ADRA2C | ENSG00000184160 | NCBI 152

Details for: ADRA2C

Gene ID: 152

Symbol: ADRA2C

Ensembl ID: ENSG00000184160

Description: adrenoceptor alpha 2C

Associated with

Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Adrenaline signalling through alpha-2 adrenergic receptor
(R-HSA-392023)
Adrenoceptors
(R-HSA-390696)
Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (z) signalling events
(R-HSA-418597)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Hemostasis
(R-HSA-109582)
Integration of energy metabolism
(R-HSA-163685)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Regulation of insulin secretion
(R-HSA-422356)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Surfactant metabolism
(R-HSA-5683826)
Activation of protein kinase b activity
(GO:0032148)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adrenergic receptor signaling pathway
(GO:0071875)
Alpha-2a adrenergic receptor binding
(GO:0031694)
Alpha2-adrenergic receptor activity
(GO:0004938)
Cell-cell signaling
(GO:0007267)
Cytoplasm
(GO:0005737)
Endosome
(GO:0005768)
Epinephrine binding
(GO:0051379)
G protein-coupled receptor signaling pathway
(GO:0007186)
Negative regulation of epinephrine secretion
(GO:0032811)
Negative regulation of norepinephrine secretion
(GO:0010700)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of neuron differentiation
(GO:0045666)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Receptor transactivation
(GO:0035624)
Regulation of smooth muscle contraction
(GO:0006940)
Regulation of vasoconstriction
(GO:0019229)

Other Information

Proteins

Alpha-2C adrenergic receptor

Genular Protein ID: 2230842375

Symbol: ADA2C_HUMAN

Name: Alpha-2C adrenergic receptor

UniProtKB Accession Codes:

P18825 P35369 Q9HB49

Database IDs:

Citations:

PubMed ID: 2842764

Title: Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

PubMed ID: 2842764

DOI: 10.1073/pnas.85.17.6301

PubMed ID: 9371698

Title: Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene.

PubMed ID: 9371698

DOI: 10.1042/bj3280431

PubMed ID: 10801795

Title: A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors.

PubMed ID: 10801795

DOI: 10.1074/jbc.m000796200

PubMed ID: 15319474

Title: Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.

PubMed ID: 15319474

DOI: 10.1073/pnas.0405074101

PubMed ID: 1849485

Title: Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.

PubMed ID: 1849485

DOI: 10.1016/0014-5793(91)80301-i

Sequence Information:

Length: 462
Mass: 49522
Checksum: E1EF9CA21E7F6EDA
Sequence:

MASPALAAAL AVAAAAGPNA SGAGERGSGG VANASGASWG PPRGQYSAGA VAGLAAVVGF 
LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV ATLVMPFSLA NELMAYWYFG 
QVWCGVYLAL DVLFCTSSIV HLCAISLDRY WSVTQAVEYN LKRTPRRVKA TIVAVWLISA 
VISFPPLVSL YRQPDGAAYP QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR 
TRTLSEKRAP VGPDGASPTT ENGLGAAAGA GENGHCAPPP ADVEPDESSA AAERRRRRGA 
LRRGGRRRAG AEGGAGGADG QGAGPGAAES GALTASRSPG PGGRLSRASS RSVEFFLSRR 
RRARSSVCRR KVAQAREKRF TFVLAVVMGV FVLCWFPFFF SYSLYGICRE ACQVPGPLFK 
FFFWIGYCNS SLNPVIYTVF NQDFRRSFKH ILFRRRRRGF RQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADRA2C

Associated with

Other Information

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. PubMed ID: 2842764

Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene. PubMed ID: 9371698

A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. PubMed ID: 10801795