Gene CTSS - ENSG00000163131 | NCBI Gene ID: 1520

Details for: CTSS

Gene ID: 1520

Symbol: CTSS

Ensembl ID: ENSG00000163131

Description: cathepsin S

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Collagen formation
(R-HSA-1474290)
Degradation of the extracellular matrix
(R-HSA-1474228)
Endosomal/vacuolar pathway
(R-HSA-1236977)
Extracellular matrix organization
(R-HSA-1474244)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Mhc class ii antigen presentation
(R-HSA-2132295)
Neutrophil degranulation
(R-HSA-6798695)
Toll-like receptor cascades
(R-HSA-168898)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation
(GO:0019882)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Antigen processing and presentation of peptide antigen
(GO:0048002)
Apoptotic process
(GO:0006915)
Basement membrane disassembly
(GO:0034769)
Cellular response to thyroid hormone stimulus
(GO:0097067)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cysteine-type endopeptidase activity
(GO:0004197)
Endolysosome lumen
(GO:0036021)
Extracellular matrix disassembly
(GO:0022617)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Ficolin-1-rich granule lumen
(GO:1904813)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Laminin binding
(GO:0043236)
Late endosome
(GO:0005770)
Lysosomal lumen
(GO:0043202)
Lysosome
(GO:0005764)
Phagocytic vesicle
(GO:0045335)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of cation channel activity
(GO:2001259)
Positive regulation of peptidase activity
(GO:0010952)
Protein processing
(GO:0016485)
Proteoglycan binding
(GO:0043394)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Response to acidic ph
(GO:0010447)
Serine-type endopeptidase activity
(GO:0004252)
Tertiary granule lumen
(GO:1904724)
Toll-like receptor signaling pathway
(GO:0002224)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.48
Marker Score: 250416
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 4.26
Marker Score: 1857
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.68
Marker Score: 8876
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.59
Marker Score: 7002.5
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.58
Marker Score: 4090
Cell Name: blood cell (CL0000081)
Fold Change: 3.52
Marker Score: 40941.5
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.42
Marker Score: 4128
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.07
Marker Score: 7648.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.01
Marker Score: 3010
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.95
Marker Score: 75633.5
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.87
Marker Score: 24969
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.64
Marker Score: 2599
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.57
Marker Score: 6669
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.56
Marker Score: 15575
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.41
Marker Score: 854
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.38
Marker Score: 990
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.37
Marker Score: 1429
Cell Name: ciliated cell (CL0000064)
Fold Change: 2.35
Marker Score: 8093
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.25
Marker Score: 3926
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.23
Marker Score: 4231
Cell Name: enterocyte (CL0000584)
Fold Change: 2.21
Marker Score: 10625
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.19
Marker Score: 6865
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.16
Marker Score: 1190
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.16
Marker Score: 1470
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 2.09
Marker Score: 1079
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.03
Marker Score: 2995
Cell Name: early promyelocyte (CL0002154)
Fold Change: 2.01
Marker Score: 1610
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.99
Marker Score: 812
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 1.96
Marker Score: 1670
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.9
Marker Score: 819
Cell Name: myelocyte (CL0002193)
Fold Change: 1.87
Marker Score: 809
Cell Name: memory B cell (CL0000787)
Fold Change: 1.87
Marker Score: 1416
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.85
Marker Score: 878
Cell Name: mature T cell (CL0002419)
Fold Change: 1.84
Marker Score: 18253
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.83
Marker Score: 5056
Cell Name: naive B cell (CL0000788)
Fold Change: 1.82
Marker Score: 1626
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.81
Marker Score: 1249
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.81
Marker Score: 3786
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.79
Marker Score: 1091
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 1.79
Marker Score: 623.5
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.78
Marker Score: 1810
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.78
Marker Score: 1671
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.74
Marker Score: 2094.5
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.74
Marker Score: 1163
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.71
Marker Score: 10940
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.7
Marker Score: 7065
Cell Name: immature B cell (CL0000816)
Fold Change: 1.7
Marker Score: 1125
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.65
Marker Score: 1130
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.65
Marker Score: 379
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.64
Marker Score: 1570
Cell Name: macrophage (CL0000235)
Fold Change: 1.63
Marker Score: 1818
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.63
Marker Score: 2252
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.62
Marker Score: 5124
Cell Name: monocyte (CL0000576)
Fold Change: 1.62
Marker Score: 2111
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.62
Marker Score: 1568
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.61
Marker Score: 2558
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.59
Marker Score: 3619
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.57
Marker Score: 779
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.56
Marker Score: 587
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.56
Marker Score: 1310
Cell Name: microglial cell (CL0000129)
Fold Change: 1.55
Marker Score: 2817
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.55
Marker Score: 906
Cell Name: neutrophil (CL0000775)
Fold Change: 1.54
Marker Score: 938
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.54
Marker Score: 536
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.53
Marker Score: 1608
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 1.52
Marker Score: 525
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.52
Marker Score: 1421
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.52
Marker Score: 889
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.49
Marker Score: 15084.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.48
Marker Score: 7768
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.48
Marker Score: 1164
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.48
Marker Score: 9617
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.47
Marker Score: 1596
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.47
Marker Score: 4126.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.47
Marker Score: 4289
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.46
Marker Score: 4332
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.45
Marker Score: 1052
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.44
Marker Score: 5909
Cell Name: mural cell (CL0008034)
Fold Change: 1.44
Marker Score: 165417
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.44
Marker Score: 75910
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.43
Marker Score: 6150
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.43
Marker Score: 411
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 1.43
Marker Score: 1367
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.42
Marker Score: 431
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.42
Marker Score: 1071
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.41
Marker Score: 2771.5
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 1.4
Marker Score: 435
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4
Marker Score: 1395
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.4
Marker Score: 350
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.39
Marker Score: 948
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.38
Marker Score: 499
Cell Name: club cell (CL0000158)
Fold Change: 1.38
Marker Score: 1607
Cell Name: centroblast (CL0009112)
Fold Change: 1.38
Marker Score: 678
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.38
Marker Score: 1226.5
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.37
Marker Score: 625
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 1.36
Marker Score: 752
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.36
Marker Score: 296
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.36
Marker Score: 289
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.35
Marker Score: 390
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 1.35
Marker Score: 725

