed ID: 16339146

DOI: 10.1074/jbc.m508381200

PubMed ID: 18562523

Title: Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide.

PubMed ID: 18562523

DOI: 10.1128/jvi.00415-08

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26953343

Title: Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV).

PubMed ID: 26953343

DOI: 10.1074/jbc.m116.716100

PubMed ID: 30425301

Title: Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

PubMed ID: 30425301

DOI: 10.1038/s41436-018-0355-3

PubMed ID: 32142651

Title: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor.

PubMed ID: 32142651

DOI: 10.1016/j.cell.2020.02.052

PubMed ID: 32361028

Title: Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment.

PubMed ID: 32361028

DOI: 10.1016/j.ijantimicag.2020.106004

PubMed ID: 32221306

Title: Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.

PubMed ID: 32221306

DOI: 10.1038/s41467-020-15562-9

PubMed ID: 32855215

Title: MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

PubMed ID: 32855215

DOI: 10.1126/science.abb3753

PubMed ID: 34159616

Title: TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.

PubMed ID: 34159616

DOI: 10.15252/embj.2021107821

PubMed ID: 8896443

Title: Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

PubMed ID: 8896443

DOI: 10.1002/j.1460-2075.1996.tb00934.x

PubMed ID: 9141479

Title: The crystal structure of human cathepsin L complexed with E-64.

PubMed ID: 9141479

DOI: 10.1016/s0014-5793(97)00216-0

Sequence Information:

Length: 333
Mass: 37564
Checksum: 8CD17D00EF859D85
Sequence:

MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMHNRLY GMNEEGWRRA VWEKNMKMIE 
LHNQEYREGK HSFTMAMNAF GDMTSEEFRQ VMNGFQNRKP RKGKVFQEPL FYEAPRSVDW 
REKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGRLIS LSEQNLVDCS GPQGNEGCNG 
GLMDYAFQYV QDNGGLDSEE SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA 
TVGPISVAID AGHESFLFYK EGIYFEPDCS SEDMDHGVLV VGYGFESTES DNNKYWLVKN 
SWGEEWGMGG YVKMAKDRRN HCGIASAASY PTV

Genular Protein ID: 178632525

Symbol: Q9HBQ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HBQ7

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 151
Mass: 16839
Checksum: 539C686EE95C80B3
Sequence:

MDYAFQYVQD NGGLDSEESY PYEATEESCK YNPKYSVAND TGFVDIPKQE KALMKAVATV 
GPISVAIDAG HESFLFYKEG IYFEPDCSSE DMDHGVLVVG YGFESTESDN NKYWLVKNSW 
GEEWGMGGYV KMAKDRRNHC GIASAASYPT V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTSL

Associated with

Cells (max top 100)

Other Information

Isolation and sequence of a cDNA for human pro-(cathepsin L). PubMed ID: 3421948

Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. PubMed ID: 2835398

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amino acid sequences of the human kidney cathepsins H and L. PubMed ID: 3342889

The major ras induced protein in NIH3T3 cells is cathepsin L. PubMed ID: 3550705

The N-terminal amino acid sequences of the heavy and light chains of human cathepsin L. Relationship to a cDNA clone for a major cysteine proteinase from a mouse macrophage cell line. PubMed ID: 3545185

Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro. PubMed ID: 9468501

Secreted cathepsin L generates endostatin from collagen XVIII. PubMed ID: 10716919

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. PubMed ID: 15099520

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. PubMed ID: 16081529

SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. PubMed ID: 16339146

Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide. PubMed ID: 18562523

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

Resveratrol-induced changes of the human adipocyte secretion profile. PubMed ID: 22905912

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). PubMed ID: 26953343

Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin. PubMed ID: 30425301

SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. PubMed ID: 32142651

Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment. PubMed ID: 32361028

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. PubMed ID: 32221306

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. PubMed ID: 32855215

TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells. PubMed ID: 34159616

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. PubMed ID: 8896443

The crystal structure of human cathepsin L complexed with E-64. PubMed ID: 9141479

The sequence of the human genome. PubMed ID: 11181995