Details for: ADRA2C

Gene ID: 152

Symbol: ADRA2C

Ensembl ID: ENSG00000184160

Description: adrenoceptor alpha 2C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 8.8105
    Cell Significance Index: 182.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.8811
    Cell Significance Index: 83.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9089
    Cell Significance Index: 41.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.5964
    Cell Significance Index: 39.9100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8296
    Cell Significance Index: 13.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6691
    Cell Significance Index: 108.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5638
    Cell Significance Index: 33.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5365
    Cell Significance Index: 11.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4843
    Cell Significance Index: 47.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4723
    Cell Significance Index: 16.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4478
    Cell Significance Index: 23.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4198
    Cell Significance Index: 48.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3569
    Cell Significance Index: 67.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2228
    Cell Significance Index: 3.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1982
    Cell Significance Index: 21.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1953
    Cell Significance Index: 106.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1944
    Cell Significance Index: 1.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1306
    Cell Significance Index: 2.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0890
    Cell Significance Index: 16.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0878
    Cell Significance Index: 6.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0762
    Cell Significance Index: 27.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0524
    Cell Significance Index: 10.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0233
    Cell Significance Index: 4.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0082
    Cell Significance Index: 5.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0036
    Cell Significance Index: -0.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0038
    Cell Significance Index: -0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0112
    Cell Significance Index: -8.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0113
    Cell Significance Index: -6.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0220
    Cell Significance Index: -6.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0243
    Cell Significance Index: -1.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0258
    Cell Significance Index: -11.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0266
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0312
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0343
    Cell Significance Index: -7.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0350
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0375
    Cell Significance Index: -6.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0422
    Cell Significance Index: -1.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0461
    Cell Significance Index: -2.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0479
    Cell Significance Index: -3.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0500
    Cell Significance Index: -5.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0568
    Cell Significance Index: -2.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0594
    Cell Significance Index: -1.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0599
    Cell Significance Index: -8.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0678
    Cell Significance Index: -1.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0703
    Cell Significance Index: -9.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0795
    Cell Significance Index: -6.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0808
    Cell Significance Index: -3.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0819
    Cell Significance Index: -0.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0834
    Cell Significance Index: -3.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0836
    Cell Significance Index: -1.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0855
    Cell Significance Index: -0.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0879
    Cell Significance Index: -2.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0951
    Cell Significance Index: -1.9900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0970
    Cell Significance Index: -1.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1104
    Cell Significance Index: -7.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1214
    Cell Significance Index: -7.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1224
    Cell Significance Index: -9.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1431
    Cell Significance Index: -10.9800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1504
    Cell Significance Index: -2.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1522
    Cell Significance Index: -7.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1606
    Cell Significance Index: -9.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1631
    Cell Significance Index: -5.3400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1642
    Cell Significance Index: -1.4800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1681
    Cell Significance Index: -0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1684
    Cell Significance Index: -9.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1756
    Cell Significance Index: -8.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1759
    Cell Significance Index: -8.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1841
    Cell Significance Index: -6.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1864
    Cell Significance Index: -4.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1867
    Cell Significance Index: -11.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1900
    Cell Significance Index: -4.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2038
    Cell Significance Index: -6.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2213
    Cell Significance Index: -11.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2306
    Cell Significance Index: -6.5800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2408
    Cell Significance Index: -3.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2450
    Cell Significance Index: -6.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2452
    Cell Significance Index: -7.0300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2476
    Cell Significance Index: -2.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2557
    Cell Significance Index: -7.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2601
    Cell Significance Index: -9.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2612
    Cell Significance Index: -7.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2761
    Cell Significance Index: -7.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2826
    Cell Significance Index: -7.5600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2831
    Cell Significance Index: -5.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2842
    Cell Significance Index: -4.0700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2894
    Cell Significance Index: -2.4600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2967
    Cell Significance Index: -1.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3003
    Cell Significance Index: -7.4900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3134
    Cell Significance Index: -1.9200
  • Cell Name: lung perichondrial fibroblast (CL4033026)
    Fold Change: -0.3145
    Cell Significance Index: -2.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3193
    Cell Significance Index: -6.4100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3209
    Cell Significance Index: -6.4000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3276
    Cell Significance Index: -3.7200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3285
    Cell Significance Index: -3.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** The alpha-2C adrenergic receptor is a G-protein coupled receptor (GPCR) that belongs to the class A/1 (rhodopsin-like receptors) family. It is characterized by its seven transmembrane domains and its ability to bind to the endogenous ligands adrenaline and noradrenaline. 2. **Expression Pattern:** The ADRA2C gene is widely expressed in various tissues, including the cardiovascular system, nervous system, and gastrointestinal tract. It is particularly abundant in the heart, smooth muscle cells, and neurons. 3. **Signal Transduction:** The activation of the alpha-2C adrenergic receptor triggers a signaling cascade that involves the activation of protein kinase B (PKB) and the inhibition of adenylate cyclase. This leads to a decrease in intracellular cAMP levels and a subsequent relaxation of smooth muscle cells. **Pathways and Functions:** 1. **Regulation of Insulin Secretion:** The alpha-2C adrenergic receptor is involved in the regulation of insulin secretion in pancreatic beta cells. Its activation inhibits insulin release, which is important for maintaining blood glucose levels. 2. **Smooth Muscle Contraction:** The alpha-2C adrenergic receptor is involved in the regulation of smooth muscle contraction in various tissues, including the heart, blood vessels, and gastrointestinal tract. 3. **Vasoconstriction:** The alpha-2C adrenergic receptor is involved in the regulation of vasoconstriction in blood vessels. Its activation leads to a decrease in blood flow and an increase in blood pressure. 4. **Neurotransmission:** The alpha-2C adrenergic receptor is involved in the regulation of neurotransmission in the nervous system. Its activation inhibits the release of neurotransmitters, such as dopamine and norepinephrine. **Clinical Significance:** 1. **Hypertension:** The alpha-2C adrenergic receptor is involved in the regulation of blood pressure. Its dysregulation has been implicated in the development of hypertension. 2. **Cardiovascular Disease:** The alpha-2C adrenergic receptor is involved in the regulation of cardiovascular function. Its dysregulation has been implicated in the development of cardiovascular disease. 3. **Diabetes:** The alpha-2C adrenergic receptor is involved in the regulation of insulin secretion. Its dysregulation has been implicated in the development of diabetes. 4. **Cancer:** The alpha-2C adrenergic receptor is involved in the regulation of cell proliferation and differentiation. Its dysregulation has been implicated in the development of certain types of cancer. In conclusion, the ADRA2C gene encodes for the alpha-2C adrenergic receptor, a subtype of adrenoceptors that plays a crucial role in various physiological processes. Its dysregulation has been implicated in several diseases, including hypertension, cardiovascular disease, and diabetes. Further research is needed to fully understand the role of the alpha-2C adrenergic receptor in human health and disease.

