Details for: Hck
Associated with
Other Information
Genular Protein ID: 671321810
Symbol: HCK_MOUSE
Name: Tyrosine-protein kinase HCK
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3684607
PubMed ID: 3317404
Title: Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells.
PubMed ID: 3317404
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1875927
Title: Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.
PubMed ID: 1875927
PubMed ID: 8125254
Title: Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
PubMed ID: 8125254
DOI: 10.1101/gad.8.4.387
PubMed ID: 8666673
Title: Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.
PubMed ID: 8666673
PubMed ID: 9400828
Title: Bacterial LPS and IFN-gamma trigger the tyrosine phosphorylation of vav in macrophages: evidence for involvement of the hck tyrosine kinase.
PubMed ID: 9400828
DOI: 10.1002/jlb.62.6.859
PubMed ID: 10547366
Title: Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.
PubMed ID: 10547366
PubMed ID: 9916742
Title: Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.
PubMed ID: 9916742
PubMed ID: 10799548
Title: Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
PubMed ID: 10799548
PubMed ID: 10934191
Title: Modulation of the catalytic activity of the Src family tyrosine kinase Hck by autophosphorylation at a novel site in the unique domain.
PubMed ID: 10934191
PubMed ID: 12235133
Title: Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
PubMed ID: 12235133
PubMed ID: 14551197
Title: Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.
PubMed ID: 14551197
PubMed ID: 16684964
Title: Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.
PubMed ID: 16684964
PubMed ID: 16809022
Title: CpG DNA enhances macrophage cell spreading by promoting the Src-family kinase-mediated phosphorylation of paxillin.
PubMed ID: 16809022
PubMed ID: 17513616
Title: The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.
PubMed ID: 17513616
PubMed ID: 18246197
Title: Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.
PubMed ID: 18246197
DOI: 10.1172/jci34013
PubMed ID: 18625913
Title: Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
PubMed ID: 18625913
DOI: 10.1189/jlb.0208118
PubMed ID: 19144319
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
PubMed ID: 19144319
PubMed ID: 19897576
Title: Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis.
PubMed ID: 19897576
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 19903482
Title: c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
PubMed ID: 19903482
Sequence Information:
- Length: 524
- Mass: 59129
- Checksum: DF72FD69B38C9706
- Sequence:
MGGRSSCEDP GCPRSEGRAP RMGCVKSRFL RDGSKASKTE PSANQKGPVY VPDPTSSSKL GPNNSNSMPP GFVEGSEDTI VVALYDYEAI HREDLSFQKG DQMVVLEEAG EWWKARSLAT KKEGYIPSNY VARVNSLETE EWFFKGISRK DAERHLLAPG NMLGSFMIRD SETTKGSYSL SVRDFDPQHG DTVKHYKIRT LDSGGFYISP RSTFSSLQEL VLHYKKGKDG LCQKLSVPCV SPKPQKPWEK DAWEIPRESL QMEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF LAEANLMKSL QHDKLVKLHA VVSQEPIFIV TEFMAKGSLL DFLKSEEGSK QPLPKLIDFS AQISEGMAFI EQRNYIHRDL RAANILVSAS LVCKIADFGL ARIIEDNEYT AREGAKFPIK WTAPEAINFG SFTIKSDVWS FGILLMEIVT YGRIPYPGMS NPEVIRALEH GYRMPRPDNC PEELYNIMIR CWKNRPEERP TFEYIQSVLD DFYTATESQY QQQP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.