Genular: Defining Cellular Identity and Function

Details for: Hcls1

Gene ID: 15163

Symbol: Hcls1

Ensembl ID: ENSMUSG00000022831

Description: hematopoietic cell specific Lyn substrate 1

Associated with

Actin filament
(GO:0005884)
Actin filament binding
(GO:0051015)
Actin filament organization
(GO:0007015)
Cellular response to cytokine stimulus
(GO:0071345)
Cortical actin cytoskeleton
(GO:0030864)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Erythrocyte differentiation
(GO:0030218)
Granulocyte colony-stimulating factor signaling pathway
(GO:0038158)
Mitochondrion
(GO:0005739)
Negative regulation of leukocyte apoptotic process
(GO:2000107)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear transport
(GO:0051169)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of granulocyte differentiation
(GO:0030854)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of actin filament polymerization
(GO:0030833)
Response to hormone
(GO:0009725)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sh3 domain binding
(GO:0017124)
Signaling adaptor activity
(GO:0035591)
Site of polarized growth
(GO:0030427)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Hematopoietic lineage cell-specific protein
Q8CA06_MOUSE

Genular Protein ID: 496630780

Symbol: HCLS1_MOUSE

Name: Hematopoietic lineage cell-specific protein

UniProtKB Accession Codes:

P49710 Q922I8

Database IDs:

Citations:

PubMed ID: 7535527

Title: Molecular cloning and characterization of mouse HS1.

PubMed ID: 7535527

DOI: 10.1006/bbrc.1995.1452

PubMed ID: 7628441

Title: LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56(lck).

PubMed ID: 7628441

DOI: 10.1002/j.1460-2075.1995.tb07346.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8943564

Title: Distinct binding patterns of HS1 to the Src SH2 and SH3 domains reflect possible mechanisms of recruitment and activation of downstream molecules.

PubMed ID: 8943564

DOI: 10.1093/intimm/8.11.1699

PubMed ID: 10590261

Title: Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3.

PubMed ID: 10590261

DOI: 10.1093/intimm/11.12.1957

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 19064729

Title: Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.

PubMed ID: 19064729

DOI: 10.1182/blood-2008-04-153452

PubMed ID: 19001085

Title: Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.

PubMed ID: 19001085

DOI: 10.1128/mcb.00904-08

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 486
Mass: 54240
Checksum: 0EE14FEFA0A31412
Sequence:

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 
VSEEHDILKK KELESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVADVEKH SSQTDAARGF 
GGKYGVERDR ADKSAVGFDY KGEVEKHASQ KDYSHGFGGR YGVEKDKRDK AALGYDYKGE 
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGARGLKA 
KFESLAEEKR KREEEEKAQQ MARQQQERKA VVKMSREVQQ PSMPVEEPAA PAQLPKKISS 
EVWPPAESHL PPESQPVRSR REYPVPSLPT RQSPLQNHLE DNEEPPALPP RTPEGLQVVE 
EPVYEAAPEL EPEPEPDYEP EPETEPDYED VGELDRQDED AEGDYEDVLE PEDTPSLSYQ 
AGPSAGAGGA GISAIALYDY QGEGSDELSF DPDDIITDIE MVDEGWWRGQ CRGHFGLFPA 
NYVKLL

Genular Protein ID: 784081688

Symbol: Q8CA06_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CA06

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 139
Mass: 15501
Checksum: BDD32FF52960D87C
Sequence:

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 
VSEEHDILKK KELESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVADVEKH SSQTDAARGF 
GGKYGVERDR ADKSAVGFD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hcls1

Associated with

Other Information

Molecular cloning and characterization of mouse HS1. PubMed ID: 7535527

LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56(lck). PubMed ID: 7628441

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Distinct binding patterns of HS1 to the Src SH2 and SH3 domains reflect possible mechanisms of recruitment and activation of downstream molecules. PubMed ID: 8943564

Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. PubMed ID: 10590261

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. PubMed ID: 19064729

Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells. PubMed ID: 19001085

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073