Genular Protein ID: 2230842375

Symbol: ADA2C_HUMAN

Name: Alpha-2C adrenergic receptor

UniProtKB Accession Codes:

P18825 P35369 Q9HB49

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 78 DrugCentral 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2842764

Title: Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

PubMed ID: 2842764

DOI: 10.1073/pnas.85.17.6301

PubMed ID: 9371698

Title: Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene.

PubMed ID: 9371698

DOI: 10.1042/bj3280431

PubMed ID: 10801795

Title: A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors.

PubMed ID: 10801795

DOI: 10.1074/jbc.m000796200

PubMed ID: 15319474

Title: Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.

PubMed ID: 15319474

DOI: 10.1073/pnas.0405074101

PubMed ID: 1849485

Title: Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.

PubMed ID: 1849485

DOI: 10.1016/0014-5793(91)80301-i

Sequence Information:

  • Length: 462
  • Mass: 49522
  • Checksum: E1EF9CA21E7F6EDA
  • Sequence:
    • MASPALAAAL AVAAAAGPNA SGAGERGSGG VANASGASWG PPRGQYSAGA VAGLAAVVGF 
LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG 
QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA 
VISFPPLVSL YRQPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR 
TRTLSEKRAP VGPDGASPTT ENGLGAAAGA GENGHCAPPP ADVEPDESSA AAERRRRRGA 
LRRGGRRRAG AEGGAGGADG QGAGPGAAES GALTASRSPG PGGRLSRASS RSVEFFLSRR 
RRARSSVCRR KVAQAREKRF TFVLAVVMGV FVLCWFPFFF SYSLYGICRE ACQVPGPLFK 
FFFWIGYCNS SLNPVIYTVF NQDFRRSFKH ILFRRRRRGF RQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.