Genular: Defining Cellular Identity and Function

Details for: Hdac3

Gene ID: 15183

Symbol: Hdac3

Ensembl ID: ENSMUSG00000024454

Description: histone deacetylase 3

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Chromatin modifying enzymes
(R-MMU-3247509)
Cytoprotection by hmox1
(R-MMU-9707564)
Developmental biology
(R-MMU-1266738)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdacs deacetylate histones
(R-MMU-3214815)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Notch-hlh transcription pathway
(R-MMU-350054)
Nr1h2 and nr1h3-mediated signaling
(R-MMU-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-MMU-9029569)
Regulation of lipid metabolism by pparalpha
(R-MMU-400206)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by alk
(R-MMU-201556)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Stat3 nuclear events downstream of alk signaling
(R-MMU-9701898)
Transcriptional regulation of white adipocyte differentiation
(R-MMU-381340)
Cellular response to fluid shear stress
(GO:0071498)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Chromatin organization
(GO:0006325)
Circadian regulation of gene expression
(GO:0032922)
Cornified envelope assembly
(GO:1903575)
Cyclin binding
(GO:0030332)
Cytoplasm
(GO:0005737)
Deacetylase activity
(GO:0019213)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Dna repair-dependent chromatin remodeling
(GO:0140861)
Enzyme binding
(GO:0019899)
Epidermis development
(GO:0008544)
Establishment of mitotic spindle orientation
(GO:0000132)
Establishment of skin barrier
(GO:0061436)
Gene expression
(GO:0010467)
Golgi apparatus
(GO:0005794)
Gtpase binding
(GO:0051020)
Histone deacetylase activity
(GO:0004407)
Histone deacetylase binding
(GO:0042826)
Histone deacetylase complex
(GO:0000118)
Histone decrotonylase activity
(GO:0160009)
Hydrolase activity
(GO:0016787)
In utero embryonic development
(GO:0001701)
Negative regulation of cardiac muscle cell differentiation
(GO:2000726)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of interleukin-1 production
(GO:0032692)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of protein export from nucleus
(GO:0046826)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nf-kappab binding
(GO:0051059)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of tor signaling
(GO:0032008)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type b pancreatic cell apoptotic process
(GO:2000676)
Protein binding
(GO:0005515)
Protein de-2-hydroxyisobutyrylase activity
(GO:0160010)
Protein deacetylation
(GO:0006476)
Protein decrotonylase activity
(GO:0160008)
Protein lysine deacetylase activity
(GO:0033558)
Protein modification process
(GO:0036211)
Regulation of circadian rhythm
(GO:0042752)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of multicellular organism growth
(GO:0040014)
Regulation of protein stability
(GO:0031647)
Rhythmic process
(GO:0048511)
Spindle assembly
(GO:0051225)
Transcription by rna polymerase ii
(GO:0006366)
Transcription corepressor activity
(GO:0003714)
Transcription corepressor binding
(GO:0001222)
Transcription factor binding
(GO:0008134)
Ubiquitin-specific protease binding
(GO:1990381)

Other Information

Proteins

Protein deacetylase HDAC3
Q9JM08_MOUSE

Genular Protein ID: 3768073730

Symbol: HDAC3_MOUSE

Name: Protein deacetylase HDAC3

UniProtKB Accession Codes:

O88895 O88896 Q3UM33

Database IDs:

Citations:

PubMed ID: 10491319

Title: Cloning and characterization of the murine histone deacetylase (HDAC3).

PubMed ID: 10491319

DOI: 10.1006/bbrc.1999.1389

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10984530

Title: Identification of a nuclear domain with deacetylase activity.

PubMed ID: 10984530

DOI: 10.1073/pnas.97.19.10330

PubMed ID: 11022042

Title: Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.

PubMed ID: 11022042

DOI: 10.1074/jbc.m007364200

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 12130660

Title: Tissue-specific regulation of retinal and pituitary precursor cell proliferation.

PubMed ID: 12130660

DOI: 10.1126/science.1073263

PubMed ID: 15711539

Title: Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.

PubMed ID: 15711539

DOI: 10.1038/nn1408

PubMed ID: 16326862

Title: Kruppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1).

PubMed ID: 16326862

DOI: 10.1093/nar/gki985

PubMed ID: 16537907

Title: PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.

PubMed ID: 16537907

DOI: 10.1128/mcb.26.7.2626-2636.2006

PubMed ID: 19037247

Title: Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology.

PubMed ID: 19037247

DOI: 10.1038/nature07541

PubMed ID: 19204783

Title: HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3.

PubMed ID: 19204783

DOI: 10.1371/journal.pone.0004363

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20675388

Title: Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.

PubMed ID: 20675388

DOI: 10.1074/jbc.m110.116418

PubMed ID: 23911289

Title: A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

PubMed ID: 23911289

DOI: 10.1016/j.celrep.2013.06.016

PubMed ID: 25875095

Title: A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.

PubMed ID: 25875095

DOI: 10.1371/journal.pone.0124293

PubMed ID: 26776516

Title: Distinct roles of HDAC3 in the core circadian negative feedback loop are critical for clock function.

PubMed ID: 26776516

DOI: 10.1016/j.celrep.2015.12.076

PubMed ID: 30455454

Title: Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition.

PubMed ID: 30455454

DOI: 10.1038/s41593-018-0266-2

PubMed ID: 30279482

Title: Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.

PubMed ID: 30279482

DOI: 10.1038/s41598-018-32927-9

Sequence Information:

Length: 428
Mass: 48821
Checksum: 1CB84DE250C3BB2C
Sequence:

MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR 
FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN 
KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 
FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 
SQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 
TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN 
DKESDVEI

Genular Protein ID: 736594382

Symbol: Q9JM08_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9JM08

Database IDs:

Citations:

PubMed ID: 10542131

Title: Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5.

PubMed ID: 10542131

DOI: 10.1006/mcbr.1999.0156

Sequence Information:

Length: 428
Mass: 48891
Checksum: 995EFFB8275688D4
Sequence:

MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR 
FHSEDYIDFL QRVSPTNMQG FTKSLDAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN 
KICDIAINWA RGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 
FYLTDRVMTV SFHKYGNYFF PGAGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 
SQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 
TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN 
DKESDVEI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hdac3

Associated with

Other Information

Cloning and characterization of the murine histone deacetylase (HDAC3). PubMed ID: 10491319

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a nuclear domain with deacetylase activity. PubMed ID: 10984530

Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. PubMed ID: 11022042

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. PubMed ID: 11533236

Tissue-specific regulation of retinal and pituitary precursor cell proliferation. PubMed ID: 12130660

Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression. PubMed ID: 15711539

Kruppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1). PubMed ID: 16326862

PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. PubMed ID: 16537907

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. PubMed ID: 19037247

HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. PubMed ID: 19204783

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. PubMed ID: 20675388

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. PubMed ID: 23911289

A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis. PubMed ID: 25875095

Distinct roles of HDAC3 in the core circadian negative feedback loop are critical for clock function. PubMed ID: 26776516

Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. PubMed ID: 30455454

Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. PubMed ID: 30279482

Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5. PubMed ID: 10542131