Details for: Ptpn6

Gene ID: 15170

Symbol: Ptpn6

Ensembl ID: ENSMUSG00000004266

Description: protein tyrosine phosphatase, non-receptor type 6

Associated with

Other Information

Genular Protein ID: 2338184338

Symbol: PTN6_MOUSE

Name: Tyrosine-protein phosphatase non-receptor type 6

UniProtKB Accession Codes:

P29351 O35128 Q63872 Q63873 Q63874 Q921G3 Q9QVA6 Q9QVA7 Q9QVA8 Q9R0V6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 3 CTD 1 CarbonylDB 1 ChEBI 4 ChiTaRS 1 DIP 1 DNASU 1 EC 2 ELM 1 EMBL 17 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 51 Gene3D 2 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 14 RefSeq 2 Rhea 3 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1732748

Title: Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

PubMed ID: 1732748

DOI: 10.1128/mcb.12.2.836-846.1992

PubMed ID: 1373816

Title: Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

PubMed ID: 1373816

DOI: 10.1128/mcb.12.5.2396-2405.1992

PubMed ID: 8324828

Title: Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

PubMed ID: 8324828

DOI: 10.1016/0092-8674(93)90369-2

PubMed ID: 9445485

Title: Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.

PubMed ID: 9445485

PubMed ID: 10419485

Title: Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1.

PubMed ID: 10419485

DOI: 10.1074/jbc.274.31.21725

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1385421

Title: Protein tyrosine phosphatase-1C is rapidly phosphorylated in tyrosine in macrophages in response to colony stimulating factor-1.

PubMed ID: 1385421

DOI: 10.1016/s0021-9258(18)35855-1

PubMed ID: 1932742

Title: Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification.

PubMed ID: 1932742

PubMed ID: 9712903

Title: High expression of inhibitory receptor SHPS-1 and its association with protein tyrosine phosphatase SHP-1 in macrophages.

PubMed ID: 9712903

DOI: 10.1074/jbc.273.35.22719

PubMed ID: 9528781

Title: SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.

PubMed ID: 9528781

DOI: 10.1128/mcb.18.4.2089

PubMed ID: 9867848

Title: The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells.

PubMed ID: 9867848

DOI: 10.1074/jbc.274.1.335

PubMed ID: 10026201

Title: gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization.

PubMed ID: 10026201

DOI: 10.1074/jbc.274.9.5791

PubMed ID: 9973385

Title: Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B.

PubMed ID: 9973385

PubMed ID: 14662855

Title: CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation.

PubMed ID: 14662855

DOI: 10.4049/jimmunol.171.12.6541

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19419305

Title: New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification.

PubMed ID: 19419305

DOI: 10.1359/jbmr.090417

PubMed ID: 19948503

Title: Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src.

PubMed ID: 19948503

DOI: 10.1083/jcb.200904150

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20526344

Title: An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.

PubMed ID: 20526344

DOI: 10.1038/ni.1886

PubMed ID: 23112346

Title: Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.

PubMed ID: 23112346

DOI: 10.1126/scisignal.2002936

PubMed ID: 29247647

Title: Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages.

PubMed ID: 29247647

DOI: 10.1016/j.bbrc.2017.12.061

Sequence Information:

  • Length: 595
  • Mass: 67559
  • Checksum: CF17300D032638D2
  • Sequence:
    • MVRWFHRDLS GPDAETLLKG RGVPGSFLAR PSRKNQGDFS LSVRVDDQVT HIRIQNSGDF 
YDLYGGEKFA TLTELVEYYT QQQGILQDRD GTIIHLKYPL NCSDPTSERW YHGHISGGQA 
ESLLQAKGEP WTFLVRESLS QPGDFVLSVL NDQPKAGPGS PLRVTHIKVM CEGGRYTVGG 
SETFDSLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA 
KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KSKNRYKNIL PFDHSRVILQ GRDSNIPGSD 
YINANYVKNQ LLGPDENSKT YIASQGCLDA TVNDFWQMAW QENTRVIVMT TREVEKGRNK 
CVPYWPEVGT QRVYGLYSVT NSREHDTAEY KLRTLQISPL DNGDLVREIW HYQYLSWPDH 
GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ESISTKGLDC 
DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEIIQSQK GQESEYGNIT 
YPPAVRSAHA KASRTSSKHK EEVYENVHSK SKKEEKVKKQ RSADKEKNKG SLKRK

Genular Protein ID: 2963673732

Symbol: Q3UB72_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UB72

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 Rhea 3 SAM 1 SMART 3 SUPFAM 2

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 595
  • Mass: 67599
  • Checksum: DD1DD9996FAF5CA8
  • Sequence:
    • MVRWFHRDLS GPDAETLLKG RGVPGSFLAR PSRKNQGDFS LSVRVDDQVT HIRIQNSGDF 
YDLYGGEKFA TLTELVEYYT QQQGILQDRD GTIIHLKYPL NCSDPTSERW YHGHISGGQA 
ESLLQAKGEP WTFLVRESLS QHGDFVLSVL NDQPKAGPGS PLRVTHIKVM CEGGRYTVGG 
SETFDSLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA 
KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KSKNRYKNIL PFDHSRVILQ GRDSNIPGSD 
YINANYVKNQ LLGPDENSKT YIASQGCLDA TVNDFWQMAW QENTRVIVMT TREVEKGRNK 
CVPYWPEVGT QRVYGLYSVT NSREHDTAEY KLRTLQISPL DNGDLVREIW HYQYLSWPDH 
GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ESISTKGLDC 
DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEIIQSQK GQESEYGNIT 
YPPAVRSAHA KASRTSSKHK EEVYENVHSK SKKEEKVKKQ RSADKEKNKG SLKRK

Genular Protein ID: 3166568599

Symbol: Q3UCJ0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UCJ0

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 ExpressionAtlas 1 GO 17 Gene3D 2 InterPro 8 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 2 PROSITE 7 PROSITE-ProRule 1 Pfam 2 RefSeq 1 Rhea 3 SAM 1 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 597
  • Mass: 67717
  • Checksum: E8491CE77E06E989
  • Sequence:
    • MLSRGWFHRD LSGPDAETLL KGRGVPGSFL ARPSRKNQGD FSLSVRVDDQ VTHIRIQNSG 
DFYDLYGGEK FATLTELVEY YTQQQGILQD RDGTIIHLKY PLNCSDPTSE RWYHGHISGG 
QAESLLQAKG EPWTFLVRES LSQPGDFVLS VLNDQPKAGP GSPLRVTHIK VMCEGGRYTV 
GGSETFDSLT DLVEHFKKTG IEEASGAFVY LRQPYYATRV NAADIENRVL ELNKKQESED 
TAKAGFWEEF ESLQKQEVKN LHQRLEGQRP ENKSKNRYKN ILPFDHSRVI LQGRDSNIPG 
SDYINANYVK NQLLGPDENS KTYIASQGCL DATVNDFWQM AWQENTRVIV MTTREVEKGR 
NKCVPYWPEV GTQRVYGLYS VTNSREHDTA EYKLRTLQIS PLDNGDLVRE IWHYQYLSWP 
DHGVPSEPGG VLSFLDQINQ RQESLPHAGP IIVHCSAGIG RTGTIIVIDM LMESISTKGL 
DCDIDIQKTI QMVRAQRSGM VQTEAQYKFI YVAIAQFIET TKKKLEIIQS QKGQESEYGN 
ITYPPAVRSA HAKASRTSSK HKEEVYENVH SKSKKEEKVK KQRSADKEKN KGSLKRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.