CTSV | ENSG00000136943 | NCBI 1515

Details for: CTSV

Gene ID: 1515

Symbol: CTSV

Ensembl ID: ENSG00000136943

Description: cathepsin V

Associated with

Activation of matrix metalloproteinases
(R-HSA-1592389)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Collagen formation
(R-HSA-1474290)
Degradation of the extracellular matrix
(R-HSA-1474228)
Endosomal/vacuolar pathway
(R-HSA-1236977)
Extracellular matrix organization
(R-HSA-1474244)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Mhc class ii antigen presentation
(R-HSA-2132295)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-HSA-8939242)
Toll-like receptor cascades
(R-HSA-168898)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Transcriptional regulation by runx1
(R-HSA-8878171)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Apoptotic process
(GO:0006915)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Extracellular matrix disassembly
(GO:0022617)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Lysosomal lumen
(GO:0043202)
Lysosome
(GO:0005764)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of peptidase activity
(GO:0010952)
Protein binding
(GO:0005515)
Proteolysis involved in protein catabolic process
(GO:0051603)
Serine-type endopeptidase activity
(GO:0004252)

Other Information

Proteins

Cathepsin L2
B2R717_HUMAN

Genular Protein ID: 64704437

Symbol: CATL2_HUMAN

Name: Cathepsin L2

UniProtKB Accession Codes:

O60911 O60233 Q2TB86 Q5T1U0

Database IDs:

Citations:

PubMed ID: 9563472

Title: Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.

PubMed ID: 9563472

PubMed ID: 9727401

Title: Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.

PubMed ID: 9727401

PubMed ID: 10029531

Title: Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.

PubMed ID: 10029531

DOI: 10.1021/bi982175f

PubMed ID: 10382972

Title: Genomic organization and chromosomal localization of the human cathepsin L2 gene.

PubMed ID: 10382972

DOI: 10.1093/dnares/6.2.137

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22967898

Title: Determination of cathepsin V activity and intracellular trafficking by N-glycosylation.

PubMed ID: 22967898

DOI: 10.1016/j.febslet.2012.08.001

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11027133

Title: Crystal structure of human cathepsin V.

PubMed ID: 11027133

DOI: 10.1021/bi000951p

PubMed ID: 30425301

Title: Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

PubMed ID: 30425301

DOI: 10.1038/s41436-018-0355-3

Sequence Information:

Length: 334
Mass: 37329
Checksum: CD2DE51AC5F242C8
Sequence:

MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA VWEKNMKMIE 
LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF RKGKVFREPL FLDLPKSVDW 
RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG 
GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV 
ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK 
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV

Genular Protein ID: 3143954622

Symbol: B2R717_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R717

Database IDs:

Sequence Information:

Length: 334
Mass: 37371
Checksum: 3148F006A0E75877
Sequence:

MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA VWEKNMKMIE 
LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF RKGKVFREPL FLDLPKSVDW 
RKKGYVTPVK NQKQCVSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG 
GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV 
ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK 
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTSV

Associated with

Other Information

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. PubMed ID: 9563472

Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. PubMed ID: 9727401

Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. PubMed ID: 10029531

Genomic organization and chromosomal localization of the human cathepsin L2 gene. PubMed ID: 10382972

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Determination of cathepsin V activity and intracellular trafficking by N-glycosylation. PubMed ID: 22967898

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Crystal structure of human cathepsin V. PubMed ID: 11027133

Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin. PubMed ID: 30425301