Gene CTSO - ENSG00000256043 | NCBI Gene ID: 1519

Details for: CTSO

Gene ID: 1519

Symbol: CTSO

Ensembl ID: ENSG00000256043

Description: cathepsin O

Associated with

Adaptive immune system
(R-HSA-1280218)
Immune system
(R-HSA-168256)
Mhc class ii antigen presentation
(R-HSA-2132295)
Cysteine-type endopeptidase activity
(GO:0004197)
Extracellular space
(GO:0005615)
Lysosome
(GO:0005764)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 3.63
Marker Score: 1582
Cell Name: keratocyte (CL0002363)
Fold Change: 1.22
Marker Score: 281
Cell Name: decidual cell (CL2000002)
Fold Change: 1.06
Marker Score: 4565
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.04
Marker Score: 1423.5
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.02
Marker Score: 1060
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30398
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2399
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 478
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 435
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.91
Marker Score: 2381
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2707
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.88
Marker Score: 2354
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5245
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.86
Marker Score: 4884
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.83
Marker Score: 2048
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.82
Marker Score: 1636
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.82
Marker Score: 1324
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.81
Marker Score: 539
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.77
Marker Score: 8711
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.77
Marker Score: 1744
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.76
Marker Score: 6688
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 563.5
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.73
Marker Score: 213
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.71
Marker Score: 269
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 637
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.7
Marker Score: 3010
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.66
Marker Score: 164
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 169
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.66
Marker Score: 2754
Cell Name: fibroblast (CL0000057)
Fold Change: 0.65
Marker Score: 624
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.64
Marker Score: 925
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.64
Marker Score: 648
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.64
Marker Score: 237
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.63
Marker Score: 178
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.62
Marker Score: 410
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.62
Marker Score: 3977
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.62
Marker Score: 360
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.6
Marker Score: 519
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.59
Marker Score: 133
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.58
Marker Score: 518
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.58
Marker Score: 1459
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.57
Marker Score: 213
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.56
Marker Score: 565
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.56
Marker Score: 480
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.56
Marker Score: 392
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.55
Marker Score: 132
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.55
Marker Score: 2153
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.54
Marker Score: 4697
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 431
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.54
Marker Score: 575
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.53
Marker Score: 491
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.53
Marker Score: 322
Cell Name: supporting cell (CL0000630)
Fold Change: 0.53
Marker Score: 996
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.53
Marker Score: 522
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.52
Marker Score: 371
Cell Name: stromal cell (CL0000499)
Fold Change: 0.52
Marker Score: 607
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.52
Marker Score: 326
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.52
Marker Score: 543
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.51
Marker Score: 235
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.51
Marker Score: 282
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.51
Marker Score: 13104
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.51
Marker Score: 325
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.5
Marker Score: 2712
Cell Name: melanocyte (CL0000148)
Fold Change: 0.5
Marker Score: 203
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.5
Marker Score: 3239
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.5
Marker Score: 207
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.49
Marker Score: 727
Cell Name: ionocyte (CL0005006)
Fold Change: 0.49
Marker Score: 148
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.48
Marker Score: 462
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.48
Marker Score: 437
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.48
Marker Score: 139
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.48
Marker Score: 167
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.48
Marker Score: 1995
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.48
Marker Score: 327.5
Cell Name: osteoblast (CL0000062)
Fold Change: 0.47
Marker Score: 255
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.47
Marker Score: 568
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.47
Marker Score: 507
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.46
Marker Score: 3020
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.46
Marker Score: 1173
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.46
Marker Score: 257
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.46
Marker Score: 1085
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.46
Marker Score: 287
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.45
Marker Score: 443
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.45
Marker Score: 850
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.44
Marker Score: 1579.5
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.44
Marker Score: 704
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.44
Marker Score: 102
Cell Name: theca cell (CL0000503)
Fold Change: 0.44
Marker Score: 314
Cell Name: thymocyte (CL0000893)
Fold Change: 0.44
Marker Score: 457
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.44
Marker Score: 297
Cell Name: reticular cell (CL0000432)
Fold Change: 0.44
Marker Score: 159
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.44
Marker Score: 291
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.43
Marker Score: 181
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.43
Marker Score: 719
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.43
Marker Score: 245
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.43
Marker Score: 612
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.43
Marker Score: 101
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.43
Marker Score: 113

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**Key characteristics:** * Gene name: CTSO * Ensembl ID: ENSG00000256043 * Protein name: Cathepsin O * Protein length: 103 amino acids * Protein function: Cysteine-type endopeptidase activity * Pathway: Adaptive immune system, Cysteine-type endopeptidase activity * Ontology: Extracellular space, Immune system, Lysosome, Mhc class ii antigen presentation **Pathways and functions:** * Cathepsin O is a key enzyme involved in the proteolytic degradation of extracellular matrix proteins, contributing to the remodeling and turnover of tissues. * It is expressed in epithelial cells of the skin, lungs, pancreas, intestine, and other tissues. * In the skin, cathepsin O is involved in the degradation of proteoglycans, which are important components of the extracellular matrix. * It also plays a role in the regulation of immune responses and inflammation. **Clinical significance:** * Mutations in the CTSO gene have been linked to various diseases, including psoriasis, rheumatoid arthritis, and cancer. * Cathepsin O is a potential therapeutic target for these diseases, as it can be used to inhibit the activity of the enzyme and suppress inflammation. * Studies have shown that blocking cathepsin O signaling can ameliorate disease symptoms in animal models.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cathepsin O

Genular Protein ID: 1789404409

Symbol: CATO_HUMAN

Name: Cathepsin O

UniProtKB Accession Codes:

P43234

Database IDs:

Citations:

PubMed ID: 7929457

Title: Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.

PubMed ID: 7929457

DOI: 10.1016/s0021-9258(18)47135-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 321
Mass: 35958
Checksum: F48011ECA9E0BC45
Sequence:

MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR HRYLNSLFPS 
ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH MSIPNVSLPL RFDWRDKQVV 
TQVRNQQMCG GCWAFSVVGA VESAYAIKGK PLEDLSVQQV IDCSYNNYGC NGGSTLNALN 
WLNKMQVKLV KDSEYPFKAQ NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP 
LVVIVDAVSW QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY 
AHVKMGSNVC GIADSVSSIF V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.