Details for: CTSO

Gene ID: 1519

Symbol: CTSO

Ensembl ID: ENSG00000256043

Description: cathepsin O

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 101.2567
    Cell Significance Index: -15.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.8946
    Cell Significance Index: -13.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.5378
    Cell Significance Index: -15.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.0455
    Cell Significance Index: -17.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 31.8633
    Cell Significance Index: -16.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.0672
    Cell Significance Index: -15.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.8553
    Cell Significance Index: -15.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3754
    Cell Significance Index: -14.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9178
    Cell Significance Index: -15.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3995
    Cell Significance Index: -7.4400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.1472
    Cell Significance Index: 18.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0026
    Cell Significance Index: 163.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9610
    Cell Significance Index: 95.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9161
    Cell Significance Index: 827.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7873
    Cell Significance Index: 85.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7598
    Cell Significance Index: 11.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7330
    Cell Significance Index: 38.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5651
    Cell Significance Index: 11.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4845
    Cell Significance Index: 66.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4808
    Cell Significance Index: 6.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4548
    Cell Significance Index: 12.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4465
    Cell Significance Index: 30.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3659
    Cell Significance Index: 17.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3530
    Cell Significance Index: 63.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3089
    Cell Significance Index: 5.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3008
    Cell Significance Index: 6.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2943
    Cell Significance Index: 37.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2843
    Cell Significance Index: 14.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2708
    Cell Significance Index: 6.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2598
    Cell Significance Index: 13.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2427
    Cell Significance Index: 29.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1918
    Cell Significance Index: 104.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1765
    Cell Significance Index: 4.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1527
    Cell Significance Index: 4.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1363
    Cell Significance Index: 60.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1115
    Cell Significance Index: 12.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0762
    Cell Significance Index: 15.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0721
    Cell Significance Index: 49.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0683
    Cell Significance Index: 5.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0485
    Cell Significance Index: 0.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0456
    Cell Significance Index: 1.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0401
    Cell Significance Index: 8.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0317
    Cell Significance Index: 4.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0293
    Cell Significance Index: 5.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0267
    Cell Significance Index: 19.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0251
    Cell Significance Index: 4.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0201
    Cell Significance Index: 1.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0057
    Cell Significance Index: 2.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0031
    Cell Significance Index: 0.1100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0022
    Cell Significance Index: 4.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0058
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -14.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0083
    Cell Significance Index: -6.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0097
    Cell Significance Index: -14.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0107
    Cell Significance Index: -6.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0114
    Cell Significance Index: -7.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0123
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0129
    Cell Significance Index: -8.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0140
    Cell Significance Index: -19.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0150
    Cell Significance Index: -0.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0171
    Cell Significance Index: -1.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0235
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0250
    Cell Significance Index: -2.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0273
    Cell Significance Index: -0.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0310
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0422
    Cell Significance Index: -8.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0574
    Cell Significance Index: -16.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0640
    Cell Significance Index: -7.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0675
    Cell Significance Index: -3.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0846
    Cell Significance Index: -1.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0863
    Cell Significance Index: -0.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0869
    Cell Significance Index: -10.2500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0913
    Cell Significance Index: -0.5700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1064
    Cell Significance Index: -1.1300
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1166
    Cell Significance Index: -0.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1176
    Cell Significance Index: -3.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1220
    Cell Significance Index: -2.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1428
    Cell Significance Index: -2.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1508
    Cell Significance Index: -4.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1516
    Cell Significance Index: -15.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1587
    Cell Significance Index: -4.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1796
    Cell Significance Index: -13.7800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1797
    Cell Significance Index: -1.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1803
    Cell Significance Index: -14.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1952
    Cell Significance Index: -11.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1966
    Cell Significance Index: -5.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2088
    Cell Significance Index: -13.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2108
    Cell Significance Index: -5.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2498
    Cell Significance Index: -11.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2541
    Cell Significance Index: -13.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2563
    Cell Significance Index: -3.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2585
    Cell Significance Index: -3.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2620
    Cell Significance Index: -4.6300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2622
    Cell Significance Index: -3.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2717
    Cell Significance Index: -9.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2903
    Cell Significance Index: -3.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2935
    Cell Significance Index: -8.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cysteine-type endopeptidase**: Cathepsin O is a member of the lysosomal cysteine protease family, characterized by its ability to cleave peptide bonds at cysteine residues. 2. **Antigen presentation**: Cathepsin O is involved in the processing and presentation of antigens to the adaptive immune system, particularly through the MHC class II pathway. 3. **Proteolysis**: Cathepsin O participates in the degradation of proteins, including those involved in immune responses and cellular signaling. 4. **Expression in multiple cell types**: Cathepsin O is expressed in various cell types, including epithelial cells, fibroblasts, and immune cells, suggesting its involvement in diverse cellular processes. **Pathways and Functions:** 1. **Adaptive immune system**: Cathepsin O is involved in the processing and presentation of antigens to T-cells, facilitating the adaptive immune response. 2. **Cysteine-type endopeptidase activity**: Cathepsin O's enzymatic activity is crucial for protein degradation and the processing of peptides for antigen presentation. 3. **Lysosome-mediated proteolysis**: Cathepsin O is a key component of lysosomes, where it participates in the degradation of proteins and lipids. 4. **Immune system regulation**: Cathepsin O's expression and activity are modulated by various immune cells and cytokines, suggesting its role in regulating immune responses. **Clinical Significance:** 1. **Autoimmune diseases**: Aberrant expression or activity of cathepsin O has been implicated in various autoimmune diseases, including rheumatoid arthritis and multiple sclerosis, highlighting its potential as a therapeutic target. 2. **Cancer**: Cathepsin O's role in protein degradation and antigen presentation makes it a potential target for cancer immunotherapy. 3. **Infectious diseases**: Cathepsin O's involvement in immune regulation and antigen presentation may contribute to the pathogenesis of infectious diseases, such as tuberculosis and HIV. 4. **Tissue homeostasis**: Cathepsin O's expression in epithelial cells and fibroblasts suggests its role in maintaining tissue homeostasis and preventing disease. In conclusion, cathepsin O is a multifaceted protein involved in various cellular processes, including proteolysis, antigen presentation, and immune regulation. Its expression in multiple cell types and involvement in diverse pathways highlight its importance in maintaining tissue homeostasis and immune function. Further research is needed to fully elucidate the role of cathepsin O in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1789404409

Symbol: CATO_HUMAN

Name: Cathepsin O

UniProtKB Accession Codes:

P43234

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7929457

Title: Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.

PubMed ID: 7929457

DOI: 10.1016/s0021-9258(18)47135-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 321
  • Mass: 35958
  • Checksum: F48011ECA9E0BC45
  • Sequence:
    • MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR HRYLNSLFPS 
ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH MSIPNVSLPL RFDWRDKQVV 
TQVRNQQMCG GCWAFSVVGA VESAYAIKGK PLEDLSVQQV IDCSYNNYGC NGGSTLNALN 
WLNKMQVKLV KDSEYPFKAQ NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP 
LVVIVDAVSW QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY 
AHVKMGSNVC GIADSVSSIF V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.