Hover over a box to see details here...

**Key characteristics:** * The CTSS gene is located on chromosome 19p13.1. * It is a member of the cathepsin family of cysteine proteases. * It is expressed in a variety of cell types, including monocyte, macrophage, and epithelial cells. **Pathways and functions:** * The CTSS protein is involved in the adaptive immune system, where it helps to process and present antigens to activate T cells. * It is also involved in the assembly of collagen fibrils and other multimeric structures. * It is involved in the regulation of inflammation and tissue remodeling. **Clinical significance:** * Mutations in the CTSS gene have been linked to several human diseases, including rheumatoid arthritis, osteoarthritis, and cancer. * Cathepsin S is a potential target for therapeutic intervention in these diseases. **Additional information:** * The CTSS gene is also known as CTSH, CASP, and SDF. * It is a highly conserved protein, with a similar sequence found in organisms from humans to flies. * The CTSS protein is a multi-functional enzyme that can be activated by a variety of stimuli, including calcium, zinc, and reactive oxygen species.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cathepsin S

Genular Protein ID: 3195240742

Symbol: CATS_HUMAN

Name: Cathepsin S

UniProtKB Accession Codes:

P25774 B4DWC9 D3DV05 Q5T5I0 Q6FHS5 Q9BUG3

Database IDs:

Citations:

PubMed ID: 1373132

Title: Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

PubMed ID: 1373132

DOI: 10.1016/s0021-9258(18)42513-6

PubMed ID: 1377692

Title: Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S.

PubMed ID: 1377692

DOI: 10.1016/s0021-9258(18)42271-5

PubMed ID: 8157683

Title: Human cathepsin S: chromosomal localization, gene structure, and tissue distribution.

PubMed ID: 8157683

DOI: 10.1016/s0021-9258(19)78156-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9524075

Title: Sorting of non-glycosylated human procathepsin S in mammalian cells.

PubMed ID: 9524075

DOI: 10.1515/bchm.1998.379.2.219

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30612035

Title: The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.

PubMed ID: 30612035

DOI: 10.1016/j.isci.2018.12.015

PubMed ID: 9876921

Title: Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics.

PubMed ID: 9876921

DOI: 10.1093/protein/11.11.1007

PubMed ID: 11856830

Title: Structure of a Cys25-->Ser mutant of human cathepsin S.

PubMed ID: 11856830

DOI: 10.1107/s0907444901021825

PubMed ID: 17469812

Title: Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.

PubMed ID: 17469812

DOI: 10.1021/jm070111+

Sequence Information:

Length: 331
Mass: 37496
Checksum: 86093619DB6F0269
Sequence:

MKRLVCVLLV CSSAVAQLHK DPTLDHHWHL WKKTYGKQYK EKNEEAVRRL IWEKNLKFVM 
LHNLEHSMGM HSYDLGMNHL GDMTSEEVMS LMSSLRVPSQ WQRNITYKSN PNRILPDSVD 
WREKGCVTEV KYQGSCGACW AFSAVGALEA QLKLKTGKLV SLSAQNLVDC STEKYGNKGC 
NGGFMTTAFQ YIIDNKGIDS DASYPYKAMD QKCQYDSKYR AATCSKYTEL PYGREDVLKE 
AVANKGPVSV GVDARHPSFF LYRSGVYYEP SCTQNVNHGV LVVGYGDLNG KEYWLVKNSW 
GHNFGEEGYI RMARNKGNHC GIASFPSYPE I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CTSS

Associated with

Cells (max top 100)

Other Information

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. PubMed ID: 1373132

Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. PubMed ID: 1377692

Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. PubMed ID: 8157683

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sorting of non-glycosylated human procathepsin S in mammalian cells. PubMed ID: 9524075

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. PubMed ID: 30612035

Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics. PubMed ID: 9876921

Structure of a Cys25--&gt;Ser mutant of human cathepsin S. PubMed ID: 11856830

Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode. PubMed ID: 17469812