Details for: CTSV

Gene ID: 1515

Symbol: CTSV

Ensembl ID: ENSG00000136943

Description: cathepsin V

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 7.73
    Marker Score: 3375
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.64
    Marker Score: 15636
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.29
    Marker Score: 8497
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.16
    Marker Score: 2383
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.84
    Marker Score: 2841
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.73
    Marker Score: 2838
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.61
    Marker Score: 6340
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.25
    Marker Score: 617
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.16
    Marker Score: 503
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.15
    Marker Score: 1212.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.02
    Marker Score: 10306
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.99
    Marker Score: 1420
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.97
    Marker Score: 290
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1975
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5265
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.92
    Marker Score: 626
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13978
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.89
    Marker Score: 871
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.87
    Marker Score: 1095
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1545
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 619.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.79
    Marker Score: 227
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1275
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.77
    Marker Score: 2209
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.76
    Marker Score: 1874
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.74
    Marker Score: 954
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 457
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.68
    Marker Score: 1202
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.6
    Marker Score: 213
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.57
    Marker Score: 564
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 339
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.55
    Marker Score: 1285
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 219
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.52
    Marker Score: 1412
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.47
    Marker Score: 985
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 222
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.46
    Marker Score: 3018
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.46
    Marker Score: 3974
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.46
    Marker Score: 314
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.46
    Marker Score: 155
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.45
    Marker Score: 428
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.41
    Marker Score: 345
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.41
    Marker Score: 132
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.41
    Marker Score: 130
  • Cell Name: prickle cell (CL0000649)
    Fold Change: 0.4
    Marker Score: 2667
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4
    Marker Score: 981
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.38
    Marker Score: 246
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.38
    Marker Score: 402.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.35
    Marker Score: 375
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.35
    Marker Score: 181
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.34
    Marker Score: 472
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.34
    Marker Score: 4564
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.33
    Marker Score: 11508
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.33
    Marker Score: 122
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.33
    Marker Score: 602
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.33
    Marker Score: 173
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.33
    Marker Score: 81
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.33
    Marker Score: 351
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.32
    Marker Score: 735
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.32
    Marker Score: 341
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3
    Marker Score: 516
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.27
    Marker Score: 211
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.27
    Marker Score: 178
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.26
    Marker Score: 626
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.26
    Marker Score: 144
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.25
    Marker Score: 182
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.25
    Marker Score: 167
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.24
    Marker Score: 861
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.24
    Marker Score: 213
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 105
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.24
    Marker Score: 68
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.23
    Marker Score: 231
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.22
    Marker Score: 70
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.22
    Marker Score: 1610
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.22
    Marker Score: 47
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73

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Other Information

**Key characteristics:** - Cathepsin V is a cysteine-type endopeptidase that is involved in the degradation of extracellular matrix proteins. - It is a key enzyme in the formation of the extracellular matrix, which is essential for the structural integrity of tissues. - Cathepsin V is also involved in the processing and presentation of antigens to immune cells. **Pathways and functions:** - Cathepsin V is involved in the activation of matrix metalloproteinases, which are enzymes that break down extracellular matrix proteins. - It is also involved in the adaptive immune system, where it is produced by antigen-presenting cells and presented to T cells. - Cathepsin V is also involved in the assembly of collagen fibrils and other multimeric structures. **Clinical significance:** - Cathepsin V is a potential therapeutic target for a variety of diseases, including psoriasis, rheumatoid arthritis, and cancer. - Cathepsin V inhibitors can block the activity of the enzyme and suppress inflammation. - By targeting cathepsin V, it may be possible to treat these diseases by reducing inflammation and tissue damage. **Other notable points:** - Cathepsin V is a highly conserved protein that is found in mammals and birds. - It is expressed in high levels in the skin, where it is involved in the formation of the epidermal barrier. - Cathepsin V is also expressed in the lungs, where it is involved in the degradation of extracellular matrix proteins in mucus.

Genular Protein ID: 64704437

Symbol: CATL2_HUMAN

Name: Cathepsin L2

UniProtKB Accession Codes:

O60911 O60233 Q2TB86 Q5T1U0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 8 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 25 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SABIO-RK 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9563472

Title: Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.

PubMed ID: 9563472

PubMed ID: 9727401

Title: Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.

PubMed ID: 9727401

PubMed ID: 10029531

Title: Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.

PubMed ID: 10029531

DOI: 10.1021/bi982175f

PubMed ID: 10382972

Title: Genomic organization and chromosomal localization of the human cathepsin L2 gene.

PubMed ID: 10382972

DOI: 10.1093/dnares/6.2.137

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22967898

Title: Determination of cathepsin V activity and intracellular trafficking by N-glycosylation.

PubMed ID: 22967898

DOI: 10.1016/j.febslet.2012.08.001

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11027133

Title: Crystal structure of human cathepsin V.

PubMed ID: 11027133

DOI: 10.1021/bi000951p

PubMed ID: 30425301

Title: Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.

PubMed ID: 30425301

DOI: 10.1038/s41436-018-0355-3

Sequence Information:

  • Length: 334
  • Mass: 37329
  • Checksum: CD2DE51AC5F242C8
  • Sequence:
    • MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA VWEKNMKMIE 
LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF RKGKVFREPL FLDLPKSVDW 
RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG 
GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV 
ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK 
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV

Genular Protein ID: 3143954622

Symbol: B2R717_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R717

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 4 SUPFAM 1

Sequence Information:

  • Length: 334
  • Mass: 37371
  • Checksum: 3148F006A0E75877
  • Sequence:
    • MNLSLVLAAF CLGIASAVPK FDQNLDTKWY QWKATHRRLY GANEEGWRRA VWEKNMKMIE 
LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ MMGCFRNQKF RKGKVFREPL FLDLPKSVDW 
RKKGYVTPVK NQKQCVSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG 
GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV 
ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK 
NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.