Details for: Hdac2

Gene ID: 15182

Symbol: Hdac2

Ensembl ID: ENSMUSG00000019777

Description: histone deacetylase 2

Associated with

  • Cardiac muscle cell development
    (GO:0055013)
  • Cardiac muscle cell proliferation
    (GO:0060038)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to trichostatin a
    (GO:0035984)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin dna binding
    (GO:0031490)
  • Chromatin organization
    (GO:0006325)
  • Chromatin remodeling
    (GO:0006338)
  • Chromosome, telomeric region
    (GO:0000781)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Deacetylase activity
    (GO:0019213)
  • Dendrite development
    (GO:0016358)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Embryonic digit morphogenesis
    (GO:0042733)
  • Enzyme binding
    (GO:0019899)
  • Epidermal cell differentiation
    (GO:0009913)
  • Eyelid development in camera-type eye
    (GO:0061029)
  • Fungiform papilla formation
    (GO:0061198)
  • Hair follicle placode formation
    (GO:0060789)
  • Heat shock protein binding
    (GO:0031072)
  • Heterochromatin
    (GO:0000792)
  • Heterochromatin formation
    (GO:0031507)
  • Hippocampus development
    (GO:0021766)
  • Histone binding
    (GO:0042393)
  • Histone deacetylase activity
    (GO:0004407)
  • Histone deacetylase binding
    (GO:0042826)
  • Histone deacetylase complex
    (GO:0000118)
  • Histone decrotonylase activity
    (GO:0160009)
  • Histone h4k16 deacetylase activity
    (GO:0034739)
  • Hydrolase activity
    (GO:0016787)
  • Krueppel-associated box domain binding
    (GO:0035851)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cardiac muscle cell proliferation
    (GO:0060044)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of dendritic spine development
    (GO:0061000)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of intrinsic apoptotic signaling pathway
    (GO:2001243)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of neuron projection development
    (GO:0010977)
  • Negative regulation of peptidyl-lysine acetylation
    (GO:2000757)
  • Negative regulation of stem cell population maintenance
    (GO:1902455)
  • Negative regulation of transcription by competitive promoter binding
    (GO:0010944)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Neuron differentiation
    (GO:0030182)
  • Nf-kappab binding
    (GO:0051059)
  • Nucleus
    (GO:0005634)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of interleukin-1 production
    (GO:0032732)
  • Positive regulation of male mating behavior
    (GO:1902437)
  • Positive regulation of oligodendrocyte differentiation
    (GO:0048714)
  • Positive regulation of proteolysis
    (GO:0045862)
  • Positive regulation of signaling receptor activity
    (GO:2000273)
  • Positive regulation of stem cell population maintenance
    (GO:1902459)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Protein de-2-hydroxyisobutyrylase activity
    (GO:0160010)
  • Protein deacetylation
    (GO:0006476)
  • Protein lysine deacetylase activity
    (GO:0033558)
  • Protein modification process
    (GO:0036211)
  • Regulation of cell fate specification
    (GO:0042659)
  • Regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051896)
  • Regulation of protein deacetylation
    (GO:0090311)
  • Regulation of sarcomere organization
    (GO:0060297)
  • Regulation of stem cell differentiation
    (GO:2000736)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription corepressor binding
    (GO:0001222)

Other Information

Genular Protein ID: 3215155946

Symbol: HDAC2_MOUSE

Name: YY1 transcription factor-binding protein

UniProtKB Accession Codes:

P70288 B2RRP3

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 16 ChEMBL 3 ChiTaRS 1 ComplexPortal 5 DIP 1 DNASU 1 EC 1 EMBL 3 EPD 1 GO 84 Gene3D 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 Rhea 16 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8917507

Title: Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.

PubMed ID: 8917507

DOI: 10.1073/pnas.93.23.12845

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9702189

Title: SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.

