CTSL | ENSG00000135047 | NCBI 1514

Details for: CTSL

Gene ID: 1514

Symbol: CTSL

Ensembl ID: ENSG00000135047

Description: cathepsin L

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Attachment and entry
(R-HSA-9694614)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Collagen degradation
(R-HSA-1442490)
Collagen formation
(R-HSA-1474290)
Degradation of the extracellular matrix
(R-HSA-1474228)
Disease
(R-HSA-1643685)
Early sars-cov-2 infection events
(R-HSA-9772572)
Endosomal/vacuolar pathway
(R-HSA-1236977)
Extracellular matrix organization
(R-HSA-1474244)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Mhc class ii antigen presentation
(R-HSA-2132295)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-HSA-8939242)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Toll-like receptor cascades
(R-HSA-168898)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Transcriptional regulation by runx1
(R-HSA-8878171)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation
(GO:0019882)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Antigen processing and presentation of peptide antigen
(GO:0048002)
Apical plasma membrane
(GO:0016324)
Cd4-positive, alpha-beta t cell lineage commitment
(GO:0043373)
Cellular response to thyroid hormone stimulus
(GO:0097067)
Chromaffin granule
(GO:0042583)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Elastin catabolic process
(GO:0060309)
Endocytic vesicle lumen
(GO:0071682)
Endolysosome lumen
(GO:0036021)
Enkephalin processing
(GO:0034230)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Fusion of virus membrane with host endosome membrane
(GO:0039654)
Fusion of virus membrane with host plasma membrane
(GO:0019064)
Golgi apparatus
(GO:0005794)
Histone binding
(GO:0042393)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosomal lumen
(GO:0043202)
Lysosome
(GO:0005764)
Macrophage apoptotic process
(GO:0071888)
Multivesicular body
(GO:0005771)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of peptidase activity
(GO:0010952)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Proteoglycan binding
(GO:0043394)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Receptor-mediated endocytosis of virus by host cell
(GO:0019065)
Serpin family protein binding
(GO:0097655)
Symbiont entry into host cell
(GO:0046718)
Zymogen activation
(GO:0031638)

Other Information

Proteins

Major excreted protein
Q9HBQ7_HUMAN

Genular Protein ID: 1142374600

Symbol: CATL1_HUMAN

Name: Major excreted protein

UniProtKB Accession Codes:

P07711 Q6IAV1 Q96QJ0

Database IDs:

Citations:

PubMed ID: 3421948

Title: Isolation and sequence of a cDNA for human pro-(cathepsin L).

PubMed ID: 3421948

DOI: 10.1042/bj2530303

PubMed ID: 2835398

Title: Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.

PubMed ID: 2835398

DOI: 10.1172/jci113497

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3342889

Title: Amino acid sequences of the human kidney cathepsins H and L.

PubMed ID: 3342889

DOI: 10.1016/0014-5793(88)80028-0

PubMed ID: 3550705

Title: The major ras induced protein in NIH3T3 cells is cathepsin L.

PubMed ID: 3550705

DOI: 10.1093/nar/15.7.3186

PubMed ID: 3545185

Title: The N-terminal amino acid sequences of the heavy and light chains of human cathepsin L. Relationship to a cDNA clone for a major cysteine proteinase from a mouse macrophage cell line.

PubMed ID: 3545185

DOI: 10.1042/bj2400373

PubMed ID: 9468501

Title: Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro.

PubMed ID: 9468501

DOI: 10.1074/jbc.273.8.4478

PubMed ID: 10716919

Title: Secreted cathepsin L generates endostatin from collagen XVIII.

PubMed ID: 10716919

DOI: 10.1093/emboj/19.6.1187

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15099520

Title: A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.

PubMed ID: 15099520

DOI: 10.1016/s1097-2765(04)00209-6

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16081529

Title: Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.

PubMed ID: 16081529

DOI: 10.1073/pnas.0505577102

PubMed ID: 16339146

Title: SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.

