CTSS | ENSG00000163131 | NCBI 1520

Details for: CTSS

Gene ID: 1520

Symbol: CTSS

Ensembl ID: ENSG00000163131

Description: cathepsin S

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Collagen formation
(R-HSA-1474290)
Degradation of the extracellular matrix
(R-HSA-1474228)
Endosomal/vacuolar pathway
(R-HSA-1236977)
Extracellular matrix organization
(R-HSA-1474244)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Mhc class ii antigen presentation
(R-HSA-2132295)
Neutrophil degranulation
(R-HSA-6798695)
Toll-like receptor cascades
(R-HSA-168898)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Adaptive immune response
(GO:0002250)
Antigen processing and presentation
(GO:0019882)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Antigen processing and presentation of peptide antigen
(GO:0048002)
Apoptotic process
(GO:0006915)
Basement membrane disassembly
(GO:0034769)
Cellular response to thyroid hormone stimulus
(GO:0097067)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cysteine-type endopeptidase activity
(GO:0004197)
Endolysosome lumen
(GO:0036021)
Extracellular matrix disassembly
(GO:0022617)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Ficolin-1-rich granule lumen
(GO:1904813)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Laminin binding
(GO:0043236)
Late endosome
(GO:0005770)
Lysosomal lumen
(GO:0043202)
Lysosome
(GO:0005764)
Phagocytic vesicle
(GO:0045335)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of cation channel activity
(GO:2001259)
Positive regulation of peptidase activity
(GO:0010952)
Protein processing
(GO:0016485)
Proteoglycan binding
(GO:0043394)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Response to acidic ph
(GO:0010447)
Serine-type endopeptidase activity
(GO:0004252)
Tertiary granule lumen
(GO:1904724)
Toll-like receptor signaling pathway
(GO:0002224)

Other Information

Proteins

Cathepsin S

Genular Protein ID: 3195240742

Symbol: CATS_HUMAN

Name: Cathepsin S

UniProtKB Accession Codes:

P25774 B4DWC9 D3DV05 Q5T5I0 Q6FHS5 Q9BUG3

Database IDs:

Citations:

PubMed ID: 1373132

Title: Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

PubMed ID: 1373132

DOI: 10.1016/s0021-9258(18)42513-6

PubMed ID: 1377692

Title: Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S.

PubMed ID: 1377692

DOI: 10.1016/s0021-9258(18)42271-5

PubMed ID: 8157683

Title: Human cathepsin S: chromosomal localization, gene structure, and tissue distribution.

PubMed ID: 8157683

DOI: 10.1016/s0021-9258(19)78156-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9524075

Title: Sorting of non-glycosylated human procathepsin S in mammalian cells.

PubMed ID: 9524075

DOI: 10.1515/bchm.1998.379.2.219

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30612035

Title: The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.

PubMed ID: 30612035

DOI: 10.1016/j.isci.2018.12.015

PubMed ID: 9876921

Title: Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics.

PubMed ID: 9876921

DOI: 10.1093/protein/11.11.1007

PubMed ID: 11856830

Title: Structure of a Cys25-->Ser mutant of human cathepsin S.

PubMed ID: 11856830

DOI: 10.1107/s0907444901021825

PubMed ID: 17469812

Title: Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.

PubMed ID: 17469812

DOI: 10.1021/jm070111+

Sequence Information:

Length: 331
Mass: 37496
Checksum: 86093619DB6F0269
Sequence:

MKRLVCVLLV CSSAVAQLHK DPTLDHHWHL WKKTYGKQYK EKNEEAVRRL IWEKNLKFVM 
LHNLEHSMGM HSYDLGMNHL GDMTSEEVMS LMSSLRVPSQ WQRNITYKSN PNRILPDSVD 
WREKGCVTEV KYQGSCGACW AFSAVGALEA QLKLKTGKLV SLSAQNLVDC STEKYGNKGC 
NGGFMTTAFQ YIIDNKGIDS DASYPYKAMD QKCQYDSKYR AATCSKYTEL PYGREDVLKE 
AVANKGPVSV GVDARHPSFF LYRSGVYYEP SCTQNVNHGV LVVGYGDLNG KEYWLVKNSW 
GHNFGEEGYI RMARNKGNHC GIASFPSYPE I

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CTSS

Associated with

Other Information

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. PubMed ID: 1373132

Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. PubMed ID: 1377692

Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. PubMed ID: 8157683

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sorting of non-glycosylated human procathepsin S in mammalian cells. PubMed ID: 9524075

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. PubMed ID: 30612035

Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics. PubMed ID: 9876921

Structure of a Cys25--&gt;Ser mutant of human cathepsin S. PubMed ID: 11856830

Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode. PubMed ID: 17469812