PubMed ID: 9702189

DOI: 10.1016/s1097-2765(00)80111-2

PubMed ID: 10984530

Title: Identification of a nuclear domain with deacetylase activity.

PubMed ID: 10984530

DOI: 10.1073/pnas.97.19.10330

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 11788710

Title: Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases.

PubMed ID: 11788710

DOI: 10.1093/nar/30.2.475

PubMed ID: 12398767

Title: An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.

PubMed ID: 12398767

DOI: 10.1042/bj20020854

PubMed ID: 15226430

Title: Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation.

PubMed ID: 15226430

DOI: 10.1128/mcb.24.14.6278-6287.2004

PubMed ID: 16107708

Title: Structural characterization of the histone variant macroH2A.

PubMed ID: 16107708

DOI: 10.1128/mcb.25.17.7616-7624.2005

PubMed ID: 16537907

Title: PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.

PubMed ID: 16537907

DOI: 10.1128/mcb.26.7.2626-2636.2006

PubMed ID: 17707228

Title: Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.

PubMed ID: 17707228

DOI: 10.1016/j.molcel.2007.06.039

PubMed ID: 17666527

Title: Repression of Six3 by a corepressor regulates rhodopsin expression.

PubMed ID: 17666527

DOI: 10.1073/pnas.0705878104

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18754010

Title: S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons.

PubMed ID: 18754010

DOI: 10.1038/nature07238

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20071335

Title: Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway.

PubMed ID: 20071335

DOI: 10.1074/jbc.m109.079095

PubMed ID: 20519513

Title: Regulation of NF-kappaB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis.

PubMed ID: 20519513

DOI: 10.1074/jbc.m110.139469

PubMed ID: 28314777

Title:

PubMed ID: 28314777

DOI: 10.1074/jbc.a117.139469

PubMed ID: 20972425

Title: GAPDH mediates nitrosylation of nuclear proteins.

PubMed ID: 20972425

DOI: 10.1038/ncb2114

PubMed ID: 21177534

Title: A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription.

PubMed ID: 21177534

DOI: 10.1074/jbc.m110.178780

PubMed ID: 22391310

Title: ZFP932 suppresses cellular Hedgehog response and Patched1 transcription.

PubMed ID: 22391310

DOI: 10.1016/b978-0-12-394622-5.00014-6

PubMed ID: 24227653

Title: Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.

PubMed ID: 24227653

DOI: 10.1242/dev.097642

PubMed ID: 27806305

Title: A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.

PubMed ID: 27806305

DOI: 10.1016/j.celrep.2016.10.022

PubMed ID: 34180153

Title: PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.

PubMed ID: 34180153

DOI: 10.1002/advs.202102060

PubMed ID: 30279482

Title: Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.

PubMed ID: 30279482

DOI: 10.1038/s41598-018-32927-9

PubMed ID: 34075040

Title: Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.

PubMed ID: 34075040

DOI: 10.1038/s41467-021-23378-4

PubMed ID: 35341968

Title: The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis.

PubMed ID: 35341968

DOI: 10.1016/j.jgg.2022.03.005

Sequence Information:

  • Length: 488
  • Mass: 55302
  • Checksum: B9843D24A775157C
  • Sequence:
    • MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVAK TFNLPLLMLG 
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDPKGA 
KSEQLSNP

Genular Protein ID: 2049810135

Symbol: A0A0R4J008_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J008

Database IDs:

AGR 1 ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DNASU 1 EC 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 45 Gene3D 1 GeneTree 1 InterPro 5 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 3 PRINTS 2 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 12 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.M800451-MCP200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 488
  • Mass: 55330
  • Checksum: 675519C9D9AE07FA
  • Sequence:
    • MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG 
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDPKGA 
KSEQLSNP

Genular Protein ID: 853847647

Symbol: Q3TMT1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TMT1

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 Google 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 50
  • Mass: 5925
  • Checksum: 2FD6BCCC32512451
  • Sequence:
    • MAYSQGGGKK KMCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.