PubMed ID: 16339146

DOI: 10.1074/jbc.m508381200

PubMed ID: 18562523

Title: Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide.

PubMed ID: 18562523

DOI: 10.1128/jvi.00415-08

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26953343

Title: Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV).

PubMed ID: 26953343

DOI: 10.1074/jbc.m116.716100

PubMed ID: 30425301

Title: Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

PubMed ID: 30425301

DOI: 10.1038/s41436-018-0355-3

PubMed ID: 32142651

Title: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor.

PubMed ID: 32142651

DOI: 10.1016/j.cell.2020.02.052

PubMed ID: 32361028

Title: Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment.

PubMed ID: 32361028

DOI: 10.1016/j.ijantimicag.2020.106004

PubMed ID: 32221306

Title: Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.

PubMed ID: 32221306

DOI: 10.1038/s41467-020-15562-9

PubMed ID: 32855215

Title: MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

PubMed ID: 32855215

DOI: 10.1126/science.abb3753

PubMed ID: 34159616

Title: TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.

PubMed ID: 34159616

DOI: 10.15252/embj.2021107821

PubMed ID: 8896443

Title: Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

PubMed ID: 8896443

DOI: 10.1002/j.1460-2075.1996.tb00934.x

PubMed ID: 9141479

Title: The crystal structure of human cathepsin L complexed with E-64.

PubMed ID: 9141479

DOI: 10.1016/s0014-5793(97)00216-0

Sequence Information:

Length: 333
Mass: 37564
Checksum: 8CD17D00EF859D85
Sequence:

MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMHNRLY GMNEEGWRRA VWEKNMKMIE 
LHNQEYREGK HSFTMAMNAF GDMTSEEFRQ VMNGFQNRKP RKGKVFQEPL FYEAPRSVDW 
REKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGRLIS LSEQNLVDCS GPQGNEGCNG 
GLMDYAFQYV QDNGGLDSEE SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA 
TVGPISVAID AGHESFLFYK EGIYFEPDCS SEDMDHGVLV VGYGFESTES DNNKYWLVKN 
SWGEEWGMGG YVKMAKDRRN HCGIASAASY PTV

Genular Protein ID: 178632525

Symbol: Q9HBQ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HBQ7

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 151
Mass: 16839
Checksum: 539C686EE95C80B3
Sequence:

MDYAFQYVQD NGGLDSEESY PYEATEESCK YNPKYSVAND TGFVDIPKQE KALMKAVATV 
GPISVAIDAG HESFLFYKEG IYFEPDCSSE DMDHGVLVVG YGFESTESDN NKYWLVKNSW 
GEEWGMGGYV KMAKDRRNHC GIASAASYPT V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTSL

Associated with

Other Information

Isolation and sequence of a cDNA for human pro-(cathepsin L). PubMed ID: 3421948

Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. PubMed ID: 2835398

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amino acid sequences of the human kidney cathepsins H and L. PubMed ID: 3342889

The major ras induced protein in NIH3T3 cells is cathepsin L. PubMed ID: 3550705

The N-terminal amino acid sequences of the heavy and light chains of human cathepsin L. Relationship to a cDNA clone for a major cysteine proteinase from a mouse macrophage cell line. PubMed ID: 3545185

Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro. PubMed ID: 9468501

Secreted cathepsin L generates endostatin from collagen XVIII. PubMed ID: 10716919

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. PubMed ID: 15099520

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. PubMed ID: 16081529

SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. PubMed ID: 16339146

Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide. PubMed ID: 18562523

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

Resveratrol-induced changes of the human adipocyte secretion profile. PubMed ID: 22905912

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). PubMed ID: 26953343

Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin. PubMed ID: 30425301

SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. PubMed ID: 32142651

Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment. PubMed ID: 32361028

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. PubMed ID: 32221306

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. PubMed ID: 32855215

TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells. PubMed ID: 34159616

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. PubMed ID: 8896443

The crystal structure of human cathepsin L complexed with E-64. PubMed ID: 9141479

The sequence of the human genome. PubMed ID: 11181995